| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Si-Yi Guo, Gui-Tian Chen, Jun Shi, Yan-Ting Wu, Jian-Hui Lai, Xiao-Qi X. [Study on physicochemical properties of paeonol-Helix aspersa muller nanogel and its inhibitory effects on hypertrophic scar tissue in rabbit ear]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 22. 2020-01-10. PMID:31872593. |
the hypertrophic scar model in rabbit ears was established,and the new zealand rabbits were randomly divided into blank group,model group,positive drug group,pae-gels group and pae-ham-gels group. |
2020-01-10 |
2023-08-13 |
mouse |
| Si-Yi Guo, Gui-Tian Chen, Jun Shi, Yan-Ting Wu, Jian-Hui Lai, Xiao-Qi X. [Study on physicochemical properties of paeonol-Helix aspersa muller nanogel and its inhibitory effects on hypertrophic scar tissue in rabbit ear]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 22. 2020-01-10. PMID:31872593. |
masson staining showed that as compared with the model group,the number of collagen fibers and muscle fibers was small and the arrangement was loose and tidy in the pae-ham-gels group,with regular arrangement of chondrocytes and a small number of inflammatory cells and microvessels.pae-ham-gels have good transdermal properties and dermal retention without skin irritation,offering a promising therapeutic strategy for transdermal delivery during the prevention and treatment of hypertrophic scar in rabbit ears. |
2020-01-10 |
2023-08-13 |
mouse |
| Yiqun Zhou, Wancheng Wang, Tianyi Li. Harvest of Costal Cartilage Through Periareolar Incision for Rhinoplasty in Mastopexy. The Journal of craniofacial surgery. vol 30. issue 8. 2020-01-08. PMID:31232993. |
this technique has several advantages compared to the traditional method, including less invasion, minimal chance of a hypertrophic scar and easier postoperative care. |
2020-01-08 |
2023-08-13 |
Not clear |
| Ting He, Yue Zhang, Yang Liu, Hongtao Wang, Wanfu Zhang, Jiaqi Liu, Na Li, Yan Li, Luxu Wang, Songtao Xie, Dahai H. MicroRNA-494 targets PTEN and suppresses PI3K/AKT pathway to alleviate hypertrophic scar formation. Journal of molecular histology. vol 50. issue 4. 2020-01-06. PMID:31069607. |
microrna-494 targets pten and suppresses pi3k/akt pathway to alleviate hypertrophic scar formation. |
2020-01-06 |
2023-08-13 |
mouse |
| Ting He, Yue Zhang, Yang Liu, Hongtao Wang, Wanfu Zhang, Jiaqi Liu, Na Li, Yan Li, Luxu Wang, Songtao Xie, Dahai H. MicroRNA-494 targets PTEN and suppresses PI3K/AKT pathway to alleviate hypertrophic scar formation. Journal of molecular histology. vol 50. issue 4. 2020-01-06. PMID:31069607. |
hypertrophic scar is a common complication after skin injury. |
2020-01-06 |
2023-08-13 |
mouse |
| Ting He, Yue Zhang, Yang Liu, Hongtao Wang, Wanfu Zhang, Jiaqi Liu, Na Li, Yan Li, Luxu Wang, Songtao Xie, Dahai H. MicroRNA-494 targets PTEN and suppresses PI3K/AKT pathway to alleviate hypertrophic scar formation. Journal of molecular histology. vol 50. issue 4. 2020-01-06. PMID:31069607. |
micrornas have been reported related to hypertrophic scar through posttranscriptional control of genes. |
2020-01-06 |
2023-08-13 |
mouse |
| Ting He, Yue Zhang, Yang Liu, Hongtao Wang, Wanfu Zhang, Jiaqi Liu, Na Li, Yan Li, Luxu Wang, Songtao Xie, Dahai H. MicroRNA-494 targets PTEN and suppresses PI3K/AKT pathway to alleviate hypertrophic scar formation. Journal of molecular histology. vol 50. issue 4. 2020-01-06. PMID:31069607. |
