| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer Gansau, Emily E McDonnell, Conor T Buckle. Development and characterization of antacid microcapsules to buffer the acidic intervertebral disc microenvironment. Journal of biomedical materials research. Part A. vol 112. issue 11. 2024-09-02. PMID:38817021. |
during intervertebral disc (ivd) degeneration, microenvironmental challenges such as decreasing levels of glucose, oxygen, and ph play crucial roles in cell survival and matrix turnover. |
2024-09-02 |
2024-09-04 |
Not clear |
| Petra Cazzanelli, Mikkael Lamoca, Johannes Hasler, Oliver Nic Hausmann, Addisu Mesfin, Varun Puvanesarajah, Wolfgang Hitzl, Karin Wuertz-Koza. The role of miR-155-5p in inflammation and mechanical loading during intervertebral disc degeneration. Cell communication and signaling : CCS. vol 22. issue 1. 2024-08-28. PMID:39192354. |
the catabolic shift observed in ivd cells during degeneration leads to increased inflammation, extracellular matrix (ecm) degradation, aberrant intracellular signaling and cell loss. |
2024-08-28 |
2024-08-30 |
Not clear |
| Imke Rudnik-Jansen, Sanda van Kruining Kodele, Laura Creemers, Bert Jooste. Biomolecular therapies for chronic discogenic low back pain: A narrative review. JOR spine. vol 7. issue 3. 2024-08-08. PMID:39114580. |
degenerative processes in the ivd, such as inflammation and extra-cellular matrix breakdown, result in neurotrophin release. |
2024-08-08 |
2024-08-10 |
Not clear |
| Imke Rudnik-Jansen, Sanda van Kruining Kodele, Laura Creemers, Bert Jooste. Biomolecular therapies for chronic discogenic low back pain: A narrative review. JOR spine. vol 7. issue 3. 2024-08-08. PMID:39114580. |
furthermore, the tissue regenerative and neuro inhibitory properties of extracellular matrix components or transplanted mesenchymal stem cells are potentially interesting biomolecular approaches to not only block ivd degeneration but also impede pain sensitization. |
2024-08-08 |
2024-08-10 |
Not clear |
| Manmeet S Dhiman, Taylor J Bader, Dragana Ponjevic, Paul T Salo, David A Hart, Ganesh Swamy, John R Matyas, Neil A Dunca. Collagen integrity of the annulus fibrosus in degenerative disc disease individuals quantified with collagen hybridizing peptide. JOR spine. vol 7. issue 3. 2024-08-02. PMID:39092166. |
extra-cellular matrix degradation of the annulus fibrosus (af) has been linked with degeneration of the ivd. |
2024-08-02 |
2024-08-05 |
Not clear |
| Qingshuang Zhou, Xiaojiang Pu, Zhuang Qian, Haojie Chen, Nannan Wang, Sinian Wang, Zhenhua Feng, Zezhang Zhu, Bin Wang, Yong Qiu, Xu Su. Nuclear receptor Rev-erbα alleviates intervertebral disc degeneration by recruiting NCoR-HDAC3 co-repressor and inhibiting NLRP3 inflammasome. Cell proliferation. 2024-07-24. PMID:39045886. |
rev-erbα deficiency accelerated needle puncture or aging-induced ivd degeneration, characterized by increased extracellular matrix (ecm) catabolism and nucleus pulposus (np) cell apoptosis. |
2024-07-24 |
2024-07-26 |
Not clear |
| Huagui Huang, Kaizhong Wang, Xianyan Liu, Jinzuo Wang, Moran Suo, Xin Liu, Zhonghai L. Can self-powered piezoelectric materials be used to treat disc degeneration by means of electrical stimulation? Frontiers in bioengineering and biotechnology. vol 12. 2024-05-24. PMID:38784767. |
for this reason, we propose to utilize tissue-engineered scaffolds prepared from piezoelectric biomaterials with excellent biocompatibility and self-powered properties to be implanted into degenerated ivd to help restore cell type and number, restore extracellular matrix, and modulate immune responses. |
