| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anastasiia Vasetska, Eva-Maria Packeiser, Hanna Körber, Selim Aslan, Serhan Ay, Murat Findik, Firdevs Binli, Murat Selçuk, Christelle Speiser-Fontaine, Sandra Goericke-Pesc. Molecular response of canine testis to GnRH agonist: Insights into AR, HIF-1α, and HSPs expression during arrest and recovery of spermatogenesis. Cell stress & chaperones. vol 30. issue 1. 2024-12-17. PMID:39631561. |
ar, hypoxia-inducible factor 1 (hif1a), heat shock proteins heat shock protein 72 (hsp72), heat shock protein 73 (heat shock cognate, hspa8) (hsp73), heat shock protein a2 (hspa2), heat shock protein 90 alpha (inducible isoform) (hsp90aa1), and heat shock protein 90 beta (constitutive isoform) (hsp90ab1) were investigated by quantitative real-time polymerase chain reaction and ar, hsp72, hsp73, and hsp90 immunohistochemically. |
2024-12-17 |
2024-12-21 |
Not clear |
| Jiajia Lu, Xiaojian Shi, Zhibin Zhou, Nan Lu, Guangxin Chu, Hai Jin, Lei Zhu, Aimin Che. Enhancing Fracture Healing with 3D Bioprinted Hif1a-Overexpressing BMSCs Hydrogel: A Novel Approach to Accelerated Bone Repair. Advanced healthcare materials. 2024-11-24. PMID:39580668. |
addressing the urgent need for effective fracture treatments, this study investigates the efficacy of a 3d bioprinted biomimetic hydrogel, enriched with bone marrow mesenchymal stem cells (bmscs) and targeted hypoxia-inducible factor 1 alpha (hif1a) gene activation, in enhancing fracture healing. |
2024-11-24 |
2024-11-27 |
rat |
| Xu Yang, Xian Xue, Yinglong He, Peng Song, Lili Guo, Xiaogai Ho. Exploring the Effect of Active Components in Oil Tree Peony Seed Meal on Swine Disease Resistance and its Potential Mechanisms Based on Network Pharmacology and Molecular Docking. Chemistry & biodiversity. 2024-10-22. PMID:39172434. |
a total of 8 core targets were obtained through protein-protein interaction networks analysis, including protein kinase camp-activated catalytic subunit alpha (prkaca), non-receptor tyrosine kinase (src), mitogen-activated protein kinase 1 (mapk1), e1a binding protein p300 (ep300), hypoxia inducible factor 1 subunit alpha (hif1a), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta (pik3cb), c-x-c chemokine receptor type 4 (cxcr4) and estrogen receptor 2 (esr2). |
2024-10-22 |
2024-10-24 |
Not clear |
| Jing Xie, Jun Jiang, Xiuxian Wang, Xiangrong Zuo, Yuhong Ji. RNA binding protein ELAVL1-mediated USP33 stabilizes HIF1A to promote pathological proliferation, migration and angiogenesis of RECs. International ophthalmology. vol 44. issue 1. 2024-09-25. PMID:39320536. |
hypoxia-inducible factor 1 alpha (hif1a) is activated by hypoxia and contributes to rop progression. |
2024-09-25 |
2024-09-27 |
human |
| Akihiro Nakamura, Sungsin Jo, Sayaka Nakamura, Mansi K Aparnathi, Shaghayegh Foroozan Boroojeni, Mariia Korshko, Ye-Soo Park, Himanshi Gupta, Sandra Vijayan, Jason S Rockel, Mohit Kapoor, Igor Jurisica, Tae-Hwan Kim, Nigil Haroo. HIF-1α and MIF enhance neutrophil-driven type 3 immunity and chondrogenesis in a murine spondyloarthritis model. Cellular & molecular immunology. 2024-06-05. PMID:38839914. |
herein, we identified hypoxia-inducible factor-1 alpha (hif1a) as an interacting partner molecule of mif that drives spa pathologies, including inflammation and nbf. |
2024-06-05 |
2024-06-08 |
mouse |
| Dandan Feng, Jie Gao, Ruiqiong Liu, Wei Liu, Tianyang Gao, Yunkai Yang, Die Zhang, Tianshu Yang, Xin Yin, Hefen Yu, Wei Huang, Yan Wan. CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A. Protein & cell. 2024-03-13. PMID:38476024. |
genome-wide analysis of carm1 showed that carm1 is recruited by hypoxia-inducible factor 1 subunit alpha (hif1a) and occupy the promoters of cdk4, cyclin d1, β-catenin, hif1a, malat1, and six1 critically involved in cell cycle, hif-1 signaling pathway, wnt signaling pathway, vegf signaling pathway, thereby modulating the proliferation and invasion of tnbc cells. |
2024-03-13 |
