| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert D Dayton, David B Wang, Cooper D Cain, Lisa M Schrott, Julio J Ramirez, Michael A King, Ronald L Klei. Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus. Experimental neurology. vol 233. issue 2. 2012-03-26. PMID:22177996. |
to model the hippocampal neurodegeneration and memory-related behavioral impairment that occurs in ftld and other tau and tdp-43 proteinopathy diseases, we used an adeno-associated virus serotype 9 (aav9) vector to induce bilateral expression of either microtubule-associated protein tau or transactive response dna binding protein 43 kda (tdp-43) in adult rat dorsal hippocampus. |
2012-03-26 |
2023-08-12 |
human |
| Robert D Dayton, David B Wang, Cooper D Cain, Lisa M Schrott, Julio J Ramirez, Michael A King, Ronald L Klei. Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus. Experimental neurology. vol 233. issue 2. 2012-03-26. PMID:22177996. |
the data demonstrate that tdp-43 produced mild behavioral impairment and hippocampal neurodegeneration in rats, whereas tau did not. |
2012-03-26 |
2023-08-12 |
human |
| Robert D Dayton, David B Wang, Cooper D Cain, Lisa M Schrott, Julio J Ramirez, Michael A King, Ronald L Klei. Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus. Experimental neurology. vol 233. issue 2. 2012-03-26. PMID:22177996. |
the models could be of value for studying mechanisms of ftld and other diseases with tau and tdp-43 pathology in the hippocampus including alzheimer's disease, with relevance to early stage mild impairment. |
2012-03-26 |
2023-08-12 |
human |
| Ana Paula Costa, Ana Carolina Tramontina, Regina Biasibetti, Cristiane Batassini, Mark William Lopes, Krista Minéia Wartchow, Caren Bernardi, Lucas Silva Tortorelli, Rodrigo Bainy Leal, Carlos-Alberto Gonçalve. Neuroglial alterations in rats submitted to the okadaic acid-induced model of dementia. Behavioural brain research. vol 226. issue 2. 2012-03-25. PMID:21982813. |
memory impairment induced by intra-hippocampal injection of oa has been reported, accompanied by remarkable neuropathological changes including hippocampal neurodegeneration, a paired helical filament-like phosphorylation of tau protein, and formation of β-amyloid containing plaque-like structures. |
2012-03-25 |
2023-08-12 |
rat |
| Jose L Cantero, Bernardo Moreno-Lopez, Federico Portillo, Alicia Rubio, Eva Hita-Yañez, Jesus Avil. Role of tau protein on neocortical and hippocampal oscillatory patterns. Hippocampus. vol 21. issue 8. 2012-03-16. PMID:20607795. |
role of tau protein on neocortical and hippocampal oscillatory patterns. |
2012-03-16 |
2023-08-12 |
mouse |
| Jose L Cantero, Bernardo Moreno-Lopez, Federico Portillo, Alicia Rubio, Eva Hita-Yañez, Jesus Avil. Role of tau protein on neocortical and hippocampal oscillatory patterns. Hippocampus. vol 21. issue 8. 2012-03-16. PMID:20607795. |
because of its elevated expression in neocortical regions and hippocampus, tau might play a role in sculpting collective neural responses underlying slow and fast brain oscillations and/or long-range synchronization patterns between hippocampus and neocortex. |
2012-03-16 |
2023-08-12 |
mouse |
| Jose L Cantero, Bernardo Moreno-Lopez, Federico Portillo, Alicia Rubio, Eva Hita-Yañez, Jesus Avil. Role of tau protein on neocortical and hippocampal oscillatory patterns. Hippocampus. vol 21. issue 8. 2012-03-16. PMID:20607795. |
to test this hypothesis, local field potentials were recorded in tau-deficient (tau(-/-) ) and wild-type mice from different neocortical regions and from the hippocampus during spontaneous motor exploratory behavior. |
2012-03-16 |
2023-08-12 |
mouse |
| Jose L Cantero, Bernardo Moreno-Lopez, Federico Portillo, Alicia Rubio, Eva Hita-Yañez, Jesus Avil. Role of tau protein on neocortical and hippocampal oscillatory patterns. Hippocampus. vol 21. issue 8. 2012-03-16. PMID:20607795. |
we found that tau(-/-) mice showed hippocampal theta slowing and reduced levels of gamma long-range synchronization involving the frontal cortex. |
2012-03-16 |
2023-08-12 |
mouse |
| Jose L Cantero, Bernardo Moreno-Lopez, Federico Portillo, Alicia Rubio, Eva Hita-Yañez, Jesus Avil. Role of tau protein on neocortical and hippocampal oscillatory patterns. Hippocampus. vol 21. issue 8. 2012-03-16. PMID:20607795. |
also, the proper functioning of gap-junction channels might be compromised by the absence of tau in hippocampal networks. |
2012-03-16 |
2023-08-12 |
mouse |
| Mira Didic, Emmanuel J Barbeau, Olivier Felician, Eve Tramoni, Eric Guedj, Michel Poncet, Mathieu Ceccald. Which memory system is impaired first in Alzheimer's disease? Journal of Alzheimer's disease : JAD. vol 27. issue 1. 2012-02-27. PMID:21799246. |
however, during the "transentorhinal stage" of ad, neurofibrillary tangles (nft), related to tau protein pathology, develop in the anterior subhippocampal (perirhinal/entorhinal) cortex before the hippocampus. |
2012-02-27 |
2023-08-12 |
human |
