| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A J Schee. [Basal insulin glargine-lixisenatide fixed ratio combination (Suliqua®)]. Revue medicale de Liege. vol 74. issue 2. 2019-06-25. PMID:30793566. |
it has a good tolerance profile, with a more favourable effect on body weight compared with insulin glargine alone and less gastrointestinal adverse effects when compared with lixisenatide alone, because of a more progressive titration of the glp-1 receptor agonist component. |
2019-06-25 |
2023-08-13 |
Not clear |
| Hale M Tasyurek, Hasan Ali Altunbas, Mustafa Kemal Balci, Thomas S Griffith, Salih Sanliogl. Therapeutic Potential of Lentivirus-Mediated Glucagon-Like Peptide-1 Gene Therapy for Diabetes. Human gene therapy. vol 29. issue 7. 2019-06-24. PMID:29409356. |
postprandial glucose-induced insulin secretion from the islets of langerhans is facilitated by glucagon-like peptide-1 (glp-1)-a metabolic hormone with insulinotropic properties. |
2019-06-24 |
2023-08-13 |
human |
| Brian M Moran, Michael G Miskelly, Yasser H A Abdel-Wahab, Peter R Flatt, Aine M McKillo. Zinc-induced activation of GPR39 regulates glucose homeostasis through glucose-dependent insulinotropic polypeptide secretion from enteroendocrine K-cells. Biological chemistry. 2019-06-20. PMID:30738010. |
in glucagon like peptide-1 (glp-1) receptor knockout mice, zn2+ reduced glucose by 15-28% (p < 0.05-p < 0.01) and increased insulin release by 35-43% (p < 0.01). |
2019-06-20 |
2023-08-13 |
mouse |
| Giuseppina Costabile, Ettore Griffo, Paola Cipriano, Claudia Vetrani, Marilena Vitale, Gianfranco Mamone, Angela A Rivellese, Gabriele Riccardi, Rosalba Giacc. Subjective satiety and plasma PYY concentration after wholemeal pasta. Appetite. vol 125. 2019-06-19. PMID:29427691. |
after wholemeal pasta, glucose, triglyceride increased and glp-1 responses were not different compared to control pasta but insulin response at 30 min (p<0.05) and ghrelin at 60 min (p=0.03) were lower and pyy levels higher (auc=+44%, p=0.001). |
2019-06-19 |
2023-08-13 |
human |
| Koji Matsumoto, Tomomi Yoshitomi, Takashi Shimad. [The role of pharmacology to produce firuglipel (DS-8500a), an orally available GPR119 agonist for type 2 diabetes mellitus]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 152. issue 3. 2019-06-17. PMID:30185729. |
gpr119 (g-protein coupled receptor 119) has been shown to be highly expressed in the lower small intestinal and colorectal l-cells and pancreatic β-cells, and mediates intracellular camp concentration, glucagon like peptide (glp-1) secretion, and glucose stimulated insulin secretion (gsis). |
2019-06-17 |
2023-08-13 |
mouse |
| Jan Detka, Joanna Ślusarczyk, Anna Kurek, Mateusz Kucharczyk, Tomasz Adamus, Paweł Konieczny, Marta Kubera, Agnieszka Basta-Kaim, Władysław Lasoń, Bogusława Budziszewsk. Hypothalamic insulin and glucagon-like peptide-1 levels in an animal model of depression and their effect on corticotropin-releasing hormone promoter gene activity in a hypothalamic cell line. Pharmacological reports : PR. vol 71. issue 2. 2019-06-17. PMID:30831439. |
insulin and glucagon-like peptide-1 (glp-1), besides regulation of glucose homeostasis, also possess neurotrophic properties. |
2019-06-17 |
2023-08-13 |
Not clear |
| Jan Detka, Joanna Ślusarczyk, Anna Kurek, Mateusz Kucharczyk, Tomasz Adamus, Paweł Konieczny, Marta Kubera, Agnieszka Basta-Kaim, Władysław Lasoń, Bogusława Budziszewsk. Hypothalamic insulin and glucagon-like peptide-1 levels in an animal model of depression and their effect on corticotropin-releasing hormone promoter gene activity in a hypothalamic cell line. Pharmacological reports : PR. vol 71. issue 2. 2019-06-17. PMID:30831439. |
