| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniël J van Rensburg, Zander Lindeque, Brian H Harvey, Stephan F Stey. Ndufs4 KO mice: A model to study comorbid mood disorders associated with mitochondrial dysfunction. Pharmacology, biochemistry, and behavior. vol 234. 2023-12-13. PMID:38070656. |
serotonin levels of ko mice, compared to het controls, were increased on pnd36, together with increased tryptophan to serotonin and kynurenine turnover. |
2023-12-13 |
2023-12-17 |
mouse |
| Serena B Gumusoglu, Michaela D Kiel, Aleigha Gugel, Brandon M Schickling, Kaylee R Weaver, Marisol C Lauffer, Hannah R Sullivan, Kaylie J Coulter, Brianna M Blaine, Mushroor Kamal, Yuping Zhang, Eric J Devor, Donna A Santillan, Stephanie C Gantz, Mark K Santilla. Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-10-17. PMID:37848733. |
in rgs2 ko, serotonergic gene expression was sex-specifically changed (e.g., cortical htr2a, maoa increased in females but all serotonin targets unchanged or decreased in males); redox-related expression increased in paraventricular nucleus and aorta; and angiogenic gene expression was changed in male but not female cortex. |
2023-10-17 |
2023-11-08 |
mouse |
| Serena B Gumusoglu, Michaela D Kiel, Aleigha Gugel, Brandon M Schickling, Kaylee R Weaver, Marisol C Lauffer, Hannah R Sullivan, Kaylie J Coulter, Brianna M Blaine, Mushroor Kamal, Yuping Zhang, Eric J Devor, Donna A Santillan, Stephanie C Gantz, Mark K Santilla. Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-10-17. PMID:37848733. |
whole-cell recordings from dorsal raphe serotonin neurons revealed altered 5-ht1a receptor-dependent inhibitory postsynaptic currents (5-ht1a-ipscs) in female but not male ko neurons. |
2023-10-17 |
2023-11-08 |
mouse |
| Serena B Gumusoglu, Michaela D Kiel, Aleigha Gugel, Brandon M Schickling, Kaylee R Weaver, Marisol C Lauffer, Hannah R Sullivan, Kaylie J Coulter, Brianna M Blaine, Mushroor Kamal, Yuping Zhang, Eric J Devor, Donna A Santillan, Stephanie C Gantz, Mark K Santilla. Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-10-17. PMID:37848733. |
additionally, serotonin transporter blockade by the ssri sertraline increased the amplitude and time-to-peak of 5-ht1a-ipscs in ko neurons to a greater extent than in wt neurons in females only. |
2023-10-17 |
2023-11-08 |
mouse |
| Yuki Moriya, Yoshiyuki Kasahara, Kana Ishihara, Frank Scott Hall, Yoko Hagino, René Hen, Kazutaka Ikeda, George R Uhl, Ichiro Sor. Heterozygous and homozygous gene knockout of the 5-HT1B receptor have different effects on methamphetamine-induced behavioral sensitization. Behavioural pharmacology. 2023-09-05. PMID:37668157. |
to clarify the action of meth in 5-ht1b ko mice the effects of meth on extracellular levels of da (daec) and 5-ht (5-htec) in the caudate putamen (cpu) and the nucleus accumbens (nac) were examined. |
2023-09-05 |
2023-09-07 |
mouse |
| Takahiro Ito, Mikio Yoshida, Tomomi Aida, Itaru Kushima, Yuka Hiramatsu, Maiko Ono, Akira Yoshimi, Kohichi Tanaka, Norio Ozaki, Yukihiro Nod. Astrotactin2 (ASTN2) regulates emotional and cognitive functions by affecting neuronal morphogenesis and monoaminergic systems. Journal of neurochemistry. 2023-02-22. PMID:36807153. |
dopamine contents were decreased in the striatum, and serotonin or dopamine turnover were increased in the striatum, nucleus accumbens, and amygdala of astn2 ko mice. |
2023-02-22 |
2023-08-14 |
mouse |
| Ji Eun Kim, Ayun Seol, Yun Ju Choi, Su Jin Lee, You Jeong Jin, Yu Jeong Roh, Hee Jin Song, Jin Tae Hong, Dae Youn Hwan. Similarities and differences in constipation phenotypes between Lep knockout mice and high fat diet-induced obesity mice. PloS one. vol 17. issue 12. 2022-12-22. PMID:36548335. |
