| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kim Moorwood, Florentia M Smith, Alastair S Garfield, Michael Cowley, Lowenna J Holt, Roger J Daly, Andrew War. Grb7, Grb10 and Grb14, encoding the growth factor receptor-bound 7 family of signalling adaptor proteins have overlapping functions in the regulation of fetal growth and post-natal glucose metabolism. BMC biology. vol 22. issue 1. 2024-09-29. PMID:39343875. |
both grb10 ko and grb14 ko mice exhibit increased insulin signalling in peripheral tissues, with increased glucose and insulin sensitivity and a modestly increased ability to clear a glucose load. |
2024-09-29 |
2024-10-02 |
mouse |
| Jannis Ulke, Simran Chopra, Otsuware Linda-Josephine Kadiri, Peter Geserick, Vanessa Stein, Sahar Cheshmeh, André Kleinridders, Kai Kapper. PTPRJ is a negative regulator of insulin signaling in neuronal cells, impacting protein biosynthesis, and neurite outgrowth. Journal of neuroendocrinology. 2024-09-10. PMID:39253900. |
ptprj ko cells displayed enhanced insulin signaling, as shown by increased phosphorylation of the insulin receptor (insr), irs-1, akt, and erk1/2. |
2024-09-10 |
2024-09-13 |
Not clear |
| Wu Kainan, Chen Yuerong, Guo Runsheng, Qingtan Zeng, Yu Yu. Leptin and insulin synergize with PIK3CA mutation to enhance PD-L1 mediated immunosuppression in thyroid cancer. Experimental cell research. 2024-08-29. PMID:39209143. |
by using a combination of assays like crispr ko, cancer cell-t cell co-culture, apolive-glo™ multiplex assay and syngeneic mouse model, we show that pd-l1 protein levels are increased dose-dependently by leptin or insulin in multiple thyroid cancer cell lines. |
2024-08-29 |
2024-09-04 |
mouse |
| Michiko Hirose, Kimiko Inoue, Shogo Matoba, Takaki Tatebe, Syun Tokita, Yukiko Dodo, Toshiko Tomishima, Ayumi Hasegawa, Arata Honda, Mao Ozaki, Akiko Shinogi, Ryoko Yanagisawa, Muhammad Fauzi, Takaaki Murakami, Nobuya Inagaki, Masaru Tamura, Atsuo Ogur. Disruption of insulin receptor substrate 2 (IRS2) causes non-obese type 2 diabetes with β-cell dysfunction in the golden (Syrian) hamster. Scientific reports. vol 14. issue 1. 2024-08-12. PMID:39134590. |
however, they normally responded to insulin stimulation, unlike irs2 ko mice, an obese type 2 diabetes (t2d) model. |
2024-08-12 |
2024-08-16 |
mouse |
| Michiko Hirose, Kimiko Inoue, Shogo Matoba, Takaki Tatebe, Syun Tokita, Yukiko Dodo, Toshiko Tomishima, Ayumi Hasegawa, Arata Honda, Mao Ozaki, Akiko Shinogi, Ryoko Yanagisawa, Muhammad Fauzi, Takaaki Murakami, Nobuya Inagaki, Masaru Tamura, Atsuo Ogur. Disruption of insulin receptor substrate 2 (IRS2) causes non-obese type 2 diabetes with β-cell dysfunction in the golden (Syrian) hamster. Scientific reports. vol 14. issue 1. 2024-08-12. PMID:39134590. |
consistent with this, irs2 ko hamsters did not increase serum insulin levels upon glucose administration and showed β-cell hypoplasia in their pancreas. |
2024-08-12 |
2024-08-16 |
mouse |
| Axel Labour, Marlène Lac, Lucas Frassin, Benjamin Lair, Enda Murphy, Claire Maslo, Laurent Monbrun, Marie-Lou Calmy, Marie Marquès, Nathalie Viguerie, Geneviève Tavernier, Pierre Gourdy, Donal O'Gorman, Emilie Montastier, Claire Laurens, Alexandra Montagner, Cedric Mor. GDF15 is dispensable for the insulin-sensitizing effects of chronic exercise. Cell reports. vol 43. issue 8. 2024-08-03. PMID:39096490. |
at baseline, both under a standard nutritional state and high-fat feeding, gdf15 knockout (ko) mice display normal glucose tolerance, systemic insulin sensitivity, maximal speed, and endurance running capacity when compared to wild-type littermates independent of sex. |
2024-08-03 |
2024-08-06 |
mouse |
| Axel Labour, Marlène Lac, Lucas Frassin, Benjamin Lair, Enda Murphy, Claire Maslo, Laurent Monbrun, Marie-Lou Calmy, Marie Marquès, Nathalie Viguerie, Geneviève Tavernier, Pierre Gourdy, Donal O'Gorman, Emilie Montastier, Claire Laurens, Alexandra Montagner, Cedric Mor. GDF15 is dispensable for the insulin-sensitizing effects of chronic exercise. Cell reports. vol 43. issue 8. 2024-08-03. PMID:39096490. |
