| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrea Tura, Giovanni Pacini, Yuchiro Yamada, Yutaka Seino, Bo Ahré. Glucagon and insulin secretion, insulin clearance, and fasting glucose in GIP receptor and GLP-1 receptor knockout mice. American journal of physiology. Regulatory, integrative and comparative physiology. vol 316. issue 1. 2019-11-19. PMID:30462524. |
we therefore studied glucagon secretion after oral whey protein (60 mg) and intravenous arginine (6.25 mg), insulin clearance after intravenous glucose (0.35 g/kg) and fasting glucose, insulin, and glucagon levels after standardized 5-h fasting in female gip receptor and glp-1 receptor ko mice and their wild-type (wt) littermates. |
2019-11-19 |
2023-08-13 |
mouse |
| Andrea Tura, Giovanni Pacini, Yuchiro Yamada, Yutaka Seino, Bo Ahré. Glucagon and insulin secretion, insulin clearance, and fasting glucose in GIP receptor and GLP-1 receptor knockout mice. American journal of physiology. Regulatory, integrative and comparative physiology. vol 316. issue 1. 2019-11-19. PMID:30462524. |
furthermore, the intravenous glucose test revealed normal insulin clearance in both gip receptor and glp-1 receptor ko mice, whereas β-cell glucose sensitivity was enhanced in gip receptor ko mice and reduced in glp-1 receptor ko mice. |
2019-11-19 |
2023-08-13 |
mouse |
| David J Clayton, Jack Biddle, Tyler Maher, Mark P Funnell, Jack A Sargeant, James A King, Carl J Hulston, David J Stensel, Lewis J Jame. 24-h severe energy restriction impairs postprandial glycaemic control in young, lean males. The British journal of nutrition. vol 120. issue 10. 2019-09-09. PMID:30401004. |
plasma/serum glucose, insulin, nefa, glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic peptide (gip) and fibroblast growth factor 21 (fgf21) were assessed before and after (0 h) each 24-h dietary intervention, and throughout the 2-h ogtt. |
2019-09-09 |
2023-08-13 |
Not clear |
| David J Clayton, Jack Biddle, Tyler Maher, Mark P Funnell, Jack A Sargeant, James A King, Carl J Hulston, David J Stensel, Lewis J Jame. 24-h severe energy restriction impairs postprandial glycaemic control in young, lean males. The British journal of nutrition. vol 120. issue 10. 2019-09-09. PMID:30401004. |
during the ogtt, serum glucose iauc (p<0·001), serum insulin iauc (p<0·05) and plasma nefa tauc (p<0·01) were greater during er, but glp-1 (p=0·161), gip (p=0·473) and fgf21 (p=0·497) tauc were similar between trials. |
2019-09-09 |
2023-08-13 |
Not clear |
| Jorge Moreno-Fernandez, Javier Díaz-Castro, María J M Alférez, Inmaculada López-Aliag. Iron Deficiency and Neuroendocrine Regulators of Basal Metabolism, Body Composition and Energy Expenditure in Rats. Nutrients. vol 11. issue 3. 2019-07-25. PMID:30875895. |
neuroendocrine parameters that regulate basal metabolism and appetite (thyroid hormones, ghrelin, glucose-dependent insulinotropic polypeptide (gip), glucagon, insulin, adrenocorticotropic hormone and corticosterone), body composition, respiratory volumes, energy expenditure, haematological and biochemical were assessed. |
2019-07-25 |
2023-08-13 |
human |
| Jorge Moreno-Fernandez, Javier Díaz-Castro, María J M Alférez, Inmaculada López-Aliag. Iron Deficiency and Neuroendocrine Regulators of Basal Metabolism, Body Composition and Energy Expenditure in Rats. Nutrients. vol 11. issue 3. 2019-07-25. PMID:30875895. |
circulating levels of ghrelin were lower in the anemic group, while gip, glucagon, insulin, corticosterone and adrenocorticotropic hormone levels were higher. |
2019-07-25 |
2023-08-13 |
human |
| Hidayat Hussain, Ghulam Abbas, Ivan R Green, Iftikhar Al. Dipeptidyl peptidase IV inhibitors as a potential target for diabetes: patent review (2015-2018). Expert opinion on therapeutic patents. vol 29. issue 7. 2019-07-12. PMID:31203700. |
dipeptidyl peptidase 4 (dpp-4) belongs to the family of serine proteases and is involved in the degradation of glp-1 and gip hormones, which enhance the production and release of insulin. |
2019-07-12 |
2023-08-13 |
Not clear |
