| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bing Wang, Haomeng Kou, Yuwen Wang, Qi Zhang, Duo Jiang, Juan Wang, Ziqin Zhao, Yao Zhou, Miaomiao Zhang, Lei Sui, Mingfeng Zhao, Yancheng Liu, Yang Liu, Lei Shi, Feng Wan. LAP2α orchestrates alternative lengthening of telomeres suppression through telomeric heterochromatin regulation with HDAC1: unveiling a potential therapeutic target. Cell death & disease. vol 15. issue 10. 2024-10-19. PMID:39426946. |
in this study, we unveil that the knockdown of lamina-associated polypeptide 2 alpha (lap2α) in alt cells results in telomere dysfunction, triggering a notable increase in alt-associated hallmarks, including high frequencies of pml bodies (apbs), c-rich extrachromosomal circles (c-circles), and telomere sister chromatid exchange (t-sce). |
2024-10-19 |
2024-10-22 |
mouse |
| Yi Zhang, Jiacheng Lou, Yabin Liu, Peng Jin, Yun Tan, Huan Song, Wen Jin, Dan Wang, Fangyi Dong, Shishuang Wu, Hai Fang, Saijuan Chen, Zhu Chen, Kankan Wan. Phase separation of PML/RARα and BRD4 coassembled microspeckles governs transcriptional dysregulation in acute promyelocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 34. 2024-08-13. PMID:39136995. |
in acute promyelocytic leukemia (apl), the promyelocytic leukemia-retinoic acid receptor alpha (pml/rarα) fusion protein destroys pml nuclear bodies (nbs), leading to the formation of microspeckles. |
2024-08-13 |
2024-08-16 |
Not clear |
| Yuchen Liu, Yi Ning, Gabriel Ghiaur, Ashkan Emad. Biologic and clinical characteristics of isochromosome der(17)(q10)t(15;17) in acute promyelocytic leukemia. Acta haematologica. 2024-06-02. PMID:38824913. |
acute promyelocytic leukemia (apl) is genetically characterized by the fusion of promyelocytic leukemia gene (pml) with retinoic acid receptor alpha (rarα) resulting from a t(15;17)(q24;q21) chromosomal translocation. |
2024-06-02 |
2024-06-05 |
Not clear |
| Yue Chen, Mengge Pan, Lanxin Chen, Miaoxin Peng, Zhenyu Liu, Yiran Fang, Ying Du, Yonggong Yang, Peipei X. Identification of a novel fusion gene, RARA::ANKRD34C, in acute promyelocytic leukemia. Annals of hematology. 2024-01-31. PMID:38294534. |
acute promyelocytic leukemia (apl) is a specific subtype of acute myeloid leukemia that is distinguished by the chromosomal translocation t(15;17)(q24;q21), which leads to the fusion of the promyelocytic leukemia (pml) gene with the retinoic acid receptor alpha (rara). |
2024-01-31 |
2024-02-02 |
Not clear |
| Shatha Mallah, Fahed Owda, Hamza Hamayel, Ahmad Enaya, Osama Mallah, Dina Abugaber, Razan Ode. Successful Management of Acute Promyelocytic Leukemia in a Patient Who Presented With Acute Ischemic Stroke on Top of Subdural Hematoma. Cureus. vol 15. issue 9. 2023-10-16. PMID:37842379. |
the subsequent bone marrow biopsy confirmed the diagnosis of apl, displaying the characteristic positive promyelocytic leukemia (pml)-retinoic acid receptor alpha (rara) t(15;17) translocation. |
2023-10-16 |
2023-11-08 |
Not clear |
| Pierre Bercier, Qian Qian Wang, Ning Zang, Jie Zhang, Chang Yang, Yasen Maimaitiyiming, Majdouline Abou-Ghali, Caroline Berthier, Chengchen Wu, Michiko Niwa-Kawakita, Thassadite Dirami, Marie-Claude Geoffroy, Omar Ferhi, Samuel Quentin, Shirine Benhenda, Yasumitsu Ogra, Zoher Gueroui, Chun Zhou, Hua Naranmandura, Hugues de The, Valerie Lallemand-Breitenbac. Structural basis of PML/RARA oncoprotein targeting by arsenic unravels a cysteine rheostat controlling PML body assembly and function. Cancer discovery. 2023-09-01. PMID:37655965. |
