| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryo Nishimura, Kiyoshi Okud. Hypoxia is important for establishing vascularization during corpus luteum formation in cattle. The Journal of reproduction and development. vol 56. issue 1. 2010-04-15. PMID:19881217. |
to determine whether hif1 participates in angiogenesis in bovine cl, the present study investigated the mrna and protein expressions of the hif1 alpha subunit (hif1a) and vegf in bovine cl during the estrous cycle. |
2010-04-15 |
2023-08-12 |
cattle |
| K M Anderson, J Jajeh, P Guinan, M Rubenstei. In vitro effects of dichloroacetate and CO2 on hypoxic HeLa cells. Anticancer research. vol 29. issue 11. 2010-01-26. PMID:20032407. |
increased hypoxia-inducible factor 1, alpha subunit (hif1a) mrna expression in hypoxic hela cells and their greater reliance on d-glucose for metabolic energy confirmed the reliability of the incubation conditions. |
2010-01-26 |
2023-08-12 |
Not clear |
| Guilan Jin, Hiromichi Matsushita, Satomi Asai, Hideo Tsukamoto, Ryoichi Ono, Tetsuya Nosaka, Takashi Yahata, Shinichiro Takahashi, Hayato Miyach. FLT3-ITD induces ara-C resistance in myeloid leukemic cells through the repression of the ENT1 expression. Biochemical and biophysical research communications. vol 390. issue 3. 2009-12-29. PMID:19853583. |
in addition, the expression of hypoxia inducible factor 1 alpha subunit (hif1a) transcripts was upregulated in k562/flt3-itd cells, and the induction of hif-1alpha reduced the promoter activity of ent1 gene in k562 cells. |
2009-12-29 |
2023-08-12 |
human |
| Armina A Kazi, Kristin Happ Molitoris, Robert D Koo. Estrogen rapidly activates the PI3K/AKT pathway and hypoxia-inducible factor 1 and induces vascular endothelial growth factor A expression in luminal epithelial cells of the rat uterus. Biology of reproduction. vol 81. issue 2. 2009-11-30. PMID:19420388. |
the alpha subunit of hif1 (hif1a) was present in le cells before e(2) treatment, was unchanged 1 h after e(2), but was >2-fold higher by 4 h. chromatin immunoprecipitation analysis showed that hif1a was recruited to the vegfa promoter by 1 h and was absent again by 4 h. the e(2) activation of the pi3k/akt pathway, hif1a recruitment to the vegfa promoter, and vegfa expression were all blocked by ici 182,780. |
2009-11-30 |
2023-08-12 |
rat |
| Catriona Paul, Serena Teng, Philippa T K Saunder. A single, mild, transient scrotal heat stress causes hypoxia and oxidative stress in mouse testes, which induces germ cell death. Biology of reproduction. vol 80. issue 5. 2009-06-19. PMID:19144962. |
heat stress caused an increase in expression of hypoxia-inducible factor 1 alpha (hif1a) mrna expression and translocation of hif1a protein to the germ cell nucleus, consistent with hypoxic stress. |
2009-06-19 |
2023-08-12 |
mouse |
| Kun-xiang Liu, Xue-chuan Sun, Sheng-wei Wang, Bin H. [Association of polymorphisms of 1772 (C-->T) and 1790 (G-->A) in HIF1A gene with hypoxia adaptation in high altitude in Sherpas]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 24. issue 2. 2009-03-27. PMID:17407091. |
to investigate the association of single nucleotide polymorphisms (snps) of 1772 (c-->t) and 1790 (g-->a) in exon 12 of hypoxia-inducible factor 1, alpha subunit gene (hif1a) with hypoxia adaptation in high altitude in sherpas. |
2009-03-27 |
2023-08-12 |
Not clear |
| Yang Wang, Maha Saad, Refika I Pakunlu, Jayant J Khandare, Olga B Garbuzenko, Alexandre A Vetcher, Viatcheslav A Soldatenkov, Vitaly P Pozharov, Tamara Mink. Nonviral nanoscale-based delivery of antisense oligonucleotides targeted to hypoxia-inducible factor 1 alpha enhances the efficacy of chemotherapy in drug-resistant tumor. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 14. issue 11. 2008-08-28. PMID:18519795. |
to enhance the efficacy of cancer treatment, we propose a complex approach: simultaneous delivery to the tumor of a chemotherapeutic agent and a suppressor of hypoxia-inducible factor 1 alpha (hif1a). |
