| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shohei Yoshimoto, Fumie Tanaka, Hiromitsu Morita, Akimitsu Hiraki, Shuichi Hashimot. Hypoxia-induced HIF-1α and ZEB1 are critical for the malignant transformation of ameloblastoma via TGF-β-dependent EMT. Cancer medicine. vol 8. issue 18. 2020-09-16. PMID:31674718. |
two genes of hypoxia-inducible factor 1 alpha subunit (hif1a) and zinc finger e-box-binding homeobox 1 (zeb1) were significantly and relatively upregulated in ac than in ab. |
2020-09-16 |
2023-08-13 |
Not clear |
| Yufei Wang, Guochao Zhang, Jie Ha. HIF1A-AS2 predicts poor prognosis and regulates cell migration and invasion in triple-negative breast cancer. Journal of cellular biochemistry. vol 120. issue 6. 2020-08-05. PMID:30635931. |
the aberrant expression of hypoxia-inducible factor 1 alpha (hif1a)-antisense rna 2 (hif1a-as2) was found in various human cancers including breast cancer. |
2020-08-05 |
2023-08-13 |
human |
| Jiang Shi, Huan Wang, Wanlu Feng, Siyuan Huang, Jinlu An, Yajuan Qiu, Kai W. MicroRNA-130a targeting hypoxia-inducible factor 1 alpha suppresses cell metastasis and Warburg effect of NSCLC cells under hypoxia. Life sciences. vol 255. 2020-06-25. PMID:32450163. |
we used real-time quantitative polymerase chain reaction method to measure mir-130a expression, and found that mir-130a was downregulated in human nsclc tumors and cell lines (a549 and h1299), accompanied with upregulation of hypoxia-inducible factor 1 alpha (hif1a), a marker of hypoxia. |
2020-06-25 |
2023-08-13 |
mouse |
| Deniz Gulfem Ozturk, Muhammed Kocak, Arzu Akcay, Kubilay Kinoglu, Erdogan Kara, Yalcin Buyuk, Hilal Kazan, Devrim Gozuaci. MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress. Autophagy. vol 15. issue 3. 2020-05-13. PMID:30290719. |
abbreviations: actb: actin beta; akt: akt serine/threonine kinase; akt1s1/pras40: akt1 substrate 1; ampk: amp-activated protein kinase; atg: autophagy-related; becn1: beclin 1; deptor: dep domain containing mtor interacting protein; gabarap: gaba type a receptor-associated protein; hif1a: hypoxia inducible factor 1 subunit alpha; lamp1: lysosomal associated membrane protein 1; map1lc3b/lc3b: microtubule associated protein 1 light chain 3 beta; mapkap1/sin1: mitogen-activated protein kinase associated protein 1; mitf: melanogenesis associated transcription factor; mlst8: mtor associated protein, lst8 homolog; mre: mirna response element; mtor: mechanistic target of rapamycin kinase; mtorc1: mtor complex 1; mtorc2: mtor complex 2; prr5/protor 1: proline rich 5; prr5l/protor 2: proline rich 5 like; rack1: receptor for activated c kinase 1; rptor: regulatory associated protein of mtor complex 1; rictor: rptor independent companion of mtor complex 2; rps6kb/p70s6k: ribosomal protein s6 kinase; rt-qpcr: quantitative reverse transcription-polymerase chain reaction; sqstm1: sequestosome 1; stk11/lkb1: serine/threonine kinase 11; tfe3: transcription factor binding to ighm enhancer 3; tfeb: transcription factor eb; tsc1/2: tsc complex subunit 1/2; ulk1: unc-51 like autophagy activating kinase 1; uvrag: uv radiation resistance associated; vim: vimentin; vps11: vps11, corvet/hops core subunit; vps18: vps18, corvet/hops core subunit; wipi1: wd repeat domain, phosphoinositide interacting 1. |
2020-05-13 |
2023-08-13 |
human |
| Li-Fang Wu, Gui-Ping Xu, Qing Zhao, Li-Jing Zhou, Ding Wang, Wei-Xian Che. The association between hypoxia inducible factor 1 subunit alpha gene rs2057482 polymorphism and cancer risk: a meta-analysis. BMC cancer. vol 19. issue 1. 2020-04-06. PMID:31744467. |
the rs2057482 polymorphism in the hypoxia inducible factor 1 subunit alpha (hif1a) gene has been reported to be associated with a risk of several types of cancer, but this association has not yet been definitively confirmed. |
2020-04-06 |
2023-08-13 |
Not clear |
| Irwan Gunawan, Mochammad Hatta, Andi Fachruddin Benyamin, Andi Asadul Isla. The Hypoxic Response Expression as a Survival Biomarkers in Treatment-Naive Advanced Breast Cancer. Asian Pacific journal of cancer prevention : APJCP. vol 21. issue 3. 2020-04-02. PMID:32212787. |
