| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bo Cui, Mingquan Wu, Xiaojun She, Hongtao Li. Impulse noise exposure in rats causes cognitive deficits and changes in hippocampal neurotransmitter signaling and tau phosphorylation. Brain research. vol 1427. 2012-05-11. PMID:22055774. |
immunohistochemistry confirmed tau hyperphosphorylation in hippocampus that was most prominent in the dentate gyrus (dg) and ca1 region. |
2012-05-11 |
2023-08-12 |
rat |
| Bo Cui, Mingquan Wu, Xiaojun She, Hongtao Li. Impulse noise exposure in rats causes cognitive deficits and changes in hippocampal neurotransmitter signaling and tau phosphorylation. Brain research. vol 1427. 2012-05-11. PMID:22055774. |
these findings demonstrate that impulse noise stress impairs early spatial memory, possibly by disrupting glu-nmdar signaling and triggering aberrant tau hyperphosphorylation in hippocampus. |
2012-05-11 |
2023-08-12 |
rat |
| Xifei Yang, Ying Yang, Jianjun Liu, Geng Li, Edward Yan. Increased phosphorylation of tau and synaptic protein loss in the aged transgenic mice expressing familiar Alzheimer's disease-linked presenilin 1 mutation. Neurochemical research. vol 37. issue 1. 2012-05-09. PMID:21842270. |
the data showed that the phosphorylation of tau at ser396, ser404, thr231 and tau-1 (ser198/199/202) epitopes was significantly increased in hippocampus of the aged (twenty-one and a half-month-old) transgenic mice expressing ps-1 (l235p) compared to that of the age-matched wild-type littermates (wts). |
2012-05-09 |
2023-08-12 |
mouse |
| Karim Belarbi, Sylvie Burnouf, Francisco-Jose Fernandez-Gomez, Cyril Laurent, Sophie Lestavel, Martin Figeac, Audrey Sultan, Laetitia Troquier, Antoine Leboucher, Raphaëlle Caillierez, Marie-Eve Grosjean, Dominique Demeyer, Hélène Obriot, Ingrid Brion, Bérangère Barbot, Marie-Christine Galas, Bart Staels, Sandrine Humez, Nicolas Sergeant, Susanna Schraen-Maschke, Anne Muhr-Tailleux, Malika Hamdane, Luc Buée, David Blu. Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology. Neurobiology of disease. vol 43. issue 2. 2012-05-07. PMID:21569847. |
after 9 months of exercise, mice were evaluated for memory performance and examined for hippocampal tau pathology, cholinergic defects, inflammation and genes related to cholesterol metabolism. |
2012-05-07 |
2023-08-12 |
mouse |
| Karim Belarbi, Sylvie Burnouf, Francisco-Jose Fernandez-Gomez, Cyril Laurent, Sophie Lestavel, Martin Figeac, Audrey Sultan, Laetitia Troquier, Antoine Leboucher, Raphaëlle Caillierez, Marie-Eve Grosjean, Dominique Demeyer, Hélène Obriot, Ingrid Brion, Bérangère Barbot, Marie-Christine Galas, Bart Staels, Sandrine Humez, Nicolas Sergeant, Susanna Schraen-Maschke, Anne Muhr-Tailleux, Malika Hamdane, Luc Buée, David Blu. Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology. Neurobiology of disease. vol 43. issue 2. 2012-05-07. PMID:21569847. |
this was accompanied by a decrease in hippocampal tau pathology and a prevention of the loss of expression of choline acetyltransferase within the medial septum. |
2012-05-07 |
2023-08-12 |
mouse |
| José L Molinuevo Gui. [Role of biomarkers in the early diagnosis of Alzheimer's disease]. Revista espanola de geriatria y gerontologia. vol 46 Suppl 1. 2012-05-07. PMID:22152914. |
the use of biomarkers such as determination of the proteins involved in the disease in cerebrospinal fluid (aβ₄₂-amyloid, total and phosphorylated tau) and measurement of the hippocampus and entorhinal cortex with magnetic resonance imaging and positron emission tomography (both glucose and amyloid measurements), alone or combined, could allow early and etiologic diagnosis. |
