| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Feng, Jun-Jie Wu, Zi-Li Sun, Si-Yu Liu, Ming-Li Zou, Zheng-Dong Yuan, Shun Yu, Guo-Zhong Lv, Feng-Lai Yua. Targeted apoptosis of myofibroblasts by elesclomol inhibits hypertrophic scar formation. EBioMedicine. vol 54. 2021-01-25. PMID:32251998. |
targeted apoptosis of myofibroblasts by elesclomol inhibits hypertrophic scar formation. |
2021-01-25 |
2023-08-13 |
Not clear |
| Yi Feng, Jun-Jie Wu, Zi-Li Sun, Si-Yu Liu, Ming-Li Zou, Zheng-Dong Yuan, Shun Yu, Guo-Zhong Lv, Feng-Lai Yua. Targeted apoptosis of myofibroblasts by elesclomol inhibits hypertrophic scar formation. EBioMedicine. vol 54. 2021-01-25. PMID:32251998. |
hypertrophic scar (hs) is characterized by the increased proliferation and decreased apoptosis of myofibroblasts. |
2021-01-25 |
2023-08-13 |
Not clear |
| Shuai Yang, Jingling Zhao, Shixin Huang, Bin Shu, Ronghua Yang, Lei Chen, Yingbin Xu, Julin Xie, Xusheng Liu, Ji Jia, Shaohai Q. Reduced hydration-induced decreased caveolin-1 expression causes epithelial-to-mesenchymal transition. American journal of translational research. vol 12. issue 12. 2021-01-14. PMID:33437382. |
our findings suggest a role for caveolin-1 downregulation in linking aberrant emt to the reduced hydration environment: findings that may lead to new developments in the prevention and treatment of hypertrophic scar. |
2021-01-14 |
2023-08-13 |
Not clear |
| Jinmiao Chen, Qing Ma, Justin S King, Yan Sun, Bing Xu, Xiaoyu Zhang, Sylvia Zohrabian, Haipeng Guo, Wenqing Cai, Gavin Li, Ivone Bruno, John P Cooke, Chunsheng Wang, Maria Kontaridis, Da-Zhi Wang, Hongbo Luo, William T Pu, Zhiqiang Li. aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model. Life science alliance. vol 3. issue 1. 2021-01-11. PMID:31843959. |
4 wk after ir, ayap modrna-treated mice had better heart function as well as reduced scar size and hypertrophic remodeling. |
2021-01-11 |
2023-08-13 |
mouse |
| Datao Li, Ruhong Zhang, Qun Zhang, Zhicheng Xu, Feng Xu, Yiyuan Li, Xia Che. Clinical Results of Ear Elevations in Patients with Microtia Using Skin Grafts from Three Donor Sites: A Retrospective Study. Aesthetic plastic surgery. vol 44. issue 5. 2021-01-06. PMID:32300879. |
skin grafts, frequently used for ear elevation in ear reconstructions, may suffer from color mismatches, scar hypertrophy, secondary contraction, and auricular sulcus depth differences. |
2021-01-06 |
2023-08-13 |
Not clear |
| Bishara S Atiye. Nonsurgical Management of Hypertrophic Scars: Evidence-Based Therapies, Standard Practices, and Emerging Methods. Aesthetic plastic surgery. vol 44. issue 4. 2021-01-06. PMID:32766921. |
unfortunately, the distinction between hypertrophic scar treatments and keloid treatments is not obvious in most reports, making it difficult to assess the efficacy of hypertrophic scar treatment. |
2021-01-06 |
2023-08-13 |
Not clear |
| Mazaher Gholipourmalekabadi, Sadjad Khosravimelal, Zeinab Nokhbedehghan, Marzieh Sameni, Vahid Jajarmi, Aleksandra M Urbanska, Hadi Mirzaei, Maryam Salimi, Narendra Pal Singh Chauhan, Mohammadmahdi Mobaraki, Rui L Reis, Ali Samadikuchaksaraei, Subhas C Kund. Modulation of Hypertrophic Scar Formation Using Amniotic Membrane/Electrospun Silk Fibroin Bilayer Membrane in a Rabbit Ear Model. ACS biomaterials science & engineering. vol 5. issue 3. 2021-01-06. PMID:33405623. |
modulation of hypertrophic scar formation using amniotic membrane/electrospun silk fibroin bilayer membrane in a rabbit ear model. |
2021-01-06 |
2023-08-13 |
human |
