| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J A Tan, S H Tay, O K Siang, P S Lai, W H Boon, S Kha. Prenatal diagnosis of alpha- and beta-thalassaemias in Singapore--current status. Annals of tropical paediatrics. vol 11. issue 1. 1991-09-18. PMID:1714698. |
homozygous alpha (0)-thalassaemia was detected in four fetuses and the results were subsequently confirmed by electrophoresis of the cord blood where only hb barts was detected. |
1991-09-18 |
2023-08-11 |
Not clear |
| W Zhao, J B Wilson, B B Webber, A Kutlar, G P Tamagnini, B Kuam, T H Huisma. Hb Hekinan observed in three Chinese from Macau; identification of the GAG----GAT mutation in the alpha 1-globin gene. Hemoglobin. vol 14. issue 6. 1991-09-16. PMID:1983218. |
hb hekinan observed in three chinese from macau; identification of the gag----gat mutation in the alpha 1-globin gene. |
1991-09-16 |
2023-08-11 |
Not clear |
| W Zhao, J B Wilson, B B Webber, A Kutlar, G P Tamagnini, B Kuam, T H Huisma. Hb Hekinan observed in three Chinese from Macau; identification of the GAG----GAT mutation in the alpha 1-globin gene. Hemoglobin. vol 14. issue 6. 1991-09-16. PMID:1983218. |
hb hekinan, an alpha chain variant that is characterized by a glu----asp mutation at position alpha 27, was observed in three chinese females attending a prenatal clinic in macau. |
1991-09-16 |
2023-08-11 |
Not clear |
| J B Wilson, B B Webber, D Plaseska, P A de Alarcon, S K McMillan, T H Huisma. Hb Davenport or alpha 2(78)(EF7)Asn----His beta 2. Hemoglobin. vol 14. issue 6. 1991-09-16. PMID:2101836. |
hb davenport or alpha 2(78)(ef7)asn----his beta 2. |
1991-09-16 |
2023-08-11 |
Not clear |
| J B Wilson, B B Webber, D Plaseska, P A de Alarcon, S K McMillan, T H Huisma. Hb Davenport or alpha 2(78)(EF7)Asn----His beta 2. Hemoglobin. vol 14. issue 6. 1991-09-16. PMID:2101836. |
hb davenport is a new, stable alpha chain variant, that was detected in two members of a caucasian family living in iowa. |
1991-09-16 |
2023-08-11 |
Not clear |
| W Zhao, J B Wilson, T H Huisma. Low quantities of Hb Boyle Heights or alpha 2(6)(A4)Asp----O beta 2 observed in three members of a Caucasian family. Hemoglobin. vol 14. issue 6. 1991-09-16. PMID:2101838. |
low quantities of hb boyle heights or alpha 2(6)(a4)asp----o beta 2 observed in three members of a caucasian family. |
1991-09-16 |
2023-08-11 |
Not clear |
| T Yang, K W Olse. The thermal stability of Hb O-Indonesia [alpha 116(GH4)Glu----Lys]. Hemoglobin. vol 14. issue 6. 1991-09-16. PMID:2101839. |
the thermal stability of hb o-indonesia [alpha 116(gh4)glu----lys]. |
1991-09-16 |
2023-08-11 |
Not clear |
| C L Gaudry, P A Pitel, D L Jue, T K Hine, M H Johnson, W F Moo-Pen. Hb Jacksonville [alpha 2 beta 2(54)(D5)Val----Asp]: a new unstable variant found in a patient with hemolytic anemia. Hemoglobin. vol 14. issue 6. 1991-09-16. PMID:2101840. |
hb jacksonville [alpha 2 beta 2(54)(d5)val----asp]: a new unstable variant found in a patient with hemolytic anemia. |
1991-09-16 |
2023-08-11 |
Not clear |
| T H Jessen, R E Weber, G Fermi, J Tame, G Braunitze. Adaptation of bird hemoglobins to high altitudes: demonstration of molecular mechanism by protein engineering. Proceedings of the National Academy of Sciences of the United States of America. vol 88. issue 15. 1991-09-04. PMID:1862080. |
the hb amino acid sequences of the bar-headed and the greylag geese differ by four substitutions, of which only one is unique among bird sequences: pro-119 alpha (h2)----ala. perutz proposed that the two-carbon gap left by this substitution at the alpha 1 beta 1 contact raises the oxygen affinity, because it relaxes the tension in the deoxy or t structure [perutz, m. f. (1983) mol. |
1991-09-04 |
2023-08-11 |
human |
| G L Kropp, S Fucharoen, S H Embur. Asymmetrically primed selective amplification/temperature shift fluorescence polymerase chain reaction to detect the hemoglobin Constant Spring mutation. Blood. vol 78. issue 1. 1991-08-19. PMID:1712643. |
the methods developed have had to contend with the high degree of homology of the alpha 2-globin gene (the site of the hb constant spring mutation) and the alpha 1-globin gene. |
1991-08-19 |
2023-08-11 |
Not clear |
| G L Kropp, S Fucharoen, S H Embur. Asymmetrically primed selective amplification/temperature shift fluorescence polymerase chain reaction to detect the hemoglobin Constant Spring mutation. Blood. vol 78. issue 1. 1991-08-19. PMID:1712643. |
we have developed a single reaction polymerase chain reaction-based method that uses asymmetric priming and a temperature shift to accomplish dual ends, selective amplification of alpha 2 but not alpha 1 dna and discrimination of normal and hb constant spring alpha 2 genes by allele-specific fluorescence polymerase chain reaction. |
