| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takuro Yoshimoto, Kimie Niimi, Eiki Takahash. Serum matrix metalloproteinase 9 (MMP9) as a biochemical marker for wasting marmoset syndrome. The Journal of veterinary medical science. vol 78. issue 5. 2017-06-08. PMID:26876041. |
in this study, as a first step to finding biochemical marker(s) for the accurate diagnosis of wms, we conducted blood cell counts, including hematocrit, hemoglobin and platelets, and examined serum chemistry values, including albumin, calcium and levels of serum matrix metalloproteinase 9 (mmp9), using a colony of marmosets with and without weight loss. |
2017-06-08 |
2023-08-13 |
human |
| Takuro Yoshimoto, Kimie Niimi, Eiki Takahash. Serum matrix metalloproteinase 9 (MMP9) as a biochemical marker for wasting marmoset syndrome. The Journal of veterinary medical science. vol 78. issue 5. 2017-06-08. PMID:26876041. |
mmp9 is thought to be an enzyme responsible for the degradation of extracellular matrix components and participates in the pathogenesis of inflammatory conditions, such as human and murine inflammatory bowel disease, which, like wms, are characterized histologically by inflammatory cell infiltrations in the intestines. |
2017-06-08 |
2023-08-13 |
human |
| Huey Lin, Mia Angeli, Kwang Jin Chung, Chukwuemeka Ejimadu, Angelica Rivera Rosa, Techung Le. sFRP2 activates Wnt/β-catenin signaling in cardiac fibroblasts: differential roles in cell growth, energy metabolism, and extracellular matrix remodeling. American journal of physiology. Cell physiology. vol 311. issue 5. 2017-06-06. PMID:27605451. |
in conjunction with these phenotypic changes, cfs accelerated ecm remodeling through upregulation of expression of the matrix metalloproteinase (mmp) 1 and mmp13 genes, two members of the collagenase subfamily, and enzyme activities of mmp2 and mmp9, two members of the gelatinase subfamily. |
2017-06-06 |
2023-08-13 |
mouse |
| Wen Nie, Ting Yu, Yaxiong Sang, Xiang Ga. Tumor-promoting effect of IL-23 in mammary cancer mediated by infiltration of M2 macrophages and neutrophils in tumor microenvironment. Biochemical and biophysical research communications. vol 482. issue 4. 2017-06-06. PMID:27956175. |
il-23 promotes tumor-associate inflammatory response such as infiltration of m2 macrophages, neutrophils and their elevated secretions of immunosuppressive cytokines transforming growth factor-β (tgf-β), il-10 and vascular endothelial growth factor (vegf) into tumor tissues, meanwhile the increase of the matrix metalloprotease mmp9. |
2017-06-06 |
2023-08-13 |
Not clear |
| Chanèle Cyr-Depauw, Jason J Northey, Sébastien Tabariès, Matthew G Annis, Zhifeng Dong, Sean Cory, Michael Hallett, Jonathan P Rennhack, Eran R Andrechek, Peter M Siege. Chordin-Like 1 Suppresses Bone Morphogenetic Protein 4-Induced Breast Cancer Cell Migration and Invasion. Molecular and cellular biology. vol 36. issue 10. 2017-05-26. PMID:26976638. |
we demonstrate that bmp4 also stimulated breast cancer cell invasion and matrix degradation, in part, through enhanced metalloproteinase 2 (mmp2) and mmp9 activity that is antagonized by chrdl1. |
2017-05-26 |
2023-08-13 |
Not clear |
| Yujuan Cai, Wei Tan, Xi Shen, Yanji Zhu, Yushuo Gao, Ailing Sui, Qing Lu, Yisheng Zhong, Bing Xi. Neutralization of IL-23 depresses experimental ocular neovascularization. Experimental eye research. vol 146. 2017-05-25. PMID:26980350. |
we found a significantly higher expression of il-23 in the retinas with oxygen-induced retinopathy (oir), and after neutralizing il-23, the mrna and protein levels of the angiogenic factors vascular endothelial growth factor receptor (vegfr)1/flt-1, vegfr2/flk-1, placental growth factor (pigf), endothelial-specific receptor tyrosine kinase (tie2), inducible nitric-oxide synthase (inos), matrix metalloproteinase (mmp) 2 and mmp9 were significantly down regulated, while the opposite trend was found for the anti-angiogenic molecules chemokine (c-x-c motif) ligand (cxcl) 9 and cxcl10. |