2008-08-28 |
2023-08-12 |
Not clear |
| Aurelia Walczak-Drzewiecka, Marcin Ratajewski, Waldemar Wagner, Jaroslaw Dastyc. HIF-1alpha is up-regulated in activated mast cells by a process that involves calcineurin and NFAT. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 3. 2008-08-19. PMID:18641302. |
here, we investigated how expression of the hypoxia-inducible factor 1, alpha subunit gene (hif1a), is regulated in mast cells. |
2008-08-19 |
2023-08-12 |
Not clear |
| A J Harvey, K L Kind, J G Thompso. Regulation of gene expression in bovine blastocysts in response to oxygen and the iron chelator desferrioxamine. Biology of reproduction. vol 77. issue 1. 2007-09-25. PMID:17329595. |
however, bovine embryos, to at least the blastocyst stage, lack detectable levels of the key regulator of oxygen-sensitive gene expression, hypoxia-inducible 1 alpha (hif1a), while the less well-characterized hif2 alpha protein is readily detectable. |
2007-09-25 |
2023-08-12 |
cattle |
| Dong Zhao, Bao-Li Zhu, Takaki Ishikawa, Li Quan, Dong-Ri Li, Hitoshi Maed. Real-time RT-PCR quantitative assays and postmortem degradation profiles of erythropoietin, vascular endothelial growth factor and hypoxia-inducible factor 1 alpha mRNA transcripts in forensic autopsy materials. Legal medicine (Tokyo, Japan). vol 8. issue 2. 2006-08-11. PMID:16337823. |
the aim of the present study was to establish quantitative assays of oxygen-regulated factors including erythropoietin (epo), vascular endothelial growth factor (vegf) and hypoxia-inducible factor 1 alpha (hif1a) mrnas, and to investigate the postmortem stability of these mrna transcripts in forensic autopsy materials. |
2006-08-11 |
2023-08-12 |
Not clear |
| Yang Wang, Tamara Mink. A novel cancer therapy: combined liposomal hypoxia inducible factor 1 alpha antisense oligonucleotides and an anticancer drug. Biochemical pharmacology. vol 68. issue 10. 2005-01-25. PMID:15476674. |
the combined influence of doxorubicin (dox) and liposomal antisense oligonucleotides (asos) targeted to hypoxia-inducible factor 1 alpha (hif1a) subunit on the apoptosis signaling pathways and cellular pump and nonpump resistance were investigated. |
2005-01-25 |
2023-08-12 |
human |
| Elazar Zelzer, Roni Mamluk, Napoleone Ferrara, Randall S Johnson, Ernestina Schipani, Bjorn R Olse. VEGFA is necessary for chondrocyte survival during bone development. Development (Cambridge, England). vol 131. issue 9. 2004-07-02. PMID:15073147. |
interestingly, the extensive cell death seen in vegfa cko null bones had a striking similarity to the cell death phenotype observed when hypoxia-inducible factor 1 alpha (hif1a) expression was abolished in developing cartilage. |
2004-07-02 |
2023-08-12 |
mouse |
| Elazar Zelzer, Roni Mamluk, Napoleone Ferrara, Randall S Johnson, Ernestina Schipani, Bjorn R Olse. VEGFA is necessary for chondrocyte survival during bone development. Development (Cambridge, England). vol 131. issue 9. 2004-07-02. PMID:15073147. |
this similarity of cell death phenotypes and the deficient vegfa production in hif1a null epiphyseal chondrocytes demonstrate that hif1 alpha and vegfa are components of a key pathway to support chondrocyte survival during embryonic bone development. |
2004-07-02 |
2023-08-12 |
mouse |
| David D Kline, Ying-Jie Peng, Dominador J Manalo, Gregg L Semenza, Nanduri R Prabhaka. Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 2. 2002-04-29. PMID:11792862. |
to investigate whether the transcriptional activator hypoxia-inducible factor 1 (hif-1) is required for ventilatory responses to hypoxia, we analyzed mice that were either wild type or heterozygous for a loss-of-function (knockout) allele at the hif1a locus, which encodes the o(2)-regulated hif-1 alpha subunit. |
2002-04-29 |
2023-08-12 |
mouse |