| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kun Ma, Sun Hyung Kwon, Jagannath Padmanabhan, Dominik Duscher, Artem A Trotsyuk, Yixiao Dong, Mohammed Inayathullah, Jayakumar Rajadas, Geoffrey C Gurtne. Controlled Delivery of a Focal Adhesion Kinase Inhibitor Results in Accelerated Wound Closure with Decreased Scar Formation. The Journal of investigative dermatology. vol 138. issue 11. 2019-09-13. PMID:29775632. |
we have previously shown that inhibition of fak using local injections of a small molecule fak inhibitor (faki) can attenuate scar development in a hypertrophic scar model. |
2019-09-13 |
2023-08-13 |
mouse |
| Jingling Zhao, Jianxing Yu, Yingbin Xu, Lei Chen, Fei Zhou, Qiyi Zhai, Jun Wu, Bin Shu, Shaohai Q. Epidermal HMGB1 Activates Dermal Fibroblasts and Causes Hypertrophic Scar Formation in Reduced Hydration. The Journal of investigative dermatology. vol 138. issue 11. 2019-09-13. PMID:29787749. |
epidermal hmgb1 activates dermal fibroblasts and causes hypertrophic scar formation in reduced hydration. |
2019-09-13 |
2023-08-13 |
rabbit |
| Jingling Zhao, Jianxing Yu, Yingbin Xu, Lei Chen, Fei Zhou, Qiyi Zhai, Jun Wu, Bin Shu, Shaohai Q. Epidermal HMGB1 Activates Dermal Fibroblasts and Causes Hypertrophic Scar Formation in Reduced Hydration. The Journal of investigative dermatology. vol 138. issue 11. 2019-09-13. PMID:29787749. |
however, the function of hmgb1 in fibrotic skin diseases, such as hypertrophic scar formation, remains unclear. |
2019-09-13 |
2023-08-13 |
rabbit |
| Jingling Zhao, Jianxing Yu, Yingbin Xu, Lei Chen, Fei Zhou, Qiyi Zhai, Jun Wu, Bin Shu, Shaohai Q. Epidermal HMGB1 Activates Dermal Fibroblasts and Causes Hypertrophic Scar Formation in Reduced Hydration. The Journal of investigative dermatology. vol 138. issue 11. 2019-09-13. PMID:29787749. |
finally, local delivery of hmgb1 resulted in marked hypertrophic scar formation in rabbit hypertrophic scar models, while hmgb1 blockade exerted a clear anti-scarring effect. |
2019-09-13 |
2023-08-13 |
rabbit |
| Jingling Zhao, Jianxing Yu, Yingbin Xu, Lei Chen, Fei Zhou, Qiyi Zhai, Jun Wu, Bin Shu, Shaohai Q. Epidermal HMGB1 Activates Dermal Fibroblasts and Causes Hypertrophic Scar Formation in Reduced Hydration. The Journal of investigative dermatology. vol 138. issue 11. 2019-09-13. PMID:29787749. |
our results indicate that high hmgb1 levels induced by a reduced hydration status play an important role in hypertrophic scar formation, strongly suggesting that hmgb1 is a novel target for preventing scarring. |
2019-09-13 |
2023-08-13 |
rabbit |
| Yue-Hua Li, Jiaomei Yang, Jia-Qi Liu, Song-Tao Xie, Yi-Jie Zhang, Wei Zhang, Ju-Lei Zhang, Zhao Zheng, Da-Hai H. A Randomized, Placebo-Controlled, Double-Blind, Prospective Clinical Trial of Botulinum Toxin Type A in Prevention of Hypertrophic Scar Development in Median Sternotomy Wound. Aesthetic plastic surgery. vol 42. issue 5. 2019-09-12. PMID:30019241. |
a randomized, placebo-controlled, double-blind, prospective clinical trial of botulinum toxin type a in prevention of hypertrophic scar development in median sternotomy wound. |
2019-09-12 |
2023-08-13 |
Not clear |
| Yue-Hua Li, Jiaomei Yang, Jia-Qi Liu, Song-Tao Xie, Yi-Jie Zhang, Wei Zhang, Ju-Lei Zhang, Zhao Zheng, Da-Hai H. A Randomized, Placebo-Controlled, Double-Blind, Prospective Clinical Trial of Botulinum Toxin Type A in Prevention of Hypertrophic Scar Development in Median Sternotomy Wound. Aesthetic plastic surgery. vol 42. issue 5. 2019-09-12. PMID:30019241. |
