| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K D Vandegriff, F Medina, M A Marini, R M Winslo. Equilibrium oxygen binding to human hemoglobin cross-linked between the alpha chains by bis(3,5-dibromosalicyl) fumarate. The Journal of biological chemistry. vol 264. issue 30. 1989-11-27. PMID:2808353. |
oxygen equilibrium curves of human hemoglobin ao (hbao) and human hemoglobin cross-linked between the alpha chains (alpha alpha hb) by bis(3,5-dibromosalicyl) fumarate were measured as a function of ph and chloride or organic phosphate concentration. |
1989-11-27 |
2023-08-11 |
human |
| K D Vandegriff, F Medina, M A Marini, R M Winslo. Equilibrium oxygen binding to human hemoglobin cross-linked between the alpha chains by bis(3,5-dibromosalicyl) fumarate. The Journal of biological chemistry. vol 264. issue 30. 1989-11-27. PMID:2808353. |
compared to hbao, the oxygen affinity of alpha alpha hb was lower, cooperativity was maintained, although slightly reduced, and all heterotropic effects were diminished. |
1989-11-27 |
2023-08-11 |
human |
| K D Vandegriff, F Medina, M A Marini, R M Winslo. Equilibrium oxygen binding to human hemoglobin cross-linked between the alpha chains by bis(3,5-dibromosalicyl) fumarate. The Journal of biological chemistry. vol 264. issue 30. 1989-11-27. PMID:2808353. |
however, while the oxygen affinity of t-state alpha alpha hb was slightly reduced at physiologic chloride concentration and in the absence of organic phosphates, kt was the same for both hemoglobins in the presence of 2,3-diphosphoglycerate (or high salt) and higher for alpha alpha hb in the presence of inositol hexaphosphate. |
1989-11-27 |
2023-08-11 |
human |
| K D Vandegriff, F Medina, M A Marini, R M Winslo. Equilibrium oxygen binding to human hemoglobin cross-linked between the alpha chains by bis(3,5-dibromosalicyl) fumarate. The Journal of biological chemistry. vol 264. issue 30. 1989-11-27. PMID:2808353. |
the reduced o2 affinity arises from smaller binding constants for both t- and r-state alpha alpha hb rather than through stabilization of the low affinity conformation. |
1989-11-27 |
2023-08-11 |
human |
| K D Vandegriff, F Medina, M A Marini, R M Winslo. Equilibrium oxygen binding to human hemoglobin cross-linked between the alpha chains by bis(3,5-dibromosalicyl) fumarate. The Journal of biological chemistry. vol 264. issue 30. 1989-11-27. PMID:2808353. |
all four adair constants could be determined for alpha alpha hb under most conditions, but a3 could not be resolved for hbao without constraining a4, suggesting that the cross-link stabilizes triply ligated intermediates of hemoglobin. |
1989-11-27 |
2023-08-11 |
human |
| H Moscoso, M Shyamala, C R Kiefer, F A Garve. Monoclonal antibody to the gamma chain of human fetal hemoglobin used to develop an enzyme immunoassay. Clinical chemistry. vol 35. issue 10. 1989-11-17. PMID:2477174. |
the mab reacts with hb f (alpha 2 gamma 2), hb bart's (gamma 4), and hb kenya (gamma-beta hybrid), but does not cross-react with hb a (alpha 2 beta 2) or hb a2 (alpha 2 delta 2). |
1989-11-17 |
2023-08-11 |
human |
| H W Peng, K B Choo, C H Ho, M S Yen, W Y Liung, C K Lin, Z L Yang, H T Ng, K N Ching, S H Ha. Arrangements of alpha-globin gene cluster in Taiwan. Acta haematologica. vol 82. issue 2. 1989-11-14. PMID:2508397. |
in a gene mapping study on 217 newborn babies in taiwan with alpha- and zeta-globin probes, we have observed 4 cases (1.84%) of alpha-thalassemia-2 heterozygotes (zeta zeta-alpha/zeta zeta alpha alpha) without increased levels of hemoglobin (hb) bart's in the cord blood. |
1989-11-14 |
2023-08-11 |
human |
| H W Peng, K B Choo, C H Ho, M S Yen, W Y Liung, C K Lin, Z L Yang, H T Ng, K N Ching, S H Ha. Arrangements of alpha-globin gene cluster in Taiwan. Acta haematologica. vol 82. issue 2. 1989-11-14. PMID:2508397. |
eleven subjects (5.07%) were found to have the south east asian alpha-thalassemia-1 haplotype (zeta zeta--sea/zeta zeta alpha alpha) with increased hb bart's levels ranging from 2.2 to 9%. |
1989-11-14 |
2023-08-11 |
human |
| H W Peng, K B Choo, C H Ho, M S Yen, W Y Liung, C K Lin, Z L Yang, H T Ng, K N Ching, S H Ha. Arrangements of alpha-globin gene cluster in Taiwan. Acta haematologica. vol 82. issue 2. 1989-11-14. PMID:2508397. |
one case, with hb bart's level of 14% in the cord blood, was found to have the genotype of zeta zeta--sea/zeta zeta alpha alpha t (0.46%). |
1989-11-14 |
2023-08-11 |
human |
| J F Codrington, F Kutlar, H F Harris, J B Wilson, T A Stoming, T H Huisma. Hb A2-Wrens or alpha 2 delta 2 98(FG5) Val----Met, an unstable delta chain variant identified by sequence analysis of amplified DNA. Biochimica et biophysica acta. vol 1009. issue 1. 1989-10-30. PMID:2477064. |
hb a2-wrens or alpha 2 delta 2 98(fg5) val----met, an unstable delta chain variant identified by sequence analysis of amplified dna. |
1989-10-30 |
2023-08-11 |
