| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kit-Yi Leung, Sandra C P De Castro, Chloe Santos, Dawn Savery, Helen Prunty, Diana Gold-Diaz, Stuart Bennett, Simon Heales, Andrew J Copp, Nicholas D E Green. Regulation of glycine metabolism by the glycine cleavage system and conjugation pathway in mouse models of non-ketotic hyperglycinemia. Journal of inherited metabolic disease. vol 43. issue 6. 2021-10-07. PMID:32743799. |
elevation of brain tissue glycine occurred even in the presence of only mildly elevated plasma glycine in mice carrying a missense allele of gldc. |
2021-10-07 |
2023-08-13 |
mouse |
| Pegah Abdollahi, Esten N Vandsemb, Samah Elsaadi, Lisa M Røst, Rui Yang, Magnus A Hjort, Trygve Andreassen, Kristine Misund, Tobias S Slørdahl, Torstein B Rø, Anne-Marit Sponaas, Siver Moestue, Per Bruheim, Magne Børse. Phosphatase of regenerating liver-3 regulates cancer cell metabolism in multiple myeloma. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 3. 2021-07-26. PMID:33566385. |
glycine decarboxylase (gldc) was the most significantly induced metabolism gene. |
2021-07-26 |
2023-08-13 |
Not clear |
| Rui Liu, Lin-Wen Zeng, Rong Gong, Fanen Yuan, Hong-Bing Shu, Shu L. mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis. Nature communications. vol 12. issue 1. 2021-07-20. PMID:34244482. |
glycine decarboxylase (gldc) is a key enzyme of glycine cleavage system that converts glycine into one-carbon units. |
2021-07-20 |
2023-08-13 |
human |
| Rui Liu, Lin-Wen Zeng, Rong Gong, Fanen Yuan, Hong-Bing Shu, Shu L. mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis. Nature communications. vol 12. issue 1. 2021-07-20. PMID:34244482. |
finally, we find that gldc k514 acetylation inhibits glycine catabolism, pyrimidines synthesis and glioma tumorigenesis. |
2021-07-20 |
2023-08-13 |
human |
| Rui Liu, Lin-Wen Zeng, Rong Gong, Fanen Yuan, Hong-Bing Shu, Shu L. mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis. Nature communications. vol 12. issue 1. 2021-07-20. PMID:34244482. |
our finding reveals critical roles of post-translational modifications of gldc in regulation of its enzymatic activity, glycine metabolism and tumorigenesis, and provides potential targets for therapeutics of cancers such as glioma. |
2021-07-20 |
2023-08-13 |
human |
| Rebecca M Simmons, Sorin M McKnight, Ashley K Edwards, Guoyao Wu, Michael C Satterfiel. Obesity increases hepatic glycine dehydrogenase and aminomethyltransferase expression while dietary glycine supplementation reduces white adipose tissue in Zucker diabetic fatty rats. Amino acids. vol 52. issue 10. 2021-07-19. PMID:33057941. |
both mrna and protein expression of aminomethyltransferase (amt) and glycine dehydrogenase, decarboxylating (gldc) were increased in the livers of obese versus lean rats (p < 0.05). |
2021-07-19 |
2023-08-13 |
human |
| Joseph Farris, Md Suhail Alam, Arpitha Mysore Rajashekara, Kasturi Halda. Genomic analyses of glycine decarboxylase neurogenic mutations yield a large-scale prediction model for prenatal disease. PLoS genetics. vol 17. issue 2. 2021-06-24. PMID:33524012. |
defect in glycine decarboxylase (gldc) causes non-ketotic hyperglycinemia (nkh), a neurological disease associated with elevation of plasma glycine. |
2021-06-24 |
2023-08-13 |
mouse |