2017-05-25 |
2023-08-13 |
mouse |
| Mary Sproull, Tamalee Kramp, Anita Tandle, Uma Shankavaram, Kevin Camphause. Multivariate Analysis of Radiation Responsive Proteins to Predict Radiation Exposure in Total-Body Irradiation and Partial-Body Irradiation Models. Radiation research. vol 187. issue 2. 2017-05-25. PMID:28118115. |
in this murine study, we evaluated the efficacy of a novel combination of radiation responsive proteins, flt3 ligand (fl), serum amyloid a (saa), matrix metalloproteinase 9 (mmp9), fibrinogen beta (fgb) and pentraxin 3 (ptx3) to predict the received dose after whole- or partial-body irradiation. |
2017-05-25 |
2023-08-13 |
mouse |
| Kalu U E Ogbureke, Komal Koli, Geetu Saxen. Matrix Metalloproteinase 20 Co-expression With Dentin Sialophosphoprotein in Human and Monkey Kidneys. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 64. issue 10. 2017-05-24. PMID:27666430. |
our earlier reports have shown the co-expression of three mmps, mmp2, mmp3, and mmp9, with specific members of the sibling family: bone sialoprotein, osteopontin, and dentin matrix protein 1, respectively. |
2017-05-24 |
2023-08-13 |
human |
| Ariel B Rydeen, Joshua S Waxma. Cyp26 Enzymes Facilitate Second Heart Field Progenitor Addition and Maintenance of Ventricular Integrity. PLoS biology. vol 14. issue 11. 2017-05-24. PMID:27893754. |
molecularly, excess ra signaling negatively regulates fibroblast growth factor 8a (fgf8a) expression and positively regulates matrix metalloproteinase 9 (mmp9) expression. |
2017-05-24 |
2023-08-13 |
zebrafish |
| Si Eun Park, Sa Rang Lim, Hyung-Kyoon Choi, Jeehyeon Ba. Triazine herbicides inhibit relaxin signaling and disrupt nitric oxide homeostasis. Toxicology and applied pharmacology. vol 307. 2017-05-23. PMID:27431321. |
in addition, downstream target genes of the relaxin pathway including nitric oxide (no) synthase 2 (nos2), nos3, matrix metallopeptidase 9 (mmp9), and vascular endothelial growth factor (vegf) were downregulated in their ovaries. |
2017-05-23 |
2023-08-13 |
mouse |
| J G Ren, W Zhang, B Liu, Q W Man, X P Xiong, C Li, J Y Zhu, W M Wang, J Jia, Z J Sun, W F Zhang, G Chen, Y F Zha. Clinical Significance and Roles in Angiogenesis of Circulating Microparticles in Oral Cancer. Journal of dental research. vol 95. issue 8. 2017-05-15. PMID:27013642. |
moreover, these increased circulating mps were significantly correlated with tumor size, tnm stages, microvessel density, and expression levels of vascular endothelial growth factor (vegf) and matrix metallopeptidase 9 (mmp9) in oscc patients. |
2017-05-15 |
2023-08-13 |
human |
| Maria M Barreca, Walter Spinello, Vincenzo Cavalieri, Giuseppina Turturici, Gabriella Sconzo, Punit Kaur, Rosaria Tinnirello, Alexzander A A Asea, Fabiana Gerac. Extracellular Hsp70 Enhances Mesoangioblast Migration via an Autocrine Signaling Pathway. Journal of cellular physiology. vol 232. issue 7. 2017-05-15. PMID:27925208. |
we further demonstrate that hsp70 has a positive role in regulating matrix metalloproteinase 2 (mmp2) and mmp9 expression and that mmp2 has a more pronounced effect on cell migration, as compared to mmp9. |
2017-05-15 |
2023-08-13 |
mouse |
| Lin Xu, Zhijian Cai, Fei Yang, Ming Che. Activation‑induced upregulation of MMP9 in mast cells is a positive feedback mediator for mast cell activation. Molecular medicine reports. vol 15. issue 4. 2017-05-12. PMID:28259919. |
as a member of the matrix metalloproteinase (mmp) family, mmp9 has been previously demonstrated act in a pro‑inflammatory manner. |
2017-05-12 |
2023-08-13 |
Not clear |
| Bo Diao, Ying Liu, Yi Zhang, Jing Yu, Jun Xie, Guo-Zheng X. IQGAP1‑siRNA inhibits proliferation and metastasis of U251 and U373 glioma cell lines. Molecular medicine reports. vol 15. issue 4. 2017-05-12. PMID:28259970. |
