| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X Wang, Y Zhang, B H Jiang, Q Zhang, R P Zhou, L Zhang, Chen Wan. Study on the role of Hsa-miR-31-5p in hypertrophic scar formation and the mechanism. Experimental cell research. vol 361. issue 2. 2017-11-29. PMID:29056521. |
hypertrophic scar (hs) formation is associated with the fibrosis of fibrocytes caused by excessive extracellular matrix (ecm) synthesis and deposition, the initial event of hs formation. |
2017-11-29 |
2023-08-13 |
Not clear |
| X Wang, Y Zhang, B H Jiang, Q Zhang, R P Zhou, L Zhang, Chen Wan. Study on the role of Hsa-miR-31-5p in hypertrophic scar formation and the mechanism. Experimental cell research. vol 361. issue 2. 2017-11-29. PMID:29056521. |
in-vitro functional experiments showed hsa-mir31-5p knockdown remarkably suppressed the proliferation of hypertrophic scar fibroblasts (hsfbs) under hypoxia, promoted cell invasion, and inhibited the expression of collagen i and iii and fibronectin (fn), suggesting that hsa-mir31-5p knockdown effectively reduces hs formation caused by excessive ecm synthesis and deposition in hsfbs under hypoxia. |
2017-11-29 |
2023-08-13 |
Not clear |
| Cecelia C Yates, Austin Nuschke, Melanie Rodrigues, Diana Whaley, Jason J Dechant, Donald P Taylor, Alan Well. Improved Transplanted Stem Cell Survival in a Polymer Gel Supplemented With Tenascin C Accelerates Healing and Reduces Scarring of Murine Skin Wounds. Cell transplantation. vol 26. issue 1. 2017-11-27. PMID:27452449. |
this was most marked in a model of hypertrophic scarring, in which the scar formation was limited. |
2017-11-27 |
2023-08-13 |
mouse |
| Yan Li, Wei Zhang, Jianxin Gao, Jiaqi Liu, Hongtao Wang, Jun Li, Xuekang Yang, Ting He, Hao Guan, Zhao Zheng, Shichao Han, Maolong Dong, Juntao Han, Jihong Shi, Dahai H. Adipose tissue-derived stem cells suppress hypertrophic scar fibrosis via the p38/MAPK signaling pathway. Stem cell research & therapy. vol 7. issue 1. 2017-11-13. PMID:27484727. |
adipose tissue-derived stem cells suppress hypertrophic scar fibrosis via the p38/mapk signaling pathway. |
2017-11-13 |
2023-08-13 |
Not clear |
| Ling Chen, Jingyun Li, Qian Li, Hui Yan, Bei Zhou, Yanli Gao, Jun L. Non-Coding RNAs: The New Insight on Hypertrophic Scar. Journal of cellular biochemistry. vol 118. issue 8. 2017-11-02. PMID:28067426. |
non-coding rnas: the new insight on hypertrophic scar. |
2017-11-02 |
2023-08-13 |
Not clear |
| Xiao Liang, Bangda Chai, Ran Duan, Yiwen Zhou, Xiaolu Huang, Qingfeng L. Inhibition of FKBP10 Attenuates Hypertrophic Scarring through Suppressing Fibroblast Activity and Extracellular Matrix Deposition. The Journal of investigative dermatology. vol 137. issue 11. 2017-11-02. PMID:28774593. |
hypertrophic scar is a pathogenic form of scar formation with no recognized treatment to date. |
2017-11-02 |
2023-08-13 |
mouse |
| Xiao Liang, Bangda Chai, Ran Duan, Yiwen Zhou, Xiaolu Huang, Qingfeng L. Inhibition of FKBP10 Attenuates Hypertrophic Scarring through Suppressing Fibroblast Activity and Extracellular Matrix Deposition. The Journal of investigative dermatology. vol 137. issue 11. 2017-11-02. PMID:28774593. |
then we evaluated hypertrophic scar formation in mouse models treated with fkbp10 small interfering rna and found that knockdown of fkbp10 could attenuate hypertrophic scar formation in vivo. |
2017-11-02 |
2023-08-13 |
mouse |
| Xiao Liang, Bangda Chai, Ran Duan, Yiwen Zhou, Xiaolu Huang, Qingfeng L. Inhibition of FKBP10 Attenuates Hypertrophic Scarring through Suppressing Fibroblast Activity and Extracellular Matrix Deposition. The Journal of investigative dermatology. vol 137. issue 11. 2017-11-02. PMID:28774593. |
to further explore the underlying mechanism, fkbp10 was knocked down in human hypertrophic scar fibroblasts. |
2017-11-02 |
2023-08-13 |
mouse |
| Xiao Liang, Bangda Chai, Ran Duan, Yiwen Zhou, Xiaolu Huang, Qingfeng L. Inhibition of FKBP10 Attenuates Hypertrophic Scarring through Suppressing Fibroblast Activity and Extracellular Matrix Deposition. The Journal of investigative dermatology. vol 137. issue 11. 2017-11-02. PMID:28774593. |
in conclusion, fkbp10 plays a crucial role in hypertrophic scar formation and might be a therapeutic target for hypertrophic scars. |
2017-11-02 |
2023-08-13 |
mouse |
| E Papathanasiou, C A Trotman, A R Scott, T E Van Dyk. Current and Emerging Treatments for Postsurgical Cleft Lip Scarring: Effectiveness and Mechanisms. Journal of dental research. vol 96. issue 12. 2017-11-01. PMID:28650705. |
hypertrophic scar (hts) formation is a frequent postoperative complication that impairs soft tissue form, function, or movement. |
2017-11-01 |
2023-08-13 |
Not clear |