| Mazaher Gholipourmalekabadi, Sadjad Khosravimelal, Zeinab Nokhbedehghan, Marzieh Sameni, Vahid Jajarmi, Aleksandra M Urbanska, Hadi Mirzaei, Maryam Salimi, Narendra Pal Singh Chauhan, Mohammadmahdi Mobaraki, Rui L Reis, Ali Samadikuchaksaraei, Subhas C Kund. Modulation of Hypertrophic Scar Formation Using Amniotic Membrane/Electrospun Silk Fibroin Bilayer Membrane in a Rabbit Ear Model. ACS biomaterials science & engineering. vol 5. issue 3. 2021-01-06. PMID:33405623. |
in this study, the effects of amniotic membrane/electrospun silk fibroin on minimizing the postinjury hypertrophic scar formation were determined in the rabbit ear model. |
2021-01-06 |
2023-08-13 |
human |
| Mazaher Gholipourmalekabadi, Sadjad Khosravimelal, Zeinab Nokhbedehghan, Marzieh Sameni, Vahid Jajarmi, Aleksandra M Urbanska, Hadi Mirzaei, Maryam Salimi, Narendra Pal Singh Chauhan, Mohammadmahdi Mobaraki, Rui L Reis, Ali Samadikuchaksaraei, Subhas C Kund. Modulation of Hypertrophic Scar Formation Using Amniotic Membrane/Electrospun Silk Fibroin Bilayer Membrane in a Rabbit Ear Model. ACS biomaterials science & engineering. vol 5. issue 3. 2021-01-06. PMID:33405623. |
in vivo experiments were carried out to assess the bilayer membrane characteristics on full thickness hypertrophic scar at days 28 and 50 postimplantations. |
2021-01-06 |
2023-08-13 |
human |
| Yong Huang, Yuting Wang, Xueming Wang, Lixin Lin, Peng Wang, Junjun Sun, Lei Jian. The Effects of the Transforming Growth Factor-β1 (TGF-β1) Signaling Pathway on Cell Proliferation and Cell Migration are Mediated by Ubiquitin Specific Protease 4 (USP4) in Hypertrophic Scar Tissue and Primary Fibroblast Cultures. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-01-05. PMID:32308208. |
the effects of the transforming growth factor-β1 (tgf-β1) signaling pathway on cell proliferation and cell migration are mediated by ubiquitin specific protease 4 (usp4) in hypertrophic scar tissue and primary fibroblast cultures. |
2021-01-05 |
2023-08-13 |
human |
| Yong Huang, Yuting Wang, Xueming Wang, Lixin Lin, Peng Wang, Junjun Sun, Lei Jian. The Effects of the Transforming Growth Factor-β1 (TGF-β1) Signaling Pathway on Cell Proliferation and Cell Migration are Mediated by Ubiquitin Specific Protease 4 (USP4) in Hypertrophic Scar Tissue and Primary Fibroblast Cultures. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-01-05. PMID:32308208. |
background hypertrophic scar results from an abnormal repair response to trauma in the skin and involves fibroblasts proliferation with increased collagen deposition. |
2021-01-05 |
2023-08-13 |
human |
| Yong Huang, Yuting Wang, Xueming Wang, Lixin Lin, Peng Wang, Junjun Sun, Lei Jian. The Effects of the Transforming Growth Factor-β1 (TGF-β1) Signaling Pathway on Cell Proliferation and Cell Migration are Mediated by Ubiquitin Specific Protease 4 (USP4) in Hypertrophic Scar Tissue and Primary Fibroblast Cultures. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-01-05. PMID:32308208. |
this study aimed to investigate the effects of tgf-ßr1 and usp4 in human tissue samples of hypertrophic scar and on cell proliferation and cell migration in primary fibroblast cultures in vitro. |
2021-01-05 |
2023-08-13 |
human |
| Yong Huang, Yuting Wang, Xueming Wang, Lixin Lin, Peng Wang, Junjun Sun, Lei Jian. The Effects of the Transforming Growth Factor-β1 (TGF-β1) Signaling Pathway on Cell Proliferation and Cell Migration are Mediated by Ubiquitin Specific Protease 4 (USP4) in Hypertrophic Scar Tissue and Primary Fibroblast Cultures. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-01-05. PMID:32308208. |
