| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mira Jung, Nicole Nicholas, Scott Grindrod, Anatoly Dritschil. Dual-targeting class I HDAC inhibitor and ATM activator, SP-1-303, preferentially inhibits estrogen receptor positive breast cancer cell growth. PloS one. vol 19. issue 7. 2024-07-15. PMID:39008483. |
western analysis reveals that sp-1-303 decreases estrogen receptor alpha (er-α) expression and increases p53 protein expression, while inducing the phosphorylation of atm and its substrates, brca1 and p53, in a time-dependent manner in er+ bc cells. |
2024-07-15 |
2024-07-18 |
rat |
| Yujing Xu, Jinrong Yang, Xiaoyu Han, Chunchun Gan, Xiaopeng We. Active substance and mechanisms of Actinidia chinensis Planch for the treatment of breast cancer was explored based on network pharmacology and in silico study. Medicine. vol 103. issue 15. 2024-04-12. PMID:38608062. |
tumor protein p53 (tp53), akt serine/threonine kinase 1 (akt1), estrogen receptor 1 (esr1), erb-b2 receptor tyrosine kinase 2 (erbb2), epidermal growth factor receptor (egfr), jun proto-oncogene (jun), and heat shock protein 90 alpha family class a member 1 (hsp90aa1) selected as the most important genes were used for verification by molecular docking and molecular dynamics simulation. |
2024-04-12 |
2024-04-15 |
Not clear |
| Samir Ali Abd El-Kaream, Nabila Gaber Ali Hussein, Sohier Mahmoud El-Kholey, Ahmed Mohammed Abd Elmoez Ibrahim Elhelbaw. Microneedle combined with iontophoresis and electroporation for assisted transdermal delivery of goniothalamus macrophyllus for enhancement sonophotodynamic activated cancer therapy. Scientific reports. vol 14. issue 1. 2024-04-04. PMID:38575628. |
in addition significantly increased apoptotic genes expressions (p53, caspase (3, 9), bax, and tnf alpha) and on the other hand decreased anti- apoptotic (bcl-2) and angiogenic (vegf) genes expressions. |
2024-04-04 |
2024-04-07 |
mouse |
| Jiangang Zheng, Abdul Haseeb, Ziyang Wang, Hejie Wan. Network pharmacology, computational biology integrated surface plasmon resonance technology reveals the mechanism of ellagic acid against rotavirus. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555283. |
the results of network pharmacological analysis showed that there were 35 intersection proteins, among which interleukin-1β (il-1β), albumin (alb), nuclear factor kappa-b1 (nf-κb1), toll-like receptor 4 (tlr4), tumor necrosis factor alpha (tnf-α), tumor protein p53 (tp53), recombinant smad family member 3 (samd3), epidermal growth factor (egf) and interleukin-4 (il-4) were potential core targets of ea anti-rv. |
2024-03-30 |
2024-04-02 |
Not clear |
| Wei-Xi Shen, Guang-Hua Li, Yu-Jia Li, Peng-Fei Zhang, Jia-Xing Yu, Di Shang, Qiu-Shi Wan. Prognostic Significance of Tumor Mutation Burden among Patients with Non-small Cell Lung Cancer Who Received Platinum-based Adjuvant Chemotherapy: An Exploratory Study. Journal of cancer prevention. vol 28. issue 4. 2024-01-11. PMID:38205359. |
ngs analysis exhibited that the most common mutated somatic genes among the 78 patients were tumor suppressor protein p53 (tp53), epidermal growth factor receptor, low-density lipoprotein receptor related protein 1b, dna methyltransferase 3 alpha and fat atypical cadherin 3, and their prevalence was 56.4%, 48.7%, 37.2%, 30.7%, and 25.6%, respectively. |
2024-01-11 |
2024-01-13 |
Not clear |
| Shohei Miyata, Takashi Ishii, Susumu Kitanak. Reduction of HIF-1α/PD-L1 by Catalytic Topoisomerase Inhibitor Induces Cell Death Through Caspase Activation in Cancer Cells Under Hypoxia. Anticancer research. vol 44. issue 1. 2024-01-02. PMID:38159998. |