current study was aimed at investigating the influence of prenatal stress (ps) on insulin, glp-1 and their receptor (ir and glp-1r) levels in the hypothalamus. |
2019-06-17 |
2023-08-13 |
Not clear |
| Y Inabu, J Pyo, S Pletts, L L Guan, M A Steele, T Sugin. Effect of extended colostrum feeding on plasma glucagon-like peptide-1 concentration in newborn calves. Journal of dairy science. vol 102. issue 5. 2019-06-14. PMID:30827561. |
glucagon-like peptide-1 (glp-1) plays a role in the regulation of glucose homeostasis via the stimulation of insulin secretion. |
2019-06-14 |
2023-08-13 |
Not clear |
| Y Inabu, J Pyo, S Pletts, L L Guan, M A Steele, T Sugin. Effect of extended colostrum feeding on plasma glucagon-like peptide-1 concentration in newborn calves. Journal of dairy science. vol 102. issue 5. 2019-06-14. PMID:30827561. |
blood samples were obtained before (1 and 2 h after birth) and after (until 72 h after birth; 42 time points) the first colostrum feeding, and plasma concentrations of glucose, insulin, and glp-1 were measured. |
2019-06-14 |
2023-08-13 |
Not clear |
| Y Inabu, J Pyo, S Pletts, L L Guan, M A Steele, T Sugin. Effect of extended colostrum feeding on plasma glucagon-like peptide-1 concentration in newborn calves. Journal of dairy science. vol 102. issue 5. 2019-06-14. PMID:30827561. |
a treatment × time interaction was observed for glp-1, but unlike glucose and insulin, this was mainly the result of higher concentrations from 54 to 72 h after birth (on d 3 after birth) for c compared with m or cm. |
2019-06-14 |
2023-08-13 |
Not clear |
| Y Inabu, J Pyo, S Pletts, L L Guan, M A Steele, T Sugin. Effect of extended colostrum feeding on plasma glucagon-like peptide-1 concentration in newborn calves. Journal of dairy science. vol 102. issue 5. 2019-06-14. PMID:30827561. |
postprandial plasma concentration of glucose was not correlated with that of glp-1 but was positively correlated with that of insulin for the 4-h period after feeding on d 1 (r = 0.30) and d 3 after birth (r = 0.33). |
2019-06-14 |
2023-08-13 |
Not clear |
| Y Inabu, J Pyo, S Pletts, L L Guan, M A Steele, T Sugin. Effect of extended colostrum feeding on plasma glucagon-like peptide-1 concentration in newborn calves. Journal of dairy science. vol 102. issue 5. 2019-06-14. PMID:30827561. |
postprandial plasma concentration of glp-1 was positively correlated with that of insulin for the 4-h period after feeding on d 3 after birth (r = 0.20). |
2019-06-14 |
2023-08-13 |
Not clear |
| Y Inabu, J Pyo, S Pletts, L L Guan, M A Steele, T Sugin. Effect of extended colostrum feeding on plasma glucagon-like peptide-1 concentration in newborn calves. Journal of dairy science. vol 102. issue 5. 2019-06-14. PMID:30827561. |
these results indicate that extended colostrum feeding may increase plasma glp-1 concentrations, especially 3 d after birth, but further study is necessary to determine the effect on plasma insulin and glucose concentrations. |
2019-06-14 |
2023-08-13 |
Not clear |
| José Alberto González-Regueiro, Lidia Moreno-Castañeda, Misael Uribe, Norberto Carlos Chávez-Tapi. The Role of Bile Acids in Glucose Metabolism and Their Relation with Diabetes. Annals of hepatology. vol 16 Suppl 1. 2019-06-14. PMID:31196630. |
recent studies had revealed the way these receptors participate in regulating gluconeogenesis, peripheral insulin sensitivity, glycogen synthesis, glucagon like peptide 1 (glp-1) and insulin secretion. |
2019-06-14 |
2023-08-13 |
Not clear |