when submitted to a 4-week exercise training program, both lean and obese wild-type and gdf15 ko mice similarly improve their endurance running capacity, glucose tolerance, systemic insulin sensitivity, and peripheral glucose uptake. |
2024-08-03 |
2024-08-06 |
mouse |
| David R Powell, Deon D Doree, Melanie K Shadoan, Kenneth A Platt, Robert Brommage, Peter Vogel, Jean-Pierre Revell. Mice lacking Mrs2 magnesium transporter are hypophagic and thin when maintained on a high fat diet. Endocrinology. 2024-06-15. PMID:38878275. |
ogtt studies revealed significantly improved insulin sensitivity in mrs2 ko mice. |
2024-06-15 |
2024-06-18 |
mouse |
| David R Powell, Deon D Doree, Melanie K Shadoan, Kenneth A Platt, Robert Brommage, Peter Vogel, Jean-Pierre Revell. Mice lacking Mrs2 magnesium transporter are hypophagic and thin when maintained on a high fat diet. Endocrinology. 2024-06-15. PMID:38878275. |
we conclude that hfd-fed mrs2 ko mice are thin with improved insulin sensitivity, and that this favorable metabolic phenotype is driven by hypophagia. |
2024-06-15 |
2024-06-18 |
mouse |
| Sundararajan Mahalingam, Ramesh Bellamkonda, Kusum K Kharbanda, Madan Kumar Arumugam, Vikas Kumar, Carol A Casey, Lorenzo Leggio, Karuna Rasinen. Role of ghrelin hormone in the development of alcohol-associated liver disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 174. 2024-04-19. PMID:38640709. |
further, when the wts were pair-fed to ghsr-kos, the ko rats exhibited resistance to develop ald through improving insulin secretion/sensitivity to reduce adipose lipolysis and hepatic fatty acid uptake/synthesis and increase fatty acid oxidation. |
2024-04-19 |
2024-04-22 |
rat |
| Cierra K Boyer, Sandra E Blom, Ashleigh E Machado, Kristen E Rohli, Michelle E Maxson, Samuel B Stephen. Loss of the Golgi-localized v-ATPase subunit does not alter insulin granule formation or pancreatic islet β-cell function. American journal of physiology. Endocrinology and metabolism. 2024-01-24. PMID:38265287. |
β-cell v0a2 ko mice exhibited normal glucose tolerance in both sexes, no genotypic difference to diet-induced obesity, and normal insulin secretory responses. |
2024-01-24 |
2024-01-26 |
mouse |
| Hui Liu, Tongjuan Niu, Guobin Qiu, Sheng Cui, Di Zhan. Taurine promotes insulin synthesis by enhancing Isl-1 expression through miR-7a/RAF1/ERK1/2 pathway. In vitro cellular & developmental biology. Animal. 2023-12-20. PMID:38117455. |
the present study was thus proposed to identify the effects of taurine on the expressions of mir-7a and/or isl-1 and their relations to insulin synthesis in mouse pancreatic islet β-cells by using mir-7a2 knockout (ko) and taurine transporter (taut) ko mouse models and the related in vitro experiments. |
2023-12-20 |
2023-12-23 |
mouse |
| Hui Liu, Tongjuan Niu, Guobin Qiu, Sheng Cui, Di Zhan. Taurine promotes insulin synthesis by enhancing Isl-1 expression through miR-7a/RAF1/ERK1/2 pathway. In vitro cellular & developmental biology. Animal. 2023-12-20. PMID:38117455. |
however, the enhanced effects of taurine on isl-1 expression and insulin synthesis were mitigated in the taut ko and mir-7a2 ko mice. |
2023-12-20 |
2023-12-23 |
mouse |
| Yong Kyung Kim, Youngjung Rachel Kim, Kristen L Wells, Dylan Sarbaugh, Michelle Guney, Chia-Feng Tsai, Tiffany Zee, Gerard Karsenty, Ernesto S Nakayasu, Lori Susse. PTPN2 regulates metabolic flux to affect beta cell susceptibility to inflammatory stress. Diabetes. 2023-11-28. PMID:38015772. |
furthermore, cytokine treated ptpn2 ko islets resulted in impaired glucose-stimulated insulin secretion, mitochondrial defects and reduced glucose-induced metabolic flux, suggesting beta cells lacking ptpn2 are more susceptible to inflammatory stress associated with t1d due to maladaptive metabolic fitness. |