2012-05-07 |
2023-08-12 |
Not clear |
| Kai Liao, Dan Liu, Ling-Qiang Zh. Enriched odor exposure decrease tau phosphorylation in the rat hippocampus and cortex. Neuroscience letters. vol 507. issue 1. 2012-05-04. PMID:22155098. |
enriched odor exposure decrease tau phosphorylation in the rat hippocampus and cortex. |
2012-05-04 |
2023-08-12 |
rat |
| Kai Liao, Dan Liu, Ling-Qiang Zh. Enriched odor exposure decrease tau phosphorylation in the rat hippocampus and cortex. Neuroscience letters. vol 507. issue 1. 2012-05-04. PMID:22155098. |
we found that short-term odor enrichment did not affect the phosphorylation of tau, while long-term odor enrichment dramatically reduce the phosphorylation level of tau at ser198/199/202, thr231, ser396, and ser404 sites both in the hippocampus and cortex. |
2012-05-04 |
2023-08-12 |
rat |
| Hélène Le Freche, Jonathan Brouillette, Francisco-José Fernandez-Gomez, Pauline Patin, Raphaëlle Caillierez, Nadège Zommer, Nicolas Sergeant, Valérie Buée-Scherrer, Gilles Lebuffe, David Blum, Luc Bué. Tau phosphorylation and sevoflurane anesthesia: an association to postoperative cognitive impairment. Anesthesiology. vol 116. issue 4. 2012-05-04. PMID:22343471. |
the main aim of the present study was to investigate effects, in normothermic conditions, of acute or repeated exposure to sevoflurane, a halogenated anesthetic agent, on hippocampal tau phosphorylation and spatial memory in adult mice. |
2012-05-04 |
2023-08-12 |
mouse |
| Yue Wang, Zhe Cheng, Wei Qin, Jianping Ji. Val97Leu mutant presenilin-1 induces tau hyperphosphorylation and spatial memory deficit in mice and the underlying mechanisms. Journal of neurochemistry. vol 121. issue 1. 2012-05-03. PMID:21929538. |
additionally, the hyperphosphorylated tau and tangle-like argentophilic structures were detected at ca3 and ca4, but not ca1, region of hippocampus, and we also found tangle-like structure and wizened degenerative neurons in frontal cortex. |
2012-05-03 |
2023-08-12 |
mouse |
| Bin Zhang, Jenna Carroll, John Q Trojanowski, Yuemang Yao, Michiyo Iba, Justin S Potuzak, Anne-Marie L Hogan, Sharon X Xie, Carlo Ballatore, Amos B Smith, Virginia M-Y Lee, Kurt R Brunde. The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 11. 2012-05-01. PMID:22423084. |
moreover, the epod-treated ps19 mice had less forebrain tau pathology and increased hippocampal neuronal integrity, with no dose-limiting side effects. |
2012-05-01 |
2023-08-12 |
mouse |
| Diana A T Nijholt, Elise S van Haastert, Annemieke J M Rozemuller, Wiep Scheper, Jeroen J M Hoozeman. The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies. The Journal of pathology. vol 226. issue 5. 2012-04-27. PMID:22102449. |
the unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies. |
2012-04-27 |
2023-08-12 |
Not clear |
| Elisabete Ferreiro, Cláudia M F Pereir. Endoplasmic reticulum stress: a new playER in tauopathies. The Journal of pathology. vol 226. issue 5. 2012-04-27. PMID:22190226. |
the authors described that increased levels of upr activation markers are predominantly observed in neurons within the hippocampus, being correlated with early tau phosphorylation. |
2012-04-27 |
2023-08-12 |
Not clear |
| M Cecilia Ljungberg, Yousuf O Ali, Jie Zhu, Chia-Shan Wu, Kazuhiro Oka, R Grace Zhai, Hui-Chen L. CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy. Human molecular genetics. vol 21. issue 2. 2012-04-26. PMID:22027994. |
