| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sufang Chen, Wei Wei, Minjie Chen, Xiaobo Qin, Lianglin Qiu, Li Zhang, Yuhao Zhang, Qi Cao, Zhekang Yin. TNF Signaling Impacts Glucagon-Like Peptide-1 Expression and Secretion. Journal of molecular endocrinology. vol 61. issue 4. 2019-10-25. PMID:30021757. |
these data collectively suggest that physiological tnf signaling regulates glucose metabolism primarily through effects on glp-1 expression and secretion and subsequently insulin secretion. |
2019-10-25 |
2023-08-13 |
mouse |
| Abraham H Hulst, Maarten J Visscher, Marc B Godfried, Bram Thiel, Bas M Gerritse, Thierry V Scohy, R Arthur Bouwman, Mark G A Willemsen, Markus W Hollmann, J Hans DeVries, Benedikt Preckel, Jeroen Hermanide. Study protocol of the randomised placebo-controlled GLOBE trial: BMJ open. vol 8. issue 6. 2019-10-23. PMID:29866735. |
we hypothesise that preoperative liraglutide (a synthetic glp-1 analogue) will reduce the number of patients requiring insulin to achieve glucose values<8 mmol l |
2019-10-23 |
2023-08-13 |
Not clear |
| Jing Lu, Gary B Willar. Endothelin-converting enzyme-1 regulates glucagon-like peptide-1 receptor signalling and resensitisation. The Biochemical journal. vol 476. issue 3. 2019-10-23. PMID:30626614. |
following nutrient ingestion, glucagon-like peptide 1 (glp-1) is secreted from intestinal l-cells and mediates anti-diabetic effects, most notably stimulating glucose-dependent insulin release from pancreatic β-cells but also inhibiting glucagon release, promoting satiety and weight reduction and potentially enhancing or preserving β-cell mass. |
2019-10-23 |
2023-08-13 |
human |
| Behrouz Keleidari, Rastin Mohammadi Mofrad, Shahab Shahabi Shahmiri, Mohammad Hossein Sanei, Mohsen Kolahdouzan, Erfan Sheikhbahae. The Impacts of Gastroileostomy Rat Model on Glucagon-like Peptide-1: a Promising Model to Control Type 2 Diabetes Mellitus. Obesity surgery. vol 28. issue 10. 2019-10-21. PMID:29785472. |
we studied the early effects of a gastroileostomy on serum levels of glp-1, glucose, and insulin in rats. |
2019-10-21 |
2023-08-13 |
rat |
| Noriyasu Kamei, Nobuyuki Okada, Takamasa Ikeda, Hayoung Choi, Yui Fujiwara, Haruka Okumura, Mariko Takeda-Morishit. Effective nose-to-brain delivery of exendin-4 via coadministration with cell-penetrating peptides for improving progressive cognitive dysfunction. Scientific reports. vol 8. issue 1. 2019-10-21. PMID:30518944. |
the present study, therefore, aimed to overcome the difficulty in treating severe cognitive dysfunction using insulin by investigating potential alternatives, glucagon-like peptide-1 (glp-1) receptor agonists such as exendin-4. |
2019-10-21 |
2023-08-13 |
mouse |
| Andre F Batista, Leticia Forny-Germano, Julia R Clarke, Natalia M Lyra E Silva, Jordano Brito-Moreira, Susan E Boehnke, Andrew Winterborn, Brian C Coe, Ann Lablans, Juliana F Vital, Suelen A Marques, Ana Mb Martinez, Matthias Gralle, Christian Holscher, William L Klein, Jean-Christophe Houzel, Sergio T Ferreira, Douglas P Munoz, Fernanda G De Felic. The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease. The Journal of pathology. vol 245. issue 1. 2019-10-17. PMID:29435980. |
given the increasingly recognized link between ad and defective brain insulin signaling, we investigated the actions of liraglutide, a glucagon-like peptide-1 (glp-1) analog marketed for treatment of type 2 diabetes, in experimental models of ad. |
2019-10-17 |
2023-08-13 |
mouse |
| Lujin Wu, Ke Wang, Wei Wang, Zheng Wen, Peihua Wang, Lei Liu, Dao Wen Wan. Glucagon-like peptide-1 ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via the PPARα pathway. Aging cell. vol 17. issue 4. 2019-10-14. PMID:29659121. |
