| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Manca, P Demuro, B Masal. Hb G-Philadelphia, or [alpha 68(E17)Asn----Lys], in north Sardinia: detection by isoelectric focusing and identification by HPLC of tryptic peptides. Clinica chimica acta; international journal of clinical chemistry. vol 177. issue 3. 1989-05-10. PMID:3233770. |
11,129 individuals of the northern area of the island of sardinia (7,717 newborns and 3,412 adults) were examined for the hb g-philadelphia variant [alpha 68(e17)asn----lys]. |
1989-05-10 |
2023-08-11 |
Not clear |
| F Iu Nasyrova, A M Mirakilova, I B Ryzhova, R B Sabzanova, S A Limborskai. [Heterogeneity of globin protein synthesis in bone marrow cells of patients with homozygous beta-thalassemia from Tadzhikistan]. Molekuliarnaia genetika, mikrobiologiia i virusologiia. issue 10. 1989-04-17. PMID:2976480. |
homozygous beta-thalassemic cases with low content of hb f in blood cells (5-10%), with substantial disbalance of alpha and beta-globin synthesis and marked production of gamma-globins in bone marrow cells and in blood reticulocytes are of special interest. |
1989-04-17 |
2023-08-11 |
Not clear |
| J M Gonzalez-Redondo, J C Diaz-Chico, J J Malcorra-Azpiazu, M I Balda-Aguirre, T H Huisma. Characterization of a newly discovered alpha-thalassaemia-1 in two Spanish patients with Hb H disease. British journal of haematology. vol 70. issue 4. 1989-03-21. PMID:3219296. |
a new deletion of more than 27 kb, removing the psi zeta 1, psi alpha 2, psi alpha 1, alpha 2, alpha 1 and theta 1 globin genes has been found in four members of a spanish family, including two patients with hb h disease. |
1989-03-21 |
2023-08-11 |
Not clear |
| J G Gilma. Expression of G gamma and A gamma globin genes in human adults. Hemoglobin. vol 12. issue 5-6. 1989-02-16. PMID:2463237. |
expression of the human fetal g gamma and a gamma globin genes declines shortly after birth, and adults generally have less than 1% fetal hemoglobin or hb f (alpha 2 gamma 2). |
1989-02-16 |
2023-08-11 |
human |
| Y T Zeng, S Z Huang, M J Che. The types and distribution of alpha-thalassemia-2 in China. Hemoglobin. vol 12. issue 5-6. 1989-02-16. PMID:3209388. |
the results showed that 76 cases (68.5%) were of the deletion type, eight cases (7.2%) had hb constant spring (hb cs), and 27 cases (24.3%) were of the nondeletion and hb cs types (alpha t). |
1989-02-16 |
2023-08-11 |
Not clear |
| Y T Zeng, S Z Huang, M J Che. The types and distribution of alpha-thalassemia-2 in China. Hemoglobin. vol 12. issue 5-6. 1989-02-16. PMID:3209388. |
we studied the nondeletional hb h type by dna gene mapping, digestion with msp i, and hybridization with a 32p-alpha probe for the presence of the hb quong sze [alpha 125(h8)leu----pro] mutation. |
1989-02-16 |
2023-08-11 |
Not clear |
| Y E Hsia, J Yuen, J A Hunt, P Rattamanasay, J Hall, N Takaesu, E A Titus, J Fujita, C A For. The different types of alpha-thalassemia: practical and genetic aspects. Hemoglobin. vol 12. issue 5-6. 1989-02-16. PMID:3209390. |
gene frequencies in the unselected lao subjects were approximately 0.2 for hb e, at least 0.1 for (-alpha), usually a rightward (alpha -3.7) type, 0.04 for (-), and 0.01 for a beta-thal. |
1989-02-16 |
2023-08-11 |
human |
| V V Chan, T K Chan, D Tod. Different forms of Hb H disease in the Chinese. Hemoglobin. vol 12. issue 5-6. 1989-02-16. PMID:3209392. |
of 33 alpha-thal-2 defects studied, 26 were the rightward deletion (alpha -3.7 kb, all type i defects) and seven the leftward deletion (alpha -4.2 kb); one of the latter was associated with hb q. |
1989-02-16 |
2023-08-11 |
Not clear |
| V V Chan, T K Chan, D Tod. Different forms of Hb H disease in the Chinese. Hemoglobin. vol 12. issue 5-6. 1989-02-16. PMID:3209392. |
one patient who inherited classical hb h disease and hb new york (ny) [alpha 113(g15)val----glu] had severe anemia, and required frequent blood transfusions due to the deleterious effect of an increased alpha-ny chain turnover. |
1989-02-16 |
2023-08-11 |
Not clear |
| A Horvath, A Butkus, R J MacIsaac, L Pontefract, E M Wintou. Effect of hormone-induced premature parturition on hemoglobin switching in sheep. Pediatric research. vol 24. issue 6. 1989-02-07. PMID:2462709. |
this study examines the effect of premature delivery on the switch from fetal (alpha 2 tau 2) to adult (alpha 2 beta 2) hb, in lambs in which premature parturition was induced by the intrafetal infusion of acth or corticotropin releasing hormone. |
1989-02-07 |
2023-08-11 |
Not clear |
| R Vestri, A Crema, A Testa, O Losti. Kinetics of the Hb A to Hb C switch and erythropoietin plasma levels in sheep. Animal genetics. vol 19. issue 3. 1989-02-02. PMID:3207219. |