furthermore, the expression levels of matrix metalloproteinase (mmp)2, snail, mmp9, fibronectin 1 and twist were suppressed, and e‑cadherin was upregulated in response to sirna‑iqgap1. |
2017-05-12 |
2023-08-13 |
human |
| Monica Averna, Margherita Bavestrello, Federico Cresta, Marco Pedrazzi, Roberta De Tullio, Laura Minicucci, Bianca Sparatore, Franca Salamino, Sandro Pontremoli, Edon Mellon. Abnormal activation of calpain and protein kinase Cα promotes a constitutive release of matrix metalloproteinase 9 in peripheral blood mononuclear cells from cystic fibrosis patients. Archives of biochemistry and biophysics. vol 604. 2017-05-09. PMID:27349634. |
matrix metalloproteinase 9 (mmp9) is physiologically involved in remodeling the extracellular matrix components but its abnormal release has been observed in several human pathologies. |
2017-05-09 |
2023-08-13 |
human |
| Lianglin Qiu, Yingyun Qian, Zhenzhen Liu, Chao Wang, Jianhua Qu, Xiaoke Wang, Shoulin Wan. Perfluorooctane sulfonate (PFOS) disrupts blood-testis barrier by down-regulating junction proteins via p38 MAPK/ATF2/MMP9 signaling pathway. Toxicology. vol 373. 2017-05-08. PMID:27818224. |
bodyweight, sperm count, btb integrity and the expression of proteins including p38 mitogen-activated protein kinase (mapk), activating transcription factor 2 (atf2), matrix metalloproteinase 9 (mmp9), tissue inhibitor of metalloproteinase 1(timp1) and btb related junction proteins were evaluated. |
2017-05-08 |
2023-08-13 |
mouse |
| Ga Bin Park, Yoon Hee Chung, Daejin Ki. Induction of galectin-1 by TLR-dependent PI3K activation enhances epithelial-mesenchymal transition of metastatic ovarian cancer cells. Oncology reports. vol 37. issue 5. 2017-05-08. PMID:28350104. |
gene silencing of tlr4 and galectin-1 with sirna decreased the expression of matrix metalloproteinase-2 (mmp2) and mmp9 and reduced mesenchymal markers in lps-treated sk‑ov‑3 cells. |
2017-05-08 |
2023-08-13 |
Not clear |
| Chia-Chen Liu, Jin Hu, Na Zhao, Jian Wang, Na Wang, John R Cirrito, Takahisa Kanekiyo, David M Holtzman, Guojun B. Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 15. 2017-04-19. PMID:28275161. |
in addition, silencing of lrp1 in astrocytes led to downregulation of several major aβ-degrading enzymes, including matrix metalloproteases mmp2, mmp9, and insulin-degrading enzyme. |
2017-04-19 |
2023-08-13 |
Not clear |
| Xiaofeng Li, Chunchun Xue, Libo Wang, Dezhi Tang, Jian Huang, Yongjian Zhao, Yan Chen, Dongfeng Zhao, Qi Shi, Yongjun Wang, Bing Sh. Osteoprotective effects of osthole in a mouse model of 5/6 nephrectomy through inhibiting osteoclast formation. Molecular medicine reports. vol 14. issue 4. 2017-04-17. PMID:27571745. |
immunohistochemistry staining and reverse transcription‑quantitative polymerase chain reaction were performed to detect the expression of nuclear factor of activated t‑cells, cytoplasmic‑1 (nfatc‑1), c‑fos, cathepsin k, trap, matrix metalloproteinase 9 (mmp9), osteoprotegerin (opg) and receptor activator for nuclear factor‑κb ligand (rankl). |
2017-04-17 |
2023-08-13 |
mouse |
| Yue Shi, Duo Zuo, Xia Wang, Meng Han, Yan W. shRNA‑mediated silencing of TARBP2 inhibits NCI‑H1299 non‑small cell lung cancer cell invasion and migration via the JNK/STAT3/AKT pathway. Molecular medicine reports. vol 14. issue 4. 2017-04-17. PMID:27599909. |
western blotting and reverse transcription‑quantitative polymerase chain reaction indicated that the protein expression levels of amyloid β (a4) precursor protein (app) and zinc finger protein 395 (znf395) were upregulated, while expression levels of pro‑metastatic proteins including interleukin (il)‑1β, il‑8, cyclooxygenase (cox)‑2, matrix metalloproteinase 2 (mmp2) and mmp9 were downregulated. |
2017-04-17 |
2023-08-13 |
human |