| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Charlotte B Christiansen, Sara J Lind, Berit Svendsen, Emilie Balk-Møller, Tina Dahlby, Rune E Kuhre, Bolette Hartmann, Thomas Mandrup-Poulsen, Carolyn F Deacon, Nicolai J Wewer Albrechtsen, Jens J Hols. Acute administration of interleukin-6 does not increase secretion of glucagon-like peptide-1 in mice. Physiological reports. vol 6. issue 13. 2019-09-04. PMID:29981198. |
interleukin 6 (il-6) is a cytokine secreted from skeletal muscle in response to exercise which, based on animal and cell studies, has been suggested to contribute to glucose metabolism by increasing secretion of the incretin hormone glucagon-like peptide-1 (glp-1) and affecting secretion of insulin and glucagon from the pancreatic islets. |
2019-09-04 |
2023-08-13 |
mouse |
| Daniel J Drucke. Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1. Cell metabolism. vol 27. issue 4. 2019-09-03. PMID:29617641. |
glucagon-like peptide-1 (glp-1) released from gut enteroendocrine cells controls meal-related glycemic excursions through augmentation of insulin and inhibition of glucagon secretion. |
2019-09-03 |
2023-08-13 |
Not clear |
| Zhenxing Yang, Caiyun Guo, Jun Ma, Yang Lu, Liping Xuan, Yongmin Huang, Xiaoyu Yang, Minxia Zhao, Yaner Lu. Glucagon-like peptide-1 attenuates liver injury in the rat diabetes model. Pakistan journal of pharmaceutical sciences. vol 32. issue 1(Supplementary). 2019-09-03. PMID:30829208. |
compared with diabetes group, insulin expression of glp-1 intervention group increased significantly (p<0.05). |
2019-09-03 |
2023-08-13 |
rat |
| O V Kornyushin, A A Bakhtyukov, I I Zorina, Y G Toropova, K V Derkach, O M Berko, M N Todosenko, L S Litvinova, A O Shpakov, M M Galagudz. [The effect of different types of bariatric surgery on the metabolic and hormonal parameters in rats with decompensed form of type 2 diabetes mellitus.] Advances in gerontology = Uspekhi gerontologii. vol 32. issue 1-2. 2019-08-28. PMID:31228372. |
the aim of the work was to study the effect of it, sg and gb on the insulin, leptin, ghrelin and glucagon-like peptide-1 (glp-1) levels in the blood and on the expression of the genes encoding the main components of the hypothalamic signaling systems in rats with decompensated form of dm2, which was induced by a high-fat diet (3 months) and a single low dose of streptozotocin (25 mg/kg, 2 months after the start of the diet). |
2019-08-28 |
2023-08-13 |
rat |
| O V Kornyushin, A A Bakhtyukov, I I Zorina, Y G Toropova, K V Derkach, O M Berko, M N Todosenko, L S Litvinova, A O Shpakov, M M Galagudz. [The effect of different types of bariatric surgery on the metabolic and hormonal parameters in rats with decompensed form of type 2 diabetes mellitus.] Advances in gerontology = Uspekhi gerontologii. vol 32. issue 1-2. 2019-08-28. PMID:31228372. |
in diabetic rats, a significantly expressed hyperglycemia, an impaired glucose tolerance, a decrease in glucose-stimulated glp-1 level, a slight decrease in the insulin and leptin levels and an slight increase in ghrelin level were detected. |
2019-08-28 |
2023-08-13 |
rat |
| O V Kornyushin, A A Bakhtyukov, I I Zorina, Y G Toropova, K V Derkach, O M Berko, M N Todosenko, L S Litvinova, A O Shpakov, M M Galagudz. [The effect of different types of bariatric surgery on the metabolic and hormonal parameters in rats with decompensed form of type 2 diabetes mellitus.] Advances in gerontology = Uspekhi gerontologii. vol 32. issue 1-2. 2019-08-28. PMID:31228372. |
in the hypothalamus, the expression of the genes encoding glp-1 receptor, orexigenic agouti-related peptide (agrp), as well as phosphotyrosine phosphatase 1b and socs3, the negative regulators of the leptin and insulin pathways was increased. |
2019-08-28 |
2023-08-13 |
rat |
