| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao Yu, Xueqing Hu, Yingru Zhang, Jiajia Wang, Zhongya Ni, Yan Wang, Huirong Zh. GLDC promotes colorectal cancer metastasis through epithelial-mesenchymal transition mediated by Hippo signaling pathway. Medical oncology (Northwood, London, England). vol 40. issue 10. 2023-09-05. PMID:37668829. |
recently, abnormal expression of glycine decarboxylase (gldc) has been demonstrated in tumor progression, and gldc is up-regulated in cancers, such as lung, prostate, bladder, and cervical cancers. |
2023-09-05 |
2023-09-07 |
Not clear |
| Douglas Fraser-Pitt, Derry K Mercer, Marie-Louise Francis, David Toledo-Aparicio, Daniel W Smith, Deborah A O'Nei. Cysteamine-mediated blockade of the glycine cleavage system modulates epithelial cell inflammatory and innate immune responses to viral infection. Biochemical and biophysical research communications. vol 677. 2023-08-19. PMID:37597441. |
transient blockade of glycine decarboxylase (gldc) can restrict de novo pyrimidine synthesis, which is a well-described strategy for enhancing the host interferon response to viral infection and a target pathway for some licenced anti-inflammatory therapies. |
2023-08-19 |
2023-09-07 |
human |
| Douglas Fraser-Pitt, Derry K Mercer, Marie-Louise Francis, David Toledo-Aparicio, Daniel W Smith, Deborah A O'Nei. Cysteamine-mediated blockade of the glycine cleavage system modulates epithelial cell inflammatory and innate immune responses to viral infection. Biochemical and biophysical research communications. vol 677. 2023-08-19. PMID:37597441. |
cysteamine is known to inhibit both bacterial and the eukaryotic host glycine cleavage systems via competitive inhibition of gldc at concentrations, lower than those required for direct antimicrobial or antiviral activity. |
2023-08-19 |
2023-09-07 |
human |
| Maltesh Kambali, Yan Li, Petr Unichenko, Jessica Feria Pliego, Rachita Yadav, Jing Liu, Patrick McGuinness, Johanna G Cobb, Muxiao Wang, Rajasekar Nagarajan, Jinrui Lyu, Vanessa Vongsouthi, Colin J Jackson, Elif Engin, Joseph T Coyle, Jeaweon Shin, Michael E Talkowski, Gregg E Homanics, Vadim Y Bolshakov, Christian Henneberger, Uwe Rudolp. A marker chromosome in psychosis identifies glycine decarboxylase (GLDC) as a novel regulator of neuronal and synaptic function in the hippocampus. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398055. |
a marker chromosome in psychosis identifies glycine decarboxylase (gldc) as a novel regulator of neuronal and synaptic function in the hippocampus. |
2023-07-03 |
2023-08-14 |
Not clear |
| Li-Li Miao, Jing-Wen Wang, Hui-Hui Liu, Shuai Gao, Yu-Chen Fan, Kai Wan. Hypomethylation of glycine dehydrogenase promoter in peripheral blood mononuclear cells is a new diagnostic marker of hepatitis B virus-associated hepatocellular carcinoma. Hepatobiliary & pancreatic diseases international : HBPD INT. 2023-03-06. PMID:36878837. |
glycine dehydrogenase (gldc) plays an important role in the initiation and proliferation of several human cancers. |
2023-03-06 |
2023-08-14 |
human |
| Ye Da Chen, Ke Xin Gao, Zhu Wang, Qiong Deng, Yu Ting Chen, Hui Lian. Glycine Decarboxylase Suppresses the Renal Cell Carcinoma Growth and Regulates Its Gene Expressions and Functions. World journal of oncology. vol 13. issue 6. 2023-01-20. PMID:36660213. |
glycine decarboxylase (gldc), a key metabolic enzyme, participates in the regulation of the glycine metabolic pathway. |
2023-01-20 |
2023-08-14 |
Not clear |
| Nicole Weaver, Rebecca Winger. Delineating the role of gldcin nephron patterning during kidney development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557131. |
elevated glycine levels due to congenital mutations in gcs components, such as glycine dehydrogenase (gldc), cause devastating human birth defects and the rare disease nonketotic hyperglycinemia (nkh). |
2022-05-13 |
2023-08-13 |
mouse |
| Sergey A Krupenko, Shelley A Cole, Ruixue Hou, Karin Haack, Sandra Laston, Nitesh R Mehta, Anthony G Comuzzie, Nancy F Butte, V Saroja Vorugant. Genetic variants in ALDH1L1 and GLDC influence serine to glycine ratio in Hispanic children. The American journal of clinical nutrition. 2022-04-23. PMID:35460232. |
genetic variants in aldh1l1 and gldc influence serine to glycine ratio in hispanic children. |
2022-04-23 |
2023-08-13 |
mouse |
| Ruta Jog, Guohua Chen, Jian Wang, Todd Lef. Hormonal regulation of glycine decarboxylase and its relationship to oxidative stress. Physiological reports. vol 9. issue 15. 2021-11-18. PMID:34342168. |
the glycine cleavage system and its rate-limiting enzyme, glycine decarboxylase (gldc), is a major determinant of plasma glycine levels. |
2021-11-18 |
2023-08-13 |
mouse |
| Ruta Jog, Guohua Chen, Jian Wang, Todd Lef. Hormonal regulation of glycine decarboxylase and its relationship to oxidative stress. Physiological reports. vol 9. issue 15. 2021-11-18. PMID:34342168. |
the goals of this study were to determine if the increased expression of gldc contributes to the reduced plasma glycine levels seen in disease states, to characterize the hormonal regulation of gldc gene expression, and to determine if altered gldc expression has physiological effects that might affect the development of diabetes. |
