| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert A Wheeler, Regina M Carell. Dissecting motivational circuitry to understand substance abuse. Neuropharmacology. vol 56 Suppl 1. 2009-04-15. PMID:18625253. |
here, we review studies from our laboratory that examined nucleus accumbens (nac) cell firing and rapid dopamine signaling using electrophysiological and electrochemical recordings in behaving rodents. |
2009-04-15 |
2023-08-12 |
Not clear |
| William A Carlezon, Mark J Thoma. Biological substrates of reward and aversion: a nucleus accumbens activity hypothesis. Neuropharmacology. vol 56 Suppl 1. 2009-04-15. PMID:18675281. |
the nucleus accumbens (nac) is a critical element of the mesocorticolimbic system, a brain circuit implicated in reward and motivation. |
2009-04-15 |
2023-08-12 |
Not clear |
| J L Lukkes, C H Summers, J L Scholl, K J Renner, G L Forste. Early life social isolation alters corticotropin-releasing factor responses in adult rats. Neuroscience. vol 158. issue 2. 2009-04-15. PMID:19010398. |
we tested the hypothesis that the stress of early life isolation enhances responses to crf in adulthood by determining the effect of crf infusions into the dorsal raphe nucleus (drn) on 5-ht release in the nucleus accumbens (nac) of adult rats using in vivo microdialysis. |
2009-04-15 |
2023-08-12 |
rat |
| N M Avena, P Rada, B G Hoebe. Underweight rats have enhanced dopamine release and blunted acetylcholine response in the nucleus accumbens while bingeing on sucrose. Neuroscience. vol 156. issue 4. 2009-04-14. PMID:18790017. |
since acetylcholine (ach) in the nucleus accumbens (nac) normally increases as a meal progresses and satiety ensues, we also tested whether ach release is altered when an animal has lost weight. |
2009-04-14 |
2023-08-12 |
rat |
| Yan Xu, Man-Ying Xu, Xia L. Modulation of gamma-aminobutyric acid on painful sense in central nervous system of morphine-dependent rats. Neuroscience bulletin. vol 24. issue 5. 2009-04-14. PMID:18839020. |
to observe the effects of gamma-aminobutyric acid (gaba) on the electric activities of pain-excited neurons (pen) in nucleus accumbens (nac) in central nervous system (cns) of morphine-dependent rats. |
2009-04-14 |
2023-08-12 |
rat |
| Christopher L Nelson, Michael Milovanovic, Joseph B Wetter, Kerstin A Ford, Marina E Wol. Behavioral sensitization to amphetamine is not accompanied by changes in glutamate receptor surface expression in the rat nucleus accumbens. Journal of neurochemistry. vol 109. issue 1. 2009-04-13. PMID:19183251. |
we examined whether behavioral sensitization to amphetamine is associated with redistribution of glutamate receptors (glur) in the rat nucleus accumbens (nac) or dorsolateral striatum (dlstr). |
2009-04-13 |
2023-08-12 |
rat |
| Scott J Russo, Matthew B Wilkinson, Michelle S Mazei-Robison, David M Dietz, Ian Maze, Vaishnav Krishnan, William Renthal, Ami Graham, Shari G Birnbaum, Thomas A Green, Bruce Robison, Alan Lesselyong, Linda I Perrotti, Carlos A Bolaños, Arvind Kumar, Michael S Clark, John F Neumaier, Rachael L Neve, Asha L Bhakar, Philip A Barker, Eric J Nestle. Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 11. 2009-04-13. PMID:19295158. |
although chronic cocaine-induced changes in dendritic spines on nucleus accumbens (nac) neurons have been correlated with behavioral sensitization, the molecular pathways governing these structural changes, and their resulting behavioral effects, are poorly understood. |
2009-04-13 |
2023-08-12 |
mouse |
| Massimo Grilli, Anna Pittaluga, Emilio Merlo-Pich, Mario March. NMDA-mediated modulation of dopamine release is modified in rat prefrontal cortex and nucleus accumbens after chronic nicotine treatment. Journal of neurochemistry. vol 108. issue 2. 2009-04-08. PMID:19046354. |
in this study, we investigate the effects of chronic administration of (-)nicotine on the function of the nmda-mediated modulation of [(3)h]dopamine (da) release in rat prefrontal cortex (pfc) and nucleus accumbens (nac). |
2009-04-08 |
2023-08-12 |
rat |
| Kristen A Horner, Erika S Noble, Edward C Lauterbac. Differential regulation of prodynophin, c-fos, and serotonin transporter mRNA following withdrawal from a chronic, escalating dose regimen of D-amphetamine. Synapse (New York, N.Y.). vol 63. issue 4. 2009-04-08. PMID:19116947. |
following 24 h of withdrawal, there was an increase in pd and c-fos mrna expression in the cpu and nucleus accumbens (nac), and a decrease in pd and c-fos expression in hippocampus and amygdala. |
2009-04-08 |
2023-08-12 |
rat |
| Mridula Rewal, Rachel Jurd, T Michael Gill, Dao-Yao He, Dorit Ron, Patricia H Jana. Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 2. 2009-04-08. PMID:19144854. |
using viral-mediated rna interference (rnai), we found that reduced expression of the alpha4 subunit in the nucleus accumbens (nac) shell of rats decreased their free consumption of and preference for alcohol. |
2009-04-08 |
2023-08-12 |
rat |
| Alberto Del Arco, Gregorio Segovia, Francisco Mor. Blockade of NMDA receptors in the prefrontal cortex increases dopamine and acetylcholine release in the nucleus accumbens and motor activity. Psychopharmacology. vol 201. issue 3. 2009-04-07. PMID:18751970. |
