| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hans-Christian von Büdingen, Stephen L Hauser, Jean-Christophe Ouallet, Naoyuki Tanuma, Til Menge, Claude P Genai. Frontline: Epitope recognition on the myelin/oligodendrocyte glycoprotein differentially influences disease phenotype and antibody effector functions in autoimmune demyelination. European journal of immunology. vol 34. issue 8. 2004-09-14. PMID:15259004. |
preliminary observations of humoral immunity against the myelin oligodendrocyte glycoprotein (mog) in experimental allergic encephalomyelitis (eae) and human multiple sclerosis (ms) suggest that a subset of anti-mog autoantibodies directed against conformational epitopes is of pathogenic predominance. |
2004-09-14 |
2023-08-12 |
human |
| Naoto Kawakami, Silke Lassmann, Zhaoxia Li, Francesca Odoardi, Thomas Ritter, Tjalf Ziemssen, Wolfgang E F Klinkert, Joachim W Ellwart, Monika Bradl, Kimberly Krivacic, Hans Lassmann, Richard M Ransohoff, Hans-Dieter Volk, Hartmut Wekerle, Christopher Linington, Alexander Flüge. The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. The Journal of experimental medicine. vol 199. issue 2. 2004-09-03. PMID:14734524. |
potentially lethal eae is mediated by myelin basic protein (mbp)-specific t cells in lewis rats, whereas transfer of s100beta- or myelin oligodendrocyte glycoprotein (mog)-specific t cells causes intense inflammatory response in the central nervous system (cns) with minimal disease. |
2004-09-03 |
2023-08-12 |
rat |
| Eilhard Mix, Saleh Ibrahim, Jens Pahnke, Dirk Koczan, Christian Sina, Tobias Böttcher, Hans-Jürgen Thiesen, Arndt Rolf. Gene-expression profiling of the early stages of MOG-induced EAE proves EAE-resistance as an active process. Journal of neuroimmunology. vol 151. issue 1-2. 2004-08-18. PMID:15145614. |
experimental autoimmune encephalomyelitis (eae) induced by myelin oligodendrocyte glycoprotein (mog) is a well-established animal model of multiple sclerosis (ms) in rodents. |
2004-08-18 |
2023-08-12 |
mouse |
| Marcel Zocher, Patrick A Baeuerl. A bispecific single-chain antibody fusion protein for targeted depletion of autoreactive B cells via unstimulated human T lymphocytes. Molecular immunology. vol 41. issue 5. 2004-08-17. PMID:15183929. |
we describe the design, purification and characterization of mogxanti-cd3, a single-chain bispecific antibody fusion protein recognizing b cell receptors specific for the human myelin oligodendrocyte glycoprotein (mog) and to cd3 on human t cells. |
2004-08-17 |
2023-08-12 |
human |
| Kamruz Darabi, Alexey Y Karulin, Bernhard O Boehm, Harald H Hofstetter, Zsuzsa Fabry, Joseph C LaManna, Juan C Chavez, Magdalena Tary-Lehmann, Paul V Lehman. The third signal in T cell-mediated autoimmune disease? Journal of immunology (Baltimore, Md. : 1950). vol 173. issue 1. 2004-08-17. PMID:15210763. |
this situation is reflected after the immunization of c57bl/6 mice with the neuroantigen myelin oligodendrocyte glycoprotein (mog) with cfa, which primes a type 1 t cell response but does not lead to clinical or histological manifestation of experimental allergic encephalomyelitis unless pertussis toxin is injected in addition. |
2004-08-17 |
2023-08-12 |
mouse |
| Felix Bischof, Adriaan Bins, Michael Dürr, Yinka Zevering, Arthur Melms, Ada M Kruisbee. A structurally available encephalitogenic epitope of myelin oligodendrocyte glycoprotein specifically induces a diversified pathogenic autoimmune response. Journal of immunology (Baltimore, Md. : 1950). vol 173. issue 1. 2004-08-17. PMID:15210822. |
multiple sclerosis is an inflammatory disease of the cns that involves immune reactivity against myelin oligodendrocyte glycoprotein (mog), a type i transmembrane protein located at the outer surface of cns myelin. |
2004-08-17 |
2023-08-12 |
mouse |
