| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adrienne R Wells, Kai P Leun. Pirfenidone attenuates the profibrotic contractile phenotype of differentiated human dermal myofibroblasts. Biochemical and biophysical research communications. vol 521. issue 3. 2020-07-27. PMID:31679692. |
the antifibrotic pirfenidone has previously been shown to inhibit the initial differentiation of fibroblasts into myofibroblasts in vitro and act as a prophylactic measure against hypertrophic scar development in a mouse burn model. |
2020-07-27 |
2023-08-13 |
mouse |
| Weichang Shen, Yingqian Wang, Dewei Wang, Hong Zhou, Huafeng Zhang, Lingqiao L. miR-145-5p attenuates hypertrophic scar via reducing Smad2/Smad3 expression. Biochemical and biophysical research communications. vol 521. issue 4. 2020-07-27. PMID:31732152. |
mir-145-5p attenuates hypertrophic scar via reducing smad2/smad3 expression. |
2020-07-27 |
2023-08-13 |
mouse |
| Weichang Shen, Yingqian Wang, Dewei Wang, Hong Zhou, Huafeng Zhang, Lingqiao L. miR-145-5p attenuates hypertrophic scar via reducing Smad2/Smad3 expression. Biochemical and biophysical research communications. vol 521. issue 4. 2020-07-27. PMID:31732152. |
the study was designed to explore the underlying mechanism of micro ribonucleic acids (mir)-145-5p in the process of hypertrophic scar (hs). |
2020-07-27 |
2023-08-13 |
mouse |
| Hui Song Cui, So Young Joo, Yoon Soo Cho, June-Bum Kim, Cheong Hoon Se. CPEB1 or CPEB4 knockdown suppresses the TAK1 and Smad signalings in THP-1 macrophage-like cells and dermal fibroblasts. Archives of biochemistry and biophysics. vol 683. 2020-07-20. PMID:32113875. |
post-burn hypertrophic scar (hts) is a form of excessive dermal fibrosis characterized by cutaneous scarring, which is common in patients following burn injury. |
2020-07-20 |
2023-08-13 |
human |
| Ting He, Xiaozhi Bai, Jing Jing, Yang Liu, Hongtao Wang, Wanfu Zhang, Xiaoqiang Li, Yan Li, Luxu Wang, Songtao Xie, Dahai H. Notch signal deficiency alleviates hypertrophic scar formation after wound healing through the inhibition of inflammation. Archives of biochemistry and biophysics. vol 682. 2020-07-17. PMID:32007475. |
notch signal deficiency alleviates hypertrophic scar formation after wound healing through the inhibition of inflammation. |
2020-07-17 |
2023-08-13 |
mouse |
| Huimin Li, Qian Peng, Yisha Guo, Xiaohui Wang, Li Zhan. Preparation and in vitro and in vivo Study of Asiaticoside-Loaded Nanoemulsions and Nanoemulsions-Based Gels for Transdermal Delivery. International journal of nanomedicine. vol 15. 2020-07-17. PMID:32440114. |
asiaticoside (asi), a compound of triterpene pentacyclic saponins, has apparently therapeutic efficacy on human hypertrophic scar. |
2020-07-17 |
2023-08-13 |
human |
| Hongyi Wang, Bingyu Guo, Shixiu Lin, Peng Chang, Kai Ta. Apigenin inhibits growth and migration of fibroblasts by suppressing FAK signaling. Aging. vol 11. issue 11. 2020-07-13. PMID:31170089. |
although hypertrophic scar formation is a common surgical complication, there is still no good treatment for it. |
2020-07-13 |
2023-08-13 |
human |
| Hongyi Wang, Bingyu Guo, Shixiu Lin, Peng Chang, Kai Ta. Apigenin inhibits growth and migration of fibroblasts by suppressing FAK signaling. Aging. vol 11. issue 11. 2020-07-13. PMID:31170089. |
in the present study, we examined the effect of apigenin on hypertrophic scar. |
2020-07-13 |
2023-08-13 |
human |
| Hongyi Wang, Bingyu Guo, Shixiu Lin, Peng Chang, Kai Ta. Apigenin inhibits growth and migration of fibroblasts by suppressing FAK signaling. Aging. vol 11. issue 11. 2020-07-13. PMID:31170089. |
the results showed that apigenin dose-dependently inhibited the growth and migration of hypertrophic scar fibroblasts. |
2020-07-13 |
2023-08-13 |
human |
| Hongyi Wang, Bingyu Guo, Shixiu Lin, Peng Chang, Kai Ta. Apigenin inhibits growth and migration of fibroblasts by suppressing FAK signaling. Aging. vol 11. issue 11. 2020-07-13. PMID:31170089. |
apigenin thus appears to inhibit the growth and migration of hypertrophic scar fibroblasts by inhibiting fak signaling. |
2020-07-13 |
2023-08-13 |
human |
| Ching-Hsuan Hu, Yi-Wen Tseng, Chih-Yung Chiou, Kuan-Chun Lan, Chih-Hung Chou, Chun-San Tai, Hsien-Da Huang, Chiung-Wen Hu, Ko-Hsun Liao, Shiow-Shuh Chuang, Jui-Yung Yang, Oscar K Le. Bone marrow concentrate-induced mesenchymal stem cell conditioned medium facilitates wound healing and prevents hypertrophic scar formation in a rabbit ear model. Stem cell research & therapy. vol 10. issue 1. 2020-07-01. PMID:31462299. |