2021-11-18 |
2023-08-13 |
mouse |
| Ruta Jog, Guohua Chen, Jian Wang, Todd Lef. Hormonal regulation of glycine decarboxylase and its relationship to oxidative stress. Physiological reports. vol 9. issue 15. 2021-11-18. PMID:34342168. |
these findings suggest that the hormonal regulation of gldc contributes not only to the changes in circulating glycine levels seen in metabolic disease, but also affects glutathione production, possibly as a defense against metabolic disease-associated oxidative stress. |
2021-11-18 |
2023-08-13 |
mouse |
| Kit-Yi Leung, Sandra C P De Castro, Chloe Santos, Dawn Savery, Helen Prunty, Diana Gold-Diaz, Stuart Bennett, Simon Heales, Andrew J Copp, Nicholas D E Green. Regulation of glycine metabolism by the glycine cleavage system and conjugation pathway in mouse models of non-ketotic hyperglycinemia. Journal of inherited metabolic disease. vol 43. issue 6. 2021-10-07. PMID:32743799. |
mutation of the gcs component glycine decarboxylase (gldc) in non-ketotic hyperglycinemia (nkh) causes accumulation of glycine in body fluids, but there is a gap in our knowledge regarding the effects on glycine metabolism in tissues. |
2021-10-07 |
2023-08-13 |
mouse |
| Kit-Yi Leung, Sandra C P De Castro, Chloe Santos, Dawn Savery, Helen Prunty, Diana Gold-Diaz, Stuart Bennett, Simon Heales, Andrew J Copp, Nicholas D E Green. Regulation of glycine metabolism by the glycine cleavage system and conjugation pathway in mouse models of non-ketotic hyperglycinemia. Journal of inherited metabolic disease. vol 43. issue 6. 2021-10-07. PMID:32743799. |
here, we analysed mice carrying mutations in gldc that result in severe or mild elevations of plasma glycine and model nkh. |
2021-10-07 |
2023-08-13 |
mouse |
| Kit-Yi Leung, Sandra C P De Castro, Chloe Santos, Dawn Savery, Helen Prunty, Diana Gold-Diaz, Stuart Bennett, Simon Heales, Andrew J Copp, Nicholas D E Green. Regulation of glycine metabolism by the glycine cleavage system and conjugation pathway in mouse models of non-ketotic hyperglycinemia. Journal of inherited metabolic disease. vol 43. issue 6. 2021-10-07. PMID:32743799. |
elevation of brain tissue glycine occurred even in the presence of only mildly elevated plasma glycine in mice carrying a missense allele of gldc. |
2021-10-07 |
2023-08-13 |
mouse |
| Pegah Abdollahi, Esten N Vandsemb, Samah Elsaadi, Lisa M R\\xc3\\xb8st, Rui Yang, Magnus A Hjort, Trygve Andreassen, Kristine Misund, Tobias S Sl\\xc3\\xb8rdahl, Torstein B R\\xc3\\xb8, Anne-Marit Sponaas, Siver Moestue, Per Bruheim, Magne B\\xc3\\xb8rse. Phosphatase of regenerating liver-3 regulates cancer cell metabolism in multiple myeloma. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 3. 2021-07-26. PMID:33566385. |
glycine decarboxylase (gldc) was the most significantly induced metabolism gene. |
2021-07-26 |
2023-08-13 |
Not clear |
| Rui Liu, Lin-Wen Zeng, Rong Gong, Fanen Yuan, Hong-Bing Shu, Shu L. mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis. Nature communications. vol 12. issue 1. 2021-07-20. PMID:34244482. |
glycine decarboxylase (gldc) is a key enzyme of glycine cleavage system that converts glycine into one-carbon units. |
2021-07-20 |
2023-08-13 |
human |
| Rui Liu, Lin-Wen Zeng, Rong Gong, Fanen Yuan, Hong-Bing Shu, Shu L. mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis. Nature communications. vol 12. issue 1. 2021-07-20. PMID:34244482. |
finally, we find that gldc k514 acetylation inhibits glycine catabolism, pyrimidines synthesis and glioma tumorigenesis. |
2021-07-20 |
2023-08-13 |
human |
| Rui Liu, Lin-Wen Zeng, Rong Gong, Fanen Yuan, Hong-Bing Shu, Shu L. mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis. Nature communications. vol 12. issue 1. 2021-07-20. PMID:34244482. |
our finding reveals critical roles of post-translational modifications of gldc in regulation of its enzymatic activity, glycine metabolism and tumorigenesis, and provides potential targets for therapeutics of cancers such as glioma. |
2021-07-20 |
2023-08-13 |
human |
| Rebecca M Simmons, Sorin M McKnight, Ashley K Edwards, Guoyao Wu, Michael C Satterfiel. Obesity increases hepatic glycine dehydrogenase and aminomethyltransferase expression while dietary glycine supplementation reduces white adipose tissue in Zucker diabetic fatty rats. Amino acids. vol 52. issue 10. 2021-07-19. PMID:33057941. |
both mrna and protein expression of aminomethyltransferase (amt) and glycine dehydrogenase, decarboxylating (gldc) were increased in the livers of obese versus lean rats (p\xe2\x80\x89<\xe2\x80\x890.05). |
2021-07-19 |
2023-08-13 |
human |
| Joseph Farris, Md Suhail Alam, Arpitha Mysore Rajashekara, Kasturi Halda. Genomic analyses of glycine decarboxylase neurogenic mutations yield a large-scale prediction model for prenatal disease. PLoS genetics. vol 17. issue 2. 2021-06-24. PMID:33524012. |
defect in glycine decarboxylase (gldc) causes non-ketotic hyperglycinemia (nkh), a neurological disease associated with elevation of plasma glycine. |
2021-06-24 |
2023-08-13 |
mouse |