| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chen Xu, Qingfeng Xu, Haibing Yan. H3K27 Acetylation-Activated GLDC Accelerated the Advancement of Oral Squamous Cell Carcinoma by Suppressing the p53 Signaling Pathway. Environmental toxicology. 2024-10-17. PMID:39415627. |
glycine decarboxylase (gldc) has been identified to be dysregulated and plays pivotal roles in various cancers. |
2024-10-17 |
2024-10-19 |
Not clear |
| Maltesh Kambali, Yan Li, Petr Unichenko, Jessica A Feria Pliego, Rachita Yadav, Jing Liu, Patrick McGuinness, Johanna G Cobb, Muxiao Wang, Rajasekar Nagarajan, Jinrui Lyu, Vanessa Vongsouthi, Colin J Jackson, Elif Engin, Joseph T Coyle, Jaeweon Shin, Nathaniel W Hodgson, Takao K Hensch, Michael E Talkowski, Gregg E Homanics, Vadim Y Bolshakov, Christian Henneberger, Uwe Rudolp. An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function. Molecular psychiatry. 2024-08-30. PMID:39210012. |
using a chromosome-engineered allelic series in mice, we report that a triplication of the gene encoding the glycine-catabolizing enzyme glycine decarboxylase (gldc) - as found on a small supernumerary marker chromosome in patients with psychosis - reduces extracellular glycine levels as determined by optical fluorescence resonance energy transfer (fret) in dentate gyrus (dg) and suppresses long-term potentiation (ltp) in mpp-dg synapses but not in ca3-ca1 synapses, reduces the activity of biochemical pathways implicated in schizophrenia and mitochondrial bioenergetics, and displays deficits in schizophrenia-like behaviors which are in part known to be dependent on the activity of the dentate gyrus, e.g., prepulse inhibition, startle habituation, latent inhibition, working memory, sociability and social preference. |
2024-08-30 |
2024-09-04 |
mouse |
| Maltesh Kambali, Yan Li, Petr Unichenko, Jessica A Feria Pliego, Rachita Yadav, Jing Liu, Patrick McGuinness, Johanna G Cobb, Muxiao Wang, Rajasekar Nagarajan, Jinrui Lyu, Vanessa Vongsouthi, Colin J Jackson, Elif Engin, Joseph T Coyle, Jaeweon Shin, Nathaniel W Hodgson, Takao K Hensch, Michael E Talkowski, Gregg E Homanics, Vadim Y Bolshakov, Christian Henneberger, Uwe Rudolp. An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function. Molecular psychiatry. 2024-08-30. PMID:39210012. |
an increased copy number of glycine decarboxylase (gldc) associated with psychosis reduces extracellular glycine and impairs nmda receptor function. |
2024-08-30 |
2024-09-04 |
mouse |
| Kit-Yi Leung, Chloe Santos, Sandra C P De Castro, Diana Gold Diaz, Andrew J Copp, Simon Waddington, Nicholas D E Green. AAV-mediated expression of mouse or human GLDC normalises metabolic biomarkers in a GLDC-deficient mouse model of Non-Ketotic Hyperglycinemia. Molecular genetics and metabolism. vol 142. issue 3. 2024-05-18. PMID:38761651. |
nkh is an autosomal recessive condition and the majority of affected individuals carry mutations in gldc (glycine decarboxylase). |
2024-05-18 |
2024-05-27 |
mouse |
| Jun Zhang, Cheng Luo, Haiying Lon. Sirtuin 5 regulates acute myeloid leukemia cell viability and apoptosis by succinylation modification of glycine decarboxylase. Open life sciences. vol 19. issue 1. 2024-04-08. PMID:38585637. |
the interaction between sirt5 and glycine decarboxylase (gldc) was determined by co-immunoprecipitation and immunofluorescence staining techniques. |
2024-04-08 |
2024-04-10 |
human |
| Ming-Kun Chen, Zhuo-Yu Xiao, Zhi-Peng Huang, Kang-Yi Xue, Hui Xia, Jia-Wei Zhou, De-Ying Liao, Zhi-Jian Liang, Xiao Xie, Qing-Zhu Wei, Lin Zhong, Jian-Kun Yang, Cun-Dong Liu, Yang Liu, Shan-Chao Zha. Glycine Decarboxylase (GLDC) Plays a Crucial Role in Regulating Energy Metabolism, Invasion, Metastasis and Immune Escape for Prostate Cancer. International journal of biological sciences. vol 19. issue 15. 2023-10-02. PMID:37781511. |
