| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Busche, D Polascheck, J Lesting, J Neddens, G Teuchert-Nood. Developmentally induced imbalance of dopaminergic fibre densities in limbic brain regions of gerbils ( Meriones unguiculatus). Journal of neural transmission (Vienna, Austria : 1996). vol 111. issue 4. 2004-08-09. PMID:15057515. |
previous studies in our laboratory showed a suppressive maturation of da fibres in the prefrontal cortex (pfc) and nucleus accumbens (nac) induced by the same set of epigenetic factors. |
2004-08-09 |
2023-08-12 |
Not clear |
| Richard J Beninger, Todor Gerdjiko. The role of signaling molecules in reward-related incentive learning. Neurotoxicity research. vol 6. issue 1. 2004-08-03. PMID:15184110. |
thus, inhibition of cyclic adenosine monophosphate-dependent protein kinase (pka) in the nucleus accumbens (nac), that is activated by da acting at d1-like receptors, blocks the acquisition of conditioned approach responses, lever pressing for food, conditioned place preference (cpp) based on nac injections of amphetamine or cocaine, and conditioned activity based on nac injections of amphetamine. |
2004-08-03 |
2023-08-12 |
Not clear |
| C Giertler, I Bohn, W Haube. Transient inactivation of the rat nucleus accumbens does not impair guidance of instrumental behaviour by stimuli predicting reward magnitude. Behavioural pharmacology. vol 15. issue 1. 2004-08-02. PMID:15075627. |
the involvement of the nucleus accumbens (nac) in the determination of reaction times (rts) of instrumental responses by the expectancy of future reward was investigated. |
2004-08-02 |
2023-08-12 |
rat |
| Tomiki Sumiyoshi, Masahiko Tsunoda, Takashi Uehara, Kodai Tanaka, Hiroko Itoh, Chika Sumiyoshi, Masayoshi Kurach. Enhanced locomotor activity in rats with excitotoxic lesions of the entorhinal cortex, a neurodevelopmental animal model of schizophrenia: behavioral and in vivo microdialysis studies. Neuroscience letters. vol 364. issue 2. 2004-07-27. PMID:15196692. |
in order to examine the construct validity of rats with excitotoxic damage of the left entorhinal cortex (ec) as an animal model of schizophrenia, we measured dopamine (da)-related behaviors and methamphetamine (map)-induced da release in the accumbens nucleus (nac) in these animals. |
2004-07-27 |
2023-08-12 |
rat |
| Susana Mato, Vivien Chevaleyre, David Robbe, Angel Pazos, Pablo E Castillo, Olivier J Manzon. A single in-vivo exposure to delta 9THC blocks endocannabinoid-mediated synaptic plasticity. Nature neuroscience. vol 7. issue 6. 2004-07-20. PMID:15146190. |
here we show that in mice, a single in-vivo exposure to delta 9-tetrahydrocannabinol (thc) abolishes the retrograde signaling that underlies ecb-mediated synaptic plasticity in both nucleus accumbens (nac) and hippocampus in vitro. |
2004-07-20 |
2023-08-12 |
mouse |
| Mischa de Rover, Huibert D Mansvelder, Johannes C Lodder, George Wardeh, Anton N M Schoffelmeer, Arjen B Brussaar. Long-lasting nicotinic modulation of GABAergic synaptic transmission in the rat nucleus accumbens associated with behavioural sensitization to amphetamine. The European journal of neuroscience. vol 19. issue 10. 2004-07-12. PMID:15147319. |
a robust increase in dopaminergic transmission in the nucleus accumbens (nac) shell has been reported to be consistently associated with the long-term expression of behavioural sensitization to drugs of abuse. |
2004-07-12 |
2023-08-12 |
rat |
| Peter P Rowell, Kelly A Vol. Nicotinic activation of mesolimbic neurons assessed by rubidium efflux in rat accumbens and ventral tegmentum. Neuro-Signals. vol 13. issue 3. 2004-07-06. PMID:15067198. |
