| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Leigh Perreault, Helena Rodbard, Virginia Valentine, Eric Johnso. Optimizing Fixed-Ratio Combination Therapy in Type 2 Diabetes. Advances in therapy. vol 36. issue 2. 2020-01-22. PMID:30610613. |
two fixed-ratio combinations (frcs) of basal insulin and a glp-1 ra are now available in the usa and the eu: insulin glargine + lixisenatide (iglarlixi) and insulin degludec + liraglutide (ideglira). |
2020-01-22 |
2023-08-13 |
Not clear |
| David S Mathiesen, Jonatan I Bagger, Natasha C Bergmann, Asger Lund, Mikkel B Christensen, Tina Vilsbøll, Filip K Kno. The Effects of Dual GLP-1/GIP Receptor Agonism on Glucagon Secretion-A Review. International journal of molecular sciences. vol 20. issue 17. 2020-01-22. PMID:31443356. |
the gut-derived incretin hormones glucagon-like peptide 1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are secreted after meal ingestion and work in concert to promote postprandial insulin secretion. |
2020-01-22 |
2023-08-13 |
Not clear |
| A J Scheen, N Paquo. [Which injectable therapy after failure of oral antidiabetic agents in type 2 diabetes ?] Revue medicale de Liege. vol 75. issue 1. 2020-01-15. PMID:31920046. |
schematically, two options may be considered, either starting insulin therapy with a preference for basal insulin analogues, or adding a glucagon-like peptide-1 receptor agonist (glp-1 ra). |
2020-01-15 |
2023-08-13 |
Not clear |
| A J Scheen, N Paquo. [Which injectable therapy after failure of oral antidiabetic agents in type 2 diabetes ?] Revue medicale de Liege. vol 75. issue 1. 2020-01-15. PMID:31920046. |
a combination of the two approaches is also possible, with the recent commercialisation of fixed-ratio specialities combining a basal insulin analogue and a glp-1 ra. |
2020-01-15 |
2023-08-13 |
Not clear |
| Ryota Usui, Daisuke Yabe, Yutaka Sein. Twincretin as a potential therapeutic for the management of type 2 diabetes with obesity. Journal of diabetes investigation. vol 10. issue 4. 2020-01-13. PMID:30637966. |
although glp-1 and gip both enhance insulin secretion and subsequently ameliorate postprandial glucose excursion, most research has focused on glp-1r as a therapeutic target for type 2 diabetes. |
2020-01-13 |
2023-08-13 |
mouse |
| Sue Tsai, Shawn Winer, Daniel A Wine. Gut T Cells Feast on GLP-1 to Modulate Cardiometabolic Disease. Cell metabolism. vol 29. issue 4. 2020-01-13. PMID:30943389. |
glucagon-like peptide-1 (glp-1) is an enteroendocrine hormone that controls insulin secretion, intestinal function, and food intake. |
2020-01-13 |
2023-08-13 |
Not clear |
| David M Irwi. Variation in the rates of evolution of the insulin and glucagon hormone and receptor genes in rodents. Gene. vol 728. 2020-01-09. PMID:31866555. |
here i examined the evolution of the genes encoding insulin (ins) and glucagon (gcg, which also encodes glp-1 and glp-2) and the receptors for these hormones (insr, gcgr, glp1r, and glp2r). |
2020-01-09 |
2023-08-13 |
mouse |
| Ana Babic Perhoc, Jelena Osmanovic Barilar, Ana Knezovic, Vladimir Farkas, Robert Bagaric, Alfred Svarc, Edna Grünblatt, Peter Riederer, Melita Salkovic-Petrisi. Cognitive, behavioral and metabolic effects of oral galactose treatment in the transgenic Tg2576 mice. Neuropharmacology. vol 148. 2019-12-27. PMID:30571958. |
