| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dohoon Kim, Brian P Fiske, Kivanc Birsoy, Elizaveta Freinkman, Kenjiro Kami, Richard L Possemato, Yakov Chudnovsky, Michael E Pacold, Walter W Chen, Jason R Cantor, Laura M Shelton, Dan Y Gui, Manjae Kwon, Shakti H Ramkissoon, Keith L Ligon, Seong Woo Kang, Matija Snuderl, Matthew G Vander Heiden, David M Sabatin. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. vol 520. issue 7547. 2015-09-30. PMID:25855294. |
gldc inhibition impairs cells with high shmt2 levels as the excess glycine not metabolized by gldc can be converted to the toxic molecules aminoacetone and methylglyoxal. |
2015-09-30 |
2023-08-13 |
human |
| Nor Azimah Abdul Azize, Wan Zurinah Wan Ngah, Zulhabri Othman, Norsiah Md Desa, Chen Bee Chin, Zabedah Md Yunus, Anand Mohan, Teh Siao Hean, Syed Zulkifli Syed Zakaria, Ngu Lock-Hoc. Mutation analysis of glycine decarboxylase, aminomethyltransferase and glycine cleavage system protein-H genes in 13 unrelated families with glycine encephalopathy. Journal of human genetics. vol 59. issue 11. 2015-08-28. PMID:25231368. |
glycine encephalopathy (gce) or nonketotic hyperglycinemia is an inborn error of glycine metabolism, inherited in an autosomal recessive manner due to a defect in any one of the four enzymes aminomethyltransferase (amt), glycine decarboxylase (gldc), glycine cleavage system protein-h (gcsh) and dehydrolipoamide dehydrogenase in the glycine cleavage system. |
2015-08-28 |
2023-08-13 |
Not clear |
| Fatih Ezgu, Bahattin Çiftci, Burcu Topçu, Gülcan Adıyaman, Hatice Gökmenoğlu, Aynur Küçükçongar, Çiğdem Kasapkara, Gürsel Biberoğlu, Leyla Tümer, Alev Hasanoğl. Diagnosis of glycine encephalopathy in a pediatric patient by detection of a GLDC mutation during initial next generation DNA sequencing. Metabolic brain disease. vol 29. issue 1. 2015-06-02. PMID:24407464. |
diagnosis of glycine encephalopathy in a pediatric patient by detection of a gldc mutation during initial next generation dna sequencing. |
2015-06-02 |
2023-08-12 |
Not clear |
| Fatih Ezgu, Bahattin Çiftci, Burcu Topçu, Gülcan Adıyaman, Hatice Gökmenoğlu, Aynur Küçükçongar, Çiğdem Kasapkara, Gürsel Biberoğlu, Leyla Tümer, Alev Hasanoğl. Diagnosis of glycine encephalopathy in a pediatric patient by detection of a GLDC mutation during initial next generation DNA sequencing. Metabolic brain disease. vol 29. issue 1. 2015-06-02. PMID:24407464. |
the patient was found to have glycine encephalopathy resulting from a previously defined mutation in the gldc gene. |
2015-06-02 |
2023-08-12 |
Not clear |
| J E Kwon, D H Kim, W-H Jung, J S Ko. Expression of serine and glycine-related enzymes in phyllodes tumor. Neoplasma. vol 61. issue 5. 2015-06-01. PMID:25030440. |
tissue microarrays were prepared from 203 phyllodes tumors (pt) and stained with antibodies specific for glycine decarboxylase (gldc), phosphoserine aminotransferase 1 (psat1), phosphoserine phosphatase (psph), phosphoglycerate dehydrogenase (phgdh), and serine hydroxymethyltransferase 1 (shmt1). |
2015-06-01 |
2023-08-13 |
Not clear |
| Jennifer M Love, Debra Prosser, Donald R Love, Krishna Prakash Chintakindi, Ashwin B Dalal, Shagun Aggarwa. A novel glycine decarboxylase gene mutation in an Indian family with nonketotic hyperglycinemia. Journal of child neurology. vol 29. issue 1. 2014-08-29. PMID:23349517. |
here we report a novel mutation, c.2296g>t (p.gly766cys), in exon 19 of the glycine decarboxylase (gldc) gene (refseq accession number nm_000170.2) in a consanguineous indian couple with a history of 4 neonatal deaths. |
2014-08-29 |
2023-08-12 |
Not clear |