we aim to evaluate whether the quantitative gene and protein expression of hypoxic response tumor markers - carbonic anhydrase ix (caix) and hypoxia- inducible factor 1 alpha (hif1a) - may have a role in predicting survival in advanced breast cancer of indonesian population. |
2020-04-02 |
2023-08-13 |
Not clear |
| Yuwares Malila, Krittaporn Thanatsang, Sopacha Arayamethakorn, Tanaporn Uengwetwanit, Yanee Srimarut, Massimiliano Petracci, Gale M Strasburg, Wanilada Rungrassamee, Wonnop Visessangua. Absolute expressions of hypoxia-inducible factor-1 alpha (HIF1A) transcript and the associated genes in chicken skeletal muscle with white striping and wooden breast myopathies. PloS one. vol 14. issue 8. 2020-03-17. PMID:31393948. |
absolute expressions of hypoxia-inducible factor-1 alpha (hif1a) transcript and the associated genes in chicken skeletal muscle with white striping and wooden breast myopathies. |
2020-03-17 |
2023-08-13 |
chicken |
| Yuwares Malila, Krittaporn Thanatsang, Sopacha Arayamethakorn, Tanaporn Uengwetwanit, Yanee Srimarut, Massimiliano Petracci, Gale M Strasburg, Wanilada Rungrassamee, Wonnop Visessangua. Absolute expressions of hypoxia-inducible factor-1 alpha (HIF1A) transcript and the associated genes in chicken skeletal muscle with white striping and wooden breast myopathies. PloS one. vol 14. issue 8. 2020-03-17. PMID:31393948. |
this study aimed at investigating absolute expression of hypoxia-inducible factor-1 alpha subunit (hif1a) and genes involved in stress responses and muscle repair using a droplet digital polymerase chain reaction. |
2020-03-17 |
2023-08-13 |
chicken |
| Lixia Qin, Li Shu, Junfei Zhong, Hongxu Pan, Jifeng Guo, Qiying Sun, Xinxiang Yan, Beisha Tang, Qian X. Association of HIF1A and Parkinson's disease in a Han Chinese population demonstrated by molecular inversion probe analysis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 40. issue 9. 2020-02-12. PMID:31025220. |
previous studies implicated the involvement of the transcription factor hypoxia inducible factor 1 alpha (hif1a) in pd through its transcriptional regulation of pd-associated genes. |
2020-02-12 |
2023-08-13 |
human |
| Aleša Kristan, Nataša Debeljak, Tanja Kune. Genetic variability of hypoxia-inducible factor alpha (HIFA) genes in familial erythrocytosis: Analysis of the literature and genome databases. European journal of haematology. vol 103. issue 4. 2020-02-11. PMID:31376207. |
two other hypoxia-inducible factor alpha (hifa) subunits, hif1a and hif3a, have not yet been associated with medical history of fe, but have potential role in the development of erythrocytosis. |
2020-02-11 |
2023-08-13 |
Not clear |
| Robert L Elliott, Xian-Peng Jian. The adverse effect of gentamicin on cell metabolism in three cultured mammary cell lines: "Are cell culture data skewed?" PloS one. vol 14. issue 4. 2019-12-23. PMID:30934018. |
we found that the addition of gentamicin in media upregulated the gene expression of hypoxia inducer factor 1 alpha (hif1a), glycolytic enzymes and glucose transporters, compared to the cells cultured in gentamicin free media. |
2019-12-23 |
2023-08-13 |
human |
| Nicola Silvestris, Katia Danza, Vito Longo, Oronzo Brunetti, Livia Fucci, Antonella Argentiero, Angela Calabrese, Ivana Cataldo, Roberto Tamma, Domenico Ribatti, Stefania Tommas. Angiogenesis in adenosquamous cancer of pancreas. Oncotarget. vol 8. issue 56. 2019-11-20. PMID:29221165. |
moreover, the levels of angiopoietin-1 and -2 (ang-1, ang-2), receptor tyrosine kinase with immunoglobulin and epidermal growth factor homology domain-2 (tie-2), vascular endothelial growth factor a (vegfa), hypoxia-inducible factor 1 alpha (hif1a), mir-21-5p, mir-181a-5p, mir-122-5p, and mir-27a-3p were evaluated by real-time pcr. |
2019-11-20 |
2023-08-13 |
Not clear |