2023-11-28 |
2023-12-07 |
mouse |
| Gi-Sue Kang, Hye-Ju Jo, Ye-Rim Lee, Taerim Oh, Hye-Joon Park, G-One Ah. Sensing the oxygen and temperature in the adipose tissues - who's sensing what? Experimental & molecular medicine. 2023-11-01. PMID:37907745. |
to dissect the role of hif in specific types of cells during diet-induced obesity, researchers have generated tissue-specific knockout (ko) mice targeting hif pathways, and many studies have commonly revealed that intact hif-1 signaling in adipocytes and adipose tissue macrophages exacerbates tissue inflammation and insulin resistance. |
2023-11-01 |
2023-11-08 |
mouse |
| Fumitaka Kawakami, Motoki Imai, Yuki Isaka, Mark R Cookson, Hiroko Maruyama, Makoto Kubo, Matthew J Farrer, Makoto Kanzaki, Rei Kawashima, Tatsunori Maekawa, Shun Tamaki, Yoshifumi Kurosaki, Fumiaki Kojima, Kenichi Ohba, Takafumi Ichikaw. LRRK2 negatively regulates glucose tolerance via regulation of membrane translocation of GLUT4 in adipocytes. FEBS open bio. 2023-10-16. PMID:37845194. |
in addition, high serum insulin and leptin, as well as low serum adiponectin resulting from hfd in wt mice were improved in ko mice. |
2023-10-16 |
2023-11-08 |
mouse |
| Ara Cho, Wencheng Jin, Jeonghwan Lee, Nayeon Shin, Myoung Seok Lee, Lilin Li, Seung Hee Yang, Kyong Soo Park, Chul Woo Yang, Dong Ki Kim, Yun Kyu Oh, Chun Soo Lim, Jung Pyo Le. Periostin deficiency attenuates kidney fibrosis in diabetic nephropathy by improving pancreatic β-cell dysfunction and reducing kidney EMT. Scientific reports. vol 13. issue 1. 2023-10-16. PMID:37845302. |
furthermore, the ko stz group exhibited significantly preserved pancreatic islet integrity and insulin expression. |
2023-10-16 |
2023-11-08 |
mouse |
| Yuqi Li, Rongrong Li, Xu Luo, Fang Xu, Meizi Yang, Lanhui Zheng, Qihao Wu, Wenguo Jiang, Yana L. Vascular endothelial growth factor B regulates insulin secretion in β cells of type 2 diabetes mellitus mice via PLCγ and the IP3R‑evoked Ca2 Molecular medicine reports. vol 28. issue 4. 2023-09-08. PMID:37681454. |
the decrement of insulin secretion in islet β cell of t2dm mice were aggravated and blood glucose remained at a high level after vegfb knockout (ko). |
2023-09-08 |
2023-10-07 |
mouse |
| Amélie Massemin, Delphine Goehrig, Jean-Michel Flaman, Sara Jaber, Audrey Griveau, Sophia Djebali, Elisabeth Marcos, Léa Payen, Jacqueline Marvel, Romain Parent, Serge Adnot, Philippe Bertolino, Jennifer Rieusset, Antonin Tortereau, David Vindrieux, David Bernar. Loss of Pla2r1 decreases cellular senescence and age-related alterations caused by aging and Western diets. Aging cell. 2023-09-05. PMID:37667516. |
in this study, we investigated the role of the pro-senescent phospholipase a2 receptor 1 (pla2r1) in regulating some age-related alterations in old mice and in mice subjected to a western diet, whereas aged wild-type mice displayed a decreased ability to regulate their glycemia during glucose and insulin tolerance tests, aged pla2r1 knockout (ko) mice efficiently regulated their glycemia and displayed fewer signs of aging. |
2023-09-05 |
2023-09-07 |
mouse |
| Satsuki Takashima, Eiichi Okamura, Yusuke Ichiyama, Kiyoto Nishi, Akio Shimizu, Chisato Watanabe, Masanaga Muto, Shoma Matsumoto, Setsuko Tsukiyama-Fujii, Tomoyuki Tsukiyama, Hisakazu Ogita, Eiichiro Nishi, Masahito Ohji, Fumihiro Sugiyama, Satoru Takahashi, Seiya Mizuno, Ken-Ichi Mizutani, Masatsugu Em. Null mutation of exocyst complex component 3-like does not affect vascular development in mice. Experimental animals. 2023-09-04. PMID:37661429. |
exoc3l ko mice also showed no significant alteration in cholesterol homeostasis or insulin secretion, although several reports suggest an association of exoc3l with these processes. |
2023-09-04 |
2023-09-07 |
mouse |