| Sangam Kanekar, Debra Byle. Characteristic MRI findings in neonatal nonketotic hyperglycinemia due to sequence changes in GLDC gene encoding the enzyme glycine decarboxylase. Metabolic brain disease. vol 28. issue 4. 2014-06-20. PMID:23712728. |
characteristic mri findings in neonatal nonketotic hyperglycinemia due to sequence changes in gldc gene encoding the enzyme glycine decarboxylase. |
2014-06-20 |
2023-08-12 |
Not clear |
| Yuri Jung, Ye Jin Jang, Min Ho Kang, Young Soo Park, Su Jin Oh, Dong Chul Lee, Zhi Xie, Hyang-Sook Yoo, Kyung Chan Park, Young Il Yeo. Metabolic signature genes associated with susceptibility to pyruvate kinase, muscle type 2 gene ablation in cancer cells. Molecules and cells. vol 35. issue 4. 2014-05-22. PMID:23515579. |
pkm2 knockdown-resistant cells expressed high levels of the lactate dehydrogenase b (ldhb) and glycine decarboxylase (gldc) genes. |
2014-05-22 |
2023-08-12 |
Not clear |
| Peter R Baker, Marisa W Friederich, Michael A Swanson, Tamim Shaikh, Kaustuv Bhattacharya, Gunter H Scharer, Joseph Aicher, Geralyn Creadon-Swindell, Elizabeth Geiger, Kenneth N MacLean, Wang-Tso Lee, Charu Deshpande, Mary-Louise Freckmann, Ling-Yu Shih, Melissa Wasserstein, Malene B Rasmussen, Allan M Lund, Peter Procopis, Jessie M Cameron, Brian H Robinson, Garry K Brown, Ruth M Brown, Alison G Compton, Carol L Dieckmann, Renata Collard, Curtis R Coughlin, Elaine Spector, Michael F Wempe, Johan L K Van Hov. Variant non ketotic hyperglycinemia is caused by mutations in LIAS, BOLA3 and the novel gene GLRX5. Brain : a journal of neurology. vol 137. issue Pt 2. 2014-04-11. PMID:24334290. |
patients with nonketotic hyperglycinemia and deficient glycine cleavage enzyme activity, but without mutations in amt, gldc or gcsh, the genes encoding its constituent proteins, constitute a clinical group which we call 'variant nonketotic hyperglycinemia'. |
2014-04-11 |
2023-08-12 |
Not clear |
| Maybelle Kho Go, Wen Cai Zhang, Bing Lim, Wen Shan Ye. Glycine decarboxylase is an unusual amino acid decarboxylase involved in tumorigenesis. Biochemistry. vol 53. issue 5. 2014-04-09. PMID:24467211. |
glycine decarboxylase (gldc) is a metabolic oncogene that links glycine metabolism with tumorigenesis. |
2014-04-09 |
2023-08-12 |
Not clear |
| Maybelle Kho Go, Wen Cai Zhang, Bing Lim, Wen Shan Ye. Glycine decarboxylase is an unusual amino acid decarboxylase involved in tumorigenesis. Biochemistry. vol 53. issue 5. 2014-04-09. PMID:24467211. |
in humans, gldc is part of a multienzyme complex (which includes the lipoyl-containing h-protein) that couples the decarboxylation of glycine to the biosynthesis of serine. |
2014-04-09 |
2023-08-12 |
Not clear |
| Maybelle Kho Go, Wen Cai Zhang, Bing Lim, Wen Shan Ye. Glycine decarboxylase is an unusual amino acid decarboxylase involved in tumorigenesis. Biochemistry. vol 53. issue 5. 2014-04-09. PMID:24467211. |
this is the first report on the mechanism of the gldc-catalyzed reaction and shows that gldc is an unusual plp-containing α-amino acid decarboxylase that removes carbon dioxide from the glycine substrate without releasing the expected amine (methylamine, a metabolic precursor of toxic formaldehyde) as a product. |
2014-04-09 |
2023-08-12 |
Not clear |
| Wen Cai Zhang, Ng Shyh-Chang, He Yang, Amit Rai, Shivshankar Umashankar, Siming Ma, Boon Seng Soh, Li Li Sun, Bee Choo Tai, Min En Nga, Kishore Kumar Bhakoo, Senthil Raja Jayapal, Massimo Nichane, Qiang Yu, Dokeu A Ahmed, Christie Tan, Wong Poo Sing, John Tam, Agasthian Thirugananam, Monireh Soroush Noghabi, Yin Huei Pang, Haw Siang Ang, Wayne Mitchell, Paul Robson, Philipp Kaldis, Ross Andrew Soo, Sanjay Swarup, Elaine Hsuen Lim, Bing Li. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell. vol 148. issue 1-2. 2012-03-16. PMID:22225612. |