both the total amount of phospho-cre binding protein (creb) and the pcreb bound to nmnat2 cre sites in the cortex and the hippocampus of rtg4510 mice are significantly reduced, suggesting that nmnat2 is a direct target of creb under physiological conditions and that tau(p301l) overexpression down-regulates creb-mediated transcription. |
2012-04-26 |
2023-08-12 |
mouse |
| Wagner Zago, Manuel Buttini, Thomas A Comery, Christopher Nishioka, Shyra J Gardai, Peter Seubert, Dora Games, Frédérique Bard, Dale Schenk, Gene G Kinne. Neutralization of soluble, synaptotoxic amyloid β species by antibodies is epitope specific. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 8. 2012-04-16. PMID:22357853. |
in the current report, we demonstrated that 3d6 binds to soluble, synaptotoxic assemblies of aβ(1-42) and prevents multiple downstream functional consequences in rat hippocampal neurons including changes in glutamate ampa receptor trafficking, ad-type tau phosphorylation, and loss of dendritic spines. |
2012-04-16 |
2023-08-12 |
mouse |
| Alix de Calignon, Manuela Polydoro, Marc Suárez-Calvet, Christopher William, David H Adamowicz, Kathy J Kopeikina, Rose Pitstick, Naruhiko Sahara, Karen H Ashe, George A Carlson, Tara L Spires-Jones, Bradley T Hyma. Propagation of tau pathology in a model of early Alzheimer's disease. Neuron. vol 73. issue 4. 2012-04-16. PMID:22365544. |
tau pathology progresses from ec transgene-expressing neurons to neurons without detectable transgene expression, first to ec neighboring cells, followed by propagation to neurons downstream in the synaptic circuit such as the dentate gyrus, ca fields of the hippocampus, and cingulate cortex. |
2012-04-16 |
2023-08-12 |
mouse |
| Bettina Platt, Benjamin Drever, David Koss, Sandra Stoppelkamp, Amar Jyoti, Andrea Plano, Aneli Utan, Georgina Merrick, Duncan Ryan, Valeria Melis, Hong Wan, Marco Mingarelli, Emanuele Porcu, Louise Scrocchi, Andy Welch, Gernot Riede. Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1. PloS one. vol 6. issue 11. 2012-04-10. PMID:22096518. |
plb1(triple) mice presented with stable gene expression and age-related pathology of intra-neuronal amyloid and hyperphosphorylated tau in hippocampus and cortex from 6 months onwards. |
2012-04-10 |
2023-08-12 |
mouse |
| Ian T Marsden, Laurie S Minamide, James R Bambur. Amyloid-β-induced amyloid-β secretion: a possible feed-forward mechanism in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 24. issue 4. 2012-04-09. PMID:21297255. |
human aβd/t increased >2 fold the aβ secreted by organotypic hippocampal slices from tau knock-out mice whether or not they expressed a human tau transgene, suggesting tau plays no role in enhanced aβ secretion. |
2012-04-09 |
2023-08-12 |
mouse |
| David J Irwin, Todd J Cohen, Murray Grossman, Steven E Arnold, Sharon X Xie, Virginia M-Y Lee, John Q Trojanowsk. Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. Brain : a journal of neurology. vol 135. issue Pt 3. 2012-04-09. PMID:22366796. |
acetylated-tau pathology was compared with the sequential emergence of other tau modifications in the alzheimer's disease hippocampus using monoclonal antibodies to multiple well-characterized tau epitopes. |
2012-04-09 |
2023-08-12 |
Not clear |
| Yuu Yamazaki, Tomoyasu Matsubara, Tetsuya Takahashi, Takashi Kurashige, Eisuke Dohi, Masanori Hiji, Yoshito Nagano, Takemori Yamawaki, Masayasu Matsumot. Granulovacuolar degenerations appear in relation to hippocampal phosphorylated tau accumulation in various neurodegenerative disorders. PloS one. vol 6. issue 11. 2012-03-26. PMID:22073234. |
granulovacuolar degenerations appear in relation to hippocampal phosphorylated tau accumulation in various neurodegenerative disorders. |
2012-03-26 |
2023-08-12 |
Not clear |