| Talha Ijaz, Mohammad Jamaluddin, Yingxin Zhao, Yueqing Zhang, Jayson Jay, Celeste C Finnerty, David N Herndon, Ronald G Tilton, Allan R Brasie. Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation. Cell death & disease. vol 8. issue 2. 2017-10-31. PMID:28182006. |
our data indicate that brd4 and cdk9 have independent, coordinated roles in promoting the myofibroblast transition and suggest that inhibition of the smad3-brd4 pathway may be a useful strategy to limit hypertrophic scar formation after burn injury. |
2017-10-31 |
2023-08-13 |
human |
| Sarah Lonie, Paul Baker, Rodrigo P Teixeir. Healing time and incidence of hypertrophic scarring in paediatric scalds. Burns : journal of the International Society for Burn Injuries. vol 43. issue 3. 2017-10-23. PMID:27707637. |
scald burns, which heal in less than 14 days, are seen to be at low risk of hypertrophic scar (hts) formation. |
2017-10-23 |
2023-08-13 |
Not clear |
| Xiao-Zhi Bai, Jia-Qi Liu, Long-Long Yang, Lei Fan, Ting He, Lin-Lin Su, Ji-Hong Shi, Chao-Wu Tang, Zhao Zheng, Da-Hai H. Identification of sirtuin 1 as a promising therapeutic target for hypertrophic scars. British journal of pharmacology. vol 173. issue 10. 2017-10-17. PMID:26891034. |
however, whether it is an effective drug target in hypertrophic scar treatment is still not known. |
2017-10-17 |
2023-08-13 |
Not clear |
| Shayna Lee Gordon, Eva A Hurs. Adjuncts to Improve Nasal Reconstruction Results. Facial plastic surgery : FPS. vol 33. issue 1. 2017-10-13. PMID:28226374. |
abnormal fibroblast response can lead to hypertrophic nasal scars, and excessive angiogenesis may lead to telangiectasias or an erythematous scar. |
2017-10-13 |
2023-08-13 |
Not clear |
| Tong Han, De-Feng Lin, Hua Jian. Wound natural healing in treatment of tumor-like hypertrophic scar. Anais brasileiros de dermatologia. vol 92. issue 4. 2017-10-10. PMID:28954094. |
wound natural healing in treatment of tumor-like hypertrophic scar. |
2017-10-10 |
2023-08-13 |
Not clear |
| Fariha Shafi, Deepa Rathore, Andria Johnson, Purnima Mehta, Harpreet S Ahluwali. Medial canthal defects following tumour excision: To reconstruct or not to reconstruct? Orbit (Amsterdam, Netherlands). vol 36. issue 2. 2017-10-06. PMID:28267391. |
review of clinical photographs showed epicanthic fold in 2 patients and visible scar in 1 patient in the lfs group and 3 cases of hypopigmented scar and 7 hypertrophic scars in the ftsg group. |
2017-10-06 |
2023-08-13 |
Not clear |
| Kyoichiro Yazaki, Yoichi Ajiro, Fumiaki Mori, Masahiro Watanabe, Kei Tsukamoto, Takashi Saito, Keiko Mizobuchi, Kazunori Iwad. Multiple focal and macroreentrant left atrial tachycardias originating from a spontaneous scar at the contiguous aorta-left atrium area in a patient with hypertrophic cardiomyopathy: a case report. BMC cardiovascular disorders. vol 17. issue 1. 2017-10-03. PMID:28095774. |
multiple focal and macroreentrant left atrial tachycardias originating from a spontaneous scar at the contiguous aorta-left atrium area in a patient with hypertrophic cardiomyopathy: a case report. |
2017-10-03 |
2023-08-13 |
Not clear |
| Kyoichiro Yazaki, Yoichi Ajiro, Fumiaki Mori, Masahiro Watanabe, Kei Tsukamoto, Takashi Saito, Keiko Mizobuchi, Kazunori Iwad. Multiple focal and macroreentrant left atrial tachycardias originating from a spontaneous scar at the contiguous aorta-left atrium area in a patient with hypertrophic cardiomyopathy: a case report. BMC cardiovascular disorders. vol 17. issue 1. 2017-10-03. PMID:28095774. |
we describe a patient with hypertrophic cardiomyopathy (hcm) who developed multiple, both focal and macroreentrant left ats associated with a spontaneous scar located at the aorta-left atrium (la) contiguous area. |
2017-10-03 |
2023-08-13 |
Not clear |
| Reyna I Martinez-De Luna, Ray Y Ku, Alexandria M Aruck, Francesca Santiago, Andrea S Viczian, Diego San Mauro, Michael E Zube. Müller glia reactivity follows retinal injury despite the absence of the glial fibrillary acidic protein gene in Xenopus. Developmental biology. vol 426. issue 2. 2017-09-22. PMID:26996101. |
in the retina, gfap levels are dramatically increased in müller glia and are thought to play a role in the extensive structural changes resulting in müller cell hypertrophy and glial scar formation. |
2017-09-22 |
2023-08-13 |
xenopus_laevis |
| Zhihui Yao, Haisheng Li, Weifeng He, Sisi Yang, Xiaorong Zhang, Rixing Zhan, Rui Xu, Jianglin Tan, Junyi Zhou, Jun Wu, Gaoxing Lu. P311 Accelerates Skin Wound Reepithelialization by Promoting Epidermal Stem Cell Migration Through RhoA and Rac1 Activation. Stem cells and development. vol 26. issue 6. 2017-09-18. PMID:27927130. |
p311 is a newly discovered functional gene, and it has been proved to play a key role in blood pressure homeostasis, glioblastoma invasion, renal fibrosis, hypertrophic scar formation, and others. |
2017-09-18 |
2023-08-13 |
mouse |