linear hypertrophic scar is a common surgical problem that can be difficult to manage, especially for the median sternotomy scar. |
2019-09-12 |
2023-08-13 |
Not clear |
| Minglei Bi, Pengfei Sun, Danyi Li, Zheng Dong, Zhenyu Che. Intralesional Injection of Botulinum Toxin Type A Compared with Intralesional Injection of Corticosteroid for the Treatment of Hypertrophic Scar and Keloid: A Systematic Review and Meta-Analysis. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-10. PMID:31006769. |
intralesional injection of botulinum toxin type a compared with intralesional injection of corticosteroid for the treatment of hypertrophic scar and keloid: a systematic review and meta-analysis. |
2019-09-10 |
2023-08-13 |
human |
| Minglei Bi, Pengfei Sun, Danyi Li, Zheng Dong, Zhenyu Che. Intralesional Injection of Botulinum Toxin Type A Compared with Intralesional Injection of Corticosteroid for the Treatment of Hypertrophic Scar and Keloid: A Systematic Review and Meta-Analysis. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-10. PMID:31006769. |
background the optimal treatment for hypertrophic scar and keloid remains controversial. |
2019-09-10 |
2023-08-13 |
human |
| Minglei Bi, Pengfei Sun, Danyi Li, Zheng Dong, Zhenyu Che. Intralesional Injection of Botulinum Toxin Type A Compared with Intralesional Injection of Corticosteroid for the Treatment of Hypertrophic Scar and Keloid: A Systematic Review and Meta-Analysis. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-10. PMID:31006769. |
therefore, the aim of this systematic review and meta-analysis was to compare the effectiveness of intralesional injection of botulinum toxin type a compared with placebo and intralesional injection of corticosteroid compared with placebo in patients with hypertrophic scar and keloid. |
2019-09-10 |
2023-08-13 |
human |
| Minglei Bi, Pengfei Sun, Danyi Li, Zheng Dong, Zhenyu Che. Intralesional Injection of Botulinum Toxin Type A Compared with Intralesional Injection of Corticosteroid for the Treatment of Hypertrophic Scar and Keloid: A Systematic Review and Meta-Analysis. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-10. PMID:31006769. |
randomized controlled trials (rcts) and prospective controlled trials (pcts) were identified that compared intralesional injection of botulinum toxin type a with placebo and corticosteroid with placebo in hypertrophic scar and keloid. |
2019-09-10 |
2023-08-13 |
human |
| Minglei Bi, Pengfei Sun, Danyi Li, Zheng Dong, Zhenyu Che. Intralesional Injection of Botulinum Toxin Type A Compared with Intralesional Injection of Corticosteroid for the Treatment of Hypertrophic Scar and Keloid: A Systematic Review and Meta-Analysis. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-10. PMID:31006769. |
conclusions systematic review and meta-analysis showed that injection of intralesional botulinum toxin type a was more effective in the treatment of hypertrophic scar and keloid than injection of intralesional corticosteroid or placebo. |
2019-09-10 |
2023-08-13 |
human |
| Chen Fan, Lay Keng Priscilla Lim, See Qi Loh, Kimberley Ying Ying Lim, Zee Upton, David Leavesle. Application of "macromolecular crowding" in vitro to investigate the naphthoquinones shikonin, naphthazarin and related analogues for the treatment of dermal scars. Chemico-biological interactions. vol 310. 2019-09-09. PMID:31301289. |