a similar alteration pattern in the expression of muscarinic acetylcholine receptors (machrs) and serotonin receptors was detected in the lep ko and hfd-treated mice. |
2022-12-22 |
2023-08-14 |
mouse |
| Danielle S Roberts, Laura G Sherlock, Janelle N Posey, Jamie L Archambault, Eva S Nozik, Cassidy A Delane. Serotonin-deficient neonatal mice are not protected against the development of experimental bronchopulmonary dysplasia or pulmonary hypertension. Physiological reports. vol 10. issue 19. 2022-10-06. PMID:36200294. |
circulating (plasma and platelet) 5-ht decreased in both hypoxia-exposed wt and ko mice. |
2022-10-06 |
2023-08-14 |
mouse |
| Baiba Svalbe, Baiba Zvejniece, Gundega Stelfa, Karlis Vilks, Edijs Vavers, José Miguel Vela, Maija Dambrova, Liga Zvejniec. Antidepressive-like Behavior-Related Metabolomic Signatures of Sigma-1 Receptor Knockout Mice. Biomedicines. vol 10. issue 7. 2022-07-27. PMID:35884876. |
there were higher serotonin levels in plasma and brain tissue and higher histamine levels in the plasma of sig1r ko mice than in their age-matched wild-type counterparts. |
2022-07-27 |
2023-08-14 |
mouse |
| Volkan Uzungil, Harvey Tran, Connor Aitken, Carey Wilson, Carlos M Opazo, Shanshan Li, Jennyfer M Payet, Celeste H Mawal, Ashley I Bush, Matthew W Hale, Anthony J Hannan, Thibault Renoi. Novel Antidepressant-Like Properties of the Iron Chelator Deferiprone in a Mouse Model of Depression. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-07-21. PMID:35861925. |
using the serotonin transporter knock-out (5-htt ko) mouse model, we assessed the behavioural effects of acute deferiprone on the porsolt swim test (pst) and novelty-suppressed feeding test (nsft). |
2022-07-21 |
2023-08-14 |
mouse |
| Kei-Ichi Katayama, Naoko Morimura, Katsunori Kobayashi, Danielle Corbett, Takehito Okamoto, Veravej G Ornthanalai, Hayato Matsunaga, Wakako Fujita, Yoshifumi Matsumoto, Takumi Akagi, Tsutomu Hashikawa, Kazuyuki Yamada, Niall P Murphy, Soichi Nagao, Jun Arug. Slitrk2 deficiency causes hyperactivity with altered vestibular function and serotonergic dysregulation. iScience. vol 25. issue 7. 2022-07-05. PMID:35789858. |
slitrk2 knockout (ko) mice exhibited increased locomotor activity in novel environments, antidepressant-like behaviors, enhanced vestibular function, and increased plasticity at mossy fiber-ca3 synapses with reduced sensitivity to serotonin. |
2022-07-05 |
2023-08-14 |
mouse |
| Kei-Ichi Katayama, Naoko Morimura, Katsunori Kobayashi, Danielle Corbett, Takehito Okamoto, Veravej G Ornthanalai, Hayato Matsunaga, Wakako Fujita, Yoshifumi Matsumoto, Takumi Akagi, Tsutomu Hashikawa, Kazuyuki Yamada, Niall P Murphy, Soichi Nagao, Jun Arug. Slitrk2 deficiency causes hyperactivity with altered vestibular function and serotonergic dysregulation. iScience. vol 25. issue 7. 2022-07-05. PMID:35789858. |
a serotonin metabolite was increased in the hippocampus and amygdala, and serotonergic neurons in the raphe nuclei were decreased in slitrk2 ko mice. |
2022-07-05 |
2023-08-14 |
mouse |
| Yun Ju Choi, Hee Jin Song, Ji Eun Kim, Su Jin Lee, You Jeong Jin, Yu Jeong Roh, Ayun Seol, Hye Sung Kim, Dae Youn Hwan. Dysregulation of the Enteric Nervous System in the Mid Colon of Complement Component 3 Knockout Mice with Constipation Phenotypes. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35743302. |
excitatory transmission analysis revealed similar suppression of the 5-hydroxytryptamine (5-ht) concentration, expression of 5-ht receptors, acetylcholine (ach) concentration, ach esterase (ache) activity, and expression of muscarinic ach receptors (machrs), despite the machrs downstream signaling pathway being activated in the mid colon of c3 ko mice. |
2022-06-24 |
2023-08-14 |
mouse |