dopaminergic mesolimbic neurons, with cell bodies in the ventral tegmental area (vta) projecting to the nucleus accumbens (nac), have been shown to be involved in the development of drug dependence. |
2004-07-06 |
2023-08-12 |
rat |
| Evgeny A Budygin, Mark S Brodie, Tatyana D Sotnikova, Yolanda Mateo, Carrie E John, Michel Cyr, Raul R Gainetdinov, Sara R Jone. Dissociation of rewarding and dopamine transporter-mediated properties of amphetamine. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 20. 2004-07-06. PMID:15136721. |
moreover, systemic amph still increased extracellular da in the nucleus accumbens (nac) of mice lacking the dat, although local infusion of amph into the nac did not have this effect. |
2004-07-06 |
2023-08-12 |
mouse |
| Lu Gan, Tomas L Falzone, Kehong Zhang, Marcelo Rubinstein, Ross J Baldessarini, Frank I Taraz. Enhanced expression of dopamine D(1) and glutamate NMDA receptors in dopamine D(4) receptor knockout mice. Journal of molecular neuroscience : MN. vol 22. issue 3. 2004-06-17. PMID:14997010. |
labeling of d1 receptors was significantly increased in nucleus accumbens (nac; 39%) and caudate putamen (cpu; 42%) of d4-knockout mice vs wild-type controls. |
2004-06-17 |
2023-08-12 |
mouse |
| Karen T Delle Donne, June Chan, Helene Boudin, Didier Pélaprat, William Rostène, Virginia M Picke. Electron microscopic dual labeling of high-affinity neurotensin and dopamine D2 receptors in the rat nucleus accumbens shell. Synapse (New York, N.Y.). vol 52. issue 3. 2004-06-17. PMID:15065218. |
the dopamine d2 receptor (d2r) in the nucleus accumbens (nac) shell is implicated in schizophrenia and in psychostimulant-induced drug-seeking behavior, both of which are affected by activation of the functionally opposed high-affinity neurotensin receptor (nts1). |
2004-06-17 |
2023-08-12 |
rat |
| Eugene D Festa, Scott J Russo, Farhad M Gazi, Tipyamol Niyomchai, Lynne M Kemen, Shen-Nan Lin, Rodger Foltz, Shirzad Jenab, Vanya Quinones-Jena. Sex differences in cocaine-induced behavioral responses, pharmacokinetics, and monoamine levels. Neuropharmacology. vol 46. issue 5. 2004-06-15. PMID:14996545. |
female rats showed significant reductions in total levels of da, dopac, hva, serotonin (5-ht), 5-hydroxyindole acetic acid (5-hiaa), and dopac/da turnover in the nucleus accumbens (nac). |
2004-06-15 |
2023-08-12 |
rat |
| Daniele Lecca, Giovanna Piras, Peter Driscoll, Osvaldo Giorgi, Maria G Cord. A differential activation of dopamine output in the shell and core of the nucleus accumbens is associated with the motor responses to addictive drugs: a brain dialysis study in Roman high- and low-avoidance rats. Neuropharmacology. vol 46. issue 5. 2004-06-15. PMID:14996546. |
addictive substances like morphine and psychostimulants induce a preferential increase in dopamine (da) output in the nucleus accumbens (nac), a major terminal field of the mesolimbic dopaminergic projection. |
2004-06-15 |
2023-08-12 |
rat |
| Rutsuko Ito, Trevor W Robbins, Barry J Everit. Differential control over cocaine-seeking behavior by nucleus accumbens core and shell. Nature neuroscience. vol 7. issue 4. 2004-06-14. PMID:15034590. |
nucleus accumbens (nac) dopamine is widely implicated in mediating the reinforcing effects of drugs of abuse. |
2004-06-14 |
2023-08-12 |
rat |
| Irene A Yun, Ken T Wakabayashi, Howard L Fields, Saleem M Nicol. The ventral tegmental area is required for the behavioral and nucleus accumbens neuronal firing responses to incentive cues. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 12. 2004-06-10. PMID:15044531. |
