| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H O Rennekampff, M Tenenhau. Theoretical basis for optimal surgical incision planning to reduce hypertrophic scar formation. Medical hypotheses. vol 140. 2020-06-15. PMID:32197119. |
theoretical basis for optimal surgical incision planning to reduce hypertrophic scar formation. |
2020-06-15 |
2023-08-13 |
human |
| H O Rennekampff, M Tenenhau. Theoretical basis for optimal surgical incision planning to reduce hypertrophic scar formation. Medical hypotheses. vol 140. 2020-06-15. PMID:32197119. |
continued or unregulated stimulation of tissue fibroblasts is thought to lead to an activated state with ongoing collagen deposition resulting in a visible hypertrophic scar. |
2020-06-15 |
2023-08-13 |
human |
| Mahmoud A Hifn. The Popliteal Keystone Island Flap For Management of Contracture Around Knee Joint: A Report of Two Cases. Journal of burn care & research : official publication of the American Burn Association. vol 40. issue 2. 2020-06-12. PMID:30649335. |
although keystone flap reported for closure of full thickness burns defects, to the best of our knowledge, it has never been used previously in management of hypertrophic scar contracture around the knee joint. |
2020-06-12 |
2023-08-13 |
Not clear |
| Mahmoud A Hifn. The Popliteal Keystone Island Flap For Management of Contracture Around Knee Joint: A Report of Two Cases. Journal of burn care & research : official publication of the American Burn Association. vol 40. issue 2. 2020-06-12. PMID:30649335. |
we are presenting a two-case report with contracture hypertrophic scar over popliteal fossa where the keystone flaps were used to cover the soft tissue defects following excision of the scar contracture. |
2020-06-12 |
2023-08-13 |
Not clear |
| Bingyu Guo, Qiang Hui, Zhishan Xu, Peng Chang, Kai Ta. miR-495 inhibits the growth of fibroblasts in hypertrophic scars. Aging. vol 11. issue 9. 2020-06-12. PMID:31085805. |
after preliminary screening of the microrna (mirna) gene expression profiles, we explored the role of mir-495 in the development of hypertrophic scar by comparing expression of mir-495 and focal adhesion kinase (fak) between hypertrophic scar and normal skin tissue. |
2020-06-12 |
2023-08-13 |
human |
| Bingyu Guo, Qiang Hui, Zhishan Xu, Peng Chang, Kai Ta. miR-495 inhibits the growth of fibroblasts in hypertrophic scars. Aging. vol 11. issue 9. 2020-06-12. PMID:31085805. |
we also used 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-h-tetrazolium bromide and annexin v-fluorescein isothiocyanate/propidium iodide assays to assess the effect of mir-495 on the proliferation and apoptosis in human hypertrophic scar fibroblasts. |
2020-06-12 |
2023-08-13 |
human |
| Bingyu Guo, Qiang Hui, Zhishan Xu, Peng Chang, Kai Ta. miR-495 inhibits the growth of fibroblasts in hypertrophic scars. Aging. vol 11. issue 9. 2020-06-12. PMID:31085805. |
our findings show that mir-495 inhibits fak and its downstream mediators in vitro and vivo, and suggest that mir-495 may be a useful therapeutic target for the treatment of hypertrophic scar. |
2020-06-12 |
2023-08-13 |
human |
| Feng-Lai Yuan, Zi-Li Sun, Yi Feng, Si-Yu Liu, Yong Du, Shun Yu, Ming-Lie Yang, Guo-Zhong L. Epithelial-mesenchymal transition in the formation of hypertrophic scars and keloids. Journal of cellular physiology. vol 234. issue 12. 2020-06-05. PMID:31106425. |
despite the advances in prevention and management of hypertrophic scar and keloids, the mechanism underlying scar and keloid formation has not been fully elucidated. |
2020-06-05 |
2023-08-13 |
Not clear |
| Feng-Lai Yuan, Zi-Li Sun, Yi Feng, Si-Yu Liu, Yong Du, Shun Yu, Ming-Lie Yang, Guo-Zhong L. Epithelial-mesenchymal transition in the formation of hypertrophic scars and keloids. Journal of cellular physiology. vol 234. issue 12. 2020-06-05. PMID:31106425. |
this knowledge will facilitate an understanding of emt roles in scar formation and shed new light on the modulation and potential treatment of hypertrophic scars and keloids. |
2020-06-05 |
2023-08-13 |
Not clear |
| Asmaa Mohammed Elrefaie, Rehab Mohammed Salem, Mohamed H Fahee. High-resolution ultrasound for keloids and hypertrophic scar assessment. Lasers in medical science. vol 35. issue 2. 2020-06-05. PMID:31240510. |
high-resolution ultrasound for keloids and hypertrophic scar assessment. |
2020-06-05 |
2023-08-13 |
Not clear |
| Jialin Chen, Renpeng Zhou, Yimin Liang, Xiujun Fu, Danru Wang, Chen Wan. Blockade of lncRNA-ASLNCS5088-enriched exosome generation in M2 macrophages by GW4869 dampens the effect of M2 macrophages on orchestrating fibroblast activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 11. 2020-05-28. PMID:31373848. |