| Chloe Santos, Yun Jin Pai, M Raasib Mahmood, Kit-Yi Leung, Dawn Savery, Simon N Waddington, Andrew J Copp, Nicholas DE Green. Impaired folate 1-carbon metabolism causes formate-preventable hydrocephalus in glycine decarboxylase-deficient mice. The Journal of clinical investigation. vol 130. issue 3. 2020-11-03. PMID:31794432. |
ventriculomegaly and hydrocephalus are associated with loss of function of glycine decarboxylase (gldc) in mice and in humans suffering from non-ketotic hyperglycinemia (nkh), a neurometabolic disorder characterized by accumulation of excess glycine. |
2020-11-03 |
2023-08-13 |
mouse |
| Chloe Santos, Yun Jin Pai, M Raasib Mahmood, Kit-Yi Leung, Dawn Savery, Simon N Waddington, Andrew J Copp, Nicholas DE Green. Impaired folate 1-carbon metabolism causes formate-preventable hydrocephalus in glycine decarboxylase-deficient mice. The Journal of clinical investigation. vol 130. issue 3. 2020-11-03. PMID:31794432. |
gldc functions in the glycine cleavage system, a mitochondrial component of folate metabolism, whose malfunction results in accumulation of glycine and diminished supply of glycine-derived 1-carbon units to the folate cycle. |
2020-11-03 |
2023-08-13 |
mouse |
| Jing Lin, Jia Hui Jane Lee, Kathirvel Paramasivam, Elina Pathak, Zhenxun Wang, Zacharias Aloysius Dwi Pramono, Bing Lim, Keng Boon Wee, Uttam Suran. Induced-Decay of Glycine Decarboxylase Transcripts as an Anticancer Therapeutic Strategy for Non-Small-Cell Lung Carcinoma. Molecular therapy. Nucleic acids. vol 9. 2020-10-01. PMID:29246305. |
glycine decarboxylase, encoded by the gldc gene, is reported to be overexpressed in tic-enriched primary non-small-cell lung carcinoma (nsclc). |
2020-10-01 |
2023-08-13 |
Not clear |
| Jing Lin, Jia Hui Jane Lee, Kathirvel Paramasivam, Elina Pathak, Zhenxun Wang, Zacharias Aloysius Dwi Pramono, Bing Lim, Keng Boon Wee, Uttam Suran. Induced-Decay of Glycine Decarboxylase Transcripts as an Anticancer Therapeutic Strategy for Non-Small-Cell Lung Carcinoma. Molecular therapy. Nucleic acids. vol 9. 2020-10-01. PMID:29246305. |
gldc is a component of the mitochondrial glycine cleavage system, and its high expression is required for growth and tumorigenic capacity. |
2020-10-01 |
2023-08-13 |
Not clear |
| Chern Chiuh Woo, Kavita Kaur, Wei Xin Chan, Xing Qi Teo, Teck Hock Philip Le. Inhibiting Glycine Decarboxylase Suppresses Pyruvate-to-Lactate Metabolism in Lung Cancer Cells. Frontiers in oncology. vol 8. 2020-09-30. PMID:29911072. |
glycine decarboxylase (gldc) gene is frequently upregulated in various types of cancer including lung, prostate and brain. |
2020-09-30 |
2023-08-13 |
Not clear |
| Rengui Li, Lei Wang, Xiao Wang, Rong-Xin Geng, Ning Li, Xiu-Heng Li. Identification of hub genes associated with outcome of clear cell renal cell carcinoma. Oncology letters. vol 19. issue 4. 2020-09-28. PMID:32218839. |
the 15 most connected hub genes were identified among degs, including glycine decarboxylase (gldc), enolase 2 (eno2) and topoisomerase ii alpha. |
2020-09-28 |
2023-08-13 |
Not clear |
| Joseph Farris, Barbara Calhoun, Md Suhail Alam, Shaun Lee, Kasturi Halda. Large scale analyses of genotype-phenotype relationships of glycine decarboxylase mutations and neurological disease severity. PLoS computational biology. vol 16. issue 5. 2020-08-28. PMID:32421718. |
loss of glycine decarboxylase (gldc) can severely impact neurological development as seen in non-ketotic hyperglycinemia (nkh). |
2020-08-28 |
2023-08-13 |