1991-08-19 |
2023-08-11 |
Not clear |
| J R Hess, C E Wade, R M Winslo. Filtration-assisted exchange transfusion using alpha alpha Hb, an erythrocyte substitute. Journal of applied physiology (Bethesda, Md. : 1985). vol 70. issue 4. 1991-08-01. PMID:1905289. |
filtration-assisted exchange transfusion using alpha alpha hb, an erythrocyte substitute. |
1991-08-01 |
2023-08-11 |
human |
| J R Hess, C E Wade, R M Winslo. Filtration-assisted exchange transfusion using alpha alpha Hb, an erythrocyte substitute. Journal of applied physiology (Bethesda, Md. : 1985). vol 70. issue 4. 1991-08-01. PMID:1905289. |
the removed volume was replaced with a 14-g/dl solution of human hb cross-linked between the alpha-chains with bis(3,5-dibromosalicyl)fumarate (alpha alpha hb). |
1991-08-01 |
2023-08-11 |
human |
| M Nagai, Y Yoneyama, T Kitagaw. Unusual CO bonding geometry in abnormal subunits of hemoglobin M Boston and hemoglobin M Saskatoon. Biochemistry. vol 30. issue 26. 1991-08-01. PMID:2054349. |
to clarify the role of the proximal histidine (f8-his), distal his (e7-his), and e11 valine (e11-val) in ligand binding of hemoglobin (hb), we have investigated the resonance raman (rr) spectra of the carbon monoxide adduct of hbs m (cohb m) in which one of these residues was genetically replaced by another amino acid in either the alpha or beta subunit. |
1991-08-01 |
2023-08-11 |
Not clear |
| M F Sonati, F F Cost. Hemoglobin Bart's in a Brazilian black population. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 23. issue 5. 1991-07-05. PMID:2095287. |
the data suggest that the frequency of alpha-thalassemia gene in the brazilian black population is 0.125 since individuals with bart's hb in the 5-10% range are usually alpha(+)-thalassemia homozygotes. |
1991-07-05 |
2023-08-11 |
Not clear |
| F Kutlar, A E Felice, J L Grech, W H Bannister, A Kutlar, J B Wilson, B B Webber, H Y Hu, T H Huisma. The linkage of Hb Valletta [alpha 2 beta 287(f3)Thr----Pro] and Hb F-Malta-I [alpha 2G gamma 2117(G19)His----Arg] in the Maltese population. Human genetics. vol 86. issue 6. 1991-06-10. PMID:1709134. |
the linkage of hb valletta [alpha 2 beta 287(f3)thr----pro] and hb f-malta-i [alpha 2g gamma 2117(g19)his----arg] in the maltese population. |
1991-06-10 |
2023-08-11 |
Not clear |
| C H Shackleton, A M Falick, B N Green, H E Witkowsk. Electrospray mass spectrometry in the clinical diagnosis of variant hemoglobins. Journal of chromatography. vol 562. issue 1-2. 1991-06-10. PMID:2026691. |
thus 80 and 79% of the known variants of alpha and beta chains, respectively, can be detected in mixtures with their normal counterparts, including hb s (molecular weight difference = 30 da). |
1991-06-10 |
2023-08-11 |
Not clear |
| K Imai, K Fushitani, G Miyazaki, K Ishimori, T Kitagawa, Y Wada, H Morimoto, I Morishima, D T Shih, J Tam. Site-directed mutagenesis in haemoglobin. Functional role of tyrosine-42(C7) alpha at the alpha 1-beta 2 interface. Journal of molecular biology. vol 218. issue 4. 1991-05-31. PMID:2023248. |
to clarify the functional role of tyr-42(c7) alpha, which forms a hydrogen bond with asp-99(g1) beta at the alpha 1-beta 2 interface of human deoxyhaemoglobin, we engineered two artificial mutant haemoglobins (hb), in which tyr-42 alpha was replaced by phe (hb phe-42 alpha) or his (hb his-42 alpha), and investigated their oxygen binding properties together with structural consequences of the mutations by using various spectroscopic probes. |
1991-05-31 |
2023-08-11 |
human |
| K Imai, K Fushitani, G Miyazaki, K Ishimori, T Kitagawa, Y Wada, H Morimoto, I Morishima, D T Shih, J Tam. Site-directed mutagenesis in haemoglobin. Functional role of tyrosine-42(C7) alpha at the alpha 1-beta 2 interface. Journal of molecular biology. vol 218. issue 4. 1991-05-31. PMID:2023248. |
like most of the natural asp-99 beta mutants, hb phe-42 alpha showed a markedly increased oxygen affinity, a reduced bohr effect and diminished co-operativity. |
1991-05-31 |
2023-08-11 |
human |
| K Imai, K Fushitani, G Miyazaki, K Ishimori, T Kitagawa, Y Wada, H Morimoto, I Morishima, D T Shih, J Tam. Site-directed mutagenesis in haemoglobin. Functional role of tyrosine-42(C7) alpha at the alpha 1-beta 2 interface. Journal of molecular biology. vol 218. issue 4. 1991-05-31. PMID:2023248. |
in contrast with hb phe-42 alpha, hb his-42 alpha showed an intermediately impaired function and only moderate destabilization of the t-state, which can be explained by the formation of a new, weak hydrogen bond between his-42 alpha and asp-99 beta. |
1991-05-31 |
2023-08-11 |
human |