| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chitrakshi Pant, Genji Sukumar, Vidya Jyothi Alli, Surender Singh Jadav, Srihari Pabbaraja, Shasi V Kalivend. Allosteric Activation of SIRT1 by 2,4-Dihydroxy-azaflavanone Averts MPP ACS chemical neuroscience. 2024-07-29. PMID:39074306. |
allosteric activation of sirt1 by 2,4-dihydroxy-azaflavanone averts mpp parkinson's disease (pd) is a complex neurodegenerative disorder that affects dopamine neurons of the substantia nigra pars compacta (snpc), resulting in motor dysfunction. |
2024-07-29 |
2024-08-02 |
Not clear |
| Fang Zhao, Chuhan Li, Yinghan Zhuang, Yan Yan, Yanqin Gao, Thomas Behnisc. Apoptosis signal-regulating kinase 1 ( Frontiers in cellular neuroscience. vol 18. 2024-02-28. PMID:38414754. |
this study aimed to characterize evoked hippocampal dopamine release and assess the impact of the neurotoxin mpp |
2024-02-28 |
2024-03-01 |
Not clear |
| Sergei V Beliakov, Victor Blokhin, Sergey A Surkov, Michael V Ugrumo. LUHMES Cells: Phenotype Refinement and Development of an MPP International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614176. |
luhmes cells: phenotype refinement and development of an mpp the low effectiveness of symptomatic pharmacotherapy for parkinson's disease (pd), which compensates for dopamine (da) deficiency under degeneration of nigrostriatal dopaminergic (daergic) neurons, could apparently be improved with neuroprotective therapy, which slows down neurodegeneration and pd progression. |
2023-01-08 |
2023-08-14 |
human |
| Xing-Jie Xu, Tao Pan, Hui-Jie Fan, Xu Wang, Jie-Zhong Yu, Hai-Fei Zhang, Bao-Guo Xiao, Zhen-Yu Li, Bo Zhang, Cun-Gen Ma, Zhi Cha. Neuroprotective effect of hyperoside in MPP Metabolic brain disease. 2022-12-28. PMID:36576692. |
neuroprotective effect of hyperoside in mpp parkinson's disease (pd) is a neurodegenerative disease characterized by the pathological loss of nigrostriatal dopaminergic neurons, which causes an insufficient release of dopamine (da) and then induces motor and nonmotor symptoms. |
2022-12-28 |
2023-08-14 |
Not clear |
| Magdalena Kurnik-Łucka, Gniewomir Latacz, Joanna Goryl, Veronika Aleksandrovych, Krzysztof Gi. Salsolinol Protects SH-SY5Y Cells Against MPP Neurochemical research. 2022-11-30. PMID:36449199. |
salsolinol protects sh-sy5y cells against mpp a dopamine derivative, 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, known as salsolinol (sal), has increasingly gained attention since its first detection in the urine of parkinson's disease patients treated with levodopa, and has been proposed as a possible neurotoxic contributor to the disease. |
2022-11-30 |
2023-08-14 |
Not clear |
| Kyoung In Kim, Jeong Yeob Baek, Jae Yeong Jeong, Jin Han Nam, Eun Su Park, Eugene Bok, Won-Ho Shin, Young Cheul Chung, Byung Kwan Ji. Delayed Treatment of Capsaicin Produces Partial Motor Recovery by Enhancing Dopamine Function in MPP Experimental neurobiology. vol 28. issue 2. 2020-10-01. PMID:31138996. |
delayed treatment of capsaicin produces partial motor recovery by enhancing dopamine function in mpp transient receptor potential vanilloid subtype 1 (trpv1) on astrocytes prevents ongoing degeneration of nigrostriatal dopamine (da) neurons in mpp |
2020-10-01 |
2023-08-13 |
Not clear |