pml b-box-2 structure reveals an alpha helix driving b2 trimerization and positioning a cysteine trio to form an ideal arsenic-binding pocket. |
2023-09-01 |
2023-09-07 |
Not clear |
| Shujie Zhang, Laibo Song, Bo Liu, Yuan-Di Zhao, Wei Che. Poly(ethylene glycol) diacrylate based hydrogel filled micropore with enhanced sensing capability. Analytica chimica acta. vol 1251. 2023-03-17. PMID:36925308. |
the promyelocytic leukemia (pml)/retinoic acid receptor alpha (rara) fusion genes and adenosine triphosphate (atp) were respectively used as model analytes and the measured detection limits of 0.1 pm were achieved. |
2023-03-17 |
2023-08-14 |
Not clear |
| Ellis G Jaffray, Michael H Tatham, Barbara Mojsa, Magda Liczmanska, Alejandro Rojas-Fernandez, Yili Yin, Graeme Ball, Ronald T Ha. The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA. The Journal of cell biology. vol 222. issue 4. 2023-03-07. PMID:36880596. |
acute promyelocytic leukemia is caused by expression of the oncogenic promyelocytic leukemia (pml)-retinoic acid receptor alpha (rara) fusion protein. |
2023-03-07 |
2023-08-14 |
Not clear |
| Victoria Korsos, Wilson H Mille. How retinoic acid and arsenic transformed acute promyelocytic leukemia therapy. Journal of molecular endocrinology. vol 69. issue 4. 2022-10-12. PMID:36112505. |
this t(15;17) results in a fusion transcript of promyelocytic leukemia (pml) and retinoic acid receptor alpha (rara) genes and the expression of a functional pml/rara protein. |
2022-10-12 |
2023-08-16 |
Not clear |
| Michael J McPhee, Jonghwa Lee, Graham Dellaire, Steven Pelech, Neale D Ridgwa. CTP:phosphocholine cytidylyltransferase alpha regulates nLD biogenesis in Caco2 cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552850. |
indeed, using immunofluorescence confocal microscopy we found that oleate-treated caco2 cells formed between 5 to 10 nlds per cell that recruited both cct alpha and pml to their surface. |
2022-05-13 |
2023-08-13 |
Not clear |
| Michael J McPhee, Jonghwa Lee, Graham Dellaire, Steven Pelech, Neale D Ridgwa. CTP:phosphocholine cytidylyltransferase alpha regulates nLD biogenesis in Caco2 cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552850. |
the percentage of pml-positive nlds increased in cct alphako cells, suggesting that cct alpha and pml compete for access to the nld surface following oleate treatment. |
2022-05-13 |
2023-08-13 |
Not clear |
| Amandeep Salhotra, Matthew Me. Acute Promyelocytic Leukemia: Update on Risk Stratification and Treatment Practices. Cancer treatment and research. vol 181. 2021-11-25. PMID:34626354. |
acute promyelocytic leukemia (apl) is a rare but highly curable form of acute myeloid leukemia (aml) whose genetic hallmark is the balanced reciprocal translocation t(15;17)(q22;q12) which fuses the promyelocytic leukemia (pml) and retinoic acid receptor alpha (rarα) genes (wang and chen in blood 111:2505-2515, 2008; lallem and-breitenbach et al. |
2021-11-25 |
2023-08-13 |
Not clear |
| Saghar Yousefni. Mechanistic effects of arsenic trioxide on acute promyelocytic leukemia and other types of leukemias. Cell biology international. vol 45. issue 6. 2021-11-22. PMID:33527587. |
acute promyelocytic leukemia (apl), a subtype of acute myeloid leukemia characterized with a translocation between promyelocytic leukemia gene (pml) on chromosome 15 and retinoic acid receptor alpha gene (rarα) on chromosome 17. |
2021-11-22 |