| David Liñares, Paula Mañá, Melinda Goodyear, Anne M Chow, Chelsea Clavarino, Nicholas D Huntington, Louise Barnett, Frank Koentgen, Ryo Tomioka, Claude C A Bernard, Manuel Freire-Garabal, Hugh H Rei. The magnitude and encephalogenic potential of autoimmune response to MOG is enhanced in MOG deficient mice. Journal of autoimmunity. vol 21. issue 4. 2004-08-10. PMID:14624757. |
myelin oligodendrocyte glycoprotein (mog) is a minor component of central nervous system myelin presumably implicated in the pathogenesis of multiple sclerosis (ms). |
2004-08-10 |
2023-08-12 |
mouse |
| Joan M Boggs, Huimin Wan. Co-clustering of galactosylceramide and membrane proteins in oligodendrocyte membranes on interaction with polyvalent carbohydrate and prevention by an intact cytoskeleton. Journal of neuroscience research. vol 76. issue 3. 2004-07-29. PMID:15079863. |
myelin oligodendrocyte glycoprotein (mog), proteolipid protein (plp), mapk, and some phosphotyrosine-containing proteins were found to co-cluster with galc and mbp, but myelin-associated glycoprotein (mag) and phosphatidylinositol-4,5-bisphosphate (pip(2)) did not. |
2004-07-29 |
2023-08-12 |
cattle |
| Yi Huang, Tao Li, Yun Wang, Jawaid Ansar, Guo Lanting, Xiehe Liu, Jing Hua Zhao, Xun Hu, Pak C Sham, David Collie. Linkage disequilibrium analysis of polymorphisms in the gene for myelin oligodendrocyte glycoprotein in Tourette's syndrome patients from a Chinese sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 124B. issue 1. 2004-07-28. PMID:14681920. |
an immunopathogenic role of antibodies against myelin oligodendrocyte glycoprotein (mog) has been suggested in this syndrome. |
2004-07-28 |
2023-08-12 |
Not clear |
| Daniel Hawiger, Revati F Masilamani, Estelle Bettelli, Vijay K Kuchroo, Michel C Nussenzwei. Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo. Immunity. vol 20. issue 6. 2004-07-15. PMID:15189735. |
to examine the role of dc regulated peripheral tolerance in a model autoimmune disease, we delivered an encephalitogenic oligodendrocyte glycoprotein (mog) peptide to dcs in vivo. |
2004-07-15 |
2023-08-12 |
Not clear |
| Muriel Hobom, Maria K Storch, Robert Weissert, Katharina Maier, Anand Radhakrishnan, Birgit Kramer, Mathias Bähr, Ricarda Die. Mechanisms and time course of neuronal degeneration in experimental autoimmune encephalomyelitis. Brain pathology (Zurich, Switzerland). vol 14. issue 2. 2004-07-15. PMID:15193027. |
we analyzed the mechanism and kinetics of neuronal cell death in experimental autoimmune encephalomyelitis (eae) induced by myelin oligodendrocyte glycoprotein (mog) by combining an electrophysiological in vivo assessment of the optic pathway with the investigation of retinal ganglion cell (rgc) counts. |
2004-07-15 |
2023-08-12 |
Not clear |
| Catherine Weir, Claude C A Bernard, B Thomas Bäckströ. IL-5-deficient mice are susceptible to experimental autoimmune encephalomyelitis. International immunology. vol 15. issue 11. 2004-07-02. PMID:14565926. |
wild-type c57bl/6j and il-5(-/-) mice were immunized with myelin oligodendrocyte glycoprotein (mog)(35-55) peptide and the development of eae observed. |
2004-07-02 |
2023-08-12 |
mouse |
| Cathleen Rich, Jason M Link, Alex Zamora, Helle Jacobsen, Roberto Meza-Romero, Halina Offner, Richard Jones, Gregory G Burrows, Lars Fugger, Arthur A Vandenbar. Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice. European journal of immunology. vol 34. issue 5. 2004-06-29. PMID:15114658. |
in this study, we compared the encephalitogenic activity of three dr2-restricted myelin determinants [mouse (m) myelin oligodendrocyte glycoprotein (mog)-35-55, human (h)mog-35-55 and myelin basic protein (mbp)-87-99] in tg mice expressing the ms-associated dr2 allele, drb1*1501. |
2004-06-29 |
2023-08-12 |
mouse |