here we show that the metabolic enzyme glycine decarboxylase (gldc) is critical for tics in non-small cell lung cancer (nsclc). |
2012-03-16 |
2023-08-12 |
Not clear |
| Shigeo Kur. Two novel laboratory tests facilitating diagnosis of glycine encephalopathy (nonketotic hyperglycinemia). Brain & development. vol 33. issue 9. 2011-12-27. PMID:21470805. |
we herein describe two novel laboratory tests for diagnosis of ge, [1-(13)c]glycine breath test and the multiplex ligation-dependent probe amplification (mlpa) for detection of large deletions in gldc. |
2011-12-27 |
2023-08-12 |
Not clear |
| Catherine Brunel-Guitton, Brett Casey, Marion Coulter-Mackie, Hilary Vallance, Deborah Hewes, Sylvia Stockler-Ipsiroglu, Saadet Mercimek-Mahmutogl. Late-onset nonketotic hyperglycinemia caused by a novel homozygous missense mutation in the GLDC gene. Molecular genetics and metabolism. vol 103. issue 2. 2011-09-23. PMID:21411353. |
a 9-year-old boy with learning disability and intermittent choreoathetosis during febrile illnesses had elevated plasma glycine level and csf/plasma glycine ratio (0.044) and a novel homozygous missense mutation (c.605c>t; p.ala202val) in the gldc gene, confirming the diagnosis of nkh. |
2011-09-23 |
2023-08-12 |
Not clear |
| Sascha Meyer, Cécile Acquaviva, Mohammed Ghiath Shamdeen, Dorothea Haas, Christine Vianey-Saba. A novel missense mutation in a neonate with nonketotic hyperglycinemia. Pediatric neurology. vol 43. issue 5. 2011-02-10. PMID:20933183. |
the diagnosis of nonketotic hyperglycinemia was made biochemically and was confirmed by genetic studies, which revealed two missense mutations (one not previously described) within the glycine decarboxylase gene, gldc. |
2011-02-10 |
2023-08-12 |
Not clear |
| Y Ji, S Hebbring, H Zhu, G D Jenkins, J Biernacka, K Snyder, M Drews, O Fiehn, Z Zeng, D Schaid, D A Mrazek, R Kaddurah-Daouk, R M Weinshilbou. Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics. Clinical pharmacology and therapeutics. vol 89. issue 1. 2011-01-20. PMID:21107318. |
glycine and a glycine dehydrogenase (gldc) snp as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics. |
2011-01-20 |
2023-08-12 |
Not clear |
| Y Ji, S Hebbring, H Zhu, G D Jenkins, J Biernacka, K Snyder, M Drews, O Fiehn, Z Zeng, D Schaid, D A Mrazek, R Kaddurah-Daouk, R M Weinshilbou. Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics. Clinical pharmacology and therapeutics. vol 89. issue 1. 2011-01-20. PMID:21107318. |
the rs10975641 snp in the glycine dehydrogenase (gldc) gene was associated with treatment outcome phenotypes. |
2011-01-20 |
2023-08-12 |
Not clear |
| Ali Hellani, Aref Sammour, Lars Johansson, Abdulssamad El-Sheik. Delivery of a normal baby after preimplantation genetic diagnosis for non-ketotic hyperglycinaemia. Reproductive biomedicine online. vol 16. issue 6. 2008-08-21. PMID:18549703. |
up to 80% of nkh cases are caused by mutations in the p protein encoded by the glycine decarboxylase (gldc) gene. |
2008-08-21 |
2023-08-12 |
Not clear |
| Junko Kanno, Tim Hutchin, Fumiaki Kamada, Ayumi Narisawa, Yoko Aoki, Yoichi Matsubara, Shigeo Kur. Genomic deletion within GLDC is a major cause of non-ketotic hyperglycinaemia. Journal of medical genetics. vol 44. issue 3. 2007-04-12. PMID:17361008. |
nkh is caused by deficiency of the glycine cleavage multienzyme system with three specific components encoded by gldc, amt and gcsh. |
2007-04-12 |
2023-08-12 |
Not clear |