| Bin Wang, Haixia Shi, Liyan Ren, Zhigang Miao, Bo Wan, Hao Yang, Xiaotang Fan, Jan-Ake Gustafsson, Miao Sun, Xingshun X. Ahi1 regulates serotonin production by the GR/ERβ/TPH2 pathway involving sexual differences in depressive behaviors. Cell communication and signaling : CCS. vol 20. issue 1. 2022-06-01. PMID:35643536. |
we previously showed that ahi1 knockout (ko) mice exhibited depression-like behavior accompanied by a significant decrease in brain serotonin. |
2022-06-01 |
2023-08-13 |
mouse |
| Tanishka S Saraf, Bo Yang, Ryan P McGlynn, Raymond G Booth, Clinton E Cana. Targeting 5-HT1A Receptors to Correct Neuronal Hyperexcitability in Fmr1 Knockout Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554571. |
based on our observations of altered brain expression and in vivo function of serotonin 1a receptors (5-ht1ars) in fmr1 ko mice and correction of the audiogenic seizure phenotype by our novel 2-aminotetralin-type 5-ht1r modulator, fpt, we are testing the hypothesis that selectively activating 5-ht1ars prevents seizures and corrects neurophysiological abnormalities. |
2022-05-13 |
2023-08-13 |
mouse |
| Sharonda S Harris, Sara M Green, Mayank Kumar, Nikhil M Ur. A role for cortical dopamine in the paradoxical calming effects of psychostimulants. Scientific reports. vol 12. issue 1. 2022-02-25. PMID:35210489. |
studies using dopamine (da) transporter (dat) knockout (ko) mice have suggested that the paradoxical calming effect of psychostimulants might occur through actions on serotonin (5-ht) neurotransmission. |
2022-02-25 |
2023-08-13 |
mouse |
| Youhei Obata, Mie Kubota-Sakashita, Takaoki Kasahara, Masafumi Mizuno, Takahiro Nemoto, Tadafumi Kat. Phenethylamine is a substrate of monoamine oxidase B in the paraventricular thalamic nucleus. Scientific reports. vol 12. issue 1. 2022-01-08. PMID:34996979. |
to identify the mao-b substrate in pvt, we generated maob knockout (ko) mice and measured five candidate substrates (i.e., noradrenaline, dopamine, 3-methoxytyramine, serotonin, and phenethylamine [pea]) by liquid chromatography tandem mass spectrometry. |
2022-01-08 |
2023-08-13 |
mouse |
| Kevin Chen, Tamara Palagashvili, W Hsu, Yibu Chen, Boris Tabakoff, Frank Hong, Abigail T Shih, Jean C Shi. Brain injury and inflammation genes common to a number of neurological diseases and the genes involved in the genesis of GABAnergic neurons are altered in monoamine oxidase B knockout mice. Brain research. vol 1774. 2021-12-03. PMID:34780749. |
we reported previously that pea levels increased significantly in all brain regions, but serotonin and dopamine levels were unchanged in mao b knockout (ko) mice. |
2021-12-03 |
2023-08-13 |
mouse |
| Gary C Mouradian, Madeline Kilby, Santiago Alvarez, Kara Kaplan, Matthew R Hodge. Mortality and ventilatory effects of central serotonin deficiency during postnatal development depend on age but not sex. Physiological reports. vol 9. issue 13. 2021-11-10. PMID:34228894. |
here we utilized our established dark agouti transgenic rat lacking central serotonin ko to test the hypotheses that cns 5-ht deficiency leads to: (1) high mortality in a sex-independent manner, (2) age-dependent alterations in other cns aminergic systems, and (3) age-dependent impairment of chemoreflexes during post-natal development. |
2021-11-10 |
2023-08-13 |
rat |
| Tomohisa Mori, Naoki Uzawa, Daiki Masukawa, Shigeto Hirayama, Yoshiyuki Iwase, Mayuna Hokazono, Yuya Udagawa, Tsutomu Suzuk. Enhancement of the rewarding effects of 3,4-methylenedioxymethamphetamine in orexin knockout mice. Behavioural brain research. vol 396. 2021-11-09. PMID:32653557. |
increases in 5-ht and dopamine release in the nucleus accumbens induced by mdma were not altered by knockout of orexin; the steady-state level of g protein activation was higher in the limbic forebrain of orexin ko mice. |
2021-11-09 |
2023-08-13 |
mouse |