glucagon-like peptide-1 (glp-1) has aroused considerable interest as a novel therapeutic target for diabetes mellitus because it stimulates insulin secretion. |
2019-10-14 |
2023-08-13 |
mouse |
| Darline Garibay, Jon Lou, Seon A Lee, Karolina E Zaborska, Margot H Weissman, Erica Sloma, Leanne Donahue, Andrew D Miller, Andrew C White, M Dodson Michael, Kyle W Sloop, Bethany P Cumming. β Cell GLP-1R Signaling Alters α Cell Proglucagon Processing after Vertical Sleeve Gastrectomy in Mice. Cell reports. vol 23. issue 4. 2019-10-01. PMID:29694904. |
glp-1 plays a critical role in islet function by potentiating glucose-stimulated insulin secretion; however, the mechanisms remain incompletely defined. |
2019-10-01 |
2023-08-13 |
mouse |
| Pádraigín A Harnedy, Vadivel Parthsarathy, Chris M McLaughlin, Martina B O'Keeffe, Philip J Allsopp, Emeir M McSorley, Finbarr P M O'Harte, Richard J FitzGeral. Atlantic salmon (Salmo salar) co-product-derived protein hydrolysates: A source of antidiabetic peptides. Food research international (Ottawa, Ont.). vol 106. 2019-09-30. PMID:29579965. |
the gelatin hydrolysate generated with alcalase 2.4l and flavourzyme 500l exhibited significantly higher (p < 0.001) insulin and glp-1 secretory activity from pancreatic brin-bd11 and enteroendocrine glutag cells, respectively, when tested at 2.5 mg/ml compared to hydrolysates generated with alcalase 2.4l or promod 144mg. |
2019-09-30 |
2023-08-13 |
Not clear |
| Pádraigín A Harnedy, Vadivel Parthsarathy, Chris M McLaughlin, Martina B O'Keeffe, Philip J Allsopp, Emeir M McSorley, Finbarr P M O'Harte, Richard J FitzGeral. Atlantic salmon (Salmo salar) co-product-derived protein hydrolysates: A source of antidiabetic peptides. Food research international (Ottawa, Ont.). vol 106. 2019-09-30. PMID:29579965. |
the salmon trimmings hydrolysate generated with alcalase 2.4l and flavourzyme 500l when subjected to simulated gastrointestinal digestion (sgid) was shown to retain its glp-1 secretory and dpp-iv inhibitory activities, in addition to improving its insulin secretory activity. |
2019-09-30 |
2023-08-13 |
Not clear |
| Hui Wang, Xinxin Fa, Wei Qu, Jindong Fu, Kaiyun Fan, Jinxian Liu, Feng L. Therapeutic Effects of Sleeve Gastrectomy and Ileal Transposition on Type 2 Diabetes in a Non-Obese Rat Model by Regulating Blood Glucose and Reducing Ghrelin Levels. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-23. PMID:31068569. |
at 2 months post-surgery, insulin, glucose, triglycerides (tg), total cholesterol (tc), glucose tolerance, glucagon-like peptide-1 (glp-1) levels, and insulin sensitivity were evaluated. |
2019-09-23 |
2023-08-13 |
rat |
| Hui Wang, Xinxin Fa, Wei Qu, Jindong Fu, Kaiyun Fan, Jinxian Liu, Feng L. Therapeutic Effects of Sleeve Gastrectomy and Ileal Transposition on Type 2 Diabetes in a Non-Obese Rat Model by Regulating Blood Glucose and Reducing Ghrelin Levels. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-23. PMID:31068569. |
conclusions in non-obese rats with spontaneous diabetes, both sg and it surgery were found to control diabetes by regulating body weight and levels of glucose, ghrelin, glp-1, ogtt glucose, insulin, tc, and tg. |
2019-09-23 |
2023-08-13 |
rat |
| Habib Yaribeygi, Thozhukat Sathyapalan, Amirhossein Sahebka. Molecular mechanisms by which GLP-1 RA and DPP-4i induce insulin sensitivity. Life sciences. vol 234. 2019-09-20. PMID:31425698. |
molecular mechanisms by which glp-1 ra and dpp-4i induce insulin sensitivity. |