the level of insulin, glucagon-like peptide-1 (glp-1) and soluble amyloid β1-42 (saβ1-42) was measured by elisa and the protein expression of insulin receptor (ir), glycogen synthase kinase-3β (gsk-3β), and pre-/post-synaptic markers by western blot analysis. |
2019-12-27 |
2023-08-13 |
mouse |
| Ana Babic Perhoc, Jelena Osmanovic Barilar, Ana Knezovic, Vladimir Farkas, Robert Bagaric, Alfred Svarc, Edna Grünblatt, Peter Riederer, Melita Salkovic-Petrisi. Cognitive, behavioral and metabolic effects of oral galactose treatment in the transgenic Tg2576 mice. Neuropharmacology. vol 148. 2019-12-27. PMID:30571958. |
improvement of reduced grooming behavior and normalization in reduced plasma insulin levels were seen only in 5m+2m tg2576 mice while in 10m+2m tg2576 mice oral galactose induced metabolic exacerbation at the level of plasma insulin, glp-1 homeostasis and glucose intolerance, and additionally increased hippocampal saβ1-42 level, decreased ir expression and increased gsk-3β activity. |
2019-12-27 |
2023-08-13 |
mouse |
| Cong Tang, Iwona Ksiazek, Noemie Siccardi, Berangere Gapp, Delphine Weber, Johann Wirsching, Valerie Beck, Matthias Reist, Laurent Gaudet, Nathalie Stuber, Sabrina Silvia Surber, Xiaohong Mao, Thomas B Nicholson, Walter Carbone, Martin Beibel, Guglielmo Roma, Caroline Gubser Keller, Frederic Bassilan. UTS2B Defines a Novel Enteroendocrine Cell Population and Regulates GLP-1 Secretion Through SSTR5 in Male Mice. Endocrinology. vol 160. issue 12. 2019-12-23. PMID:31556942. |
furthermore, administration of uts2b to starved mice demonstrates that it is capable of regulating blood glucose and plasma concentrations of glp-1 and insulin in vivo. |
2019-12-23 |
2023-08-13 |
mouse |
| Martin Hagve, Petter F Gjessing, Mikal J Hole, Kirsten M Jansen, Ole Martin Fuskevåg, Tom Eirik Mollnes, Terje S Larsen, Øivind Irtu. Perioperative Infusion of Glucagon-Like Peptide-1 Prevents Insulin Resistance After Surgical Trauma in Female Pigs. Endocrinology. vol 160. issue 12. 2019-12-23. PMID:31589305. |
the incretin hormone glucagon-like peptide-1 (glp-1) potentiates glucose-induced insulin release from the pancreas but may also increase insulin sensitivity in skeletal muscle and directly suppress hepatic glucose release. |
2019-12-23 |
2023-08-13 |
Not clear |
| Martin Hagve, Petter F Gjessing, Mikal J Hole, Kirsten M Jansen, Ole Martin Fuskevåg, Tom Eirik Mollnes, Terje S Larsen, Øivind Irtu. Perioperative Infusion of Glucagon-Like Peptide-1 Prevents Insulin Resistance After Surgical Trauma in Female Pigs. Endocrinology. vol 160. issue 12. 2019-12-23. PMID:31589305. |
here, we investigated whether a perioperative infusion of glp-1 could counteract the development of insulin resistance after surgery. |
2019-12-23 |
2023-08-13 |
Not clear |
| Martin Hagve, Petter F Gjessing, Mikal J Hole, Kirsten M Jansen, Ole Martin Fuskevåg, Tom Eirik Mollnes, Terje S Larsen, Øivind Irtu. Perioperative Infusion of Glucagon-Like Peptide-1 Prevents Insulin Resistance After Surgical Trauma in Female Pigs. Endocrinology. vol 160. issue 12. 2019-12-23. PMID:31589305. |
hepatic insulin sensitivity (i.e., egr) remained unchanged in the surgery/control group but was enhanced after glp-1 infusion in both surgery and sham animals (40% and 104%, respectively, both p < 0.05). |
2019-12-23 |
2023-08-13 |
Not clear |
