| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Annie M Goettemoeller, Emmie Banks, Prateek Kumar, Viktor J Olah, Katharine E McCann, Kelly South, Christina C Ramelow, Anna Eaton, Duc M Duong, Nicholas T Seyfried, David Weinshenker, Srikant Rangaraju, Matthew Jm Rowa. Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology. bioRxiv : the preprint server for biology. 2024-07-15. PMID:39005389. |
entorhinal cortex vulnerability to human app expression promotes hyperexcitability and tau pathology. |
2024-07-15 |
2024-07-18 |
mouse |
| Nina Engels-Domínguez, Joost M Riphagen, Maxime Van Egroo, Elouise A Koops, Lindsay F Smegal, J Alex Becker, Prokopis C Prokopiou, Elisenda Bueichekú, Kenneth K Kwong, Dorene M Rentz, David H Salat, Reisa A Sperling, Keith A Johnson, Heidi I L Jacob. Lower Locus Coeruleus Integrity Signals Elevated Entorhinal Tau and Clinical Progression in Asymptomatic Older Individuals. Annals of neurology. 2024-07-15. PMID:39007398. |
elevated entorhinal cortex (ec) tau in low beta-amyloid individuals can predict accumulation of pathology and cognitive decline. |
2024-07-15 |
2024-07-18 |
Not clear |
| Youngnam Kang, Hiroki Toyoda, Mitsuru Sait. Search for unknown neural link between the masticatory and cognitive brain systems to clarify the involvement of its impairment in the pathogenesis of Alzheimer's disease. Frontiers in cellular neuroscience. vol 18. 2024-07-12. PMID:38994328. |
neuronal degeneration of the two neuronal nuclei leads to a decrease in neurotrophic factors such as brain-derived neurotrophic factor (bdnf) in the hippocampus and cerebral cortex, which results in the accumulation of aβ and hyperphosphorylated tau protein and ultimately causes neuronal cell death in those cortices. |
2024-07-12 |
2024-07-14 |
human |
| Hendrik Theis, Michael T Barbe, Alexander Drzezga, Gereon R Fink, Bernd Neumaier, Gérard N Bischof, Thilo van Eimere. Progressive Supranuclear Palsy: Subcortical Tau Depositions Are Associated with Cortical Perfusion in Frontal and Limbic Regions. Journal of Parkinson's disease. 2024-07-12. PMID:38995804. |
tau in subcortical regions showed significant negative correlation with perfusion in limbic cortex. |
2024-07-12 |
2024-07-15 |
Not clear |
| Cara Sophie Schreiber, Ivo Wiesweg, Stephanie Stanelle-Bertram, Sebastian Beck, Nancy Mounogou Kouassi, Berfin Schaumburg, Gülsah Gabriel, Franziska Richter, Christopher Käufe. Sex-specific biphasic alpha-synuclein response and alterations of interneurons in a COVID-19 hamster model. EBioMedicine. vol 105. 2024-06-12. PMID:38865747. |
we previously demonstrated neuroinflammation in the olfactory bulb of intranasally infected hamsters, followed by alpha-synuclein and tau accumulation in cortex, thus mirroring pathogenesis of neurodegenerative diseases such as parkinson's or alzheimer's disease. |
2024-06-12 |
2024-06-15 |
Not clear |
| Katrien Princen, Tom Van Dooren, Marit van Gorsel, Nikolaos Louros, Xiaojuan Yang, Michael Dumbacher, Ilse Bastiaens, Kristel Coupet, Shana Dupont, Eva Cuveliers, Annick Lauwers, Mohamed Laghmouchi, Thomas Vanwelden, Sofie Carmans, Nele Van Damme, Hein Duhamel, Seppe Vansteenkiste, Jovan Prerad, Karolien Pipeleers, Olivier Rodiers, Liese De Ridder, Sofie Claes, Yoni Busschots, Lentel Pringels, Vanessa Verhelst, Eveline Debroux, Marinka Brouwer, Sam Lievens, Jan Tavernier, Melissa Farinelli, Sandrine Hughes-Asceri, Marieke Voets, Joris Winderickx, Stefaan Wera, Joris de Wit, Joost Schymkowitz, Frederic Rousseau, Henrik Zetterberg, Jeffrey L Cummings, Wim Annaert, Tom Cornelissen, Hans De Winter, Koen De Witte, Marc Fivaz, Gerard Griffioe. Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease. Science (New York, N.Y.). vol 384. issue 6699. 2024-05-30. PMID:38815015. |