| O V Kornyushin, A A Bakhtyukov, I I Zorina, Y G Toropova, K V Derkach, O M Berko, M N Todosenko, L S Litvinova, A O Shpakov, M M Galagudz. [The effect of different types of bariatric surgery on the metabolic and hormonal parameters in rats with decompensed form of type 2 diabetes mellitus.] Advances in gerontology = Uspekhi gerontologii. vol 32. issue 1-2. 2019-08-28. PMID:31228372. |
in diabetic rats, the it reduced the glucose levels 120 minutes after glucose load, increased the basal and glucose-stimulated glp-1 levels, normalized the gene expression for phosphotyrosine phosphatase 1b, socs3, agrp and glp-1 receptor, which indicates the restoration of the hypothalamic signaling responsible for the control of energy metabolism and insulin sensitivity. |
2019-08-28 |
2023-08-13 |
rat |
| Xian Wu Cheng, Megumi Narisawa, Enze Jin, Chenglin Yu, Wenhu Xu, Limei Pia. Dose rectification of an imbalance between DPP4 and GLP-1 ameliorates chronic stress-related vascular aging and atherosclerosis? Clinical and experimental pharmacology & physiology. vol 45. issue 5. 2019-08-16. PMID:29220092. |
over the past decade, emerging data has revealed unexpected roles for dpp-4 and glp-1 in intracellular signaling, oxidative stress production, lipid metabolism, cell apoptosis, immune activation, insulin resistance, and inflammation. |
2019-08-16 |
2023-08-13 |
Not clear |
| Julie Charpentier, Aurélie Waget, Pascale Klopp, Christophe Magnan, Céline Cruciani-Guglielmacci, Shin Jae Lee, Rémy Burcelin, Estelle Grasse. Lixisenatide requires a functional gut-vagus nerve-brain axis to trigger insulin secretion in controls and type 2 diabetic mice. American journal of physiology. Gastrointestinal and liver physiology. vol 315. issue 5. 2019-08-16. PMID:30070580. |
endogenous glucagon-like peptide-1 (glp-1) regulates glucose-induced insulin secretion through both direct β-cell-dependent and indirect gut-brain axis-dependent pathways. |
2019-08-16 |
2023-08-13 |
mouse |
| Julie Charpentier, Aurélie Waget, Pascale Klopp, Christophe Magnan, Céline Cruciani-Guglielmacci, Shin Jae Lee, Rémy Burcelin, Estelle Grasse. Lixisenatide requires a functional gut-vagus nerve-brain axis to trigger insulin secretion in controls and type 2 diabetic mice. American journal of physiology. Gastrointestinal and liver physiology. vol 315. issue 5. 2019-08-16. PMID:30070580. |
we studied the effects of lixisenatide (intraperitoneal injection) on insulin secretion, gastric emptying, vagus nerve activity, and brain c-fos activation in naive, chronically vagotomized, glp-1 receptor knockout (ko), high-fat diet-fed diabetic mice, or db/db mice. |
2019-08-16 |
2023-08-13 |
mouse |
| Julie Charpentier, Aurélie Waget, Pascale Klopp, Christophe Magnan, Céline Cruciani-Guglielmacci, Shin Jae Lee, Rémy Burcelin, Estelle Grasse. Lixisenatide requires a functional gut-vagus nerve-brain axis to trigger insulin secretion in controls and type 2 diabetic mice. American journal of physiology. Gastrointestinal and liver physiology. vol 315. issue 5. 2019-08-16. PMID:30070580. |
altogether, our findings show that lixisenatide requires a functional vagus nerve and neuronal gut-brain-islets axis as well as the glp-1 receptor to regulate glucose-induced insulin secretion in healthy and diabetic mice. |
2019-08-16 |
2023-08-13 |
mouse |
| Julie Charpentier, Aurélie Waget, Pascale Klopp, Christophe Magnan, Céline Cruciani-Guglielmacci, Shin Jae Lee, Rémy Burcelin, Estelle Grasse. Lixisenatide requires a functional gut-vagus nerve-brain axis to trigger insulin secretion in controls and type 2 diabetic mice. American journal of physiology. Gastrointestinal and liver physiology. vol 315. issue 5. 2019-08-16. PMID:30070580. |
here, we demonstrated that lixisenatide activates the vagus nerve and recruits the gut-brain axis through the glp-1 receptor to decrease gastric emptying and stimulate insulin secretion to improve glycemia. |
2019-08-16 |
2023-08-13 |
mouse |