2024-03-15 |
Not clear |
| José M Delgado, Christopher J Shoemake. An unexpected journey for BNIP3. Autophagy. 2024-03-07. PMID:38449384. |
historically, bnip3 regulation was thought to be primarily transcriptional through hif1a (hypoxia inducible factor 1 subunit alpha). |
2024-03-07 |
2024-03-09 |
Not clear |
| Taylor E Murphy, Jasmine C Harris, Bernard B Ree. Hypoxia-inducible factor 1 alpha protein increases without changes in mRNA during acute hypoxic exposure of the Gulf killifish, Fundulus grandis. Biology open. 2023-12-20. PMID:38116983. |
while the hypoxia-responsiveness of hif1 is generally attributed to the stabilization of the alpha protein subunit (hif1α) at low oxygen, several studies on fish report increased tissue levels of hif1a mrna during hypoxia, suggesting transcriptional regulation. |
2023-12-20 |
2023-12-23 |
Not clear |
| Ying Wang, Xueying Chen, Yan Wang, Hong Zhong, Liqin Liu, Yang Y. Network pharmacology integrated with molecular docking technology to reveal the potential mechanism of Shuganfang against drug-induced liver injury. Medicine. vol 102. issue 48. 2023-12-05. PMID:38050247. |
the core targets implicated in the study were il6, estrogen receptor 1 (esr1), hypoxia-inducible factor alpha subunit 1 (hif1a), myc and vascular endothelial growth factor a (vegfa). |
2023-12-05 |
2023-12-10 |
Not clear |
| Nicholas Downes, Henri Niskanen, Vanesa Tomas Bosch, Mari Taipale, Mehvash Godiwala, Mari-Anna Väänänen, Tiia A Turunen, Einari Aavik, Nihay Laham-Karam, Seppo Ylä-Herttuala, Minna U Kaikkone. Hypoxic regulation of hypoxia inducible factor 1 alpha via antisense transcription. The Journal of biological chemistry. vol 299. issue 11. 2023-10-28. PMID:37748649. |
notably, we identify a novel antisense long noncoding rna that convergently overlaps the majority of the hypoxia inducible factor 1 alpha (hif1a) locus, which is expressed across several cell types and elevated in atherosclerotic lesions. |
2023-10-28 |
2023-11-08 |
Not clear |
| Xi-Ying Tan, Jing Tao, Yu Zhang, Ru-Xin G. [Mechanism of Astragali Radix-Curcumae Rhizoma in treating gastric cancer based on network pharmacology and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 18. 2023-10-06. PMID:37802848. |
the cell experiments demonstrated that hqez significantly downregulated the expression of atp-binding cassette subfamily b member 1(abcb1), epidermal growth factor receptor(egfr), phosphorylated serine/threonine kinase(p-akt), hypoxia inducible factor 1 subunit alpha(hif1a), b-cell lymphoma 2(bcl2), breast cancer susceptibility protein 1(brca1), dna polymerase theta(polh), ribonucleotide reductase m1(rrm1), and excision repair cross-complementation group 1(ercc1), and upregulated the expression of tumor protein p53(tp53) and cysteinyl aspartate-specific proteinase(caps3). |
2023-10-06 |
2023-10-15 |
Not clear |
| Yan Meng, Kai-Wen Kong, Yong-Qing Chang, Xiao-Ming Deng, Tao Yan. Histone methyltransferase SETD2 inhibits M1 macrophage polarization and glycolysis by suppressing HIF-1α in sepsis-induced acute lung injury. Medical microbiology and immunology. 2023-09-01. PMID:37658121. |
luciferase reporter assay and chromatin immunoprecipitation assay were conducted to detect the binding of setd2 or h3k36me3 with the hypoxia-inducible factor 1, alpha subunit (hif1a) gene. |
2023-09-01 |
2023-09-07 |
mouse |
| Shufang Wang, Xihua Chen, Shige Guo, Fang Zhou, Xin Zhang, Cong Lu, Xuqing Yang, Qianxing Wang, Bin He, Jiedong Wang, Hanbi Wang, Xiangbo X. CXCR4, regulated by HIF1A, promotes endometrial breakdown via CD45 Reproductive biology. vol 23. issue 3. 2023-07-01. PMID:37392490. |
this study aimed to clarify the role of cxcr4 in endometrial breakdown and its regulation by hypoxia-inducible factor-1 alpha (hif1a). |
2023-07-01 |
2023-08-14 |
mouse |
| Chengyi Dai, Yuhang Li. Comprehensive analysis of the diagnostic and therapeutic value of the hypoxia-related gene PLAUR in the progression of atherosclerosis. Scientific reports. vol 13. issue 1. 2023-05-26. PMID:37237021. |