aberrant tau accumulation leads to uncontrolled activation of store-operated calcium channels (soccs) by remodeling septin filaments at the cell cortex. |
2024-05-30 |
2024-06-14 |
mouse |
| Alicia Uceda-Heras, Gonzalo Aparicio-Rodríguez, Miguel Ángel García-Cabeza. Hyperphosphorylated tau in Alzheimer's disease disseminates along pathways predicted by the Structural Model for Cortico-cortical Connections. The Journal of comparative neurology. vol 532. issue 5. 2024-05-28. PMID:38803103. |
in alzheimer´s disease (ad), hyperphosphorylated tau spreads along the cerebral cortex in a stereotypical pattern that parallels cognitive deterioration. |
2024-05-28 |
2024-06-05 |
human |
| Alicia Uceda-Heras, Gonzalo Aparicio-Rodríguez, Miguel Ángel García-Cabeza. Hyperphosphorylated tau in Alzheimer's disease disseminates along pathways predicted by the Structural Model for Cortico-cortical Connections. The Journal of comparative neurology. vol 532. issue 5. 2024-05-28. PMID:38803103. |
in summary, we show that hyperphosphorylated tau initially accumulates in allo-, meso-, and isocortical types, offer a proof of concept for the validity of the structural model to predict synaptic pathway organization in the human cerebral cortex, and highlight the relevance of nonhuman primate tract-tracing studies to understand human neuropathology. |
2024-05-28 |
2024-06-05 |
human |
| Chao Qi, Ryota Kobayashi, Shinobu Kawakatsu, Fuyuki Kametani, Sjors H W Scheres, Michel Goedert, Masato Hasegaw. Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G. Acta neuropathologica. vol 147. issue 1. 2024-05-17. PMID:38758288. |
here we report that tau inclusions were concentrated in layers ii/iii of the frontotemporal cortex in a case of vacuolar tauopathy. |
2024-05-17 |
2024-05-27 |
Not clear |
| Elise E Dunning, Boris Decourt, Nasser H Zawia, Holly A Shill, Marwan N Sabbag. Pharmacotherapies for the Treatment of Progressive Supranuclear Palsy: A Narrative Review. Neurology and therapy. 2024-05-14. PMID:38743312. |
progressive supranuclear palsy (psp) is a neurodegenerative disorder resulting from the deposition of misfolded and neurotoxic forms of tau protein in specific areas of the midbrain, basal ganglia, and cortex. |
2024-05-14 |
2024-05-27 |
Not clear |
| Mattia Cort. Exploring tau protein and amyloid-beta propagation: a sensitivity analysis of mathematical models based on biological data. ArXiv. 2024-05-07. PMID:38711430. |
we calibrate the model parameters using biological measurements in the brain cortex for the tau protein and the amyloid-$eta$ in alzheimer's patients and controls. |
2024-05-07 |
2024-05-27 |
Not clear |
| Karly A Cody, Rebecca E Langhough, Matthew D Zammit, Lindsay Clark, Nathaniel Chin, Bradley T Christian, Tobey J Betthauser, Sterling C Johnso. Characterizing brain tau and cognitive decline along the amyloid timeline in Alzheimer's disease. Brain : a journal of neurology. 2024-04-26. PMID:38667631. |
regional analyses indicated that tau burden in the entorhinal cortex was detectable, on average, within ten years of a+ onset. |
2024-04-26 |
2024-04-28 |
human |
| Junfang Zhang, Haijuan Chen, Jie Wang, Qi Huang, Xiaomeng Xu, Wenjing Wang, Wei Xu, Yihui Guan, Jun Liu, Joanna M Wardlaw, Yulei Deng, Fang Xie, Binyin L. Linking white matter hyperintensities to regional cortical thinning, amyloid deposition, and synaptic density loss in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-04-22. PMID:38648354. |
