| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao Zhuang, Qiang Li, Xinran Zhang, Xuda Ma, Zun Wang, Yun Liu, Xianfu Yi, Ruibing Chen, Feng Han, Ning Zhang, Yongmei L. Downregulation of glycine decarboxylase enhanced cofilin-mediated migration in hepatocellular carcinoma cells. Free radical biology & medicine. vol 120. 2019-06-25. PMID:29524606. |
glycine decarboxylase (gldc), an oxidoreductase, plays an important role in amino acid metabolism. |
2019-06-25 |
2023-08-13 |
Not clear |
| Tanya M Teslovich, Daniel Seung Kim, Xianyong Yin, Alena Stancáková, Anne U Jackson, Matthias Wielscher, Adam Naj, John R B Perry, Jeroen R Huyghe, Heather M Stringham, James P Davis, Chelsea K Raulerson, Ryan P Welch, Christian Fuchsberger, Adam E Locke, Xueling Sim, Peter S Chines, Narisu Narisu, Antti J Kangas, Pasi Soininen, Mika Ala-Korpela, Vilmundur Gudnason, Solomon K Musani, Marjo-Riitta Jarvelin, Gerard D Schellenberg, Elizabeth K Speliotes, Johanna Kuusisto, Francis S Collins, Michael Boehnke, Markku Laakso, Karen L Mohlk. Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study. Human molecular genetics. vol 27. issue 9. 2019-02-11. PMID:29481666. |
in addition to the seven novel gene associations, we identified five independent signals at established amino acid loci, including two rare variant signals at gldc (rs138640017, maf=0.95%, pconditional = 5.8×10-40) with glycine levels and hal (rs141635447, maf = 0.46%, pconditional = 9.4×10-11) with histidine levels. |
2019-02-11 |
2023-08-13 |
Not clear |
| Suyan Li, Yota Uno, Uwe Rudolph, Johanna Cobb, Jing Liu, Thea Anderson, Deborah Levy, Darrick T Balu, Joseph T Coyl. Astrocytes in primary cultures express serine racemase, synthesize d-serine and acquire A1 reactive astrocyte features. Biochemical pharmacology. vol 151. 2019-01-09. PMID:29305854. |
while the levels of glial fibrillary acidic protein (gfap), glycine decarboxylase (gldc) and phosphoglycerate dehydrogenase (phgdh), the initial enzyme in the pathway converting glycine to l-serine, remained constant in culture, the expression of lipocalin-2, a marker for pan-reactive astrocytes, increased several-fold. |
2019-01-09 |
2023-08-13 |
mouse |
| Suyan Li, Yota Uno, Uwe Rudolph, Johanna Cobb, Jing Liu, Thea Anderson, Deborah Levy, Darrick T Balu, Joseph T Coyl. Astrocytes in primary cultures express serine racemase, synthesize d-serine and acquire A1 reactive astrocyte features. Biochemical pharmacology. vol 151. 2019-01-09. PMID:29305854. |
astrocytes grown from mice with a copy number variant associated with psychosis, which have four copies of the gldc gene, showed a more rapid production of d-serine and a reduction in glycine in the culture medium. |
2019-01-09 |
2023-08-13 |
mouse |
| Hai-Yan Wei, Rui Feng, Hua Shao, Bin Feng, Hong-Qiang Liu, Jin-Long Men, Wei Zo. Serum glycine dehydrogenase is associated with increased risk of lung cancer and promotes malignant transformation by regulating DNA methyltransferases expression. Molecular medicine reports. vol 18. issue 2. 2018-10-29. PMID:29956770. |
recently, it has been reported that glycine dehydrogenase (gldc) can drive the formation of lung cancer initiating cells. |
2018-10-29 |
2023-08-13 |
human |
| Kit-Yi Leung, Yun Jin Pai, Qiuying Chen, Chloe Santos, Enrica Calvani, Sonia Sudiwala, Dawn Savery, Markus Ralser, Steven S Gross, Andrew J Copp, Nicholas D E Green. Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure. Cell reports. vol 21. issue 7. 2018-06-22. PMID:29141214. |
similarly, the inability to use glycine as a one-carbon donor to the folate cycle causes ntds in glycine decarboxylase (gldc)-deficient embryos. |