this optimised in vitro model has been found to hold similar properties, such as increased collagen i, interleukins and transforming growth factor beta-1 expression, compared to that observed in hypertrophic scar tissue in vivo. |
2019-09-09 |
2023-08-13 |
human |
| Chen Fan, Lay Keng Priscilla Lim, See Qi Loh, Kimberley Ying Ying Lim, Zee Upton, David Leavesle. Application of "macromolecular crowding" in vitro to investigate the naphthoquinones shikonin, naphthazarin and related analogues for the treatment of dermal scars. Chemico-biological interactions. vol 310. 2019-09-09. PMID:31301289. |
in addition, shikonin has been previously demonstrated to hold potential as a novel hypertrophic scar treatment due to its apoptosis-inducing property on hypertrophic scar fibroblasts. |
2019-09-09 |
2023-08-13 |
human |
| Chen Fan, Lay Keng Priscilla Lim, See Qi Loh, Kimberley Ying Ying Lim, Zee Upton, David Leavesle. Application of "macromolecular crowding" in vitro to investigate the naphthoquinones shikonin, naphthazarin and related analogues for the treatment of dermal scars. Chemico-biological interactions. vol 310. 2019-09-09. PMID:31301289. |
the data generated from the study offers a novel in vitro collagen-rich model of hypertrophic scar tissue. |
2019-09-09 |
2023-08-13 |
human |
| Rongrong Zhang, Yanping Wu, Fei Xie, Yiliang Zhong, Yu Wang, Mengxue Xu, Jinzhou Feng, Jason Charish, Philippe P Monnier, Xinyue Qi. RGMa mediates reactive astrogliosis and glial scar formation through TGFβ1/Smad2/3 signaling after stroke. Cell death and differentiation. vol 25. issue 8. 2019-09-09. PMID:29396549. |
knockdown of rgma abrogated key steps of reactive astrogliosis and glial scar formation induced by tgfβ1, including cellular hypertrophy, glial fibrillary acidic protein upregulation, cell migration, and cspgs secretion. |
2019-09-09 |
2023-08-13 |
rat |
| Xiaolu Ye, Zhiying Pang, Ningwen Zh. Dihydromyricetin attenuates hypertrophic scar formation by targeting activin receptor-like kinase 5. European journal of pharmacology. vol 852. 2019-09-03. PMID:30807748. |
dihydromyricetin attenuates hypertrophic scar formation by targeting activin receptor-like kinase 5. |
2019-09-03 |
2023-08-13 |
mouse |
| Xiaolu Ye, Zhiying Pang, Ningwen Zh. Dihydromyricetin attenuates hypertrophic scar formation by targeting activin receptor-like kinase 5. European journal of pharmacology. vol 852. 2019-09-03. PMID:30807748. |
hypertrophic scar (hps) is a manifestation of abnormal tissue repair, representing excessive extracellular matrix production and abnormal function of fibroblasts, for which no satisfactory treatment is available at present. |
2019-09-03 |
2023-08-13 |
mouse |
| Yingying Shi, Luping Wang, Pijun Yu, Yi Liu, Wei Che. MicroRNA‑486‑5p inhibits the growth of human hypertrophic scar fibroblasts by regulating Smad2 expression. Molecular medicine reports. vol 19. issue 6. 2019-09-03. PMID:31059039. |
microrna‑486‑5p inhibits the growth of human hypertrophic scar fibroblasts by regulating smad2 expression. |
2019-09-03 |
2023-08-13 |
human |
| Yingying Shi, Luping Wang, Pijun Yu, Yi Liu, Wei Che. MicroRNA‑486‑5p inhibits the growth of human hypertrophic scar fibroblasts by regulating Smad2 expression. Molecular medicine reports. vol 19. issue 6. 2019-09-03. PMID:31059039. |
the aim of the current study was to investigate the expression and role of microrna‑486‑5p (mir‑486‑5p) in hypertrophic scar (hs) formation, and to examine the associated mechanisms. |
2019-09-03 |
2023-08-13 |
human |