2024-05-24 |
2024-05-27 |
Not clear |
| Kunyu Zhan, Keying Zhu, Bingyan Gu, Sai Yao, Fangda Fu, Hanbing Zeng, Kun Tian, Weifeng Ji, Hongting Jin, Peijian Tong, Chengliang Wu, Ming Yue, Hongfeng Rua. MINK1 deficiency stimulates nucleus pulposus cell pyroptosis and exacerbates intervertebral disc degeneration. International immunopharmacology. vol 134. 2024-05-09. PMID:38723371. |
our findings indicated a notable decline in mink1 expression in np tissues of patients with ivd degeneration and both mouse models as degeneration progresses, accompanied by heightened matrix degradation and increased np pyroptosis. |
2024-05-09 |
2024-05-27 |
mouse |
| Yin Liu, Li Li, Xuan Li, Hosni Cherif, Shuaibing Jiang, Farshid Ghezelbash, Michael H Weber, David Juncker, Nicole Y K Li-Jessen, Lisbet Haglund, Jianyu L. Viscoelastic hydrogels regulate adipose-derived mesenchymal stem cells for nucleus pulposus regeneration. Acta biomaterialia. 2024-04-14. PMID:38615812. |
here, we investigated the role of matrix viscoelasticity in regulating asc differentiation for ivd regeneration. |
2024-04-14 |
2024-04-17 |
human |
| Yin Liu, Li Li, Xuan Li, Hosni Cherif, Shuaibing Jiang, Farshid Ghezelbash, Michael H Weber, David Juncker, Nicole Y K Li-Jessen, Lisbet Haglund, Jianyu L. Viscoelastic hydrogels regulate adipose-derived mesenchymal stem cells for nucleus pulposus regeneration. Acta biomaterialia. 2024-04-14. PMID:38615812. |
these findings highlight the critical role of matrix viscoelasticity in regulating asc behavior and suggest that viscoelasticity is a key parameter for novel biomaterials design to improve the efficacy of stem cell therapy for ivd regeneration. |
2024-04-14 |
2024-04-17 |
human |
| Shuai Li, Jinpeng Du, Yunfei Huang, Shenglong Gao, Zhigang Zhao, Zhen Chang, Xuefang Zhang, BaoRong H. From hyperglycemia to intervertebral disc damage: exploring diabetic-induced disc degeneration. Frontiers in immunology. vol 15. 2024-03-06. PMID:38444852. |
diabetes and advanced glycation end products (ages) accumulation- can lead to various adverse effects on the ivd, including cell senescence, apoptosis, pyroptosis, proliferation, and extracellular matrix (ecm) degradation. |
2024-03-06 |
2024-03-08 |
Not clear |
| Shota Tamagawa, Daisuke Sakai, Hidetoshi Nojiri, Yoshihiko Nakamura, Takayuki Warita, Erika Matsushita, Jordy Schol, Hazuki Soma, Shota Ogasawara, Daiki Munesada, Masato Koike, Takahiko Shimizu, Masato Sato, Muneaki Ishijima, Masahiko Watanab. SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential. Redox biology. vol 71. 2024-02-27. PMID:38412803. |
through a comprehensive set of in vitro and in vivo experiments, we found a suggestive association between excessive mitochondrial superoxide, cellular senescence, and matrix degradation in human and mouse ivd cells. |
2024-02-27 |
2024-03-01 |
mouse |
| Daokuan Gao, Quanlai Zhao, Chen Liu, Yu Zhang, Liang Xia. Abnormal stress promotes intervertebral disc degeneration through WTAP/YTHDF2-dependent TIMP3 m6A modification. Journal of cellular physiology. 2024-02-12. PMID:38345407. |
in this study, we reveal the molecular mechanisms of wtap/ythdf2-mediated m6a modification in abnormal stress-induced intervertebral disc (ivd) matrix degradation. |
2024-02-12 |
2024-02-15 |
human |
| Letizia Penolazzi, Anna Chierici, Maria Pina Notarangelo, Beatrice Dallan, Gina Lisignoli, Elisabetta Lambertini, Pantaleo Greco, Roberta Piva, Claudio Nastruzz. Wharton's jelly-derived multifunctional hydrogels: New tools to promote intervertebral disc regeneration in vitro and ex vivo. Journal of biomedical materials research. Part A. 2024-02-03. PMID:38308554. |