| Peter Almgren, Andreas Lindqvist, Ulrika Krus, Liisa Hakaste, Emilia Ottosson-Laakso, Olof Asplund, Emily Sonestedt, Rashmi B Prasad, Esa Laurila, Marju Orho-Melander, Olle Melander, Tiinamaija Tuomi, Jens Juul Holst, Peter M Nilsson, Nils Wierup, Leif Groop, Emma Ahlqvis. Genetic determinants of circulating GIP and GLP-1 concentrations. JCI insight. vol 2. issue 21. 2019-07-10. PMID:29093273. |
the secretion of insulin and glucagon from the pancreas and the incretin hormones glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic peptide (gip) from the gastrointestinal tract is essential for glucose homeostasis. |
2019-07-10 |
2023-08-13 |
human |
| Peter Almgren, Andreas Lindqvist, Ulrika Krus, Liisa Hakaste, Emilia Ottosson-Laakso, Olof Asplund, Emily Sonestedt, Rashmi B Prasad, Esa Laurila, Marju Orho-Melander, Olle Melander, Tiinamaija Tuomi, Jens Juul Holst, Peter M Nilsson, Nils Wierup, Leif Groop, Emma Ahlqvis. Genetic determinants of circulating GIP and GLP-1 concentrations. JCI insight. vol 2. issue 21. 2019-07-10. PMID:29093273. |
in order to identify new potential therapeutic targets for treatment of t2d, we performed a meta-analysis of a gwas and an exome-wide association study of circulating insulin, glucagon, gip, and glp-1 concentrations measured during an oral glucose tolerance test in up to 7,828 individuals. |
2019-07-10 |
2023-08-13 |
human |
| Eri Ikeguchi, Norio Harada, Yoshinori Kanemaru, Akiko Sankoda, Shunsuke Yamane, Kanako Iwasaki, Masamichi Imajo, Yuki Murata, Kazuyo Suzuki, Erina Joo, Nobuya Inagak. Transcriptional factor Pdx1 is involved in age-related GIP hypersecretion in mice. American journal of physiology. Gastrointestinal and liver physiology. vol 315. issue 2. 2019-07-02. PMID:29723041. |
gip receptor knockout mice show reduced fat mass and improved insulin sensitivity associated with aging. |
2019-07-02 |
2023-08-13 |
mouse |
| Eri Ikeguchi, Norio Harada, Yoshinori Kanemaru, Akiko Sankoda, Shunsuke Yamane, Kanako Iwasaki, Masamichi Imajo, Yuki Murata, Kazuyo Suzuki, Erina Joo, Nobuya Inagak. Transcriptional factor Pdx1 is involved in age-related GIP hypersecretion in mice. American journal of physiology. Gastrointestinal and liver physiology. vol 315. issue 2. 2019-07-02. PMID:29723041. |
therefore, gip is involved in fat accumulation and insulin resistance with aging. |
2019-07-02 |
2023-08-13 |
mouse |
| Line Engelbrechtsen, Yuvaraj Mahendran, Anna Jonsson, Anette Prior Gjesing, Peter E Weeke, Marit E Jørgensen, Kristine Færch, Daniel R Witte, Jens J Holst, Torben Jørgensen, Niels Grarup, Oluf Pedersen, Henrik Vestergaard, Signe Torekov, Jørgen K Kanters, Torben Hanse. Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses. BMC genetics. vol 19. issue 1. 2019-06-28. PMID:29548277. |
subsequently, we aimed to evaluate the effect of two common gain-of-function variants in herg (rs36210421 and rs1805123) on qt interval and plasma levels of glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic polypeptide (gip), insulin and glucagon during an oral glucose tolerance test (ogtt). |
2019-06-28 |
2023-08-13 |
human |
| Line Engelbrechtsen, Yuvaraj Mahendran, Anna Jonsson, Anette Prior Gjesing, Peter E Weeke, Marit E Jørgensen, Kristine Færch, Daniel R Witte, Jens J Holst, Torben Jørgensen, Niels Grarup, Oluf Pedersen, Henrik Vestergaard, Signe Torekov, Jørgen K Kanters, Torben Hanse. Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses. BMC genetics. vol 19. issue 1. 2019-06-28. PMID:29548277. |
the danish addition-pro cohort was used (n = 1329) to study genetic associations with levels of glp-1, gip, insulin and glucagon during an ogtt. |
2019-06-28 |
2023-08-13 |
human |
| Hartmut Ruetten, Mathias Gebauer, Ralph H Raymond, Roberto A Calle, Claudio Cobelli, Atalanta Ghosh, R Paul Robertson, Sudha S Shankar, Myrlene A Staten, Darko Stefanovski, Adrian Vella, Kathryn Wright, David A Frybur. Mixed Meal and Intravenous L-Arginine Tests Both Stimulate Incretin Release Across Glucose Tolerance in Man: Lack of Correlation with β Cell Function. Metabolic syndrome and related disorders. vol 16. issue 8. 2019-06-26. PMID:30117761. |