in hypertrophic scar (hs) formation, the type 2 immune response induces the alternatively activated macrophages (m2), which manipulate fibroblasts to differentiate into myofibroblasts with active biologic functions and proliferation. |
2020-05-28 |
2023-08-13 |
Not clear |
| Kenneth N Dolynchuk, Edward E Tredge. A Preliminary Report of the Biochemical and Clinical Effects of 1,4-Diaminobutane on Prevention of Human Hypertrophic Scars. Plastic and reconstructive surgery. vol 145. issue 1. 2020-05-27. PMID:31881614. |
objective evidence for the role of inhibition of collagen cross-linking in human scar using a nontoxic topical inhibitor, 1,4-diaminobutane (1,4 dab), in patients with scars at risk for hypertrophic scar formation is presented. |
2020-05-27 |
2023-08-13 |
human |
| Raluca Ţuţuianu, Ana Maria Roşca, Gabriela Florea, Vasile Prună, Daniela Mădălina Iacomi, Luminiţa Andreea Rădulescu, Tiberiu Paul Neagu, Ioan Lascăr, Irina Domnica Titorenc. Heterogeneity of human fibroblasts isolated from hypertrophic scar. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 60. issue 3. 2020-05-12. PMID:31912089. |
heterogeneity of human fibroblasts isolated from hypertrophic scar. |
2020-05-12 |
2023-08-13 |
human |
| Corrie L Gallant-Behm, Joseph Piper, Joshua M Lynch, Anita G Seto, Seok Jong Hong, Thomas A Mustoe, Catherine Maari, Linda A Pestano, Christina M Dalby, Aimee L Jackson, Paul Rubin, William S Marshal. A MicroRNA-29 Mimic (Remlarsen) Represses Extracellular Matrix Expression and Fibroplasia in the Skin. The Journal of investigative dermatology. vol 139. issue 5. 2020-05-07. PMID:30472058. |
these results suggest that remlarsen may be an effective therapeutic to prevent formation of a fibrotic scar (hypertrophic scar or keloid) or to prevent cutaneous fibrosis, such as scleroderma. |
2020-05-07 |
2023-08-13 |
mouse |
| Ya Gao, Jia Zhou, Zhibo Xie, Jing Wang, Chia-Kang Ho, Yifan Zhang, Qingfeng L. Mechanical strain promotes skin fibrosis through LRG-1 induction mediated by ELK1 and ERK signalling. Communications biology. vol 2. 2020-05-04. PMID:31602408. |
in skin fibrosis, dermal fibroblasts and vascular endothelial cells are integral to hypertrophic scar formation. |
2020-05-04 |
2023-08-13 |
mouse |
| Ya Gao, Jia Zhou, Zhibo Xie, Jing Wang, Chia-Kang Ho, Yifan Zhang, Qingfeng L. Mechanical strain promotes skin fibrosis through LRG-1 induction mediated by ELK1 and ERK signalling. Communications biology. vol 2. 2020-05-04. PMID:31602408. |
we discover that lrg-1 is overexpressed in hypertrophic scar tissues, and that depletion of lrg-1 in mouse skin causes mild neovascularization and skin fibrosis formation in a hypertrophic scarring model. |
2020-05-04 |
2023-08-13 |
mouse |
| Baoguo Chen, Huichao Li, Wei Xi. Imiquimod regulating Th1 and Th2 cell-related chemokines to inhibit scar hyperplasia. International wound journal. vol 16. issue 6. 2020-04-21. PMID:31475447. |
a rabbit ear hypertrophic scar model was built. |
2020-04-21 |
2023-08-13 |
rabbit |
| Mitchell Peake, Kristen Pan, R Maxwell Rotatori, Heather Powell, Laura Fowler, Laura James, Elizabeth Dal. Incorporation of 3D stereophotogrammetry as a reliable method for assessing scar volume in standard clinical practice. Burns : journal of the International Society for Burn Injuries. vol 45. issue 7. 2020-04-20. PMID:31208769. |
measurements of scar models by two independent observers were compared to determine inter-rater reliability, and measurements from 3d images of burn patient hypertrophic scars were compared to determine the consistency of the method between observers. |
2020-04-20 |
2023-08-13 |
Not clear |
| Xiaolin Nong, Girju Rajbanshi, Ling Chen, Jiaquan Li, Zhan Li, Taotao Liu, Shihai Chen, Gao Wei, Jushang L. Effect of artesunate and relation with TGF-β1 and SMAD3 signaling on experimental hypertrophic scar model in rabbit ear. Archives of dermatological research. vol 311. issue 10. 2020-04-20. PMID:31396694. |
effect of artesunate and relation with tgf-β1 and smad3 signaling on experimental hypertrophic scar model in rabbit ear. |
2020-04-20 |
2023-08-13 |
rabbit |
| Xiaolin Nong, Girju Rajbanshi, Ling Chen, Jiaquan Li, Zhan Li, Taotao Liu, Shihai Chen, Gao Wei, Jushang L. Effect of artesunate and relation with TGF-β1 and SMAD3 signaling on experimental hypertrophic scar model in rabbit ear. Archives of dermatological research. vol 311. issue 10. 2020-04-20. PMID:31396694. |
the research was designed to study the significance of artesunate (art) on the expression of transforming growth factor (tgf-β1) and small mother against decapentaplegic (smad3) in rabbit's ear hypertrophic scar model. |
2020-04-20 |
2023-08-13 |
rabbit |