hypertrophic scar-derived fibroblast model and mice incision model were used to see the expression of microrna-494 and whether the level changes of microrna-494 could affect scar formation. |
2020-01-06 |
2023-08-13 |
mouse |
| Ting He, Yue Zhang, Yang Liu, Hongtao Wang, Wanfu Zhang, Jiaqi Liu, Na Li, Yan Li, Luxu Wang, Songtao Xie, Dahai H. MicroRNA-494 targets PTEN and suppresses PI3K/AKT pathway to alleviate hypertrophic scar formation. Journal of molecular histology. vol 50. issue 4. 2020-01-06. PMID:31069607. |
it was found that in hypertrophic scar, the expression of microrna-494 decreased. |
2020-01-06 |
2023-08-13 |
mouse |
| Ting He, Yue Zhang, Yang Liu, Hongtao Wang, Wanfu Zhang, Jiaqi Liu, Na Li, Yan Li, Luxu Wang, Songtao Xie, Dahai H. MicroRNA-494 targets PTEN and suppresses PI3K/AKT pathway to alleviate hypertrophic scar formation. Journal of molecular histology. vol 50. issue 4. 2020-01-06. PMID:31069607. |
in conclusion, we confirmed that microrna-494 could be a key regulator to suppress hypertrophic scar formation. |
2020-01-06 |
2023-08-13 |
mouse |
| Ting He, Yue Zhang, Yang Liu, Hongtao Wang, Wanfu Zhang, Jiaqi Liu, Na Li, Yan Li, Luxu Wang, Songtao Xie, Dahai H. MicroRNA-494 targets PTEN and suppresses PI3K/AKT pathway to alleviate hypertrophic scar formation. Journal of molecular histology. vol 50. issue 4. 2020-01-06. PMID:31069607. |
the suppression of microrna-494 could eliminate its inhibition effect to pten and finally decrease the expression of collagen and inhibit hypertrophic scar formation. |
2020-01-06 |
2023-08-13 |
mouse |
| Jie Zhang, Sijia Na, Shuting Pan, Sang Long, Yuqi Xin, Qingkun Jiang, Zhongwei Lai, Junfeng Yan, Zhongyi Ca. Inhibition of USP4 attenuates pathological scarring by downregulation of the TGF‑β/Smad signaling pathway. Molecular medicine reports. vol 20. issue 2. 2020-01-06. PMID:31173246. |
pathological scarring is a result of the hypertrophy of scar tissue during tissue repair following trauma. |
2020-01-06 |
2023-08-13 |
Not clear |
| Maha M Arafah, Mohammad M Al-Qattan, Durria A Abdulmaged-Ahmed, Ghada A Al-Nafesah, Nessrin Y Jadu, Reginald S Bagayawa, Medhat K Shier, Amir Marzouk, Hend S Almalk. The Use of Antifibrotic Recombinant nAG Protein in a Rat Liver Fibrosis Model. BioMed research international. vol 2019. 2020-01-03. PMID:31275996. |
the antifibrotic properties were later confirmed in a rabbit skin hypertrophic scar model as well as in a rat spinal cord injury model. |
2020-01-03 |
2023-08-13 |
rat |
| Daisuke Maeda, Tateki Kubo, Koichiro Kiya, Kenichiro Kawai, Shinsuke Matsuzaki, Daichi Kobayashi, Toshihiro Fujiwara, Taiichi Katayama, Ko Hosokaw. Periostin is induced by IL-4/IL-13 in dermal fibroblasts and promotes RhoA/ROCK pathway-mediated TGF-β1 secretion in abnormal scar formation. Journal of plastic surgery and hand surgery. vol 53. issue 5. 2019-12-31. PMID:31066603. |
excess scar formation can occur after skin injurふy and lead to abnormal scar formation, such as keloids and hypertrophic scars, which are characterised by substantial deposition of extracellular matrix in the dermis. |
2019-12-31 |
2023-08-13 |
human |
| Mustafa Tunca, Mehmet Gamsızkan, Aslan Yürekli, Berk Alp Göksel, Ali Fuat Çiçek, Ercan Çalışka. Cryosurgery to remove perichondrium for the rabbit ear hypertrophic scar model: a simplified method. Acta dermatovenerologica Alpina, Pannonica, et Adriatica. vol 28. issue 2. 2019-12-31. PMID:31233167. |
