| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shengzhou Shan, Yifan Zhang, Min Wu, Bo Yi, Jing Wang, Qingfeng L. Naringenin attenuates fibroblast activation and inflammatory response in a mechanical stretch-induced hypertrophic scar mouse model. Molecular medicine reports. vol 16. issue 4. 2018-05-21. PMID:28849050. |
histological studies were performed to evaluate scar hypertrophy by hematoxylin and eosin, as well as masson's trichrome staining. |
2018-05-21 |
2023-08-13 |
mouse |
| Chong Shen, Lifang Jiang, Huawei Shao, Chuangang You, Guoliang Zhang, Sitong Ding, Tingwei Bian, Chunmao Han, Qin Men. Targeted killing of myofibroblasts by biosurfactant di-rhamnolipid suggests a therapy against scar formation. Scientific reports. vol 6. 2018-05-17. PMID:27901027. |
the anti-fibrotic function of di-rhamnolipid was further verified in rabbit ear hypertrophic scar models by presenting the significant reduction of scar elevation index, type i collagen fibers and α-sma expression. |
2018-05-17 |
2023-08-13 |
rabbit |
| Zhe Wang, Qibin Song, Hongqiu L. Suppressive effects of human fetal keratinocytes on the proliferation, differentiation and extracellular matrix synthesis of human hypertrophic scar fibroblasts in vitro. Molecular medicine reports. vol 16. issue 4. 2018-05-11. PMID:28849177. |
suppressive effects of human fetal keratinocytes on the proliferation, differentiation and extracellular matrix synthesis of human hypertrophic scar fibroblasts in vitro. |
2018-05-11 |
2023-08-13 |
human |
| Zhe Wang, Qibin Song, Hongqiu L. Suppressive effects of human fetal keratinocytes on the proliferation, differentiation and extracellular matrix synthesis of human hypertrophic scar fibroblasts in vitro. Molecular medicine reports. vol 16. issue 4. 2018-05-11. PMID:28849177. |
a hypertrophic scar is characterized by fibroblast proliferation and excessive extracellular matrix deposition. |
2018-05-11 |
2023-08-13 |
human |
| Zhe Wang, Qibin Song, Hongqiu L. Suppressive effects of human fetal keratinocytes on the proliferation, differentiation and extracellular matrix synthesis of human hypertrophic scar fibroblasts in vitro. Molecular medicine reports. vol 16. issue 4. 2018-05-11. PMID:28849177. |
in the present study, human kcs of different gestational ages were isolated and co‑cultured with human hypertrophic scar fibroblasts (hsfbs) or normal skin fibroblasts. |
2018-05-11 |
2023-08-13 |
human |
| Qun Xie, Dandan Liu, Mosheng Yu, Xiaowei Wu, Yueqiang Zhao, Qiang Hu, Qi Wan. Homeobox B9 facilitates hypertrophic scar formation via activating the mitogen-activated protein kinase signaling pathway. Molecular medicine reports. vol 16. issue 2. 2018-05-04. PMID:28656236. |
homeobox b9 facilitates hypertrophic scar formation via activating the mitogen-activated protein kinase signaling pathway. |
2018-05-04 |
2023-08-13 |
Not clear |
| Qun Xie, Dandan Liu, Mosheng Yu, Xiaowei Wu, Yueqiang Zhao, Qiang Hu, Qi Wan. Homeobox B9 facilitates hypertrophic scar formation via activating the mitogen-activated protein kinase signaling pathway. Molecular medicine reports. vol 16. issue 2. 2018-05-04. PMID:28656236. |
the functions and underlying mechanisms of homeobox b9 (hoxb9) in scar formation remain unclear; therefore, the present study aimed to investigate whether hoxb9 is highly expressed in hypertrophic scar formation. |
2018-05-04 |
2023-08-13 |
Not clear |
| Qun Xie, Dandan Liu, Mosheng Yu, Xiaowei Wu, Yueqiang Zhao, Qiang Hu, Qi Wan. Homeobox B9 facilitates hypertrophic scar formation via activating the mitogen-activated protein kinase signaling pathway. Molecular medicine reports. vol 16. issue 2. 2018-05-04. PMID:28656236. |
immunohistochemistry was performed to examine the expression levels of laminin, fibronectin (fn), collagen type i (col1) and hoxb9 in hypertrophic scar and healthy skin tissues, and in lentivirus‑constructed hoxb9‑overexpressed or ‑silenced fibroblasts (fbs). |
2018-05-04 |
2023-08-13 |
Not clear |
| Qun Xie, Dandan Liu, Mosheng Yu, Xiaowei Wu, Yueqiang Zhao, Qiang Hu, Qi Wan. Homeobox B9 facilitates hypertrophic scar formation via activating the mitogen-activated protein kinase signaling pathway. Molecular medicine reports. vol 16. issue 2. 2018-05-04. PMID:28656236. |
it was demonstrated that hoxb9, laminin, fn and col1 were upregulated in hypertrophic scar tissues, and hoxb9 upregulated laminin, fn, col1, p‑erk, p‑jnk and p38, potentially by interacting directly with p38. |
2018-05-04 |
2023-08-13 |
Not clear |
| Qun Xie, Dandan Liu, Mosheng Yu, Xiaowei Wu, Yueqiang Zhao, Qiang Hu, Qi Wan. Homeobox B9 facilitates hypertrophic scar formation via activating the mitogen-activated protein kinase signaling pathway. Molecular medicine reports. vol 16. issue 2. 2018-05-04. PMID:28656236. |