| Daniel Offen, Yossi Gilgun-Sherki, Yael Barhum, Moran Benhar, Leonid Grinberg, Reuven Reich, Eldad Melamed, Daphne Atla. A low molecular weight copper chelator crosses the blood-brain barrier and attenuates experimental autoimmune encephalomyelitis. Journal of neurochemistry. vol 89. issue 5. 2004-06-18. PMID:15147517. |
in the myelin oligodendrocyte glycoprotein (mog)-induced experimental autoimmune encephalomyelitis (eae), a mouse model of ms, oral administration of ad4 drastically reduced the clinical signs, inflammation, mmp-9 activity, and protected axons from demylination damages. |
2004-06-18 |
2023-08-12 |
mouse |
| Jun Kawanokuchi, Tetsuya Mizuno, Hideki Kato, Norimasa Mitsuma, Akio Suzumur. Effects of interferon-beta on microglial functions as inflammatory and antigen presenting cells in the central nervous system. Neuropharmacology. vol 46. issue 5. 2004-06-15. PMID:14996551. |
it also suppressed microglial il-12 production and differentiation of myelin oligodendrocyte glycoprotein (mog)-sensitized t cells into the t helper 1 phenotype, which use microglia as antigen presenting cells. |
2004-06-15 |
2023-08-12 |
Not clear |
| Adriana Carvalho, Gabriele Sant'anna, Cláudio Cirne Santos, Izabel Palmer Frugulhetti, Soniza Alves Leon, Thereza Quírico-Santo. [Determination of autoantibody for myelin antigens in the serum of patients HLA-DQB1*0602 with multiple sclerosis]. Arquivos de neuro-psiquiatria. vol 61. issue 4. 2004-06-08. PMID:14762600. |
we determined the serum levels of autoantibodies for myelin basic protein (mbp), proteolipid (plp) and myelin oligodendrocyte glycoprotein sequence mog 92-106 in a group of 54 healthy individuals and 26 ms patients expressing or not hla-dqb1*0602. |
2004-06-08 |
2023-08-12 |
human |
| A Jansson, J Ernerudh, M Kvarnström, C Ekerfelt, M Vrethe. Elispot assay detection of cytokine secretion in multiple sclerosis patients treated with interferon-beta1a or glatiramer acetate compared with untreated patients. Multiple sclerosis (Houndmills, Basingstoke, England). vol 9. issue 5. 2004-06-03. PMID:14582766. |
spontaneous and myelin induced (myelin basic protein (mbp), myelin oligodendrocyte glycoprotein (mog)-14-39 and mog 63-87) ifn-gamma, il-4, il-5 and il-10 secretion was studied. |
2004-06-03 |
2023-08-12 |
Not clear |
| Biying Xu, David W Scot. A novel retroviral gene therapy approach to inhibit specific antibody production and suppress experimental autoimmune encephalomyelitis induced by MOG and MBP. Clinical immunology (Orlando, Fla.). vol 111. issue 1. 2004-05-27. PMID:15093551. |
herein, we demonstrate that inhibition of antibody production specific for myelin oligodendrocyte glycoprotein (mog) and suppression of chronic eae induced by mog in susceptible mice can be elicited by mog-ig gene therapy. |
2004-05-27 |
2023-08-12 |
mouse |
| Juliane Klehmet, Carey Shive, Rocio Guardia-Wolff, Ines Petersen, Edward G Spack, Bernhard O Boehm, Robert Weissert, Thomas G Forsthube. T cell epitope spreading to myelin oligodendrocyte glycoprotein in HLA-DR4 transgenic mice during experimental autoimmune encephalomyelitis. Clinical immunology (Orlando, Fla.). vol 111. issue 1. 2004-05-27. PMID:15093552. |
t cell epitope spreading has been demonstrated in rodents for myelin basic protein (mbp) and proteolipid protein (plp) determinants, but not for myelin oligodendrocyte glycoprotein (mog), another important myelin antigen. |
2004-05-27 |
2023-08-12 |
mouse |
| Nirit Lev, Yael Barhum, Eldad Melamed, Daniel Offe. Bax-ablation attenuates experimental autoimmune encephalomyelitis in mice. Neuroscience letters. vol 359. issue 3. 2004-05-25. PMID:15050683. |
here, we studied the role of the pro-apoptotic gene bax in myelin oligodendrocyte glycoprotein (mog)-induced experimental autoimmune encephalomyelitis (eae), the animal model for ms. we demonstrate that the clinical signs were markedly reduced in the eae bax-deficient mice as compared to wild type (2.3 +/- 0.5 vs. 1.02 +/- 0.32, respectively, p < 0.05). |
2004-05-25 |
2023-08-12 |
mouse |