| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susan M Ferguson, Ellen S Mitchell, John F Neumaie. Increased expression of 5-HT6 receptors in the nucleus accumbens blocks the rewarding but not psychomotor activating properties of cocaine. Biological psychiatry. vol 63. issue 2. 2008-02-27. PMID:17631868. |
although serotonin-6 receptors (5-ht6rs) are abundantly expressed in the brain regions thought to underlie these phenomena, such as the nucleus accumbens (nac), surprisingly little is known about the role of 5-ht6rs in the rewarding and psychomotor activating effects of cocaine. |
2008-02-27 |
2023-08-12 |
Not clear |
| Yanyan Wan. Differential effect of aging on synaptic plasticity in the ventral and dorsal striatum. Neurobiology of learning and memory. vol 89. issue 1. 2008-02-21. PMID:17942327. |
in this study, we investigated the effects of aging on synaptic plasticity in brain slices containing the nucleus accumbens (nac) or caudate-putamen (cpu), using electrophysiological recordings. |
2008-02-21 |
2023-08-12 |
mouse |
| Stan B Floresc. Dopaminergic regulation of limbic-striatal interplay. Journal of psychiatry & neuroscience : JPN. vol 32. issue 6. 2008-02-19. PMID:18043763. |
neurochemical, electrophysiological and behavioural evidence indicates that certain forms of goal-directed behaviours are mediated by complex and reciprocal interactions between limbic and dopamine (da) inputs in the nucleus accumbens (nac). |
2008-02-19 |
2023-08-12 |
Not clear |
| Sylvia Navailles, Delphine Moison, Kathryn A Cunningham, Umberto Spampinat. Differential regulation of the mesoaccumbens dopamine circuit by serotonin2C receptors in the ventral tegmental area and the nucleus accumbens: an in vivo microdialysis study with cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 2. 2008-02-06. PMID:17429406. |
stimulation of central serotonin2c receptor (5-ht(2c)r) inhibits dopamine (da)-dependent neurochemical and behavioral effects of cocaine, while 5-ht(2c)rs locally expressed into the ventral tegmental area (vta) and the nucleus accumbens (nac) exert opposite functional control over cocaine-induced behavioral effects. |
2008-02-06 |
2023-08-12 |
rat |
| Andrej Nikoshkov, Katarina Drakenberg, Xinyu Wang, Monika Cs Horvath, Eva Keller, Yasmin L Hur. Opioid neuropeptide genotypes in relation to heroin abuse: dopamine tone contributes to reversed mesolimbic proenkephalin expression. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 2. 2008-02-06. PMID:18184800. |
such individuals tended to express higher penk mrna than the 81-bp homozygotes, but penk levels within the nucleus accumbens (nac) shell were most strongly correlated to catecholamine-o-methyltransferase (comt) genotype. |
2008-02-06 |
2023-08-12 |
human |
| Catharine A Winstanle. The orbitofrontal cortex, impulsivity, and addiction: probing orbitofrontal dysfunction at the neural, neurochemical, and molecular level. Annals of the New York Academy of Sciences. vol 1121. 2008-02-04. PMID:17846162. |
both processes are heavily regulated by limbic corticostriatal circuits including the orbitofrontal cortex (ofc) and nucleus accumbens (nac), and are modulated by dopamine (da) and serotonin (5-ht). |
2008-02-04 |
2023-08-12 |
Not clear |
| R Mark Wightman, Michael L A V Heien, Kate M Wassum, Leslie A Sombers, Brandon J Aragona, Amina S Khan, Jennifer L Ariansen, Joseph F Cheer, Paul E M Phillips, Regina M Carell. Dopamine release is heterogeneous within microenvironments of the rat nucleus accumbens. The European journal of neuroscience. vol 26. issue 7. 2008-01-29. PMID:17868375. |
here we employ a voltammetric sensor technology coupled with principal component regression to examine the dynamics of dopamine concentrations in the nucleus accumbens (nac) of awake and unrestrained rats. |
2008-01-29 |
2023-08-12 |
rat |
| Bartley G Hoebel, Nicole M Avena, Pedro Rad. Accumbens dopamine-acetylcholine balance in approach and avoidance. Current opinion in pharmacology. vol 7. issue 6. 2008-01-24. PMID:18023617. |
research on the neural organization and functions of the dorsal striatum in movement disorders, such as huntington's and parkinson's disease, can inform the study of the nucleus accumbens (nac) in motivational disorders, such as addiction and depression. |
2008-01-24 |
2023-08-12 |
Not clear |
| Tiziana Pascucci, Rossella Ventura, Emanuele Claudio Latagliata, Simona Cabib, Stefano Puglisi-Allegr. The medial prefrontal cortex determines the accumbens dopamine response to stress through the opposing influences of norepinephrine and dopamine. Cerebral cortex (New York, N.Y. : 1991). vol 17. issue 12. 2008-01-23. PMID:17322559. |
to test this hypothesis, we first evaluated the dynamics of norepinephrine (ne) and da release in the mpfc and of da release in the nucleus accumbens (nac) of acutely stressed rats. |
2008-01-23 |
2023-08-12 |
rat |
| Daniele Lecca, Valentina Valentini, Fabio Cacciapaglia, Elio Acquas, Gaetano Di Chiar. Reciprocal effects of response contingent and noncontingent intravenous heroin on in vivo nucleus accumbens shell versus core dopamine in the rat: a repeated sampling microdialysis study. Psychopharmacology. vol 194. issue 1. 2008-01-23. PMID:17541779. |
although passive administration of heroin to drug-naive rats increases extracellular dopamine (da) in the nucleus accumbens (nac), its ability to do so also after active drug exposure (self-administration) is debated. |