2018-06-22 |
2023-08-13 |
mouse |
| Waseem Khraim, Bassam Abu-Libdeh, Suhail Ayesh, Imad Dweika. Clinical heterogeneity of glycine encephalopathy in three Palestinian siblings: A novel mutation in the glycine decarboxylase (GLDC) gene. Brain & development. vol 39. issue 7. 2018-04-03. PMID:28325525. |
clinical heterogeneity of glycine encephalopathy in three palestinian siblings: a novel mutation in the glycine decarboxylase (gldc) gene. |
2018-04-03 |
2023-08-13 |
Not clear |
| Tie-Jia Jiang, Jing-Jing Jiang, Jia-Lu Xu, Jing Zhen, Pei-Fang Jiang, Feng Ga. [Clinical and genetic analyses of a family with atypical nonketotic hyperglycinemia caused by compound heterozygous mutations in the GLDC gene]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 19. issue 10. 2017-12-21. PMID:29046206. |
h293t cells transfected with these two mutants of the gldc gene had a down-regulated activity of glycine decarboxylase. |
2017-12-21 |
2023-08-13 |
Not clear |
| Chiao-Fan Chiu, Ju-Li Lin, Jainn-Jim Lin, Min-Hua Tseng, Fu-Sung Lo, Ming-Chou Chian. Nonketotic Hyperglycinemia of Infants in Taiwan. Pediatrics and neonatology. vol 57. issue 5. 2017-09-27. PMID:26947380. |
we report the clinical and genetic features of typical neonatal nkh with novel splicing mutation, c.1058+3a>c, in the intron 7 of the glycine decarboxylase (gldc) gene. |
2017-09-27 |
2023-08-13 |
Not clear |
| Majid Alfadhel, Marwan Nashabat, Hanan Al Qahtani, Ahmed Alfares, Fuad Al Mutairi, Hesham Al Shaalan, Ganka V Douglas, Klaas Wierenga, Jane Juusola, Muhammad Talal Alrifai, Stefan T Arold, Fowzan Alkuraya, Qais Abu Al. Mutation in SLC6A9 encoding a glycine transporter causes a novel form of non-ketotic hyperglycinemia in humans. Human genetics. vol 135. issue 11. 2017-05-19. PMID:27481395. |
glycine cleavage system (gcs) catalyzes the degradation of glycine and disruption of its components encoded by gldc, amt and gcsh are the only known causes of glycine encephalopathy, also known as non-ketotic hyperglycinemia (nkh). |
2017-05-19 |
2023-08-13 |
Not clear |
| Sabina Berezowska, José A Galván, Rupert Langer, Lukas Bubendorf, Spasenija Savic, Mathias Gugger, Ralph A Schmid, Thomas M Mart. Glycine decarboxylase and HIF-1α expression are negative prognostic factors in primary resected early-stage non-small cell lung cancer. Virchows Archiv : an international journal of pathology. vol 470. issue 3. 2017-03-16. PMID:28062918. |
glycine decarboxylase (gldc) was recently described as a critical enzyme of tumor-initiating cells and, thus, a driver of tumorigenesis in lung non-small cell cancer (nscc). |
2017-03-16 |
2023-08-13 |
Not clear |
| Bethany K Redel, Lee D Spate, Kiho Lee, Jiude Mao, Kristin M Whitworth, Randall S Prathe. Glycine supplementation in vitro enhances porcine preimplantation embryo cell number and decreases apoptosis but does not lead to live births. Molecular reproduction and development. vol 83. issue 3. 2016-12-13. PMID:26824641. |
genes involved in glycine transport (slc6a9), glycine metabolism (gldc, gcsh, dld, and amt), and serine metabolism (psat1, psph, and phgdh) were differentially expressed. |
2016-12-13 |
2023-08-13 |
Not clear |
| Sarah L Nickerson, Shanti Balasubramaniam, Philippa A Dryland, Jennifer M Love, Maina P Kava, Donald R Love, Debra O Prosse. Two Novel GLDC Mutations in a Neonate with Nonketotic Hyperglycinemia. Journal of pediatric genetics. vol 5. issue 3. 2016-09-12. PMID:27617160. |