| Xiaoni Zhan, Gehua Wen, Enzhu Jiang, Fengrui Li, Xu Wu, Hao Pan. Secretogranin III upregulation is involved in parkinsonian toxin-mediated astroglia activation. The Journal of toxicological sciences. vol 45. issue 5. 2020-09-11. PMID:32404559. |
in the current study, we used the parkinsonian toxins dopamine (da), active metabolite of mptp (mpp |
2020-09-11 |
2023-08-13 |
Not clear |
| Jianzhong Zhu, Shan Wang, Weiwei Qi, Xue Xu, Yingyin Lian. Overexpression of miR-153 promotes oxidative stress in MPP International journal of clinical and experimental pathology. vol 11. issue 8. 2020-01-21. PMID:31949812. |
overexpression of mir-153 promotes oxidative stress in mpp increasing evidence points to oxidative stress as a chief mediator of parkinson's disease (pd) characterized by progressive loss of dopamine neurons in the pars compacta of the substantia nigra. |
2020-01-21 |
2023-08-13 |
Not clear |
| Mara Zilocchi, Giovanna Finzi, Marta Lualdi, Fausto Sessa, Mauro Fasano, Tiziana Alberi. Mitochondrial alterations in Parkinson's disease human samples and cellular models. Neurochemistry international. vol 118. 2019-09-16. PMID:29704589. |
indeed, sh-sy5y cells were treated with either dopamine or 1-methyl-4-phenylpyridinium (mpp |
2019-09-16 |
2023-08-13 |
human |
| Xiaotong Gu, Lei Liu, Qi Shen, Da Xin. Photoactivation of ERK/CREB/VMAT2 pathway attenuates MPP Cellular signalling. vol 37. 2018-05-22. PMID:28627368. |
photoactivation of erk/creb/vmat2 pathway attenuates mpp the vesicular monoamine transporter 2 (vmat2) pumps dopamine from cytoplasm into synaptic vesicles for subsequent release, and the deficits of vmat2 has been implicated in the dopaminergic neuronal cell loss which is considered as a typical pathological feature of parkinson's disease (pd). |
2018-05-22 |
2023-08-13 |
Not clear |
| Juliann D Jaumotte, Stephanie L Wyrostek, Michael J Zigmon. Protection of cultured dopamine neurons from MPP(+) requires a combination of neurotrophic factors. The European journal of neuroscience. vol 44. issue 1. 2017-12-22. PMID:27098376. |
protection of cultured dopamine neurons from mpp(+) requires a combination of neurotrophic factors. |
2017-12-22 |
2023-08-13 |
rat |
| Guohua Yu, Ajun Deng, Wanbin Tang, Junzhi Ma, Chonggang Yuan, Jiyan M. Hydroxytyrosol induces phase II detoxifying enzyme expression and effectively protects dopaminergic cells against dopamine- and 6-hydroxydopamine induced cytotoxicity. Neurochemistry international. vol 96. 2017-12-12. PMID:26970393. |
we found that ht effectively protected dopaminergic sh-sy5y cells against dopamine (da) and 6-hydroxydopamine (6-ohda) induced cell death, but had no apparent effect on 1-methyl-4-phenylpyridinium (mpp(+))-induced cytotoxicity. |
2017-12-12 |
2023-08-13 |
Not clear |
| Chi Zhang, Xianrui Yuan, Zhongliang Hu, Songlin Liu, Haoyu Li, Ming Wu, Jian Yuan, Zijin Zhao, Jun Su, Xiangyu Wang, Yiwei Liao, Qing Li. Valproic Acid Protects Primary Dopamine Neurons from MPP BioMed research international. vol 2017. 2017-05-01. PMID:28421199. |
valproic acid protects primary dopamine neurons from mpp valproic acid (vpa), a drug widely used to treat manic disorder and epilepsy, has recently shown neuroprotective effects in several neurological diseases, particularly in parkinson's disease (pd). |
2017-05-01 |
2023-08-13 |
Not clear |