we combined cross-validation results from multiple databases to predict that hcg17-hsa-mir-424-5p-hif1a, a competitive endogenous rna (cerna) network, may regulate hypoxia inducible factor 1 subunit alpha (hif1a) expression. |
2023-05-26 |
2023-08-14 |
mouse |
| Bingtan Kong, Jie Zhou, Hao Wang, Yinan Li, Yuancan Pan, Hui Zhu, Qing Zhang, Qingsheng Fan, Xiaomin Wang, Ganlin Zhan. Histopathological growth pattern evolution of tumor in VX2 liver cancer model. Pathology, research and practice. vol 244. 2023-03-11. PMID:36905696. |
additionally, fibrin deposition and neovascularization were evaluated by masson staining and immunohistochemical analysis of cd31, hypoxia-inducible factor-1 alpha (hif1a) and vascular endothelial growth factor (vegf). |
2023-03-11 |
2023-08-14 |
Not clear |
| Ning Zhang, Da Huang, Xiaohao Ruan, Ada Tsui-Lin Ng, James Hok-Leung Tsu, Guangliang Jiang, Jingyi Huang, Yongle Zhan, Rong N. CRISPR screening reveals gleason score and castration resistance related oncodriver ring finger protein 19 A (RNF19A) in prostate cancer. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. vol 67. 2023-01-09. PMID:36623445. |
mechanistically, transcriptomics, quantitative and ubiquitination proteomic analysis showed that rnf19a ubiquitylated thyroid hormone receptor interactor 13 (trip13) and was transcriptionally activated by androgen receptor (ar) and hypoxia inducible factor 1 subunit alpha (hif1a). |
2023-01-09 |
2023-08-14 |
Not clear |
| Ruipeng Wang, Xiaoye Qiao, Xiaobin Wan. Exploring the mechanisms of Gui Zhi Fu Ling Wan on varicocele via network pharmacology and molecular docking. Andrologia. 2022-11-13. PMID:36372090. |
the main targets of the active components on vc were tumour protein p53 (tp53), tumour necrosis factor (tnf), hypoxia inducible factor 1 subunit alpha (hif1a), interleukin-6 (il-6), caspase 3 (casp3), catalase (cat), prostaglandin-endoperoxide synthase 2 (ptgs2), vascular endothelial growth factor a (vegfa). |
2022-11-13 |
2023-08-14 |
cat |
| Yuxiang Zhang, Saidi Wang, Haiyan Hu, Xiaoman L. A systematic study of HIF1A cofactors in hypoxic cancer cells. Scientific reports. vol 12. issue 1. 2022-11-08. PMID:36347941. |
hypoxia inducible factor 1 alpha (hif1a) is a transcription factor (tf) that forms highly structural and functional protein-protein interactions with other tfs to promote gene expression in hypoxic cancer cells. |
2022-11-08 |
2023-08-14 |
Not clear |
| Ujjaldeep Jaggi, Harry H Matundan, Dhong Hyun Lee, Homayon Ghias. Blocking Autophagy in M1 Macrophages Enhances Virus Replication and Eye Disease in Ocularly Infected Transgenic Mice. Journal of virology. 2022-10-26. PMID:36286481. |
analysis of 62 autophagy genes and 32 cytokines/chemokines from infected bone marrow-derived macrophages from m1-γ34.5, m2-γ34.5, and wt mice suggested that upregulation of autophagy-blocking genes (i.e., hif1a, mtmr14, mtor, mtmr3, stk11, and ulk2) and the inflammatory tumor necrosis factor alpha (tnf-α) gene in m1-γ34.5 transgenic mice correlated with increased pathogenicity, while upregulation of proautophagy genes (nrbf2 and rb1cc1) in m2-γ34.5 macrophages correlated with reduced pathogenicity. |
2022-10-26 |
2023-08-14 |
mouse |
| Nattawan Suwannakul, Napat Armartmuntree, Raynoo Thanan, Kaoru Midorikawa, Tetsuo Kon, Shinji Oikawa, Hatasu Kobayashi, Ning Ma, Shosuke Kawanishi, Mariko Murat. Targeting fructose metabolism by glucose transporter 5 regulation in human cholangiocarcinoma. Genes & diseases. vol 9. issue 6. 2022-09-26. PMID:36157482. |
furthermore, in the metabolic pathways of fructolysis-warburg effect, the expression levels of relative downstream genes, including ketohexokinase (khk), aldolase b (aldob), lactate dehydrogenase a (ldha), and monocarboxylate transporter 4 (mct4), as well as hypoxia-inducible factor 1 alpha (hif1a), were altered in a glut5 expression-dependent manner. |
2022-09-26 |
2023-08-14 |
mouse |