we investigated the association between white matter hyperintensities (wmh) and regional cortical thickness, amyloid and tau deposition, and synaptic density in the wmh-connected cortex using multimodal images. |
2024-04-22 |
2024-04-26 |
Not clear |
| Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R Harrington, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model. Cells. vol 13. issue 7. 2024-04-12. PMID:38607082. |
the strongest phenotypic reversal coincided with a normalization of the tau load in the cortex and hippocampus of l1, suggesting that tau accumulation underpins the loss of cholinergic markers in the basal forebrain and its projection targets. |
2024-04-12 |
2024-04-14 |
mouse |
| Masumi Sugiyama, Kenneth S Kosik, Eleni Panagioto. Mathematical topology and geometry-based classification of tauopathies. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555402. |
neurodegenerative diseases, like alzheimer's, are associated with the presence of neurofibrillary lesions formed by tau protein filaments in the cerebral cortex. |
2024-03-30 |
2024-04-02 |
Not clear |
| Ian Cheong, Yong Du, Gwenn Smith, Jun Hua, Xu Li, Alexander Pantelya. Cerebral tau deposition in co-morbid progressive supranuclear palsy and amyotrophic lateral sclerosis: an [18F]-flortaucipir and 7T MRI study. Neuro-degenerative diseases. 2024-03-25. PMID:38527450. |
conclusion in vivo tau pet imaging of an individual with psp-als overlap demonstrated increased tau burden in the motor cortex that was not observed in psp-rs or control participants. |
2024-03-25 |
2024-03-28 |
human |
| Chaitali Anand, Justin Torok, Farras Abdelnour, Pedro D Maia, Ashish Ra. Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectome. bioRxiv : the preprint server for biology. 2024-03-18. PMID:38496606. |
brain regions in alzheimer's (ad) exhibit distinct vulnerability to the disease's hallmark pathology, with the entorhinal cortex and hippocampus succumbing early to tau tangles while others like primary sensory cortices remain resilient. |
2024-03-18 |
2024-03-20 |
Not clear |
| Zhongying Shao, Yanjun Lu, Aihong Xing, Xiying He, Hongyan Xie, Ming H. Effect of outer membrane vesicles of Lactobacillus pentosus on Tau phosphorylation and CDK5-Calpain pathway in mice. Experimental gerontology. 2024-03-14. PMID:38484904. |
immunohistochemistry and western blot assessments unveiled elevated levels of hyperphosphorylated tau in the cortex and hippocampus of mice treated with ad-omvs. |
2024-03-14 |
2024-03-17 |
mouse |
| Patricia Rodriguez-Rodriguez, Luis Enrique Arroyo-Garcia, Christina Tsagkogianni, Lechuan Li, Wei Wang, Ákos Végvári, Isabella Salas-Allende, Zakary Plautz, Angel Cedazo-Minguez, Subhash C Sinha, Olga Troyanskaya, Marc Flajolet, Vicky Yao, Jean-Pierre Roussari. A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons. Brain : a journal of neurology. 2024-03-11. PMID:38462574. |
neurons from layer ii of the entorhinal cortex (ecii) are the first to accumulate tau protein aggregates and degenerate during prodromal alzheimer's disease (ad). |
2024-03-11 |
2024-03-14 |
mouse |
| Muhammad Ali, Pierre Garcia, Laetitia P Lunkes, Alessia Sciortino, Melanie Thomas, Tony Heurtaux, Kamil Grzyb, Rashi Halder, Djalil Coowar, Alex Skupin, Luc Buée, David Blum, Manuel Buttini, Enrico Glaa. Single cell transcriptome analysis of the THY-Tau22 mouse model of Alzheimer's disease reveals sex-dependent dysregulations. Cell death discovery. vol 10. issue 1. 2024-03-07. PMID:38453894. |
to gain insights into early ad-associated molecular changes and their sex dependency for tau pathology in the cortex, we performed single-cell rna-seq in the thy-tau22 ad mouse model. |
2024-03-07 |
2024-03-10 |
mouse |