| Toshio Obata, Michiko Nakashim. Opening of ATP-sensitive K(+) (KATP) channels enhance hydroxyl radical generation induced by MPP(+) in rat striatum. Journal of the neurological sciences. vol 366. 2017-04-25. PMID:27288802. |
mpp(+) (5mm) enhanced generation of oh with concomitant increased efflux of dopamine (da). |
2017-04-25 |
2023-08-13 |
rat |
| Harriet Keane, Brent J Ryan, Brendan Jackson, Alan Whitmore, Richard Wade-Martin. Protein-protein interaction networks identify targets which rescue the MPP+ cellular model of Parkinson's disease. Scientific reports. vol 5. 2016-09-26. PMID:26608097. |
as an exemplar, parkinson's disease (pd) involves multiple perturbed cellular functions, including mitochondrial dysfunction and autophagic dysregulation in preferentially-sensitive dopamine neurons, a selective pathophysiology recapitulated in vitro using the neurotoxin mpp(+). |
2016-09-26 |
2023-08-13 |
Not clear |
| Yueting Shao, Daniel Figeys, Zhibin Ning, Ryan Mailloux, Hing Man Cha. Methylmercury can induce Parkinson's-like neurotoxicity similar to 1-methyl-4- phenylpyridinium: a genomic and proteomic analysis on MN9D dopaminergic neuron cells. The Journal of toxicological sciences. vol 40. issue 6. 2016-08-22. PMID:26558463. |
our previous study showed that methylmercury (mehg) exposure can disrupt synthesis, uptake and metabolism of dopamine similar to 1-methyl-4-phenylpyridinium (mpp(+)). |
2016-08-22 |
2023-08-13 |
Not clear |
| Shan-Shan Guo, Xiao-Lan Cui, Wolf-Dieter Rausc. Ganoderma Lucidum polysaccharides protect against MPP(+) and rotenone-induced apoptosis in primary dopaminergic cell cultures through inhibiting oxidative stress. American journal of neurodegenerative disease. vol 5. issue 2. 2016-06-23. PMID:27335703. |
results revealed that glp can protect dopamine neurons against mpp(+) and rotenone at the concentrations of 100, 50 and 25 μg/ml in primary mesencephalic cultures in a dose-dependent manner. |
2016-06-23 |
2023-08-13 |
mouse |
| Mona Bains, James L Robert. Estrogen protects against dopamine neuron toxicity in primary mesencephalic cultures through an indirect P13K/Akt mediated astrocyte pathway. Neuroscience letters. vol 610. 2016-05-09. PMID:26520464. |
previous data from our lab suggests indirect actions of estrogen through erα in neighboring astroglia to protect dopamine neurons against 1-methyl-4-phenylpyridinium (mpp(+)) toxicity in mouse mesencephalic cultures. |
2016-05-09 |
2023-08-13 |
mouse |
| Mona Bains, James L Robert. Estrogen protects against dopamine neuron toxicity in primary mesencephalic cultures through an indirect P13K/Akt mediated astrocyte pathway. Neuroscience letters. vol 610. 2016-05-09. PMID:26520464. |
primary mesencephalic cultures pre-treated with 17β-estradiol and the membrane impermeable estrogen, e2-bsa, were both neuroprotective against mpp(+) -induced dopamine neuron toxicity, suggesting membrane-initiated neuroprotection. |
2016-05-09 |
2023-08-13 |
mouse |
| Mona Bains, James L Robert. Estrogen protects against dopamine neuron toxicity in primary mesencephalic cultures through an indirect P13K/Akt mediated astrocyte pathway. Neuroscience letters. vol 610. 2016-05-09. PMID:26520464. |
estrogen signaling via astrocytes is rapidly initiated at the membrane level and requires pi3 kinase signaling in order to protect primary mesencephalic dopamine neurons from mpp(+) neurotoxicity. |
2016-05-09 |
2023-08-13 |
mouse |