we report two novel mutations of the glycine decarboxylase (gldc) gene observed in a compound heterozygous state in a neonate of mixed maori and caucasian parentage: c.395c>t p.(ser132leu) in exon 3, and c.256-?_334+?del p.(ser86valfs*119), resulting in an out-of-frame deletion of exon 2. |
2016-09-12 |
2023-08-13 |
Not clear |
| Xiangdong Li, Chaoyang Cui, Yuan Guo, Guang Yan. Glycine Decarboxylase Expression Increased in p53-Mutated B Cell Lymphoma Mice. Oncology research and treatment. vol 38. issue 11. 2016-09-06. PMID:26599272. |
to understand the relationship between p53 mutations and glycine decarboxylase (gldc) expression in b cell lymphoma, we established b cell lymphoma animal models to study gldc expression in b cell lymphoma mice. |
2016-09-06 |
2023-08-13 |
mouse |
| Hyae Lim Min, Jin Kim, Woo Ho Kim, Bo Gun Jang, Min A Ki. Epigenetic Silencing of the Putative Tumor Suppressor Gene GLDC (Glycine Dehydrogenase) in Gastric Carcinoma. Anticancer research. vol 36. issue 1. 2016-05-11. PMID:26722042. |
epigenetic silencing of the putative tumor suppressor gene gldc (glycine dehydrogenase) in gastric carcinoma. |
2016-05-11 |
2023-08-13 |
Not clear |
| Hyae Lim Min, Jin Kim, Woo Ho Kim, Bo Gun Jang, Min A Ki. Epigenetic Silencing of the Putative Tumor Suppressor Gene GLDC (Glycine Dehydrogenase) in Gastric Carcinoma. Anticancer research. vol 36. issue 1. 2016-05-11. PMID:26722042. |
the metabolic enzyme, glycine dehydrogenase (gldc), involved in glycine metabolism, is known to be involved in non-ketotic hyperglycinemia but not in cancer. |
2016-05-11 |
2023-08-13 |
Not clear |
| Yun Jin Pai, Kit-Yi Leung, Dawn Savery, Tim Hutchin, Helen Prunty, Simon Heales, Margaret E Brosnan, John T Brosnan, Andrew J Copp, Nicholas D E Green. Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice. Nature communications. vol 6. 2016-02-08. PMID:25736695. |
glycine decarboxylase (gldc) acts in the glycine cleavage system to decarboxylate glycine and transfer a one-carbon unit into folate one-carbon metabolism. |
2016-02-08 |
2023-08-13 |
mouse |
| Yun Jin Pai, Kit-Yi Leung, Dawn Savery, Tim Hutchin, Helen Prunty, Simon Heales, Margaret E Brosnan, John T Brosnan, Andrew J Copp, Nicholas D E Green. Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice. Nature communications. vol 6. 2016-02-08. PMID:25736695. |
we show that reduced expression of gldc in mice suppresses glycine cleavage system activity and causes two distinct disease phenotypes. |
2016-02-08 |
2023-08-13 |
mouse |
| Yun Jin Pai, Kit-Yi Leung, Dawn Savery, Tim Hutchin, Helen Prunty, Simon Heales, Margaret E Brosnan, John T Brosnan, Andrew J Copp, Nicholas D E Green. Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice. Nature communications. vol 6. 2016-02-08. PMID:25736695. |
in addition to elevated glycine, gldc disruption also results in abnormal tissue folate profiles, with depletion of one-carbon-carrying folates, as well as growth retardation and reduced cellular proliferation. |
2016-02-08 |
2023-08-13 |
mouse |
| Dohoon Kim, Brian P Fiske, Kivanc Birsoy, Elizaveta Freinkman, Kenjiro Kami, Richard L Possemato, Yakov Chudnovsky, Michael E Pacold, Walter W Chen, Jason R Cantor, Laura M Shelton, Dan Y Gui, Manjae Kwon, Shakti H Ramkissoon, Keith L Ligon, Seong Woo Kang, Matija Snuderl, Matthew G Vander Heiden, David M Sabatin. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. vol 520. issue 7547. 2015-09-30. PMID:25855294. |
in human glioblastoma multiforme, mitochondrial serine hydroxymethyltransferase (shmt2) and glycine decarboxylase (gldc) are highly expressed in the pseudopalisading cells that surround necrotic foci. |
2015-09-30 |
2023-08-13 |
human |