2008-01-23 |
2023-08-12 |
rat |
| Elisa S Na, Michael J Morris, Ralph F Johnson, Terry G Beltz, Alan Kim Johnso. The neural substrates of enhanced salt appetite after repeated sodium depletions. Brain research. vol 1171. 2008-01-11. PMID:17822683. |
fos-ir activity was quantified in the paraventricular nucleus (pvn), subfornical organ (sfo), supraoptic nucleus (son), nucleus accumbens (nac) shell and core, basolateral (bla) and central amygdala (cea), and medial prefrontal cortex (mpfc). |
2008-01-11 |
2023-08-12 |
rat |
| Hackjin Kim, Ralph Adolphs, John P O'Doherty, Shinsuke Shimoj. Temporal isolation of neural processes underlying face preference decisions. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 46. 2008-01-10. PMID:17989234. |
activity in reward-related brain structures-the nucleus accumbens (nac) and orbitofrontal cortex (ofc)-was found to occur at temporally dissociable phases while subjects decided which of two unfamiliar faces they preferred. |
2008-01-10 |
2023-08-12 |
human |
| Yao-Chang Chiang, Jin-Chung Che. The role of the cannabinoid type 1 receptor and down-stream cAMP/DARPP-32 signal in the nucleus accumbens of methamphetamine-sensitized rats. Journal of neurochemistry. vol 103. issue 6. 2008-01-08. PMID:17953657. |
microinjection of cb(1) antagonist [5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-n-(1-piperidinyl)-1h-pyrazole-3-carboxamide] into the nucleus accumbens (nac) at withdrawal day 7, significantly suppressed the behavioral sensitization to methamphetamine. |
2008-01-08 |
2023-08-12 |
rat |
| William Renthal, Ian Maze, Vaishnav Krishnan, Herbert E Covington, Guanghua Xiao, Arvind Kumar, Scott J Russo, Ami Graham, Nadia Tsankova, Tod E Kippin, Kerry A Kerstetter, Rachael L Neve, Stephen J Haggarty, Timothy A McKinsey, Rhonda Bassel-Duby, Eric N Olson, Eric J Nestle. Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron. vol 56. issue 3. 2008-01-08. PMID:17988634. |
chronic, but not acute, exposure to cocaine or stress decreases hdac5 function in the nucleus accumbens (nac), a major brain reward region, which allows for increased histone acetylation and transcription of hdac5 target genes. |
2008-01-08 |
2023-08-12 |
Not clear |
| Dean Sabatinelli, Margaret M Bradley, Peter J Lang, Vincent D Costa, Francesco Versac. Pleasure rather than salience activates human nucleus accumbens and medial prefrontal cortex. Journal of neurophysiology. vol 98. issue 3. 2008-01-07. PMID:17596422. |
here we find in two studies that free viewing of pleasant images of erotic and romantic couples prompts clear, reliable increases in nucleus accumbens (nac) and medial prefrontal cortex (mpfc) activity, whereas equally arousing (salient) unpleasant images, and neutral pictures, do not. |
2008-01-07 |
2023-08-12 |
human |
| Jon E Grant, Suck Won Kim, Brian L Odlau. N-acetyl cysteine, a glutamate-modulating agent, in the treatment of pathological gambling: a pilot study. Biological psychiatry. vol 62. issue 6. 2008-01-02. PMID:17445781. |
n-acetyl cysteine (nac), an amino acid, seems to restore extracellular glutamate concentration in the nucleus accumbens and therefore offers promise in reducing addictive behavior. |
2008-01-02 |
2023-08-12 |
Not clear |
| Clinton B McCracken, Anthony A Grac. High-frequency deep brain stimulation of the nucleus accumbens region suppresses neuronal activity and selectively modulates afferent drive in rat orbitofrontal cortex in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 46. 2007-12-19. PMID:18003839. |
high-frequency deep-brain stimulation (dbs) of the nucleus accumbens (nac) region is an effective therapeutic avenue for patients with treatment-resistant obsessive-compulsive disorder (ocd). |
2007-12-19 |
2023-08-12 |
rat |
| David R Benavides, Jennifer J Quinn, Ping Zhong, Ammar H Hawasli, Ralph J DiLeone, Janice W Kansy, Peter Olausson, Zhen Yan, Jane R Taylor, James A Bib. Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 47. 2007-12-18. PMID:18032670. |
behavioral changes were accompanied by increased excitability of medium spiny neurons in the nucleus accumbens (nac) in cdk5 cko mice. |
2007-12-18 |
2023-08-12 |
mouse |
| Jing Liang, Yijing Li, Xingjie Ping, Peng Yu, Yanfang Zuo, Liuzhen Wu, Ji-Sheng Han, Cailian Cu. The possible involvement of endogenous ligands for mu-, delta- and kappa-opioid receptors in modulating morphine-induced CPP expression in rats. Peptides. vol 27. issue 12. 2007-12-06. PMID:17097192. |
injection of micrograms doses of the selective mu-opioid receptor agonist damgo, delta-agonist dpdpe or kappa-agonist u-50,488h or (c) microinjection of damgo, dpdpe or u50488h into the shell of the nucleus accumbens (nac). |
2007-12-06 |
2023-08-12 |
rat |
| Daniela Mohr, Peter K D Pilz, Claudia F Plappert, Markus Fend. Accumbal dopamine D2 receptors are important for sensorimotor gating in C3H mice. Neuroreport. vol 18. issue 14. 2007-12-06. PMID:17712281. |
to investigate the role of dopamine d1 and d2 receptors within the nucleus accumbens (nac) in sensorimotor gating in mice, we infused dopamine d1 and d2 receptor agonists (dihydrexidine and quinpirole respectively) directly into the nac and measured the effects on ppi and on prepulse facilitation. |
2007-12-06 |
2023-08-12 |
mouse |