bone marrow concentrate-induced mesenchymal stem cell conditioned medium facilitates wound healing and prevents hypertrophic scar formation in a rabbit ear model. |
2020-07-01 |
2023-08-13 |
rabbit |
| Zhe-Wen Zhou, Xiao-Dong Chen, Xiao-Yan W. 5-ALA PDT successfully treats facial hidradenitis suppurativa-induced severe hypertrophic scar. Photodiagnosis and photodynamic therapy. vol 28. 2020-06-30. PMID:31614224. |
5-ala pdt successfully treats facial hidradenitis suppurativa-induced severe hypertrophic scar. |
2020-06-30 |
2023-08-13 |
Not clear |
| Zhe-Wen Zhou, Xiao-Dong Chen, Xiao-Yan W. 5-ALA PDT successfully treats facial hidradenitis suppurativa-induced severe hypertrophic scar. Photodiagnosis and photodynamic therapy. vol 28. 2020-06-30. PMID:31614224. |
in this report, one case of severe hypertrophic scar induced by facial hs achieved resolution of skin lesions after combined treatment with high concentration single-dose 5-aminolevulinic acid photodynamic therapy (5-ala pdt). |
2020-06-30 |
2023-08-13 |
Not clear |
| Zhe-Wen Zhou, Xiao-Dong Chen, Xiao-Yan W. 5-ALA PDT successfully treats facial hidradenitis suppurativa-induced severe hypertrophic scar. Photodiagnosis and photodynamic therapy. vol 28. 2020-06-30. PMID:31614224. |
the 5-ala pdt based treatment could improve the severe hypertrophic scar induced by hs in an effective and safe manner. |
2020-06-30 |
2023-08-13 |
Not clear |
| Shi-Kang Deng, Jian-Zhong Tang, Yan Jin, Ping-Hai Hu, Jun-Feng Wang, Xiao-Wen Zhan. Activin B signaling may promote the conversion of normal fibroblasts to scar fibroblasts. Medicine. vol 99. issue 24. 2020-06-29. PMID:32541451. |
this study is to explore the molecular mechanism of benign bile duct hypertrophic scar formation.differential proteins between the normal fibroblast (nfb) and scar fibroblast (scfb) were screened by protein chip assay, and analyzed by pathway-enrichment analysis and function-enrichment analysis. |
2020-06-29 |
2023-08-13 |
human |
| Yukun Liu, Shuyun Xu, Tingjian Zu, Feng Li, Shengbo Sang, Cynthia Liu, Yang An, Bobin Mi, Dennis P Orgill, George F Murphy, Christine G Lia. Reversal of TET-mediated 5-hmC loss in hypoxic fibroblasts by ascorbic acid. Laboratory investigation; a journal of technical methods and pathology. vol 99. issue 8. 2020-06-26. PMID:30837678. |
hypoxia resulting in hypoxia-inducible factor-1 alpha (hif-1α) induction is known to drive scar formation during cutaneous wound healing, and may be responsible for excessive fibrosis inherent to hypertrophic scars and keloids. |
2020-06-26 |
2023-08-13 |
human |
| Chi-Yung Chai, Junlong Song, Zhenwei Tan, I-Chun Tai, Chaoying Zhang, Shengrong Su. Adipose tissue-derived stem cells inhibit hypertrophic scar (HS) fibrosis via p38/MAPK pathway. Journal of cellular biochemistry. vol 120. issue 3. 2020-06-22. PMID:30260015. |
adipose tissue-derived stem cells inhibit hypertrophic scar (hs) fibrosis via p38/mapk pathway. |
2020-06-22 |
2023-08-13 |
Not clear |
| Chi-Yung Chai, Junlong Song, Zhenwei Tan, I-Chun Tai, Chaoying Zhang, Shengrong Su. Adipose tissue-derived stem cells inhibit hypertrophic scar (HS) fibrosis via p38/MAPK pathway. Journal of cellular biochemistry. vol 120. issue 3. 2020-06-22. PMID:30260015. |
the current study was designed to investigate the effects and underlying mechanisms of adipose tissue-derived stem cells (adscs) on hypertrophic scar (hs) fibrosis. |
2020-06-22 |
2023-08-13 |
Not clear |
| Katharina Hoerst, Lenie van den Broek, Christoph Sachse, Oliver Klein, Uwe von Fritschen, Sue Gibbs, Sarah Hedtric. Regenerative potential of adipocytes in hypertrophic scars is mediated by myofibroblast reprogramming. Journal of molecular medicine (Berlin, Germany). vol 97. issue 6. 2020-06-19. PMID:30891616. |
key messages: adipocytes induce distinct regenerative effects in hypertrophic scar tissue. |
2020-06-19 |
2023-08-13 |
Not clear |
| Yan Li, Julei Zhang, Qin Zhou, Hongtao Wang, Songtao Xie, Xuekang Yang, Peng Ji, Wanfu Zhang, Ting He, Yang Liu, Kejia Wang, Xiaoqiang Li, Jihong Shi, Dahai H. Linagliptin inhibits high glucose-induced transdifferentiation of hypertrophic scar-derived fibroblasts to myofibroblasts via IGF/Akt/mTOR signalling pathway. Experimental dermatology. vol 28. issue 1. 2020-06-17. PMID:30308704. |
hypertrophic scar (hs) is a fibroproliferative disease after serious burns; the underlying mechanism remains unknown. |
2020-06-17 |
2023-08-13 |
Not clear |