| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xihua Chen, Jianbing Liu, Bin He, Yunfeng Li, Shuyan Liu, Bin Wu, Shufang Wang, Shucheng Zhang, Xiangbo Xu, Jiedong Wan. Vascular endothelial growth factor (VEGF) regulation by hypoxia inducible factor-1 alpha (HIF1A) starts and peaks during endometrial breakdown, not repair, in a mouse menstrual-like model. Human reproduction (Oxford, England). vol 30. issue 9. 2016-06-20. PMID:26113661. |
how is vascular endothelial growth factor (vegf) expression regulated by hypoxia inducible factor 1 alpha (hif1a) during menstruation? |
2016-06-20 |
2023-08-13 |
mouse |
| Javier Fernández-Torres, Cristina Hernández-Díaz, Rolando Espinosa-Morales, Javier Camacho-Galindo, Norma del Carmen Galindo-Sevilla, Ámbar López-Macay, Yessica Zamudio-Cuevas, Karina Martínez-Flores, Mónica Guadalupe Santamaría-Olmedo, Carlos Pineda, Julio Granados, Gabriela Angélica Martínez-Nava, Marwin Gutiérrez, Alberto G López-Reye. Polymorphic variation of hypoxia inducible factor-1 A (HIF1A) gene might contribute to the development of knee osteoarthritis: a pilot study. BMC musculoskeletal disorders. vol 16. 2016-05-26. PMID:26293784. |
hif-1 alpha regulates oxygen homeostasis in hypoxic tissues such as joint cartilage; efficiency of transcriptional activity of the hif1a gene is strongly influenced by the presence of polymorphic variants. |
2016-05-26 |
2023-08-13 |
Not clear |
| Hun-Way Hwang, Laura L Baxter, Stacie K Loftus, Julia C Cronin, Niraj S Trivedi, Bhavesh Borate, William J Pava. Distinct microRNA expression signatures are associated with melanoma subtypes and are regulated by HIF1A. Pigment cell & melanoma research. vol 27. issue 5. 2016-05-16. PMID:24767210. |
we also demonstrated that hypoxia-inducible factor 1 alpha (hif1a) is increased in tgfβ1 pathway-expressing melanoma cells and that hif1a upregulates mir-210, mir-218, mir-224, and mir-452. |
2016-05-16 |
2023-08-13 |
mouse |
| Hiroshi Kameyama, Orie Udagawa, Tomoaki Hoshi, Yoko Toukairin, Tomomi Arai, Makoto Nogam. The mRNA expressions and immunohistochemistry of factors involved in angiogenesis and lymphangiogenesis in the early stage of rat skin incision wounds. Legal medicine (Tokyo, Japan). vol 17. issue 4. 2016-03-21. PMID:25794881. |
in this study, we assessed the changes in the mrna expressions of various factors possibly involved in angiogenesis including angiopoietin (angpt) 1 and 2, cadherin 5 (cdh5), granulocyte-macrophage colony stimulating factor (csf2/gm-csf), granulocyte colony stimulating factor (csf3/g-csf), chemokine (c-x-c motif) ligand 2 (cxcl2), chemokine (c-x-c motif) ligand12 (cxcl12/sdf1), endothelin 1 (et1), fibroblast growth factor 1 (fgf 1), hepatocyte growth factor (hgf), hypoxia inducible factor 1 alpha (hif1a), leptin, matrix metallopepitidase 9 (mmp9), serpine/plasminogen activator inhibitor1 (pai1), platelet-derived growth factor-a (pdgf-a), transforming growth factor alpha and beta 1 (tgfa and b1), tenomodulin (tnmd), and troponin i type 2 (tnni2) in the early stage of the rat skin incision wounds by real time rt-pcr. |
2016-03-21 |
2023-08-13 |
rat |
| Yipeng Ding, Danlei Yang, Xiaojie Xun, Zhifeng Wang, Pei Sun, Dongchuan Xu, Ping He, Huan Niu, Tianbo Ji. Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Hainan population: a case-control study. International journal of chronic obstructive pulmonary disease. vol 10. 2015-09-15. PMID:25565795. |
recently, variants in the hypoxia-inducible factor 1α (hif1a), cholinergic receptor, neuronal nicotinic, alpha polypeptide-5, and iron-responsive element-binding protein 2 gene (ireb2) genes were found to be associated with copd. |
2015-09-15 |
2023-08-13 |
Not clear |
| Almudena Zapatero, Manuel Morente, Carmen Martín de Vidales, Magdalena Adrados, Consuelo Lopez, Santiago Nieto, María Jesús Artiga González, Ramón Arellano, Alfonso Cruz Conde, Feliciano Garcia Vicent. HIF1A expression in localized prostate cancer treated with dose escalation radiation therapy. Cancer biomarkers : section A of Disease markers. vol 15. issue 1. 2015-08-26. PMID:25524941. |