under severe hypoxia, cellular apoptosis is induced through hypoxia-inducible factor 1, alpha subunit (hif-1α)-dependent p53 accumulation and p53 phosphorylation via ataxia telangiectasia mutated and ataxia telangiectasia and rad3-related (atr) activation via replication stress-induced dna damage response (ddr) activation. |
2024-01-02 |
2024-01-05 |
Not clear |
| Xiao-Qin Zhong, Da-Feng Hu, Yu Wang, Zhen-Qiu Ning, Min-Zhen Den. [Mechanism of Zhongfeng Xingnao Decoction in improving microcirculatory disorders in cerebral hemorrhage based on network pharmacology and molecular docking techniques]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 22. 2023-12-19. PMID:38114219. |
molecular docking results revealed that the common components β-sitosterol of rhei radix et rhizoma, notoginseng radix et rhizoma, and ginseng radix et rhizoma rubra showed good docking with proto-oncogene tyrosine-protein kinase(src), signal transducer and activator of transcription 3(stat3), phosphoinositide-3-kinase catalytic alpha polypeptide gene(pik3ca), recombinant protein tyrosine phosphatase non receptor type 11(ptpn11), akt1, epidermal growth factor receptor(egfr), calcium adhesion-associated protein beta 1(ctnnb1), vascular endothelial growth factor a(vegfa), and tumor protein p53(tp53). |
2023-12-19 |
2023-12-23 |
mouse |
| Taito Itoh, Yuko Omori, Mitsuru Seino, Katsuya Hirose, Fumiko Date, Yusuke Ono, Yusuke Mizukami, Shuichi Aoki, Masaharu Ishida, Masamichi Mizuma, Takanori Morikawa, Ryota Higuchi, Goro Honda, Yasunobu Okamura, Kengo Kinoshita, Michiaki Unno, Toru Furukaw. Gene rearrangement and expression of PRKACA and PRKACB governs morpho-biology of pancreatobiliary oncocytic neoplasms. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2023-10-23. PMID:37871652. |
we analyzed prkaca/b fusion genes including atp1b1-prkaca, dnajb1-prkaca, and atp1b1-prkacb by reverse transcription pcr (rt-pcr); mrna expression of fusion genes and non-rearranged prkaca/b genes by quantitative rt-pcr; mutations in kras, braf, and gnas by targeted sequencing or droplet digital pcr; and the expression of camp-dependent protein kinase catalytic subunit alpha (prkaca) and beta (prkacb), phosphorylated-creb, and aberrations of p16, p53, smad4, stk11, and β-catenin by immunohistochemistry. |
2023-10-23 |
2023-11-08 |
Not clear |
| Xi-Ying Tan, Jing Tao, Yu Zhang, Ru-Xin G. [Mechanism of Astragali Radix-Curcumae Rhizoma in treating gastric cancer based on network pharmacology and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 18. 2023-10-06. PMID:37802848. |
the cell experiments demonstrated that hqez significantly downregulated the expression of atp-binding cassette subfamily b member 1(abcb1), epidermal growth factor receptor(egfr), phosphorylated serine/threonine kinase(p-akt), hypoxia inducible factor 1 subunit alpha(hif1a), b-cell lymphoma 2(bcl2), breast cancer susceptibility protein 1(brca1), dna polymerase theta(polh), ribonucleotide reductase m1(rrm1), and excision repair cross-complementation group 1(ercc1), and upregulated the expression of tumor protein p53(tp53) and cysteinyl aspartate-specific proteinase(caps3). |
2023-10-06 |
2023-10-15 |
Not clear |
| Qiannan Ren, Qiming Sun, Junfen F. Dysfunction of autophagy in high-fat diet-induced nonalcoholic fatty liver disease. Autophagy. 2023-09-13. PMID:37700498. |
