| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Charles Duyckaerts, Claire Perruchini, Thibaud Lebouvier, Marie-Claude Potie. [The lesions of Alzheimer's disease: which therapeutic perspectives?]. Bulletin de l'Academie nationale de medecine. vol 192. issue 2. 2008-11-14. PMID:18819685. |
abeta deposits first occur in the neocortex, while intracellular tau accumulation mainly affect the hippocampal region. |
2008-11-14 |
2023-08-12 |
mouse |
| Charles Duyckaerts, Claire Perruchini, Thibaud Lebouvier, Marie-Claude Potie. [The lesions of Alzheimer's disease: which therapeutic perspectives?]. Bulletin de l'Academie nationale de medecine. vol 192. issue 2. 2008-11-14. PMID:18819685. |
tau lesions successively involve the hippocampal regions, multi- and uni-modal areas and finally the primary cortices in stereotyped stages. |
2008-11-14 |
2023-08-12 |
mouse |
| Jose A Rodríguez-Navarro, Ana Gómez, Izaskun Rodal, Juan Perucho, Armando Martinez, Vicente Furió, Israel Ampuero, María J Casarejos, Rosa M Solano, Justo García de Yébenes, Maria A Men. Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice. Human molecular genetics. vol 17. issue 20. 2008-11-12. PMID:18640988. |
pk(-/-)/tau(vlw) mice have abnormal behaviour and severe drop out of dopamine neurons in the ventral midbrain, up to 70%, at 12 months and abundant phosphorylated tau positive neuritic plaques, neuro-fibrillary tangles, astrogliosis, microgliosis and plaques of murine beta-amyloid in the hippocampus. |
2008-11-12 |
2023-08-12 |
mouse |
| Yue Wang, Jun-Xia Zhang, Xiao-Xia Du, Li Zhao, Qing Tian, Ling-Qiang Zhu, Shao-Hui Wang, Jian-Zhi Wan. Temporal correlation of the memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3. Journal of neurochemistry. vol 106. issue 6. 2008-11-07. PMID:18643871. |
we observed that the severe memory deficit occurred at 24 and 48 h, and simultaneously, gsk-3 activation, tau hyperphosphorylation at thr231, ser396, and ser404 and decline of ach in hippocampus were detected, and these changes were mostly recovered at 72 and 96 h after the injection of wt/gfx. |
2008-11-07 |
2023-08-12 |
rat |
| Yue Wang, Jun-Xia Zhang, Xiao-Xia Du, Li Zhao, Qing Tian, Ling-Qiang Zhu, Shao-Hui Wang, Jian-Zhi Wan. Temporal correlation of the memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3. Journal of neurochemistry. vol 106. issue 6. 2008-11-07. PMID:18643871. |
our data provide direct evidence demonstrating that activation of gsk-3 by wt/gfx may cause memory deficit through tau hyperphosphorylation and suppression of ach in hippocampus. |
2008-11-07 |
2023-08-12 |
rat |
| Roxana C Sinjoanu, Sara Kleinschmidt, Robert S Bitner, Jorge D Brioni, Achim Moeller, Adriana Ferreir. The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons. Neurochemistry international. vol 53. issue 3-4. 2008-11-06. PMID:18590784. |
the novel calpain inhibitor a-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons. |
2008-11-06 |
2023-08-12 |
Not clear |
| Roxana C Sinjoanu, Sara Kleinschmidt, Robert S Bitner, Jorge D Brioni, Achim Moeller, Adriana Ferreir. The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons. Neurochemistry international. vol 53. issue 3-4. 2008-11-06. PMID:18590784. |
we have previously shown that beta-amyloid (abeta) oligomers induced dynamin 1 and tau cleavage in cultured hippocampal neurons. |
2008-11-06 |
2023-08-12 |
Not clear |
| Roxana C Sinjoanu, Sara Kleinschmidt, Robert S Bitner, Jorge D Brioni, Achim Moeller, Adriana Ferreir. The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons. Neurochemistry international. vol 53. issue 3-4. 2008-11-06. PMID:18590784. |
in the present study, we tested the ability of a-705253, a novel water-soluble calpain inhibitor with oral availability and enhanced metabolic stability, to prevent abeta-induced dynamin 1 and tau cleavage in cultured hippocampal neurons. |
2008-11-06 |
2023-08-12 |
Not clear |
| Octavio Mercado-Gómez, Karla Hernández-Fonseca, Alexa Villavicencio-Queijeiro, Lourdes Massieu, Jesús Chimal-Monroy, Clorinda Aria. Inhibition of Wnt and PI3K signaling modulates GSK-3beta activity and induces morphological changes in cortical neurons: role of tau phosphorylation. Neurochemical research. vol 33. issue 8. 2008-11-03. PMID:18461448. |
thus, in the present investigation we analyzed the effects of different negative modulators of the wnt and the pi3k pathways on gsk-3beta activation and phosphorylation of tau at the phf-1 epitope in cortical cultured neurons and hippocampal slices from adult rat brain. |
2008-11-03 |
2023-08-12 |
rat |
| E B Shubenina, V S Kudrin, P M Klodt, A A Pokrovskiĭ, T A Gudasheva, T A Voronina, R U Ostrovskai. [Interstrain differences in the content of excitatory and inhibitory amino acids in the brain of DBA/2J, Balb/c and C57BL/6 mice: characteristics of the effect of a dipeptide antipsychotic drug dilept]. Eksperimental'naia i klinicheskaia farmakologiia. vol 71. issue 4. 2008-10-27. PMID:18819433. |