2023-08-13 |
Not clear |
| Mariam Fatima, Salik Javed Kakar, Fazal Adnan, Khalid Khan, Afsar Ali Mian, Dilawar Kha. AXL receptor tyrosine kinase: a possible therapeutic target in acute promyelocytic leukemia. BMC cancer. vol 21. issue 1. 2021-10-22. PMID:34140003. |
acute promyelocytic leukemia (apl) is a subset of acute myeloid leukemia (aml) which is characterized by the fusion of promyelocytic leukemia pml and retinoic acid receptor- alpha (rar-alpha) genes. |
2021-10-22 |
2023-08-13 |
Not clear |
| Jhansi Rani Arumugam, B K Karthik Bommannan, Jayachandran Perumal Kalaiyarasi, Shirley Sundersing. Cytogenetics and FISH negative cryptic acute promyelocytic leukemia with CD56 expression. Indian journal of pathology & microbiology. vol 64. issue 2. 2021-10-06. PMID:33851647. |
however, rare cases of apl show a cryptic insertion of retinoic acid receptor alpha (rara) gene into promyelocytic leukemia (pml) gene which is negative both by fluorescence in situ hybridization (fish) and conventional cytogenetics (cc). |
2021-10-06 |
2023-08-13 |
Not clear |
| Nicolas Jacquet-Francillon, Jerome Cornillon, Pascale Flandrin, Lauren Rigollet, Nathalie Prevot, Emmanuelle Tavernier, Pierre-Benoit Bonnefo. Utility of 18F-FDG PET/CT in medical care of a promyelocytic sarcoma. Current research in translational medicine. vol 69. issue 2. 2021-07-28. PMID:33476934. |
it is characterized, like acute promyelocytic leukemia (apl), by a chromosomal translocation t(15;17) involving the retinoic acid receptor alpha (raralpha) and the promyelocytic gene (pml). |
2021-07-28 |
2023-08-13 |
Not clear |
| Musa Yilmaz, Hagop Kantarjian, Farhad Ravand. Acute promyelocytic leukemia current treatment algorithms. Blood cancer journal. vol 11. issue 6. 2021-07-21. PMID:34193815. |
apl, accounting for 10-15% of the newly diagnosed aml cases, results from a balanced translocation, t(15;17) (q22;q12-21), which leads to the fusion of the promyelocytic leukemia (pml) gene with the retinoic acid receptor alpha (rara) gene. |
2021-07-21 |
2023-08-13 |
Not clear |
| Kuo-Sheng Hsu, Hung-Ying Ka. PML: Regulation and multifaceted function beyond tumor suppression. Cell & bioscience. vol 8. 2020-09-29. PMID:29416846. |
promyelocytic leukemia protein (pml) was originally identified as a fusion partner of retinoic acid receptor alpha in acute promyelocytic leukemia patients with the (15;17) chromosomal translocation, giving rise to pml-rarα and rarα-pml fusion proteins. |
2020-09-29 |
2023-08-13 |
Not clear |
| Yiping Liu, Fang Xu, Hong Hu, Jingjing Wen, Jing Su, Qiaolin Zhou, Wen Q. A rare case of acute promyelocytic leukemia with IRF2BP2-RARA fusion; and literature review. OncoTargets and therapy. vol 12. 2020-09-29. PMID:31447564. |
acute promyelocytic leukemia (apl) is commonly characterized by the fusion of retinoic acid receptor alpha (rara) with promyelocytic leukemia (pml). |
2020-09-29 |
2023-08-13 |
Not clear |
| Xavier Thoma. Acute Promyelocytic Leukemia: A History over 60 Years-From the Most Malignant to the most Curable Form of Acute Leukemia. Oncology and therapy. vol 7. issue 1. 2020-09-28. PMID:32700196. |
acute promyelocytic leukemia (apl) is a distinct subtype of acute myeloid leukemia (aml) that is cytogenetically characterized by a balanced reciprocal translocation between chromosomes 15 and 17, which results in the fusion of the promyelocytic leukemia (pml) and retinoic acid receptor alpha (rarα) genes. |
2020-09-28 |
2023-08-13 |
Not clear |