material and methods skin excision tissue samples with adjacent normal skin were obtained from 15 patients with hypertrophic scar, which provided tissue sections and primary fibroblast culture for analysis. |
2021-01-05 |
2023-08-13 |
human |
| Yong Huang, Yuting Wang, Xueming Wang, Lixin Lin, Peng Wang, Junjun Sun, Lei Jian. The Effects of the Transforming Growth Factor-β1 (TGF-β1) Signaling Pathway on Cell Proliferation and Cell Migration are Mediated by Ubiquitin Specific Protease 4 (USP4) in Hypertrophic Scar Tissue and Primary Fibroblast Cultures. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-01-05. PMID:32308208. |
results the expression of usp4 and tgf-ßr1 in hypertrophic scar were increased compared with normal skin. |
2021-01-05 |
2023-08-13 |
human |
| Yong Huang, Yuting Wang, Xueming Wang, Lixin Lin, Peng Wang, Junjun Sun, Lei Jian. The Effects of the Transforming Growth Factor-β1 (TGF-β1) Signaling Pathway on Cell Proliferation and Cell Migration are Mediated by Ubiquitin Specific Protease 4 (USP4) in Hypertrophic Scar Tissue and Primary Fibroblast Cultures. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-01-05. PMID:32308208. |
fibroblasts cultured from hypertrophic scar tissue showed increased expression of of usp4 and tgf-ßr1. |
2021-01-05 |
2023-08-13 |
human |
| Yong Huang, Yuting Wang, Xueming Wang, Lixin Lin, Peng Wang, Junjun Sun, Lei Jian. The Effects of the Transforming Growth Factor-β1 (TGF-β1) Signaling Pathway on Cell Proliferation and Cell Migration are Mediated by Ubiquitin Specific Protease 4 (USP4) in Hypertrophic Scar Tissue and Primary Fibroblast Cultures. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-01-05. PMID:32308208. |
conclusions usp4 regulated the proliferation, migration, and apoptosis of hypertrophic scar fibroblasts by regulating the tgf-ß1 signaling pathway. |
2021-01-05 |
2023-08-13 |
human |
| T Shao, W Tang, Y Li, D Gao, K Lv, P He, Y Song, S Gao, M Liu, Y Chen, Z Y. Research on function and mechanisms of a novel small molecule WG449E for hypertrophic scar. Journal of the European Academy of Dermatology and Venereology : JEADV. vol 34. issue 3. 2021-01-04. PMID:31650631. |
research on function and mechanisms of a novel small molecule wg449e for hypertrophic scar. |
2021-01-04 |
2023-08-13 |
Not clear |
| Zehua Li, Shenghong Li, Kecheng Li, Xiao Jiang, Jinrong Zhang, Hongwei Li. A highly simulated scar model developed by grafting human thin split-thickness skin on back of nude mouse: The remodeling process, histological characteristics of scars. Biochemical and biophysical research communications. vol 526. issue 3. 2020-12-17. PMID:32265030. |
the aim of this study was to build a model that recapitulated the developing process and outcomes of human hypertrophic scar (hs). |
2020-12-17 |
2023-08-13 |
mouse |
| Sara Al Janahi, Sang Ju Lee, Jean S McGee, Hye Jin Chun. Hypertrophic Scar After Treatment of Ecchymoses With Pulsed-Dye Laser. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. vol 46. issue 6. 2020-12-15. PMID:30882510. |
hypertrophic scar after treatment of ecchymoses with pulsed-dye laser. |
2020-12-15 |
2023-08-13 |
Not clear |
| Akira Sugiyama, Rumi Ito, Muneyoshi Okada, Hideyuki Yamawak. Long-term administration of recombinant canstatin prevents adverse cardiac remodeling after myocardial infarction. Scientific reports. vol 10. issue 1. 2020-12-09. PMID:32732948. |
canstatin significantly inhibited scar thinning in the infarcted area and significantly suppressed cardiac hypertrophy, nuclear translocation of nuclear factor of activated t-cells, interstitial fibrosis and increase of myofibroblasts in the non-infarcted area. |
2020-12-09 |
2023-08-13 |
mouse |