acox1: acyl-coa oxidase 1; adh5: alcohol dehydrogenase 5 (class iii), chi polypeptide; adipoq: adiponectin, c1q and collagen domain containing; atg: autophagy related; becn1: beclin 1; crtc2: creb regulated transcription coactivator 2; er: endoplasmic reticulum; f2rl1: f2r like trypsin receptor 1; fa: fatty acid; foxo1: forkhead box o1; glp1r: glucagon like peptide 1 receptor; grk2: g protein-coupled receptor kinase 2; gtpase: guanosine triphosphatase; hfd: high-fat diet; hscs: hepatic stellate cells; htra2: htra serine peptidase 2; irgm: immunity related gtpase m; kd: knockdown; kdm6b: lysine demethylase 6b; ko: knockout; lamp2: lysosomal associated membrane protein 2; lap: lc3-associated phagocytosis; lds: lipid droplets; li ko: liver-specific knockout; lsecs: liver sinusoidal endothelial cells; map1lc3/lc3: microtubule associated protein 1 light chain 3; map3k5: mitogen-activated protein kinase kinase kinase 5; med1: mediator complex subunit 1; mtor: mechanistic target of rapamycin kinase; mtorc1: mechanistic target of rapamycin complex 1; nafld: non-alcoholic fatty liver disease; nash: non-alcoholic steatohepatitis; nfe2l2: nfe2 like bzip transcription factor 2; nos3: nitric oxide synthase 3; nr1h3: nuclear receptor subfamily 1 group h member 3; oa: oleic acid; oe: overexpression; osbpl8: oxysterol binding protein like 8; pa: palmitic acid; rubcnl: rubicon like autophagy enhancer; plin2: perilipin 2; plin3: perilipin 3; ppara: peroxisome proliferator activated receptor alpha; prkaa2/ampk: protein kinase amp-activated catalytic subunit alpha 2; rab: member ras oncogene family; rptor: regulatory associated protein of mtor complex 1; scd: stearoyl-coa desaturase; sirt1: sirtuin 1; sirt3: sirtuin 3; snare: soluble n-ethylmaleimide-sensitive factor attachment protein receptor; sqstm1/p62: sequestosome 1; srebf1: sterol regulatory element binding transcription factor 1;srebf2: sterol regulatory element binding transcription factor 2; sting1: stimulator of interferon response cgamp interactor 1; stx17: syntaxin 17; tags: triacylglycerols; tfeb: transcription factor eb; tp53/p53: tumor protein p53; ulk1: unc-51 like autophagy activating kinase 1; vmp1: vacuole membrane protein 1. |
2023-09-13 |
2023-10-07 |
Not clear |
| Zheyi Liu, Lu Cui, Xuefeng Li, Li Xu, Yu Zhang, Zongxi Han, Shengwang Liu, Hai L. Characterization of the Effects of Host p53 and Fos on Gallid Alpha Herpesvirus 1 Replication. Genes. vol 14. issue 8. 2023-08-26. PMID:37628666. |
characterization of the effects of host p53 and fos on gallid alpha herpesvirus 1 replication. |
2023-08-26 |
2023-09-07 |
chicken |
| Zheyi Liu, Lu Cui, Xuefeng Li, Li Xu, Yu Zhang, Zongxi Han, Shengwang Liu, Hai L. Characterization of the Effects of Host p53 and Fos on Gallid Alpha Herpesvirus 1 Replication. Genes. vol 14. issue 8. 2023-08-26. PMID:37628666. |
our previous studies have shown that transcription factors p53 and fos are essential host determinants of gallid alpha herpesvirus 1 (iltv) infection. |
2023-08-26 |
2023-09-07 |
chicken |
| Yongting Zhang, Liang Hong, Xuehui Li, Yuyu Li, Xujun Zhang, Jingjing Jiang, Fan Shi, Hongyan Dia. M1 macrophage-derived exosomes promote autoimmune liver injury by transferring long noncoding RNA H19 to hepatocytes. MedComm. vol 4. issue 4. 2023-07-03. PMID:37398637. |
mechanistically, h19 upregulated the transcription of hypoxia-inducible factor-1 alpha (hif-1α), which accumulated in the cytoplasm and mediated hepatocyte apoptosis by upregulating p53. |
2023-07-03 |
2023-08-14 |
Not clear |
| Kalpana Baghel, Mukesh Kumar Niranjan, Rashmi Srivastav. Withania somnifera inhibits photorefractoriness which triggers neuronal apoptosis in both pre-optic and paraventricular hypothalamic area of Coturnix coturnix japonica: involvement of oxidative stress induced p53 dependent Caspase-3 mediated low immunoreactivity of estrogen receptor alpha. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2023-06-02. PMID:37266906. |