the aims of this study were to 1. define the responses of glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic polypeptide (gip), glucagon, and peptide yy (pyy) to an oral meal and to intravenous l-arginine; and 2. examine correlation of enteroendocrine hormones with insulin secretion. |
2019-06-26 |
2023-08-13 |
Not clear |
| Brian M Moran, Michael G Miskelly, Yasser H A Abdel-Wahab, Peter R Flatt, Aine M McKillo. Zinc-induced activation of GPR39 regulates glucose homeostasis through glucose-dependent insulinotropic polypeptide secretion from enteroendocrine K-cells. Biological chemistry. 2019-06-20. PMID:30738010. |
gpr39 is expressed on intestinal l- and k-cells, and stimulated gip secretion plays an integral role in mediating enhanced insulin secretion and glucose tolerance following oral administration of zn2+. |
2019-06-20 |
2023-08-13 |
mouse |
| Florian Kahles, Ana Liberman, Constantin Halim, Matthias Rau, Julia Möllmann, Robert Werner Mertens, Marcia Rückbeil, Irmgard Diepolder, Benedikt Walla, Sebastian Diebold, Mathias Burgmaier, Corinna Lebherz, Nikolaus Marx, Michael Lehrk. The incretin hormone GIP is upregulated in patients with atherosclerosis and stabilizes plaques in ApoE Molecular metabolism. vol 14. 2019-05-27. PMID:29884547. |
the incretin hormone gip is upregulated in patients with atherosclerosis and stabilizes plaques in apoe the incretin hormones glp-1 (glucagon-like peptide-1) and gip (glucose-dependent insulinotropic peptide) are secreted by the gut after food intake leading to pancreatic insulin secretion and glucose lowering. |
2019-05-27 |
2023-08-13 |
mouse |
| Luisella Bocchio-Chiavetto, Roberta Zanardini, Sarah Tosato, Mariacarla Ventriglia, Clarissa Ferrari, Chiara Bonetto, Antonio Lasalvia, Franco Giubilini, Angelo Fioritti, Francesca Pileggi, Michela Pratelli, Michele Pavanati, Angela Favaro, Giovanni De Girolamo, Giovanni Battista Frisoni, Mirella Ruggeri, Massimo Gennarell. Immune and metabolic alterations in first episode psychosis (FEP) patients. Brain, behavior, and immunity. vol 70. 2019-05-21. PMID:29548996. |
in order to identify biochemical signatures of fep, the serum levels of the growth factors bdnf and vegf, the immune regulators il-1ra, il-6, il-10 and il-17, rantes/ccl5, mip-1b/ccl4, il-8 and the metabolic regulators c-peptide, ghrelin, gip, glp-1, glucagon, insulin, leptin, pai-1, resistin and visfatin were analysed in 260 subjects collected in the get up project. |
2019-05-21 |
2023-08-13 |
human |
| Yuka Kinoshit. [Body weight and bone/calcium metabolism. The effect of incretin hormones on bone and calcium metabolism.] Clinical calcium. vol 28. issue 7. 2019-05-15. PMID:29950546. |
incretins such as glucose-dependent insulinotropic peptide(gip)and glucagon-like peptide 1(glp-1)modulate glucose homeostasis by regulating glucose-dependent insulin release from pancreatic βcells. |
2019-05-15 |
2023-08-13 |
Not clear |
| Xiang Gao, Andreas Lindqvist, Monica Sandberg, Leif Groop, Nils Wierup, Leif Jansso. Effects of GIP on regional blood flow during normoglycemia and hyperglycemia in anesthetized rats. Physiological reports. vol 6. issue 8. 2019-05-13. PMID:29673130. |
the incretin hormone glucose-dependent insulinotropic polypeptide (gip) potentiates glucose-stimulated insulin secretion, and affects β-cell turnover. |
2019-05-13 |
2023-08-13 |
rat |
| D A Skuratovskaia, M A Vulf, E V Kirienkova, N I Mironyuk, P A Zatolokin, L S Litvinov. [The role of single nucleotide polymorphisms in GIPR gene in the changes of secretion in hormones and adipokines in patients with obesity with type 2 diabetes]. Biomeditsinskaia khimiia. vol 64. issue 2. 2019-05-13. PMID:29723152. |
the decrease in the level of expression of the gipr gene in adipose tissue of the small intestine mesentery in the carriers of the cc genotype rs2302382 and aa rs8111428 was associated with the increase in the plasma leptin level, whereas during normal expression, the plasma content of insulin, and gip (in persons with the genotype of the polymorphism rs2302382 and ag polymorphism rs8111428), resistin and ghrelin (in individuals with the genotype of the polymorphism rs2302382) increased. |
2019-05-13 |
2023-08-13 |
Not clear |