Not clear |
| H Wajcman, J Delaunay, A Francina, J Rosa, F Galactero. Hemoglobin Nouakchott [alpha 114(GH2)Pro----Leu]: a new hemoglobin variant displaying an unusual increase in hydrophobicity. Biochimica et biophysica acta. vol 998. issue 1. 1989-10-28. PMID:2790052. |
the most striking fact in hb nouakchott [alpha 114(gh2)pro----leu] is the highly increased hydrophobicity of the abnormal chain. |
1989-10-28 |
2023-08-11 |
Not clear |
| T Yang, K W Olse. The effect of crosslinking by bis(3,5-dibromosalicyl) fumarate on the autoxidation of hemoglobin. Biochemical and biophysical research communications. vol 163. issue 2. 1989-10-20. PMID:2783118. |
(1979) biochemistry 18, 4265) and deoxy hb a between lys 99 alpha 1 and lys 99 alpha 2 (chatterjee r. y., et al. |
1989-10-20 |
2023-08-11 |
Not clear |
| T Yang, K W Olse. The effect of crosslinking by bis(3,5-dibromosalicyl) fumarate on the autoxidation of hemoglobin. Biochemical and biophysical research communications. vol 163. issue 2. 1989-10-20. PMID:2783118. |
the autoxidation at 37 degrees c of oxy alpha 99 crosslinked hemoglobin was found to be 1.8 times as fast as that of hb a while that of the oxy beta 82 crosslinked hemoglobin was only 1.2 times as fast. |
1989-10-20 |
2023-08-11 |
Not clear |
| T Yang, K W Olse. The effect of crosslinking by bis(3,5-dibromosalicyl) fumarate on the autoxidation of hemoglobin. Biochemical and biophysical research communications. vol 163. issue 2. 1989-10-20. PMID:2783118. |
after 5 hours the formation of methemoglobin in the alpha crosslinked hb a is 21.3% compared to 10.8% in beta crosslinked hb a and 6.4% in hb a. |
1989-10-20 |
2023-08-11 |
Not clear |
| K Ishimori, I Morishima, K Imai, K Fushitani, G Miyazaki, D Shih, J Tame, J Pegnier, K Niga. NMR study of human mutant hemoglobins synthesized in Escherichia coli. Consequences of tyrosine alpha 42 substitutions. The Journal of biological chemistry. vol 264. issue 25. 1989-10-11. PMID:2670922. |
the site-directed mutagenesis of the tyr alpha 42----phe removes the hydrogen bond described above and prevents transition to the t-state so that the mutant hb is rather similar to the "r-state" even when deoxygenated. |
1989-10-11 |
2023-08-11 |
human |
| K Ishimori, I Morishima, K Imai, K Fushitani, G Miyazaki, D Shih, J Tame, J Pegnier, K Niga. NMR study of human mutant hemoglobins synthesized in Escherichia coli. Consequences of tyrosine alpha 42 substitutions. The Journal of biological chemistry. vol 264. issue 25. 1989-10-11. PMID:2670922. |
these observations indicate that the hydrogen bond formed between tyr alpha 42 and asp beta 99 is required to convert unliganded hb to the t-state. |
1989-10-11 |
2023-08-11 |
human |
| M Z Atassi, M Yoshioka, G S Bixle. T cells specific for alpha-beta interface regions of hemoglobin recognize the isolated subunit but not the tetramer and indicate presentation without processing. Proceedings of the National Academy of Sciences of the United States of America. vol 86. issue 17. 1989-10-06. PMID:2788890. |
three hemoglobin (hb) alpha-chain synthetic peptides, corresponding to areas that are situated either completely [alpha-(31-45)] or partially [alpha-(41-45) and alpha-(81-95)] within the interface between the alpha and beta subunits of hb, and a fourth peptide representing a completely exposed area in tetrameric hb were used as immunogens in sjl/j (h-2s) mice. |
1989-10-06 |
2023-08-11 |
mouse |
| M Feola, J Simoni, D Fishman, R Tran, P C Canizar. Biocompatibility of hemoglobin solutions. I. Reactions of vascular endothelial cells to pure and impure hemoglobins. Artificial organs. vol 13. issue 3. 1989-09-13. PMID:2669694. |
incubation with a nonpure hb solution (hb plus red blood cell membrane aminophospholipids; a-pls) caused cell injury with significant release of tissue factor, plus a reaction characterized by 97.5 +/- 12.5% increase in txb2 production accompanied by 25.3 +/- 3% reduction in 6-keto-pgf1 alpha. |
1989-09-13 |
2023-08-11 |
human |
| M Feola, J Simoni, D Fishman, R Tran, P C Canizar. Biocompatibility of hemoglobin solutions. I. Reactions of vascular endothelial cells to pure and impure hemoglobins. Artificial organs. vol 13. issue 3. 1989-09-13. PMID:2669694. |
a second nonpure hb [hb plus bacterial environmental endotoxin (e)] caused cell injury, the release of tissue factor, and increased production of both prostaglandins, with greater release of txb2 (197 +/- 17%) than of 6-keto-pgf1 alpha (112 +/- 8.3%). |
1989-09-13 |
2023-08-11 |
human |
| W A Schroeder, D R Powars, L M Kay, L S Chan, V Huynh, J B Shelton, J R Shelto. Beta-cluster haplotypes, alpha-gene status, and hematological data from SS, SC, and S-beta-thalassemia patients in southern California. Hemoglobin. vol 13. issue 4. 1989-08-29. PMID:2473969. |
hb a2 levels increased with decrease in the number of alpha genes. |
1989-08-29 |
2023-08-11 |
Not clear |