withania somnifera inhibits photorefractoriness which triggers neuronal apoptosis in both pre-optic and paraventricular hypothalamic area of coturnix coturnix japonica: involvement of oxidative stress induced p53 dependent caspase-3 mediated low immunoreactivity of estrogen receptor alpha. |
2023-06-02 |
2023-08-14 |
Not clear |
| Hyeon Jin Kim, Chang Woo Han, Mi Suk Jeong, Se Bok Jan. Structural study of novel vaccinia virus E3L and dsRNA-dependent protein kinase complex. Biochemical and biophysical research communications. vol 665. 2023-05-05. PMID:37146409. |
pkr inhibits the initiation of translation through alpha subunit of the initiation factor eif2 (eif2α) and mediates several transcription factors such as nf-κb, p53 or stats. |
2023-05-05 |
2023-08-14 |
Not clear |
| Rachel H Mansky, Erin A Greguske, Dahyun Yu, Nicole Zarate, Taylor A Intihar, Wei Tsai, Taylor G Brown, Mackenzie N Thayer, Kompal Kumar, Rocio Gomez-Pasto. Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington's disease. Cell reports. vol 42. issue 3. 2023-03-03. PMID:36867535. |
stabilized p53 promotes protein kinase ck2 alpha prime and e3 ligase fbxw7 transcription, both of which are responsible for hsf1 degradation. |
2023-03-03 |
2023-08-14 |
mouse |
| Robert L Fine, Yuehua Mao, Richard Dinnen, Ramon V Rosal, Anthony Raffo, Uri Hochfeld, Patrick Senatus, Jeffrey N Bruce, Gwen Nichols, Hsin Wang, Yongliang Li, Paul W Brandt-Rau. C-Terminal p53 Palindromic Tetrapeptide Restores Full Apoptotic Function to Mutant p53 Cancer Cells In Vitro and In Vivo. Biomedicines. vol 11. issue 1. 2023-01-21. PMID:36672645. |
four monomers were linked by glycine to maximize flexibility and in a palindromic order that mimics p53 tetramer formation with four orthogonal alpha helices, which is required for p53 transactivation of target genes. |
2023-01-21 |
2023-08-14 |
human |
| Efstathios T Pavlidis, Konstantinos G Sapalidis, Theodoros E Pavlidi. Modern aspects of the management of pancreatic intraductal papillary mucinous neoplasms: a narrative review. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 63. issue 3. 2023-01-02. PMID:36588487. |
the genes most frequently altered include kirsten rat sarcoma viral proto-oncogene (kras), tumor protein p53 (tp53), cyclin-dependent kinase inhibitor 2a (cdkn2a), smad family member 4 (smad4), and guanine nucleotide-binding protein, alpha stimulating (gnas). |
2023-01-02 |
2023-08-14 |
rat |
| Charlotte Van Der Stukken, Tim S Nawrot, Congrong Wang, Wouter Lefebvre, Charlotte Vanpoucke, Michelle Plusquin, Harry A Roels, Bram G Janssen, Dries S Marten. The association between ambient particulate matter exposure and the telomere-mitochondrial axis of aging in newborns. Environment international. vol 171. 2022-12-27. PMID:36574746. |
tumor suppressor p53 (p53) and peroxisome proliferator-activated receptor gamma co-activator 1 alpha (pgc-1α), are associated with prenatal air pollution and whether there are underlying mechanisms. |
2022-12-27 |
2023-08-14 |
Not clear |
| Li Xu, Zhijie Chen, Yu Zhang, Lu Cui, Zheyi Liu, Xuefeng Li, Shengwang Liu, Hai L. P53 maintains gallid alpha herpesvirus 1 replication by direct regulation of nucleotide metabolism and ATP synthesis through its target genes. Frontiers in microbiology. vol 13. 2022-12-12. PMID:36504811. |
p53 maintains gallid alpha herpesvirus 1 replication by direct regulation of nucleotide metabolism and atp synthesis through its target genes. |
2022-12-12 |
2023-08-14 |
chicken |