| Nikolaj Nerup, Rikard Ambrus, Joanna Lindhe, Michael P Achiam, Palle B Jeppesen, Lars B Svendse. The effect of glucagon-like peptide-1 and glucagon-like peptide-2 on microcirculation: A systematic review. Microcirculation (New York, N.Y. : 1994). vol 26. issue 3. 2019-08-14. PMID:28266749. |
glp-1 attenuates insulin resistance and glp-2 reduces enterocyte apoptosis and enhances crypt cell proliferation in the small intestine. |
2019-08-14 |
2023-08-13 |
rat |
| Bahadır Öztürk, Ali Sami Gürbüz, Zahide Esra Durak, Hasan Serdar Öztür. Dipeptidyl peptidase-4 and adenosine deaminase enzyme levels in polycystic ovary syndrome. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 35. issue 2. 2019-08-12. PMID:30394149. |
glucagon-like peptide-1 (glp-1), promotes insulin secretion, inhibits glucagon secretion. |
2019-08-12 |
2023-08-13 |
human |
| Philip Hom. Comment on Abd El Aziz et al., A meta-analysis comparing clinical effects of short- or long-acting GLP-1 receptor agonists versus insulin treatment from head-to-head studies in type 2 diabetic patients. Diabetes, obesity & metabolism. vol 19. issue 2. 2019-08-08. PMID:27935230. |
comment on abd el aziz et al., a meta-analysis comparing clinical effects of short- or long-acting glp-1 receptor agonists versus insulin treatment from head-to-head studies in type 2 diabetic patients. |
2019-08-08 |
2023-08-13 |
Not clear |
| Kanwal Rehman, Mehwish Bagh Ali, Muhammad Sajid Hamid Akas. Genistein enhances the secretion of glucagon-like peptide-1 (GLP-1) via downregulation of inflammatory responses. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 112. 2019-08-08. PMID:30784939. |
glucagon-like peptide-1 (glp-1) an incretin hormone, is known to regulate the glucose-mediated insulin secretion. |
2019-08-08 |
2023-08-13 |
rat |
| Kanwal Rehman, Mehwish Bagh Ali, Muhammad Sajid Hamid Akas. Genistein enhances the secretion of glucagon-like peptide-1 (GLP-1) via downregulation of inflammatory responses. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 112. 2019-08-08. PMID:30784939. |
however, reduction in the level of glp-1 is considered to be a major cause for the reduction of glp-1-dependent insulin secretory response. |
2019-08-08 |
2023-08-13 |
rat |
| Yasumasa Ohyagi, Katsue Miyoshi, Norimichi Nakamur. Therapeutic Strategies for Alzheimer's Disease in the View of Diabetes Mellitus. Advances in experimental medicine and biology. vol 1128. 2019-08-07. PMID:31062332. |
various types of antidiabetic drugs such as insulin, thiazolidinediones, dipeptidyl peptidase-4 (dpp4) inhibitors, glucagon-like peptide-1 (glp-1) agonists, biguanides, and others have been reported to be effective on cognitive impairment in animal models and patients with dm or ad. |
2019-08-07 |
2023-08-13 |
mouse |
| Valeria Booz, Charlotte Bayer Christiansen, Rune Ehrenreich Kuhre, Monika Yosifova Saltiel, Giovanna Sociali, Nicola Schaltenberg, Alexander W Fischer, Jörg Heeren, Elena Zocchi, Jens J Holst, Santina Bruzzon. Abscisic acid stimulates the release of insulin and of GLP-1 in the rat perfused pancreas and intestine. Diabetes/metabolism research and reviews. vol 35. issue 2. 2019-08-05. PMID:30468287. |
abscisic acid stimulates the release of insulin and of glp-1 in the rat perfused pancreas and intestine. |
2019-08-05 |
2023-08-13 |
rat |
| Valeria Booz, Charlotte Bayer Christiansen, Rune Ehrenreich Kuhre, Monika Yosifova Saltiel, Giovanna Sociali, Nicola Schaltenberg, Alexander W Fischer, Jörg Heeren, Elena Zocchi, Jens J Holst, Santina Bruzzon. Abscisic acid stimulates the release of insulin and of GLP-1 in the rat perfused pancreas and intestine. Diabetes/metabolism research and reviews. vol 35. issue 2. 2019-08-05. PMID:30468287. |
previous results indicate that nanomolar concentrations of abscisic acid (aba) stimulate insulin release from β-pancreatic cells in vitro and that oral aba at 50 mg/kg increases plasma glp-1 in the fasted rat. |
2019-08-05 |
2023-08-13 |
rat |