| Ismail Syed, Jennifer Lee, Pedro M Moraes-Vieira, Cynthia J Donaldson, Alexandra Sontheimer, Pratik Aryal, Kerry Wellenstein, Matthew J Kolar, Andrew T Nelson, Dionicio Siegel, Jacek Mokrosinski, I Sadaf Farooqi, Juan Juan Zhao, Mark M Yore, Odile D Peroni, Alan Saghatelian, Barbara B Kah. Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis. Cell metabolism. vol 27. issue 2. 2019-06-04. PMID:29414687. |
pahsa administration in chow-fed, but not hfd-fed, mice augments insulin and glucagon-like peptide (glp-1) secretion. |
2019-06-04 |
2023-08-13 |
mouse |
| Raffaella Gentilella, Valeria Pechtner, Antonella Corcos, Agostino Consol. Glucagon-like peptide-1 receptor agonists in type 2 diabetes treatment: are they all the same? Diabetes/metabolism research and reviews. vol 35. issue 1. 2019-05-29. PMID:30156747. |
the primary pharmacodynamic difference between short-acting (ie, exenatide twice daily and lixisenatide) and long-acting (ie, albiglutide, dulaglutide, exenatide once weekly, liraglutide, and semaglutide) glp-1 ras is that short-acting agents primarily delay gastric emptying (lowering postprandial glucose) and long-acting agents affect both fasting glucose (via enhanced glucose-dependent insulin secretion and reduced glucagon secretion in the fasting state) and postprandial glucose (via enhanced postprandial insulin secretion and inhibition of glucagon secretion). |
2019-05-29 |
2023-08-13 |
human |
| Marco Castellana, Angelo Cignarelli, Francesco Brescia, Luigi Laviola, Francesco Giorgin. GLP-1 receptor agonist added to insulin versus basal-plus or basal-bolus insulin therapy in type 2 diabetes: A systematic review and meta-analysis. Diabetes/metabolism research and reviews. vol 35. issue 1. 2019-05-29. PMID:30270567. |
glp-1 receptor agonist added to insulin versus basal-plus or basal-bolus insulin therapy in type 2 diabetes: a systematic review and meta-analysis. |
2019-05-29 |
2023-08-13 |
Not clear |
| Ari Robinson, Irit Lubitz, Dana Atrakchi-Baranes, Avital Licht-Murava, Pavel Katsel, Derek Leroith, Sigal Liraz-Zaltsman, Vahram Haroutunian, Michal Schnaider Beer. Combination of Insulin with a GLP1 Agonist Is Associated with Better Memory and Normal Expression of Insulin Receptor Pathway Genes in a Mouse Model of Alzheimer's Disease. Journal of molecular neuroscience : MN. vol 67. issue 4. 2019-05-29. PMID:30635783. |
we examined the effect of 8-month intranasal administration of insulin, exenatide (a glp-1 agonist), combination therapy (insulin + exenatide) or saline, in wild-type (wt) and an ad-like mouse model (tg2576). |
2019-05-29 |
2023-08-13 |
mouse |
| Xiaoying He, Hongyu Guan, Weiwei Liang, Zhimin Huang, Lijuan Xu, Pengyuan Zhang, Fen Xu, Yanbing L. Exendin-4 modifies adipogenesis of human adipose-derived stromal cells isolated from omentum through multiple mechanisms. International journal of obesity (2005). vol 42. issue 5. 2019-05-28. PMID:29515208. |
glucagon-like peptide-1 (glp-1) has been reported to have positive effects on improving body metabolism and to reducing insulin resistance. |
2019-05-28 |
2023-08-13 |
human |
| Yasuki Nagai, Kosuke Mukai, Michio Otsuki, Takekazu Kimura, Junji Kozawa, Hitoshi Nishizawa, Norikazu Maeda, Taka-Aki Matsuoka, Hiromi Iwahashi, Akihisa Imagawa, Iichiro Shimomur. Suppression Failure of Cortisol Secretion by Dexamethasone May Occur in Glucagon-like Peptide-1 Receptor Agonist-treated Patients with Diabetic Autonomic Neuropathy. Internal medicine (Tokyo, Japan). vol 58. issue 7. 2019-05-28. PMID:30568127. |
however, its secretion was suppressed after switching from glp-1 ras to insulin. |
2019-05-28 |
2023-08-13 |
Not clear |