to analyze the expression of hypoxia inducible factor 1 alpha (hif1a) and its correlation with clinical outcome in men with localized prostate cancer (pc) treated with dose escalation radiotherapy (rt) and androgen deprivation (ad). |
2015-08-26 |
2023-08-13 |
Not clear |
| Ronit Yalu, Adepeju Esther Oyesiji, Iris Eisenberg, Tal Imbar, Rina Meida. HIF1A-dependent increase in endothelin 2 levels in granulosa cells: role of hypoxia, LH/cAMP, and reactive oxygen species. Reproduction (Cambridge, England). vol 149. issue 1. 2015-08-04. PMID:25433027. |
hypoxia-inducible factor 1 alpha (hif1a) and endothelin 2 (edn2) are transiently expressed during the same time window in the developing corpus luteum (cl). |
2015-08-04 |
2023-08-13 |
human |
| David A Rowbotham, Katey S S Enfield, Victor D Martinez, Kelsie L Thu, Emily A Vucic, Greg L Stewart, Kevin L Bennewith, Wan L La. Multiple Components of the VHL Tumor Suppressor Complex Are Frequently Affected by DNA Copy Number Loss in Pheochromocytoma. International journal of endocrinology. vol 2014. 2014-10-09. PMID:25298778. |
vhl is part of the vhl elongin bc protein complex that also includes cul2/5, tceb1, tceb2, and rbx1; in normoxic conditions this complex targets hypoxia-inducible factor 1 alpha (hif1a) for degradation, thus preventing a hypoxic response. |
2014-10-09 |
2023-08-13 |
Not clear |
| Alejandro Cuevas, Nicolás Saavedra, Marcela F Cavalcante, Luis A Salazar, Dulcineia S P Abdall. Identification of microRNAs involved in the modulation of pro-angiogenic factors in atherosclerosis by a polyphenol-rich extract from propolis. Archives of biochemistry and biophysics. vol 557. 2014-09-15. PMID:24792245. |
among them, three mirnas (mir-181a, mir-106a and mir-20b) were over-expressed and inversely related to the expression of vegfa (vascular endothelial growth factor a) and hif1a (hypoxia inducible factor 1 alpha). |
2014-09-15 |
2023-08-13 |
mouse |
| Motoaki Yasuda, Tomoyuki Hatanaka, Hiroki Shirato, Takeshi Nishiok. Cell type-specific reciprocal regulation of HIF1A gene expression is dependent on 5'- and 3'-UTRs. Biochemical and biophysical research communications. vol 447. issue 4. 2014-08-13. PMID:24769203. |
in the present study, we demonstrated the reciprocal regulation of hypoxia-inducible factor 1 alpha (hif1a) gene expression via untranslated region-(utr) dependent mechanisms. |
2014-08-13 |
2023-08-13 |
Not clear |
| Avelino Fraga, Ricardo Ribeiro, Paulo Príncipe, Carlos Lobato, Francisco Pina, Joaquina Maurício, Cátia Monteiro, Hugo Sousa, F Calais da Silva, Carlos Lopes, Rui Medeiro. The HIF1A functional genetic polymorphism at locus +1772 associates with progression to metastatic prostate cancer and refractoriness to hormonal castration. European journal of cancer (Oxford, England : 1990). vol 50. issue 2. 2014-03-03. PMID:24090974. |
the hypoxia inducible factor 1 alpha (hif1a) is a key regulator of tumour cell response to hypoxia, orchestrating mechanisms known to be involved in cancer aggressiveness and metastatic behaviour. |
2014-03-03 |
2023-08-12 |
human |
| Dawei Li, Jikai Liu, Wenhua Zhang, Juchao Ren, Lei Yan, Hainan Liu, Zhonghua X. Association between HIF1A P582S and A588T polymorphisms and the risk of urinary cancers: a meta-analysis. PloS one. vol 8. issue 5. 2014-02-18. PMID:23723982. |
the hypoxia-inducible factor-1 alpha (hif1a) plays a vital role in cancer initiation and progression. |
2014-02-18 |
2023-08-12 |
Not clear |
| Thomas Spanberger, Anna S Berghoff, Carina Dinhof, Aysegül Ilhan-Mutlu, Manuel Magerle, Markus Hutterer, Josef Pichler, Adelheid Wöhrer, Monika Hackl, Georg Widhalm, Johannes A Hainfellner, Karin Dieckmann, Christine Marosi, Peter Birner, Daniela Prayer, Matthias Preusse. Extent of peritumoral brain edema correlates with prognosis, tumoral growth pattern, HIF1a expression and angiogenic activity in patients with single brain metastases. Clinical & experimental metastasis. vol 30. issue 4. 2013-06-11. PMID:23076770. |