in conclusion, the present study demonstrated that hoxb9 may facilitate hypertrophic scar formation via activating the mitogen‑activated protein kinase signaling pathway. |
2018-05-04 |
2023-08-13 |
Not clear |
| Jie Ding, Edward E Tredge. Transplanting Human Skin Grafts onto Nude Mice to Model Skin Scars. Methods in molecular biology (Clifton, N.J.). vol 1627. 2018-05-03. PMID:28836195. |
hypertrophic scar (hts) is a common outcome of deep dermal wound healing mainly followed mechanical, chemical, and thermal injuries in the skin. |
2018-05-03 |
2023-08-13 |
mouse |
| Layla Nabai, Aziz Ghahar. Hypertrophic Scarring in the Rabbit Ear: A Practical Model for Studying Dermal Fibrosis. Methods in molecular biology (Clifton, N.J.). vol 1627. 2018-05-03. PMID:28836196. |
excessive fibrous tissue deposition after injury in the form of hypertrophic scar remains a major clinical challenge. |
2018-05-03 |
2023-08-13 |
human |
| Layla Nabai, Aziz Ghahar. Hypertrophic Scarring in the Rabbit Ear: A Practical Model for Studying Dermal Fibrosis. Methods in molecular biology (Clifton, N.J.). vol 1627. 2018-05-03. PMID:28836196. |
here, we describe the rabbit ear model for excessive dermal scarring which has some clinical and histological resemblance to human hypertrophic scar. |
2018-05-03 |
2023-08-13 |
human |
| Katherine Marie Huber, Alicia Rose Billington, Loryn J Taylor, Kimberly Brown Maynell, C Wayne Crus. Nonoperative Treatment of a Tracheocutaneous Fistula in a Burn Patient. Journal of burn care & research : official publication of the American Burn Association. vol 38. issue 4. 2018-04-30. PMID:27893570. |
a 65-year-old woman presented with symptomatic hypertrophic burn scar contractures of the anterior neck 6 months after undergoing excision and grafting of full-thickness burns to the neck and chest. |
2018-04-30 |
2023-08-13 |
Not clear |
| Katherine Marie Huber, Alicia Rose Billington, Loryn J Taylor, Kimberly Brown Maynell, C Wayne Crus. Nonoperative Treatment of a Tracheocutaneous Fistula in a Burn Patient. Journal of burn care & research : official publication of the American Burn Association. vol 38. issue 4. 2018-04-30. PMID:27893570. |
she subsequently underwent excision of hypertrophic burn scar contractures of the neck with placement of bilayer wound matrix followed by split-thickness skin grafting. |
2018-04-30 |
2023-08-13 |
Not clear |
| Hanneke N Monsuur, Lenie J van den Broek, Renushka L Jhingoerie, Adrianus F P M Vloemans, Susan Gibb. Burn Eschar Stimulates Fibroblast and Adipose Mesenchymal Stromal Cell Proliferation and Migration but Inhibits Endothelial Cell Sprouting. International journal of molecular sciences. vol 18. issue 8. 2018-04-30. PMID:28820426. |
the majority of full-thickness burn wounds heal with hypertrophic scar formation. |
2018-04-30 |
2023-08-13 |
Not clear |
| Hanneke N Monsuur, Lenie J van den Broek, Renushka L Jhingoerie, Adrianus F P M Vloemans, Susan Gibb. Burn Eschar Stimulates Fibroblast and Adipose Mesenchymal Stromal Cell Proliferation and Migration but Inhibits Endothelial Cell Sprouting. International journal of molecular sciences. vol 18. issue 8. 2018-04-30. PMID:28820426. |
identifying the eschar factors responsible for this might give indications for therapeutic targets aimed at reducing hypertrophic scar formation which is initiated by excessive granulation tissue formation once eschar is removed. |
2018-04-30 |
2023-08-13 |
Not clear |
| Paul Diegidio, Steven Hermiz, Jonathan Hibbard, Michael Kosorok, Charles Scott Hultma. Hypertrophic Burn Scar Research: From Quantitative Assessment to Designing Clinical Sequential Multiple Assignment Randomized Trials. Clinics in plastic surgery. vol 44. issue 4. 2018-04-16. PMID:28888317. |
hypertrophic burn scar research: from quantitative assessment to designing clinical sequential multiple assignment randomized trials. |
2018-04-16 |
2023-08-13 |
human |
| Linlin Su, Xiaodong Li, Xue Wu, Bo Hui, Shichao Han, Jianxin Gao, Yan Li, Jihong Shi, Huayu Zhu, Bin Zhao, Dahai H. Simultaneous deactivation of FAK and Src improves the pathology of hypertrophic scar. Scientific reports. vol 6. 2018-04-12. PMID:27181267. |
simultaneous deactivation of fak and src improves the pathology of hypertrophic scar. |
2018-04-12 |
2023-08-13 |
Not clear |
| Linlin Su, Xiaodong Li, Xue Wu, Bo Hui, Shichao Han, Jianxin Gao, Yan Li, Jihong Shi, Huayu Zhu, Bin Zhao, Dahai H. Simultaneous deactivation of FAK and Src improves the pathology of hypertrophic scar. Scientific reports. vol 6. 2018-04-12. PMID:27181267. |
hypertrophic scar (hs) is a serious fibrotic skin condition with currently no satisfactory therapy due to undefined molecular mechanism. |
2018-04-12 |
2023-08-13 |
Not clear |