Not clear |
| J Alexander Bodkin, Michael J Coleman, Laura J Godfrey, Claudia M B Carvalho, Charity J Morgan, Raymond F Suckow, Thea Anderson, Dost Öngür, Marc J Kaufman, Kathryn E Lewandowski, Arthur J Siegel, Elliot Waldstreicher, Christopher M Grochowski, Daniel C Javitt, Dan Rujescu, Scott Hebbring, Richard Weinshilboum, Stephanie Burgos Rodriguez, Colette Kirchhoff, Timothy Visscher, Alexander Vuckovic, Allison Fialkowski, Shane McCarthy, Dheeraj Malhotra, Jonathan Sebat, Donald C Goff, James I Hudson, James R Lupski, Joseph T Coyle, Uwe Rudolph, Deborah L Lev. Targeted Treatment of Individuals With Psychosis Carrying a Copy Number Variant Containing a Genomic Triplication of the Glycine Decarboxylase Gene. Biological psychiatry. vol 86. issue 7. 2020-07-01. PMID:31279534. |
we identified two carriers (mother and son) of a triplication of the gene encoding glycine decarboxylase, gldc, presumably resulting in reduced availability of the n-methyl-d-aspartate receptor coagonists glycine and d-serine and n-methyl-d-aspartate receptor hypofunction. |
2020-07-01 |
2023-08-13 |
Not clear |
| Hao Zhuang, Fei Wu, Wen Wei, Yamei Dang, Baicai Yang, Xuda Ma, Feng Han, Yongmei L. Glycine decarboxylase induces autophagy and is downregulated by miRNA-30d-5p in hepatocellular carcinoma. Cell death & disease. vol 10. issue 3. 2020-04-20. PMID:30804330. |
glycine decarboxylase (gldc) belongs to the glycine cleavage system and is involved in one-carbon metabolism. |
2020-04-20 |
2023-08-13 |
Not clear |
| Ahmet Alptekin, Bingwei Ye, Yajie Yu, Candace J Poole, Jan van Riggelen, Yunhong Zha, Han-Fei Din. Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity. Oncogene. vol 38. issue 50. 2020-03-09. PMID:31444411. |
here, we report that the gene encoding glycine decarboxylase (gldc), which catalyzes the first and rate-limiting step in glycine breakdown with the production of the one-carbon unit 5,10-methylene-tetrahydrofolate, is a direct transcriptional target of mycn. |
2020-03-09 |
2023-08-13 |
Not clear |
| Jie Zhou, Dong Wang, Bosco Ho-Yin Wong, Cun Li, Vincent Kwok-Man Poon, Lei Wen, Xiaoyu Zhao, Man Chun Chiu, Xiaojuan Liu, Ziwei Ye, Shuofeng Yuan, Kong-Hung Sze, Jasper Fuk-Woo Chan, Hin Chu, Kelvin Kai-Wang To, Kwok Yung Yue. Identification and characterization of GLDC as host susceptibility gene to severe influenza. EMBO molecular medicine. vol 11. issue 1. 2019-08-06. PMID:30498026. |
glycine decarboxylase (gldc) was prioritized as a candidate susceptibility gene to severe influenza in humans. |
2019-08-06 |
2023-08-13 |
mouse |
| Phil Jun Kang, Jie Zheng, Gilju Lee, Daryeon Son, In Yong Kim, Gwonhwa Song, Gyuman Park, Seungkwon Yo. Glycine decarboxylase regulates the maintenance and induction of pluripotency via metabolic control. Metabolic engineering. vol 53. 2019-07-18. PMID:30779965. |
in this study, we focused on glycine decarboxylase (gldc), a key enzyme in the glycine cleavage system that regulates glycolysis and methylglyoxal production in cancer. |
2019-07-18 |
2023-08-13 |
Not clear |
| Engin Kose, Uluc Yis, Semra Hiz, Nur Arsla. A novel mutation in the glycine decarboxylase gene in patient with non-ketotic hyperglycinemia. Neurosciences (Riyadh, Saudi Arabia). vol 22. issue 2. 2019-07-08. PMID:28416785. |
between 60-90% of cases are caused by mutations in the glycine decarboxylase (gldc). |
2019-07-08 |
2023-08-13 |
Not clear |