the present study investigates the effects of injections of a specific n-methyl-d-aspartic acid (nmda) antagonist 3-[(r)-2-carboxypiperazin-4-yl]-propyl-1-phophonic acid (cpp) into the prefrontal cortex (pfc) on the extracellular concentrations of dopamine and acetylcholine in the nucleus accumbens (nac) and on motor activity in the freely moving rat. |
2009-04-07 |
2023-08-12 |
rat |
| Kenneth D Carr, Soledad Cabeza de Vaca, Yanjie Sun, Lily S Chau, Yan Pan, Julie Dela Cru. Effects of the MEK inhibitor, SL-327, on rewarding, motor- and cellular-activating effects of D-amphetamine and SKF-82958, and their augmentation by food restriction in rat. Psychopharmacology. vol 201. issue 4. 2009-04-01. PMID:18766328. |
food restriction (fr) enhances learned and unlearned behavioral responses to drugs of abuse and increases d-1 dopamine (da) receptor-mediated activation of extracellular signal-regulated kinases (erk) 1/2 map kinase in nucleus accumbens (nac). |
2009-04-01 |
2023-08-12 |
rat |
| Giovanni Hernández, Peter Shizga. Dynamic changes in dopamine tone during self-stimulation of the ventral tegmental area in rats. Behavioural brain research. vol 198. issue 1. 2009-03-30. PMID:18996152. |
in a prior study, phasic release of dopamine (da) in the nucleus accumbens (nac) was only transiently and rarely detected by means of fast-scan cyclic voltammetry (fcsv) in rats already trained to work for electrical stimulation of the ventral tegmental area (vta) on a continuous reinforcement schedule. |
2009-03-30 |
2023-08-12 |
rat |
| Gary B Kaplan, Kimberly A Leite-Morris, Michael A Klufas, Wenying Fa. Intra-VTA adenosine A1 receptor activation blocks morphine stimulation of motor behavior and cortical and limbic Fos immunoreactivity. European journal of pharmacology. vol 602. issue 2-3. 2009-03-30. PMID:19027733. |
it also examined the effects of cpa on morphine's activation of vta neurons projecting to limbic and cortical regions including the nucleus accumbens (nac), anterior cingulate cortex (acg) and prelimbic cortex (prl) via quantitation of immediate-early gene c-fos protein in these regions. |
2009-03-30 |
2023-08-12 |
mouse |
| H-Y Liu, J Jin, J-S Tang, J-M Cu. Chronic fatigue stress leads to up-regulation of nitric oxide synthase in the rat nucleus accumbens. Scandinavian journal of medicine & science in sports. vol 18. issue 6. 2009-03-26. PMID:18248551. |
in the present study, the effect of chronic fatigue stress on the neuronal nitric oxide synthase (nnos) in the rat nucleus accumbens (nac) was assessed in order to explore the neurobiology mechanism of central fatigue stress, especially the role of the nac in central fatigue. |
2009-03-26 |
2023-08-12 |
rat |
| Amanda L Mickiewicz, Jeanine E Dallimore, T Celeste Napie. The ventral pallidum is critically involved in the development and expression of morphine-induced sensitization. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 4. 2009-03-23. PMID:18668032. |
it is known that the ventral tegmental area (vta) is necessary for induction, and expression involves the nucleus accumbens (nac). |
2009-03-23 |
2023-08-12 |
rat |
| Kenneth Blum, Amanda Lih Chuan Chen, Thomas J H Chen, Eric R Braverman, Jeffrey Reinking, Seth H Blum, Kimberly Cassel, Bernard W Downs, Roger L Waite, Lonna Williams, Thomas J Prihoda, Mallory M Kerner, Tomas Palomo, David E Comings, Howard Tung, Patrick Rhoades, Marlene Oscar-Berma. Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary. Theoretical biology & medical modelling. vol 5. 2009-03-16. PMID:19014506. |
thus, acute treatment should consist of preferential blocking of postsynaptic nucleus accumbens (nac) dopamine receptors (d1-d5), whereas long term activation of the mesolimbic dopaminergic system should involve activation and/or release of dopamine (da) at the nac site. |
2009-03-16 |
2023-08-12 |
Not clear |
| Elena H Chartoff, Maria Papadopoulou, Matt L MacDonald, Aram Parsegian, David Potter, Christine Konradi, William A Carlezo. Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissue. Molecular pharmacology. vol 75. issue 3. 2009-03-16. PMID:19106229. |
the nucleus accumbens (nac) is a critical brain area for reward and motivated behavior. |
2009-03-16 |
2023-08-12 |
rat |
| Rajani Maiya, Yan Zhou, Erin H Norris, Mary Jeanne Kreek, Sidney Stricklan. Tissue plasminogen activator modulates the cellular and behavioral response to cocaine. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 6. 2009-03-10. PMID:19181855. |
compared with wt mice, tpa-/- mice injected with cocaine displayed attenuated phosphorylation of erk, camp response element binding protein (creb), and dopamine and camp-regulated phosphoprotein 32 kda (darpp-32) and blunted induction of immediate early genes (iegs) c-fos, egr-1, and homer 1a in the amygdala and the nucleus accumbens (nac). |
2009-03-10 |
2023-08-12 |
mouse |
| Leslie A Sombers, Manna Beyene, Regina M Carelli, R Mark Wightma. Synaptic overflow of dopamine in the nucleus accumbens arises from neuronal activity in the ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 6. 2009-03-06. PMID:19211880. |
dopamine concentrations fluctuate on a subsecond time scale in the nucleus accumbens (nac) of awake rats. |
2009-03-06 |
2023-08-12 |
rat |