glycine decarboxylase (gldc) plays a crucial role in regulating energy metabolism, invasion, metastasis and immune escape for prostate cancer. |
2023-10-02 |
2023-10-07 |
Not clear |
| Ming-Kun Chen, Zhuo-Yu Xiao, Zhi-Peng Huang, Kang-Yi Xue, Hui Xia, Jia-Wei Zhou, De-Ying Liao, Zhi-Jian Liang, Xiao Xie, Qing-Zhu Wei, Lin Zhong, Jian-Kun Yang, Cun-Dong Liu, Yang Liu, Shan-Chao Zha. Glycine Decarboxylase (GLDC) Plays a Crucial Role in Regulating Energy Metabolism, Invasion, Metastasis and Immune Escape for Prostate Cancer. International journal of biological sciences. vol 19. issue 15. 2023-10-02. PMID:37781511. |
glycine decarboxylase (gldc) is one of the core enzymes for glycine metabolism |
2023-10-02 |
2023-10-07 |
Not clear |
| Hao Yu, Xueqing Hu, Yingru Zhang, Jiajia Wang, Zhongya Ni, Yan Wang, Huirong Zh. GLDC promotes colorectal cancer metastasis through epithelial-mesenchymal transition mediated by Hippo signaling pathway. Medical oncology (Northwood, London, England). vol 40. issue 10. 2023-09-05. PMID:37668829. |
recently, abnormal expression of glycine decarboxylase (gldc) has been demonstrated in tumor progression, and gldc is up-regulated in cancers, such as lung, prostate, bladder, and cervical cancers. |
2023-09-05 |
2023-09-07 |
Not clear |
| Douglas Fraser-Pitt, Derry K Mercer, Marie-Louise Francis, David Toledo-Aparicio, Daniel W Smith, Deborah A O'Nei. Cysteamine-mediated blockade of the glycine cleavage system modulates epithelial cell inflammatory and innate immune responses to viral infection. Biochemical and biophysical research communications. vol 677. 2023-08-19. PMID:37597441. |
transient blockade of glycine decarboxylase (gldc) can restrict de novo pyrimidine synthesis, which is a well-described strategy for enhancing the host interferon response to viral infection and a target pathway for some licenced anti-inflammatory therapies. |
2023-08-19 |
2023-09-07 |
human |
| Douglas Fraser-Pitt, Derry K Mercer, Marie-Louise Francis, David Toledo-Aparicio, Daniel W Smith, Deborah A O'Nei. Cysteamine-mediated blockade of the glycine cleavage system modulates epithelial cell inflammatory and innate immune responses to viral infection. Biochemical and biophysical research communications. vol 677. 2023-08-19. PMID:37597441. |
cysteamine is known to inhibit both bacterial and the eukaryotic host glycine cleavage systems via competitive inhibition of gldc at concentrations, lower than those required for direct antimicrobial or antiviral activity. |
2023-08-19 |
2023-09-07 |
human |
| Maltesh Kambali, Yan Li, Petr Unichenko, Jessica Feria Pliego, Rachita Yadav, Jing Liu, Patrick McGuinness, Johanna G Cobb, Muxiao Wang, Rajasekar Nagarajan, Jinrui Lyu, Vanessa Vongsouthi, Colin J Jackson, Elif Engin, Joseph T Coyle, Jeaweon Shin, Michael E Talkowski, Gregg E Homanics, Vadim Y Bolshakov, Christian Henneberger, Uwe Rudolp. A marker chromosome in psychosis identifies glycine decarboxylase (GLDC) as a novel regulator of neuronal and synaptic function in the hippocampus. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398055. |
a marker chromosome in psychosis identifies glycine decarboxylase (gldc) as a novel regulator of neuronal and synaptic function in the hippocampus. |
2023-07-03 |
2023-08-14 |
Not clear |
| Li-Li Miao, Jing-Wen Wang, Hui-Hui Liu, Shuai Gao, Yu-Chen Fan, Kai Wan. Hypomethylation of glycine dehydrogenase promoter in peripheral blood mononuclear cells is a new diagnostic marker of hepatitis B virus-associated hepatocellular carcinoma. Hepatobiliary & pancreatic diseases international : HBPD INT. 2023-03-06. PMID:36878837. |
glycine dehydrogenase (gldc) plays an important role in the initiation and proliferation of several human cancers. |
2023-03-06 |
2023-08-14 |
human |
