| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Attems, M Preusser, M Grosinger-Quass, L Wagner, F Lintner, K Jellinge. Calcium-binding protein secretagogin-expressing neurones in the human hippocampus are largely resistant to neurodegeneration in Alzheimer's disease. Neuropathology and applied neurobiology. vol 34. issue 1. 2008-03-18. PMID:17961140. |
in this study we investigate the influence of hippocampal tau pathology on secretagogin expression in more details. |
2008-03-18 |
2023-08-12 |
human |
| J Attems, M Preusser, M Grosinger-Quass, L Wagner, F Lintner, K Jellinge. Calcium-binding protein secretagogin-expressing neurones in the human hippocampus are largely resistant to neurodegeneration in Alzheimer's disease. Neuropathology and applied neurobiology. vol 34. issue 1. 2008-03-18. PMID:17961140. |
no difference with respect to secretagogin immunoreactivity was observed in different stages of ad pathology, and similarly no significant associations were seen between the amount of secretagogin and tau immunoreactivity in the different hippocampal subfields. |
2008-03-18 |
2023-08-12 |
human |
| J Attems, M Preusser, M Grosinger-Quass, L Wagner, F Lintner, K Jellinge. Calcium-binding protein secretagogin-expressing neurones in the human hippocampus are largely resistant to neurodegeneration in Alzheimer's disease. Neuropathology and applied neurobiology. vol 34. issue 1. 2008-03-18. PMID:17961140. |
because there are no differences in the amount of hippocampal secretagogin expression between ad cases and controls (as we have shown previously), the lack of an association between the amount of secretagogin expression and tau burden together with the low frequency of colocalization of tau and secretagogin in the human hippocampus, suggest that secretagogin-expressing neurones are largely resistant to neurodegeneration in ad. |
2008-03-18 |
2023-08-12 |
human |
| Salvatore Spina, Martin R Farlow, Frederick W Unverzagt, David A Kareken, Jill R Murrell, Graham Fraser, Francine Epperson, R Anthony Crowther, Maria G Spillantini, Michel Goedert, Bernardino Ghett. The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family. Brain : a journal of neurology. vol 131. issue Pt 1. 2008-03-06. PMID:18065436. |
neuropathologically, progressive nerve cell loss, gliosis and coexistent neuronal and/or glial deposits consisting mostly of 4-repeat tau were present in frontal, cingulate, temporal and insular cortices, white matter, hippocampus, parahippocampus, basal ganglia, selected brainstem nuclei and spinal cord. |
2008-03-06 |
2023-08-12 |
Not clear |
| Tristan Bolmont, Florence Clavaguera, Melanie Meyer-Luehmann, Martin C Herzig, Rebecca Radde, Matthias Staufenbiel, Jada Lewis, Mike Hutton, Markus Tolnay, Mathias Jucke. Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice. The American journal of pathology. vol 171. issue 6. 2008-02-08. PMID:18055549. |
six months after the infusion, tau pathology was induced in the injected hippocampus but also in brain regions well beyond the injection sites such as the entorhinal cortex and amygdala, areas with neuronal projection to the injection site. |
2008-02-08 |
2023-08-12 |
mouse |
| Osamu Yokota, Kuniaki Tsuchiya, Yoshimasa Noguchi, Hisamasa Akabane, Hideki Ishizu, Yukinobu Saito, Haruhiko Akiyam. Coexistence of amyotrophic lateral sclerosis and argyrophilic grain disease: a non-demented autopsy case showing circumscribed temporal atrophy and involvement of the amygdala. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 27. issue 6. 2008-01-16. PMID:18021374. |
in the hippocampus, selective tau accumulation with minor neurofibrillary changes was observed in ca2 neurons. |
2008-01-16 |
2023-08-12 |
Not clear |
| H Hampel, S J Teipel, K Bürge. [Neurobiological early diagnosis of Alzheimer's disease]. Der Nervenarzt. vol 78. issue 11. 2008-01-15. PMID:17611728. |
to date the most promising core candidate markers are total and hyperphosphorylated tau protein and amyloid beta peptides in the csf, as well as hippocampus and whole brain volumetry using mri. |
2008-01-15 |
2023-08-12 |
human |
| Joongkyu Park, Eun Jin Yang, Joo Heon Yoon, Kwang Chul Chun. Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of Down syndrome. Molecular and cellular neurosciences. vol 36. issue 2. 2008-01-09. PMID:17720532. |
our results show that dyrk1a interacts with and directly phosphorylates tau and amyloid precursor protein in immortalized hippocampal progenitor h19-7 cells. |
2008-01-09 |
2023-08-12 |
human |
| Adam R Cole, Wendy Noble, Lidy van Aalten, Florian Plattner, Rena Meimaridou, Dale Hogan, Margaret Taylor, John LaFrancois, Frank Gunn-Moore, Alex Verkhratsky, Salvatore Oddo, Frank LaFerla, K Peter Giese, Kelly T Dineley, Karen Duff, Jill C Richardson, Shi Du Yan, Diane P Hanger, Stuart M Allan, Calum Sutherlan. Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression. Journal of neurochemistry. vol 103. issue 3. 2007-12-21. PMID:17683481. |
similarly, crmp2 phosphorylation is normal in hippocampus and cortex of tau(p301l) mice that develop tangles but not plaques. |