the induction of hb a (alpha 2 beta a2) and hb c (alpha 2 beta c2) synthesis in three adult sheep has been sequentially analysed, in relation to the reduction of the haematocrit (ht) and to the changes of erythropoietin (epo) concentration in plasma. |
1989-02-02 |
2023-08-11 |
Not clear |
| M L North, M C Piffaut, I Duwig, A G Locoh-Donou, A M Locoh-Dono. Detection of haemoglobinopathies at birth in Togo. Nouvelle revue francaise d'hematologie. vol 30. issue 4. 1989-01-12. PMID:3194188. |
our work also confirmed the presence of alpha and beta + thalassaemias (acetyl hb f greater than hb a) in togo. |
1989-01-12 |
2023-08-11 |
Not clear |
| F Baklouti, V Baudin-Chich, J Kister, M Marden, G Teyssier, C Poyart, J Delaunay, H Wajcma. Increased oxygen affinity with normal heterotropic effects in hemoglobin Loire [alpha 88(F9)Ala----Ser]. European journal of biochemistry. vol 177. issue 2. 1989-01-03. PMID:3142772. |
the effects of bezafibrate, which binds specifically to the alpha chains, was similar to that observed in hb a. |
1989-01-03 |
2023-08-11 |
Not clear |
| F Baklouti, V Baudin-Chich, J Kister, M Marden, G Teyssier, C Poyart, J Delaunay, H Wajcma. Increased oxygen affinity with normal heterotropic effects in hemoglobin Loire [alpha 88(F9)Ala----Ser]. European journal of biochemistry. vol 177. issue 2. 1989-01-03. PMID:3142772. |
the functional properties of hb loire may be explained by a slight displacement of some key residues of the c-terminal region of the alpha chain destabilizing the t structure. |
1989-01-03 |
2023-08-11 |
Not clear |
| V B Jogessar, K Westermeyer, B B Webber, J B Wilson, H Hu, J M Gonzalez-Redondo, A Kutlar, T H Huisma. Hb natal or alpha 2(minus Tyr-Arg) beta 2: a high oxygen affinity alpha chain variant with a deleted carboxy-terminus resulting from a TAC----TAA (Tyr----terminating codon) mutation in codon alpha 140. Biochimica et biophysica acta. vol 951. issue 1. 1988-12-28. PMID:3191134. |
hb natal or alpha 2(minus tyr-arg) beta 2: a high oxygen affinity alpha chain variant with a deleted carboxy-terminus resulting from a tac----taa (tyr----terminating codon) mutation in codon alpha 140. |
1988-12-28 |
2023-08-11 |
Not clear |
| V B Jogessar, K Westermeyer, B B Webber, J B Wilson, H Hu, J M Gonzalez-Redondo, A Kutlar, T H Huisma. Hb natal or alpha 2(minus Tyr-Arg) beta 2: a high oxygen affinity alpha chain variant with a deleted carboxy-terminus resulting from a TAC----TAA (Tyr----terminating codon) mutation in codon alpha 140. Biochimica et biophysica acta. vol 951. issue 1. 1988-12-28. PMID:3191134. |
the discovery is reported of a fast-moving alpha chain variant (hb natal) which is characterized by a shortened alpha polypeptide chain because of the deletion of the tyr-arg carboxy-terminal residues. |
1988-12-28 |
2023-08-11 |
Not clear |
| V B Jogessar, K Westermeyer, B B Webber, J B Wilson, H Hu, J M Gonzalez-Redondo, A Kutlar, T H Huisma. Hb natal or alpha 2(minus Tyr-Arg) beta 2: a high oxygen affinity alpha chain variant with a deleted carboxy-terminus resulting from a TAC----TAA (Tyr----terminating codon) mutation in codon alpha 140. Biochimica et biophysica acta. vol 951. issue 1. 1988-12-28. PMID:3191134. |
hb natal or alpha 2 (minus tyr-arg) beta 2 has a high affinity for oxygen without a bohr effect and heme-heme interaction. |
1988-12-28 |
2023-08-11 |
Not clear |
| S L Thein, C Hesketh, R B Wallace, D J Weatheral. The molecular basis of thalassaemia major and thalassaemia intermedia in Asian Indians: application to prenatal diagnosis. British journal of haematology. vol 70. issue 2. 1988-12-23. PMID:2903765. |
comparison of the beta-globin gene cluster haplotypes, alpha globin genotypes and beta gene mutations of the thalassaemia major group with the thalassaemia intermedia group suggests that the co-inheritance of a high hb f determinant associated with the - + - + + 5' beta haplotype and the inheritance of a mild beta-thalassaemia mutation are the major ameliorating factors of disease severity in asian indians. |
1988-12-23 |
2023-08-11 |
Not clear |
| J M González Redondo, J M De Pablo. [Association of alpha thalassemia and Hb G Philadelphia in a Spanish family]. Sangre. vol 33. issue 3. 1988-11-22. PMID:3175819. |
[association of alpha thalassemia and hb g philadelphia in a spanish family]. |
1988-11-22 |
2023-08-11 |
Not clear |
| Y Arata, Y Seno, J Otsuk. A study on the quaternary structure change of hemoglobin in the ligation process. Biochimica et biophysica acta. vol 956. issue 3. 1988-11-16. PMID:3167072. |
when either alpha or beta subunit is substituted with the corresponding subunit in carbonmonoxy hb, serious steric hindrances are produced between alpha 1fg4(92)arg and beta 2c3(37)trp or between alpha 1c6(41)thr and beta 2fg4(97)his, all of which belong to the allosteric core affected directly by ligand binding. |
1988-11-16 |
2023-08-11 |
human |