cryosurgery to remove perichondrium for the rabbit ear hypertrophic scar model: a simplified method. |
2019-12-31 |
2023-08-13 |
rabbit |
| Mustafa Tunca, Mehmet Gamsızkan, Aslan Yürekli, Berk Alp Göksel, Ali Fuat Çiçek, Ercan Çalışka. Cryosurgery to remove perichondrium for the rabbit ear hypertrophic scar model: a simplified method. Acta dermatovenerologica Alpina, Pannonica, et Adriatica. vol 28. issue 2. 2019-12-31. PMID:31233167. |
the rabbit ear hypertrophic scar model is a preferred animal model of excessive scarring for investigating the scarring process and novel treatment modalities. |
2019-12-31 |
2023-08-13 |
rabbit |
| Mustafa Tunca, Mehmet Gamsızkan, Aslan Yürekli, Berk Alp Göksel, Ali Fuat Çiçek, Ercan Çalışka. Cryosurgery to remove perichondrium for the rabbit ear hypertrophic scar model: a simplified method. Acta dermatovenerologica Alpina, Pannonica, et Adriatica. vol 28. issue 2. 2019-12-31. PMID:31233167. |
the objective of this study was to compare structural changes in scar tissues in two groups of the hypertrophic scar model: cryosurgery compared to standard conventional surgery. |
2019-12-31 |
2023-08-13 |
rabbit |
| Li Yang, Xueli Li, Shoumin Zhang, Jinghui Song, Tingting Zh. Baicalein inhibits proliferation and collagen synthesis of mice fibroblast cell line NIH/3T3 by regulation of miR-9/insulin-like growth factor-1 axis. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-12-30. PMID:31362535. |
baicalein has effects in attenuating hypertrophic scar formation. |
2019-12-30 |
2023-08-13 |
mouse |
| Xue Zhang, Dong Lan, Shuhua Ning, Hongxia Jia, Sisi Y. Botulinum toxin type A prevents the phenotypic transformation of fibroblasts induced by TGF‑β1 via the PTEN/PI3K/Akt signaling pathway. International journal of molecular medicine. vol 44. issue 2. 2019-12-23. PMID:31173164. |
hypertrophic scar (hs) is a common type of dermatosis. |
2019-12-23 |
2023-08-13 |
Not clear |
| Gregorio Scerrino, Giuseppina Melfa, Cristina Raspanti, Giulia Rotolo, Giuseppe Salamone, Leo Licari, Tommaso Fontana, Roberta Tutino, Calogero Porrello, Gaspare Gulotta, Gianfranco Cocorull. Minimally Invasive Video-Assisted Thyroidectomy: Analysis of Complications From a Systematic Review. Surgical innovation. vol 26. issue 3. 2019-12-13. PMID:30632464. |
the aim of this systematic review was enrolling a large number of studies to estimate early and late complications (transient and definitive, uni- and bilateral laryngeal nerve palsy; transient and definitive hypocalcemia; cervical hematoma; hypertrophic or keloid scar) of mivat compared with conventional technique. |
2019-12-13 |
2023-08-13 |
Not clear |
| Andrew V Schally, Xianyang Zhang, Renzhi Cai, Joshua M Hare, Riccarda Granata, Manuela Bartol. Actions and Potential Therapeutic Applications of Growth Hormone-Releasing Hormone Agonists. Endocrinology. vol 160. issue 7. 2019-12-06. PMID:31070727. |
various studies demonstrate that ghrh agonists promote repair of cardiac tissue, producing improvement of ejection fraction and reduction of infarct size in rats, reduction of infarct scar in swine, and attenuation of cardiac hypertrophy in mice, suggesting clinical applications. |
2019-12-06 |
2023-08-13 |
mouse |