2007-12-21 |
2023-08-12 |
mouse |
| M Degerman Gunnarsson, L Kilander, H Basun, L Lannfel. Reduction of phosphorylated tau during memantine treatment of Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 24. issue 4. 2007-11-27. PMID:17700020. |
it has been shown in vitro that memantine reverse induced abnormal hyperphosphorylation of tau in hippocampal neurons of rats. |
2007-11-27 |
2023-08-12 |
rat |
| Ranu Pal, Derek B Oien, Fatma Y Ersen, Jackob Moskovit. Elevated levels of brain-pathologies associated with neurodegenerative diseases in the methionine sulfoxide reductase A knockout mouse. Experimental brain research. vol 180. issue 4. 2007-11-26. PMID:17333008. |
additionally, a loss of astrocytes integrity, elevated levels of beta-amyloid deposition, and tau phosphorylation were dominant in various regions of the msra ( -/- ) hippocampus but not in the wild-type. |
2007-11-26 |
2023-08-12 |
mouse |
| Arianna Bellucci, Maria Cristina Rosi, Cristina Grossi, Anna Fiorentini, Ilaria Luccarini, Fiorella Casament. Abnormal processing of tau in the brain of aged TgCRND8 mice. Neurobiology of disease. vol 27. issue 3. 2007-10-31. PMID:17656099. |
in the neocortex and hippocampus of aged tgcrnd8 mice, tau is hyperphosphorylated at different sites recognized by phf-1, at100, at8 and cp13 antibodies. |
2007-10-31 |
2023-08-12 |
mouse |
| Arianna Bellucci, Maria Cristina Rosi, Cristina Grossi, Anna Fiorentini, Ilaria Luccarini, Fiorella Casament. Abnormal processing of tau in the brain of aged TgCRND8 mice. Neurobiology of disease. vol 27. issue 3. 2007-10-31. PMID:17656099. |
phf-1 and nitrotyrosine immunoreactivity merged within neurons surrounding amyloid deposits in cortical and hippocampal areas and immunoprecipitation studies confirmed that tau is nitrosylated. |
2007-10-31 |
2023-08-12 |
mouse |
| Junko Fujio, Hiroaki Hosono, Koichi Ishiguro, Shiro Ikegami, Shinobu C Fujit. Tau phosphorylation in the mouse brain during aversive conditioning. Neurochemistry international. vol 51. issue 2-4. 2007-10-25. PMID:17597257. |
as an initial investigation we chose contextual fear conditioning paradigm involving electric shocks, and studied tau phosphorylation in the hippocampus and a neighboring limbic region of the mouse brain. |
2007-10-25 |
2023-08-12 |
mouse |
| Junko Fujio, Hiroaki Hosono, Koichi Ishiguro, Shiro Ikegami, Shinobu C Fujit. Tau phosphorylation in the mouse brain during aversive conditioning. Neurochemistry international. vol 51. issue 2-4. 2007-10-25. PMID:17597257. |
these results suggest involvement of tau and tpki/gsk3beta phosphorylation in an early phase of memory formation in the hippocampus and amygdala, raising a possibility that a dysregulation of tau phosphorylation may underlie memory impairment in incipient alzheimer's disease. |
2007-10-25 |
2023-08-12 |
mouse |
| Diana S Woodruff-Pak, Alexis Agelan, Luis Del Vall. A rabbit model of Alzheimer's disease: valid at neuropathological, cognitive, and therapeutic levels. Journal of Alzheimer's disease : JAD. vol 11. issue 3. 2007-10-11. PMID:17851187. |
changes in neurons in the hippocampus were consistent with neurofibrillary degeneration and cytoplasmic immunoreactivity for amyloid-beta and tau. |
2007-10-11 |
2023-08-12 |
rabbit |
| G Niewiadomska, M Baksalerska-Pazera, I Lenarcik, G Riede. Compartmental protein expression of Tau, GSK-3beta and TrkA in cholinergic neurons of aged rats. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 11. 2007-09-05. PMID:16736240. |
in young animals, expression of tau isoforms and glycogen synthase kinase-3beta (gsk-3beta) was restricted to neuritic structures in cortex, hippocampus, and basal forebrain. |
2007-09-05 |
2023-08-12 |
rat |
| S Yoshida, M Maeda, S Kaku, H Ikeya, K Yamada, S Nakaik. Lithium inhibits stress-induced changes in tau phosphorylation in the mouse hippocampus. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 11. 2007-09-05. PMID:16855914. |
lithium inhibits stress-induced changes in tau phosphorylation in the mouse hippocampus. |
2007-09-05 |
2023-08-12 |
mouse |
| S Yoshida, M Maeda, S Kaku, H Ikeya, K Yamada, S Nakaik. Lithium inhibits stress-induced changes in tau phosphorylation in the mouse hippocampus. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 11. 2007-09-05. PMID:16855914. |
in the present study, we investigated the effects of cold water stress (cws) on tau phosphorylation in the mouse hippocampus and the effects of gsk-3beta inhibitor, licl, on cws-induced changes in tau phosphorylation levels by immunoblot analyses. |
2007-09-05 |
2023-08-12 |
mouse |
| S Yoshida, M Maeda, S Kaku, H Ikeya, K Yamada, S Nakaik. Lithium inhibits stress-induced changes in tau phosphorylation in the mouse hippocampus. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 11. 2007-09-05. PMID:16855914. |
these results suggest that a cws-induced increase in phosphorylated tau in the hippocampus is mediated, at least partly, by the activation of gsk-3beta. |
2007-09-05 |
2023-08-12 |
mouse |