| Ye Da Chen, Ke Xin Gao, Zhu Wang, Qiong Deng, Yu Ting Chen, Hui Lian. Glycine Decarboxylase Suppresses the Renal Cell Carcinoma Growth and Regulates Its Gene Expressions and Functions. World journal of oncology. vol 13. issue 6. 2023-01-20. PMID:36660213. |
glycine decarboxylase (gldc), a key metabolic enzyme, participates in the regulation of the glycine metabolic pathway. |
2023-01-20 |
2023-08-14 |
Not clear |
| Nicole Weaver, Rebecca Winger. Delineating the role of gldcin nephron patterning during kidney development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557131. |
elevated glycine levels due to congenital mutations in gcs components, such as glycine dehydrogenase (gldc), cause devastating human birth defects and the rare disease nonketotic hyperglycinemia (nkh). |
2022-05-13 |
2023-08-13 |
mouse |
| Sergey A Krupenko, Shelley A Cole, Ruixue Hou, Karin Haack, Sandra Laston, Nitesh R Mehta, Anthony G Comuzzie, Nancy F Butte, V Saroja Vorugant. Genetic variants in ALDH1L1 and GLDC influence serine to glycine ratio in Hispanic children. The American journal of clinical nutrition. 2022-04-23. PMID:35460232. |
genetic variants in aldh1l1 and gldc influence serine to glycine ratio in hispanic children. |
2022-04-23 |
2023-08-13 |
mouse |
| Ruta Jog, Guohua Chen, Jian Wang, Todd Lef. Hormonal regulation of glycine decarboxylase and its relationship to oxidative stress. Physiological reports. vol 9. issue 15. 2021-11-18. PMID:34342168. |
the glycine cleavage system and its rate-limiting enzyme, glycine decarboxylase (gldc), is a major determinant of plasma glycine levels. |
2021-11-18 |
2023-08-13 |
mouse |
| Ruta Jog, Guohua Chen, Jian Wang, Todd Lef. Hormonal regulation of glycine decarboxylase and its relationship to oxidative stress. Physiological reports. vol 9. issue 15. 2021-11-18. PMID:34342168. |
the goals of this study were to determine if the increased expression of gldc contributes to the reduced plasma glycine levels seen in disease states, to characterize the hormonal regulation of gldc gene expression, and to determine if altered gldc expression has physiological effects that might affect the development of diabetes. |
2021-11-18 |
2023-08-13 |
mouse |
| Ruta Jog, Guohua Chen, Jian Wang, Todd Lef. Hormonal regulation of glycine decarboxylase and its relationship to oxidative stress. Physiological reports. vol 9. issue 15. 2021-11-18. PMID:34342168. |
these findings suggest that the hormonal regulation of gldc contributes not only to the changes in circulating glycine levels seen in metabolic disease, but also affects glutathione production, possibly as a defense against metabolic disease-associated oxidative stress. |
2021-11-18 |
2023-08-13 |
mouse |
| Kit-Yi Leung, Sandra C P De Castro, Chloe Santos, Dawn Savery, Helen Prunty, Diana Gold-Diaz, Stuart Bennett, Simon Heales, Andrew J Copp, Nicholas D E Green. Regulation of glycine metabolism by the glycine cleavage system and conjugation pathway in mouse models of non-ketotic hyperglycinemia. Journal of inherited metabolic disease. vol 43. issue 6. 2021-10-07. PMID:32743799. |
mutation of the gcs component glycine decarboxylase (gldc) in non-ketotic hyperglycinemia (nkh) causes accumulation of glycine in body fluids, but there is a gap in our knowledge regarding the effects on glycine metabolism in tissues. |
2021-10-07 |
2023-08-13 |
mouse |
| Kit-Yi Leung, Sandra C P De Castro, Chloe Santos, Dawn Savery, Helen Prunty, Diana Gold-Diaz, Stuart Bennett, Simon Heales, Andrew J Copp, Nicholas D E Green. Regulation of glycine metabolism by the glycine cleavage system and conjugation pathway in mouse models of non-ketotic hyperglycinemia. Journal of inherited metabolic disease. vol 43. issue 6. 2021-10-07. PMID:32743799. |
here, we analysed mice carrying mutations in gldc that result in severe or mild elevations of plasma glycine and model nkh. |
2021-10-07 |
2023-08-13 |
mouse |