| Paola Maroni, Paola Bendinelli, Emanuela Matteucci, Maria Alfonsina Desideri. The therapeutic effect of miR-125b is enhanced by the prostaglandin endoperoxide synthase 2/cyclooxygenase 2 blockade and hampers ETS1 in the context of the microenvironment of bone metastasis. Cell death & disease. vol 9. issue 5. 2019-11-07. PMID:29700305. |
the effect of hypoxia inducible factor 1 alpha subunit (hif1a), known to promote metastatic spread by upregulating prostaglandin endoperoxide synthase 2 (ptgs2), may be dampened by mir-125b targeting ptgs2. |
2019-11-07 |
2023-08-13 |
Not clear |
| Yilan Li, Shipeng Wang, Dandan Zhang, Xueming Xu, Bo Yu, Yao Zhan. The association of functional polymorphisms in genes expressed in endothelial cells and smooth muscle cells with the myocardial infarction. Human genomics. vol 13. issue 1. 2019-07-30. PMID:30678728. |
the association of platelet endothelial cell adhesion molecule 1 (pecam1), hypoxia-inducible factor 1 subunit alpha (hif1a), and kiaa1462 in myocardial infarction (mi) was investigated. |
2019-07-30 |
2023-08-13 |
Not clear |
| L A Fatima, R S Campello, R de Souza Santos, H S Freitas, A P Frank, U F Machado, D J Cleg. Estrogen receptor 1 (ESR1) regulates VEGFA in adipose tissue. Scientific reports. vol 7. issue 1. 2019-07-05. PMID:29196658. |
additionally, we found that e2 and ppt induced the binding of hypoxia inducible factor 1 alpha subunit (hif1a) in the vegfa gene promoter. |
2019-07-05 |
2023-08-13 |
mouse |
| Xianfei Zhou, Xingjun Guo, Meiyuan Chen, Chencheng Xie, Jianxin Jian. HIF-3α Promotes Metastatic Phenotypes in Pancreatic Cancer by Transcriptional Regulation of the RhoC-ROCK1 Signaling Pathway. Molecular cancer research : MCR. vol 16. issue 1. 2019-01-16. PMID:28928287. |
previous research principally focused on hypoxia-inducible factor-1 alpha (hif-1α) and hif-2α (hif1a and epas1) as the major hypoxia-associated transcription factors in pancreatic cancer. |
2019-01-16 |
2023-08-13 |
human |
| Mijeong Jeon, Yooseok Shin, Jaeeun Jung, Ui-Won Jung, Jae-Hoon Lee, Jae-Seung Moon, Ilkoo Kim, Jin-Su Shin, Sang-Kyou Lee, Je Seon Son. HIF1A overexpression using cell-penetrating DNA-binding protein induces angiogenesis in vitro and in vivo. Molecular and cellular biochemistry. vol 437. issue 1-2. 2018-07-09. PMID:28660411. |
hypoxia-inducible factor-1 alpha (hif1a) is an important transcription factor for angiogenesis. |
2018-07-09 |
2023-08-13 |
mouse |
| Lindsay Wilde, Megan Roche, Marina Domingo-Vidal, Katherina Tanson, Nancy Philp, Joseph Curry, Ubaldo Martinez-Outschoor. Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development. Seminars in oncology. vol 44. issue 3. 2017-12-26. PMID:29248131. |
mct4 is involved in the release of monocarboxylates from cells, is regulated by catabolic transcription factors such as hypoxia inducible factor 1 alpha (hif1a) and nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb), and is highly expressed in cancer-associated fibroblasts. |
2017-12-26 |
2023-08-13 |
human |
| C L Depoix, I de Selliers, C Hubinont, F Debiev. HIF1A and EPAS1 potentiate hypoxia-induced upregulation of inhibin alpha chain expression in human term cytotrophoblasts in vitro. Molecular human reproduction. vol 23. issue 3. 2017-12-22. PMID:28115494. |
hif1a and epas1 potentiate hypoxia-induced upregulation of inhibin alpha chain expression in human term cytotrophoblasts in vitro. |
2017-12-22 |
2023-08-13 |
human |
| Joan J Castellano, Alfons Navarro, Nuria Viñolas, Ramon M Marrades, Jorge Moises, Anna Cordeiro, Adela Saco, Carmen Muñoz, Dolors Fuster, Laureano Molins, Josep Ramirez, Mariano Monz. LincRNA-p21 Impacts Prognosis in Resected Non-Small Cell Lung Cancer Patients through Angiogenesis Regulation. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. vol 11. issue 12. 2017-11-13. PMID:27496652. |
long intergenic noncoding rna-p21 (lincrna-p21) is a long noncoding rna transcriptionally activated by tumor protein p53 (tp53) and hypoxia inducible factor 1 alpha subunit (hif1a). |
2017-11-13 |
2023-08-13 |
Not clear |