| Martin Hagve, Petter F Gjessing, Mikal J Hole, Kirsten M Jansen, Ole Martin Fuskevåg, Tom Eirik Mollnes, Terje S Larsen, Øivind Irtu. Perioperative Infusion of Glucagon-Like Peptide-1 Prevents Insulin Resistance After Surgical Trauma in Female Pigs. Endocrinology. vol 160. issue 12. 2019-12-23. PMID:31589305. |
glp-1 diminished an increase in postoperative glucagon levels but did not affect skeletal muscle glycogen or insulin signaling proteins after surgery. |
2019-12-23 |
2023-08-13 |
Not clear |
| Martin Hagve, Petter F Gjessing, Mikal J Hole, Kirsten M Jansen, Ole Martin Fuskevåg, Tom Eirik Mollnes, Terje S Larsen, Øivind Irtu. Perioperative Infusion of Glucagon-Like Peptide-1 Prevents Insulin Resistance After Surgical Trauma in Female Pigs. Endocrinology. vol 160. issue 12. 2019-12-23. PMID:31589305. |
we show that glp-1 improves intraoperative glycemic control, diminishes peripheral insulin resistance after surgery, and suppresses egr. |
2019-12-23 |
2023-08-13 |
Not clear |
| Martin Hagve, Petter F Gjessing, Mikal J Hole, Kirsten M Jansen, Ole Martin Fuskevåg, Tom Eirik Mollnes, Terje S Larsen, Øivind Irtu. Perioperative Infusion of Glucagon-Like Peptide-1 Prevents Insulin Resistance After Surgical Trauma in Female Pigs. Endocrinology. vol 160. issue 12. 2019-12-23. PMID:31589305. |
this study supports the use of glp-1 to prevent development of postoperative insulin resistance. |
2019-12-23 |
2023-08-13 |
Not clear |
| Bryan Cruz, Rodolfo J Flores, Kevin P Uribe, Evangelina J Espinoza, Charles T Spencer, Katherine M Serafine, Arbi Nazarian, Laura E O'Del. Insulin modulates the strong reinforcing effects of nicotine and changes in insulin biomarkers in a rodent model of diabetes. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 6. 2019-12-20. PMID:30647447. |
after the last session, plasma levels of insulin, leptin, amylin, and glucagon-like peptide-1 (glp-1) were assessed using luminex |
2019-12-20 |
2023-08-13 |
rat |
| Jie Wu, Tianmin He, Pingfan Guo, Fanggang Cai, Chengfei Zha. An Electrochemical Sense Array Based on Aptamer and Biotin-Avidin System for the Selective Detection of Glucagon-Like Peptide-1. Clinical laboratory. vol 65. issue 6. 2019-12-16. PMID:31232038. |
glp-1 as an incretin, has the ability to decrease blood sugar levels in a glucose-dependent manner by enhancing the secretion of insulin. |
2019-12-16 |
2023-08-13 |
Not clear |
| Kalyani Sridharan, Raja Kalayarasan, Sadishkumar Kamalanathan, Jayaprakash Sahoo, Sitanshu Sekhar Kar, Lakshmana Perumal Nandhini, Rajan Palui, Harsh Durgi. Change in insulin resistance, beta cell function, glucagon-like peptide-1 and calcitonin levels two weeks after bariatric surgery. Diabetes & metabolic syndrome. vol 13. issue 3. 2019-12-13. PMID:31235148. |
the objectives of the study were to measure the change in insulin resistance, beta cell function, glp-1 and calcitonin levels before and 2 weeks after bariatric surgery. |
2019-12-13 |
2023-08-13 |
Not clear |
| Berit Svendsen, Olav Larsen, Maria Buur Nordskov Gabe, Charlotte Bayer Christiansen, Mette M Rosenkilde, Daniel J Drucker, Jens Juul Hols. Insulin Secretion Depends on Intra-islet Glucagon Signaling. Cell reports. vol 25. issue 5. 2019-12-10. PMID:30380405. |
we examined glucagon-induced insulin secretion using isolated perfused pancreata from wild-type, glp-1 receptor (glp-1r) knockout, diphtheria toxin-induced proglucagon knockdown, β cell-specific glucagon receptor (gcgr) knockout, and global gcgr knockout (gcgr |
2019-12-10 |
2023-08-13 |
mouse |