we have performed a comparative study of the content of glutamate (glu), aspartate (asp), taurine (tau), glycine (gly) and gamma-amino-butyric acid (gaba) in the cortex, hippocampus, and striatum of the dba/2j, balb/c and c57bl/6 mice brain. |
2008-10-27 |
2023-08-12 |
mouse |
| E B Shubenina, V S Kudrin, P M Klodt, A A Pokrovskiĭ, T A Gudasheva, T A Voronina, R U Ostrovskai. [Interstrain differences in the content of excitatory and inhibitory amino acids in the brain of DBA/2J, Balb/c and C57BL/6 mice: characteristics of the effect of a dipeptide antipsychotic drug dilept]. Eksperimental'naia i klinicheskaia farmakologiia. vol 71. issue 4. 2008-10-27. PMID:18819433. |
the levels of glu, tau and gaba in dba/2j hippocampus was lower than those in other experimental strains. |
2008-10-27 |
2023-08-12 |
mouse |
| Felix Geser, Matthew J Winton, Linda K Kwong, Yan Xu, Sharon X Xie, Lionel M Igaz, Ralph M Garruto, Daniel P Perl, Douglas Galasko, Virginia M-Y Lee, John Q Trojanowsk. Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam. Acta neuropathologica. vol 115. issue 1. 2008-10-14. PMID:17713769. |
these results indicate that g-pdc and g-als are associated with pathological tdp-43 similar to ftld-u with/without mnd as well as als, and that neocortical or hippocampal tdp-43 pathology distinguishes controls from disease subjects better than tau pathology. |
2008-10-14 |
2023-08-12 |
human |
| Fernanda G De Felice, Diana Wu, Mary P Lambert, Sara J Fernandez, Pauline T Velasco, Pascale N Lacor, Eileen H Bigio, Jasna Jerecic, Paul J Acton, Paul J Shughrue, Elizabeth Chen-Dodson, Gene G Kinney, William L Klei. Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers. Neurobiology of aging. vol 29. issue 9. 2008-10-13. PMID:17403556. |
here we show that, independent of the presence of fibrils, addls stimulate tau phosphorylation in mature cultures of hippocampal neurons and in neuroblastoma cells at epitopes characteristically hyperphosphorylated in ad. |
2008-10-13 |
2023-08-12 |
Not clear |
| Alicia Rubio, Mar Pérez, Luis de Lecea, Jesús Avil. Effect of cortistatin on tau phosphorylation at Ser262 site. Journal of neuroscience research. vol 86. issue 11. 2008-09-30. PMID:18438934. |
the development of intraneuronal lesions as a result of the progressive deposition of hyperphosphorylated tau at specific brain regions (such as hippocampus and cortex) plays a key role in the pathological process of alzheimer's disease. |
2008-09-30 |
2023-08-12 |
mouse |
| Bronwen Martin, Randall Brenneman, Kevin G Becker, Marjan Gucek, Robert N Cole, Stuart Maudsle. iTRAQ analysis of complex proteome alterations in 3xTgAD Alzheimer's mice: understanding the interface between physiology and disease. PloS one. vol 3. issue 7. 2008-09-24. PMID:18648646. |
the 3xtgad mice express mutant presenilin-1, amyloid precursor protein and tau, and exhibit ad-like amyloid and tau pathology in the hippocampus and cortex, and associated cognitive impairment. |
2008-09-24 |
2023-08-12 |
mouse |
| Marisol Espinoza, Rohan de Silva, Dennis W Dickson, Peter Davie. Differential incorporation of tau isoforms in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 14. issue 1. 2008-08-18. PMID:18525123. |
immunohistochemical analysis of the hippocampus in 34 ad cases performed with these antibodies showed both 3r and 4r tau isoforms in tangles. |
2008-08-18 |
2023-08-12 |
human |
| Marisol Espinoza, Rohan de Silva, Dennis W Dickson, Peter Davie. Differential incorporation of tau isoforms in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 14. issue 1. 2008-08-18. PMID:18525123. |
while biochemical studies showed that both isoforms were present in insoluble tau aggregates in ad hippocampus and cortex, not all tangles appear to be labeled with the 3r and 4r tau specific monoclonal antibodies. |
2008-08-18 |
2023-08-12 |
human |
| b' Sanna-Kaisa Herukka, Corina Pennanen, Hilkka Soininen, Tuula Pirttil\\xc3\\xa. CSF Abeta42, tau and phosphorylated tau correlate with medial temporal lobe atrophy. Journal of Alzheimer\'s disease : JAD. vol 14. issue 1. 2008-08-18. PMID:18525127.' |
tau and phospho-tau correlated inversely with hippocampal volumes and left entorhinal cortex volume in the whole study group. |
2008-08-18 |
2023-08-12 |
human |
| b' Sanna-Kaisa Herukka, Corina Pennanen, Hilkka Soininen, Tuula Pirttil\\xc3\\xa. CSF Abeta42, tau and phosphorylated tau correlate with medial temporal lobe atrophy. Journal of Alzheimer\'s disease : JAD. vol 14. issue 1. 2008-08-18. PMID:18525127.' |
in the stable group, tau correlated with hippocampal volumes. |
2008-08-18 |
2023-08-12 |
human |
| Ann C McKee, Isabel Carreras, Lokman Hossain, Hoon Ryu, William L Klein, Salvatore Oddo, Frank M LaFerla, Bruce G Jenkins, Neil W Kowall, Alpaslan Dedeogl. Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice. Brain research. vol 1207. 2008-08-13. PMID:18374906. |
ibuprofen-treated transgenic mice showed a significant decrease in intraneuronal oligomeric abeta and hyperphosphorylated tau (at8) immunoreactivity in the hippocampus. |
2008-08-13 |
2023-08-12 |
mouse |