the degeneration of intervertebral disc (ivd) is a disease of the entire joint between two vertebrae in the spine caused by loss of extracellular matrix (ecm) integrity, to date with no cure. |
2024-02-03 |
2024-02-05 |
human |
| Letizia Penolazzi, Anna Chierici, Maria Pina Notarangelo, Beatrice Dallan, Gina Lisignoli, Elisabetta Lambertini, Pantaleo Greco, Roberta Piva, Claudio Nastruzz. Wharton's jelly-derived multifunctional hydrogels: New tools to promote intervertebral disc regeneration in vitro and ex vivo. Journal of biomedical materials research. Part A. 2024-02-03. PMID:38308554. |
here we focused on the decellularized matrix obtained from human umbilical cord wharton's jelly (dwj) which retains several structural and bioactive molecules very similar to those of the ivd ecm. |
2024-02-03 |
2024-02-05 |
human |
| Peng Wang, Shuo Zhang, Weijian Liu, Xiao Lv, Baichuan Wang, Binwu Hu, Zengwu Sha. Bardoxolone methyl breaks the vicious cycle between M1 macrophages and senescent nucleus pulposus cells through the Nrf2/STING/NF-κB pathway. International immunopharmacology. vol 127. 2023-12-15. PMID:38101216. |
intervertebral disc (ivd) degeneration (idd), an age-related degenerative disease, is accompanied by the accumulation of senescent nucleus pulposus (np) cells and extracellular matrix (ecm) degradation. |
2023-12-15 |
2023-12-18 |
rat |
| Kuo-Feng Hua, Lan-Hui Li, Hsin-Chiao Yu, Wei-Ting Wong, Hsien-Ta Hs. Leptin Induces MMP-1 Expression Through the RhoA/ERK1/2/NF-κB Axis in Human Intervertebral Disc Cartilage Endplate-Derived Stem Cells. Journal of inflammation research. vol 16. 2023-12-01. PMID:38026238. |
in a prior study, we found a positive correlation between ivd degeneration and levels of matrix metalloproteinase-1 (mmp-1) and leptin. |
2023-12-01 |
2023-12-10 |
human |
| Yingjie Hao, Guangduo Zhu, Lei Yu, Zhinan Ren, Weiwei Zhou, Panke Zhang, Xu Lia. FOXO3-activated HOTTIP Sequesters MiR-615-3p Away from COL2A1 to Mitigate Intervertebral Disc Degeneration. The American journal of pathology. 2023-11-19. PMID:37981220. |
knockout of foxo3 was found to impair ivd maturation and homeostasis in postnatal mice as well as facilitating extracellular matrix (ecm) degradation. |
2023-11-19 |
2023-11-29 |
mouse |
| Xue Yin, Oraya Vesvoranan, Fotios Andreopoulos, Edward A Dauer, Weiyong Gu, C-Y Charles Huan. Analysis of Extracellular ATP Distribution in the Intervertebral Disc. Annals of biomedical engineering. 2023-11-07. PMID:37934317. |
extracellular atp can mediate a variety of physiological functions and was shown to promote extracellular matrix (ecm) production in the ivd. |
2023-11-07 |
2023-11-08 |
human |
| Shuichi Mizuno, Gianluca Vadala, James D Kan. Biological Therapeutic Modalities for Intervertebral Disc Diseases:An Orthoregeneration Network (ON) Foundation Review. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. 2023-11-02. PMID:37918699. |
promising and established treatment modalities include repair of the annulus fibrosis; injection of expanded or non-expanded autologous or allogenic cells that are chondrogenic or from a stem cell lineage used to promote matrix tissue regeneration of the intervertebral disc (ivd), including nucleus pulpous cells and mesenchymal stem cells isolated from bone marrow, umbilical cord blood, or adipose tissue; and injection of platelet rich plasma, platelet rich fibrin, or fibrin sealant. |
2023-11-02 |
2023-11-08 |
Not clear |