we recorded clinical parameters and immunohistochemically assessed the ki67 index, the microvascularization patterns and the expression of hypoxia-induced factor 1 alpha (hif1a) in the bm tissue specimens retrieved at neurosurgery. |
2013-06-11 |
2023-08-12 |
Not clear |
| Raghavendra B Nayak, Ambika Lakshmappa, Nanasaheb M Patil, Sameeran S Chate, Lohit Somasheka. Rubinstein-taybi syndrome with psychosis. Indian journal of psychological medicine. vol 34. issue 2. 2012-11-20. PMID:23162199. |
factors such as regulators of rna polymerase ii and hypoxia-inducible factor 1 alpha (hif1a) may be some common etiological factors for the association of schizophrenia or non-affective psychosis and rts. |
2012-11-20 |
2023-08-12 |
Not clear |
| Yi-Fan Jiang, Kuan-Hao Tsui, Peng-Hui Wang, Cheng-Wei Lin, Jyun-Yuan Wang, Meng-Chieh Hsu, Yi-Chen Chen, Chih-Hsien Chi. Hypoxia regulates cell proliferation and steroidogenesis through protein kinase A signaling in bovine corpus luteum. Animal reproduction science. vol 129. issue 3-4. 2012-05-25. PMID:22226573. |
recent studies have shown that cl develops in an analogous to tumorigenesis by accumulation of hypoxia-inducible factor-1 alpha subunit (hif1a) in response to hypoxia. |
2012-05-25 |
2023-08-12 |
cattle |
| Gudrun Knechtel, Joanna Szkandera, Michael Stotz, Günter Hofmann, Uwe Langsenlehner, Peter Krippl, Hellmut Samonigg, Wilfried Renner, Cord Langner, Dadbeh Dehchamani, Armin Gerge. Single nucleotide polymorphisms in the hypoxia-inducible factor-1 gene and colorectal cancer risk. Molecular carcinogenesis. vol 49. issue 9. 2010-09-03. PMID:20572162. |
the gene for the hif-1 alpha subunit (hif1a) carries two common missense mutations-p582s (rs11549465) and a588t (rs11549467)-which both have been related to increased trans-activation capacity of hif1a. |
2010-09-03 |
2023-08-12 |
mouse |
| Birgit Mazurek, Heidemarie Haupt, Ricarda Joachim, Burghard F Klapp, Timo Stöver, Agnieszka J Szczepe. Stress induces transient auditory hypersensitivity in rats. Hearing research. vol 259. issue 1-2. 2010-04-16. PMID:19840840. |
in addition, expression of the hpa-axis-associated genes: glucocorticoid receptor (gr) and hypoxia-inducible factor 1 alpha (hif1a) was modulated in the auditory tissues. |
2010-04-16 |
2023-08-12 |
rat |
| Ryo Nishimura, Kiyoshi Okud. Hypoxia is important for establishing vascularization during corpus luteum formation in cattle. The Journal of reproduction and development. vol 56. issue 1. 2010-04-15. PMID:19881217. |
to determine whether hif1 participates in angiogenesis in bovine cl, the present study investigated the mrna and protein expressions of the hif1 alpha subunit (hif1a) and vegf in bovine cl during the estrous cycle. |
2010-04-15 |
2023-08-12 |
cattle |
| K M Anderson, J Jajeh, P Guinan, M Rubenstei. In vitro effects of dichloroacetate and CO2 on hypoxic HeLa cells. Anticancer research. vol 29. issue 11. 2010-01-26. PMID:20032407. |
increased hypoxia-inducible factor 1, alpha subunit (hif1a) mrna expression in hypoxic hela cells and their greater reliance on d-glucose for metabolic energy confirmed the reliability of the incubation conditions. |
2010-01-26 |
2023-08-12 |
Not clear |
| Guilan Jin, Hiromichi Matsushita, Satomi Asai, Hideo Tsukamoto, Ryoichi Ono, Tetsuya Nosaka, Takashi Yahata, Shinichiro Takahashi, Hayato Miyach. FLT3-ITD induces ara-C resistance in myeloid leukemic cells through the repression of the ENT1 expression. Biochemical and biophysical research communications. vol 390. issue 3. 2009-12-29. PMID:19853583. |
in addition, the expression of hypoxia inducible factor 1 alpha subunit (hif1a) transcripts was upregulated in k562/flt3-itd cells, and the induction of hif-1alpha reduced the promoter activity of ent1 gene in k562 cells. |
2009-12-29 |
2023-08-12 |
human |