reward-seeking elicited by predictive cues is facilitated by the release of dopamine in the nucleus accumbens (nac), yet the contribution of dopamine to the specific nac firing patterns that underlie goal-directed behavior has remained elusive. |
2004-06-10 |
2023-08-12 |
rat |
| Wenxue Tang, Michael Wesley, Willard M Freeman, Bill Liang, Scott E Hemb. Alterations in ionotropic glutamate receptor subunits during binge cocaine self-administration and withdrawal in rats. Journal of neurochemistry. vol 89. issue 4. 2004-06-04. PMID:15140200. |
western blotting was used to compare levels of iglur protein expression (nr1-3b, glur1-7, ka2) in the ventral tegmental area (vta), substantia nigra (sn), nucleus accumbens (nac), striatum and prefrontal cortex (pfc) of rats. |
2004-06-04 |
2023-08-12 |
rat |
| S L Haberny, Y Berman, E Meller, K D Car. Chronic food restriction increases D-1 dopamine receptor agonist-induced phosphorylation of extracellular signal-regulated kinase 1/2 and cyclic AMP response element-binding protein in caudate-putamen and nucleus accumbens. Neuroscience. vol 125. issue 1. 2004-06-03. PMID:15051167. |
the purpose of the present study was to determine whether d-1 da receptor binding and/or mitogen-activated protein kinase (mapk) signaling in caudate-putamen (cpu) and nucleus accumbens (nac) are increased in food-restricted subjects. |
2004-06-03 |
2023-08-12 |
human |
| Hiroyuki Mizoguchi, Kiyofumi Yamada, Makoto Mizuno, Tomoko Mizuno, Atsumi Nitta, Yukihiro Noda, Toshitaka Nabeshim. Regulations of methamphetamine reward by extracellular signal-regulated kinase 1/2/ets-like gene-1 signaling pathway via the activation of dopamine receptors. Molecular pharmacology. vol 65. issue 5. 2004-05-28. PMID:15102958. |
hyperphosphorylation of mitogen-activated protein kinase (mapk) erk1/2, but not p38 and c-jun n-terminal kinase/stress-activated protein kinase, was found in the nucleus accumbens (nac) and striatum but not in other brain areas of map-treated cpp(+) animals. |
2004-05-28 |
2023-08-12 |
rat |
| H Kittner, E Hoffmann, U Krügel, P Ille. P2 receptor-mediated effects on the open field behaviour of rats in comparison with behavioural responses induced by the stimulation of dopamine D2-like and by the blockade of ionotrophic glutamate receptors. Behavioural brain research. vol 149. issue 2. 2004-05-28. PMID:15129782. |
the stimulation of p2 receptors in the nucleus accumbens (nac) modulates the locomotion in the direction to be to be longer lasting, more consistent and more goal directed. |
2004-05-28 |
2023-08-12 |
rat |
| Richard J Beninger, Patricia L Nakonechny, Ioulia Savin. cAMP-dependent protein kinase and reward-related learning: intra-accumbens Rp-cAMPS blocks amphetamine-produced place conditioning in rats. Psychopharmacology. vol 170. issue 1. 2004-05-17. PMID:12768275. |
dopamine may produce reward-related learning by activating d(1)-like receptors in the nucleus accumbens (nac) and stimulating the formation of cyclic adenosine monophosphate (camp) and the activation of camp-dependent protein kinase (pka). |
2004-05-17 |
2023-08-12 |
rat |
| Saleem M Nicola, Irene A Yun, Ken T Wakabayashi, Howard L Field. Cue-evoked firing of nucleus accumbens neurons encodes motivational significance during a discriminative stimulus task. Journal of neurophysiology. vol 91. issue 4. 2004-05-17. PMID:14645377. |
the nucleus accumbens (nac) has long been thought of as a limbic-motor interface. |
2004-05-17 |
2023-08-12 |
rat |