2019-09-20 |
2023-08-13 |
Not clear |
| Koji Nakashima, Hideaki Kaneto, Masashi Shimoda, Tomohiko Kimura, Kohei Kak. Pancreatic alpha cells in diabetic rats express active GLP-1 receptor: Endosomal co-localization of GLP-1/GLP-1R complex functioning through intra-islet paracrine mechanism. Scientific reports. vol 8. issue 1. 2019-09-17. PMID:29487355. |
glucagon-like peptide-1 (glp-1) stimulates insulin secretion from pancreatic beta cells and suppresses glucagon secretion from alpha cells. |
2019-09-17 |
2023-08-13 |
rat |
| Louise Lang Lehrskov, Mark Preben Lyngbaek, Line Soederlund, Grit Elster Legaard, Jan Adam Ehses, Sarah Elizabeth Heywood, Nicolai Jacob Wewer Albrechtsen, Jens Juul Holst, Kristian Karstoft, Bente Klarlund Pedersen, Helga Ellingsgaar. Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control. Cell metabolism. vol 27. issue 6. 2019-09-17. PMID:29731416. |
il-6 furthermore reduces insulin secretion in a glp-1-dependent manner while effects on gastric emptying are glp-1 independent. |
2019-09-17 |
2023-08-13 |
Not clear |
| Janelle B Gyorffy, Andrea N Keithler, Jana L Wardian, Lee A Zarzabal, Alexander Rittel, Mark W Tru. THE IMPACT OF GLP-1 RECEPTOR AGONISTS ON PATIENTS WITH DIABETES ON INSULIN THERAPY. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. vol 25. issue 9. 2019-09-17. PMID:31170363. |
the impact of glp-1 receptor agonists on patients with diabetes on insulin therapy. |
2019-09-17 |
2023-08-13 |
Not clear |
| Christa George, AhYoung Byun, Amanda Howard-Thompso. New Injectable Agents for the Treatment of Type 2 Diabetes Part 2-Glucagon-Like Peptide-1 (GLP-1) Agonists. The American journal of medicine. vol 131. issue 11. 2019-09-09. PMID:29969616. |
the us food and drug administration has recently approved several new glucagon-like peptide-1 (glp-1) agonists alone and in combination with various insulin products. |
2019-09-09 |
2023-08-13 |
Not clear |
| David J Clayton, Jack Biddle, Tyler Maher, Mark P Funnell, Jack A Sargeant, James A King, Carl J Hulston, David J Stensel, Lewis J Jame. 24-h severe energy restriction impairs postprandial glycaemic control in young, lean males. The British journal of nutrition. vol 120. issue 10. 2019-09-09. PMID:30401004. |
plasma/serum glucose, insulin, nefa, glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic peptide (gip) and fibroblast growth factor 21 (fgf21) were assessed before and after (0 h) each 24-h dietary intervention, and throughout the 2-h ogtt. |
2019-09-09 |
2023-08-13 |
Not clear |
| David J Clayton, Jack Biddle, Tyler Maher, Mark P Funnell, Jack A Sargeant, James A King, Carl J Hulston, David J Stensel, Lewis J Jame. 24-h severe energy restriction impairs postprandial glycaemic control in young, lean males. The British journal of nutrition. vol 120. issue 10. 2019-09-09. PMID:30401004. |
during the ogtt, serum glucose iauc (p<0·001), serum insulin iauc (p<0·05) and plasma nefa tauc (p<0·01) were greater during er, but glp-1 (p=0·161), gip (p=0·473) and fgf21 (p=0·497) tauc were similar between trials. |
2019-09-09 |
2023-08-13 |
Not clear |
| Danielle Alvares, Simon Hoffman, Bogdan Stankovic, Khosrow Adel. Gut peptide and neuroendocrine regulation of hepatic lipid and lipoprotein metabolism in health and disease. Biochimica et biophysica acta. Molecular and cell biology of lipids. vol 1864. issue 3. 2019-09-09. PMID:30578967. |
treatment with glp-1 analogues has been shown to reverse features of nafld including insulin resistance, and alterations in hepatic de novo lipogenesis and reactive oxygen species. |
2019-09-09 |
2023-08-13 |
Not clear |