| John L Robinson, Felix Geser, Maria M Corrada, Daniel J Berlau, Steven E Arnold, Virginia M-Y Lee, Claudia H Kawas, John Q Trojanowsk. Neocortical and hippocampal amyloid-β and tau measures associate with dementia in the oldest-old. Brain : a journal of neurology. vol 134. issue Pt 12. 2012-02-09. PMID:22120149. |
neocortical and hippocampal amyloid-β and tau measures associate with dementia in the oldest-old. |
2012-02-09 |
2023-08-12 |
human |
| John L Robinson, Felix Geser, Maria M Corrada, Daniel J Berlau, Steven E Arnold, Virginia M-Y Lee, Claudia H Kawas, John Q Trojanowsk. Neocortical and hippocampal amyloid-β and tau measures associate with dementia in the oldest-old. Brain : a journal of neurology. vol 134. issue Pt 12. 2012-02-09. PMID:22120149. |
we used quantitative and/or semi-quantitative measures to assess the burden of amyloid-β, tau, tdp-43 and α-synuclein pathologies as well as hippocampal sclerosis. |
2012-02-09 |
2023-08-12 |
human |
| John L Robinson, Felix Geser, Maria M Corrada, Daniel J Berlau, Steven E Arnold, Virginia M-Y Lee, Claudia H Kawas, John Q Trojanowsk. Neocortical and hippocampal amyloid-β and tau measures associate with dementia in the oldest-old. Brain : a journal of neurology. vol 134. issue Pt 12. 2012-02-09. PMID:22120149. |
while individuals with no dementia had limited hippocampal tau and neocortical amyloid-β pathology, dementia associated with an expansion in pathology, including increased neocortical tau and hippocampal amyloid-β plaques, more abundant neocortical amyloid-β deposition and hippocampal sclerosis with its attendant tdp-43 pathology. |
2012-02-09 |
2023-08-12 |
human |
| Liang Cheng, Shao-Hui Wang, Qi-Cai Chen, Xiao-Mei Lia. Moderate noise induced cognition impairment of mice and its underlying mechanisms. Physiology & behavior. vol 104. issue 5. 2012-02-06. PMID:21726571. |
to explore potential mechanisms, we determined levels of oxidative stress in the inferior colliculus (ic), auditory cortex (ac), and hippocampus (the structures comprising the critical encephalic region associated with the acoustic lemniscal ascending pathway), the phosphorylation of microtubule-associated protein tau in the hippocampus (important role in learning and memory), and the basic auditory response properties of neurons in the ic. |
2012-02-06 |
2023-08-12 |
mouse |
| Liang Cheng, Shao-Hui Wang, Qi-Cai Chen, Xiao-Mei Lia. Moderate noise induced cognition impairment of mice and its underlying mechanisms. Physiology & behavior. vol 104. issue 5. 2012-02-06. PMID:21726571. |
at 6 weeks after noise exposure, there was also evidence of oxidative damage in the ic, ac, and hippocampus, hyperphosphorylated tau protein in the hippocampus, and significant changes in the auditory response properties of neurons in the ic. |
2012-02-06 |
2023-08-12 |
mouse |
| Seon-Ah Chong, Iryna Benilova, Hamdy Shaban, Bart De Strooper, Herman Devijver, Dieder Moechars, Wolfgang Eberle, Carmen Bartic, Fred Van Leuven, Geert Callewaer. Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: a multi-electrode array study. Neurobiology of disease. vol 44. issue 3. 2012-02-06. PMID:21807097. |
the findings demonstrate important synaptic changes that differ considerably in the hippocampal sub-regions already at young age, well before the typical amyloid or tau pathology is evident. |
2012-02-06 |
2023-08-12 |
mouse |
| Anna Kremer, Hervé Maurin, David Demedts, Herman Devijver, Peter Borghgraef, Fred Van Leuve. Early improved and late defective cognition is reflected by dendritic spines in Tau.P301L mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 49. 2012-02-02. PMID:22159117. |
to explain how protein tau promoted spinogenesis, we analyzed hippocampal synaptosomes and dendritic spines for mouse and human tau. |
2012-02-02 |
2023-08-12 |
mouse |
| Lidia Blazquez-Llorca, Virginia Garcia-Marin, Paula Merino-Serrais, Jesús Ávila, Javier DeFelip. Abnormal tau phosphorylation in the thorny excrescences of CA3 hippocampal neurons in patients with Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 26. issue 4. 2012-01-26. PMID:21677375. |
abnormal tau phosphorylation in the thorny excrescences of ca3 hippocampal neurons in patients with alzheimer's disease. |
2012-01-26 |
2023-08-12 |
Not clear |
| Tomohiro Onishi, Hiroki Iwashita, Yumiko Uno, Jun Kunitomo, Morihisa Saitoh, Eiji Kimura, Hisashi Fujita, Noriko Uchiyama, Masakuni Kori, Masayuki Takizaw. A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(S )-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer's disease. Journal of neurochemistry. vol 119. issue 6. 2012-01-26. PMID:21992552. |
when administered to a transgenic mouse model of ad, mmbo significantly decreased hippocampal tau phosphorylation at gsk-3 sites. |
2012-01-26 |
2023-08-12 |
mouse |
| Charles Y Shao, Suzanne S Mirra, Hameetha B R Sait, Todd C Sacktor, Einar M Sigurdsso. Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced Aβ and tau pathology in transgenic mouse models of Alzheimer's disease. Acta neuropathologica. vol 122. issue 3. 2012-01-10. PMID:21630115. |
our findings support the notion that either aβ or tau can induce reduction of psd-95 in excitatory synapses in hippocampus. |
2012-01-10 |
2023-08-12 |
mouse |