| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kristy M Heppner, Jenny Ton. Mechanisms in endocrinology: regulation of glucose metabolism by the ghrelin system: multiple players and multiple actions. European journal of endocrinology. vol 171. issue 1. 2014-07-28. PMID:24714083. |
ag acts on the gh secretagogue receptor (ghsr) in the cns to promote feeding and adiposity and also acts on ghsr in the pancreas to inhibit glucose-stimulated insulin secretion. |
2014-07-28 |
2023-08-13 |
Not clear |
| T Takahashi, K Sato, S Kato, T Yonezawa, Y Kobayashi, Y Ohtani, S Ohwada, H Aso, T Yamaguchi, S G Roh, K Kato. Increased plasma ghrelin suppresses insulin release in wethers fed with a high-protein diet. The Journal of endocrinology. vol 221. issue 3. 2014-07-25. PMID:24639470. |
although the gh concentrations did not vary significantly across the groups, an injection of ghrelin-receptor antagonist enhanced insulin levels in circulation in the hp diet group. |
2014-07-25 |
2023-08-12 |
Not clear |
| T Takahashi, K Sato, S Kato, T Yonezawa, Y Kobayashi, Y Ohtani, S Ohwada, H Aso, T Yamaguchi, S G Roh, K Kato. Increased plasma ghrelin suppresses insulin release in wethers fed with a high-protein diet. The Journal of endocrinology. vol 221. issue 3. 2014-07-25. PMID:24639470. |
these results indicate that the hp diet elevated the plasma ghrelin levels by increasing its synthesis; this elevation strongly suppresses the appearance of insulin in the circulation of wethers, but it is not involved in gh secretion. |
2014-07-25 |
2023-08-12 |
Not clear |
| Astrid Ardiyanti, Tsuyoshi Abe, Nanae Tameoka, Eiji Kobayashi, Noriaki Shoji, Yoshihisa Ohtani, Keiichi Suzuki, Sang-Gun Roh, Kazuo Kato. Effects of growth hormone gene polymorphism on lipogenic gene expression levels in diaphragm tissues of Japanese black heifers. Asian-Australasian journal of animal sciences. vol 25. issue 8. 2014-07-22. PMID:25049663. |
to determine the snp effect on somatotropic hormone concentration and lipogenesis, we measured plasma gh, insulin, and insulin-like growth factor-1 (igf-1) concentrations. |
2014-07-22 |
2023-08-13 |
cattle |
| Jin Wook Ki. Modulation of the somatotropic axis in periparturient dairy cows. Asian-Australasian journal of animal sciences. vol 27. issue 1. 2014-07-22. PMID:25049937. |
to regulate this metabolic condition, key hormones of somatotropic axis such as gh, igf-i and insulin must coordinate adaptations required for the preservation of metabolic homeostasis. |
2014-07-22 |
2023-08-13 |
Not clear |
| Jin Wook Ki. Modulation of the somatotropic axis in periparturient dairy cows. Asian-Australasian journal of animal sciences. vol 27. issue 1. 2014-07-22. PMID:25049937. |
increased gh stimulates the lipolytic effects and hepatic glucose synthesis to meet the energy requirement for mammary lactose synthesis, suggesting that gh antagonizes insulin-dependent glucose uptake and attenuates insulin action to decrease gluconeogenesis. |
2014-07-22 |
2023-08-13 |
Not clear |
| Yao Huang, Yongchang Chan. Regulation of pancreatic islet beta-cell mass by growth factor and hormone signaling. Progress in molecular biology and translational science. vol 121. 2014-07-10. PMID:24373242. |
notably, somatolactogenic hormones including growth hormone (gh), prolactin (prl), and insulin-like growth factor-1 (igf-1) and their receptors (ghr, prlr, and igf-1r) are critically involved in beta-cell growth, survival, differentiation, and insulin secretion. |
2014-07-10 |
2023-08-12 |
Not clear |
| Berthil F F Clasen, Thomas Krusenstjerna-Hafstrøm, Mikkel Holm Vendelbo, Kasper Thorsen, Carlos Escande, Niels Møller, Steen B Pedersen, Jens Otto L Jørgensen, Niels Jesse. Gene expression in skeletal muscle after an acute intravenous GH bolus in human subjects: identification of a mechanism regulating ANGPTL4. Journal of lipid research. vol 54. issue 7. 2014-04-25. PMID:23606725. |
four genes involved in the jak-stat5 signaling pathway were regulated by gh, including socs1-3 and cish, in addition to three genes associated with insulin action: nfκb1a, pik3c2b, and prkag2. |
2014-04-25 |
2023-08-12 |
human |
| Yuan Gao, Peizhu Su, Chuqiong Wang, Kongqin Zhu, Xiaolan Chen, Side Liu, Jiman H. The role of PTEN in chronic growth hormone-induced hepatic insulin resistance. PloS one. vol 8. issue 6. 2014-04-24. PMID:23840818. |
chronic growth hormone (gh) therapy has been shown to cause insulin resistance, but the mechanism remains unknown. |
2014-04-24 |
2023-08-12 |
mouse |
| Yuan Gao, Peizhu Su, Chuqiong Wang, Kongqin Zhu, Xiaolan Chen, Side Liu, Jiman H. The role of PTEN in chronic growth hormone-induced hepatic insulin resistance. PloS one. vol 8. issue 6. 2014-04-24. PMID:23840818. |
in this study, we explored the effect of chronic gh on insulin signaling in the context of pten function. |
2014-04-24 |
2023-08-12 |
mouse |
| Yuan Gao, Peizhu Su, Chuqiong Wang, Kongqin Zhu, Xiaolan Chen, Side Liu, Jiman H. The role of PTEN in chronic growth hormone-induced hepatic insulin resistance. PloS one. vol 8. issue 6. 2014-04-24. PMID:23840818. |
long-term exposure to gh caused similar resistance of insulin/pi3k/akt signaling in hepg2 cells; and over-expression of pten enhanced the impairment of insulin signaling. |
2014-04-24 |
2023-08-12 |
mouse |
| Yuan Gao, Peizhu Su, Chuqiong Wang, Kongqin Zhu, Xiaolan Chen, Side Liu, Jiman H. The role of PTEN in chronic growth hormone-induced hepatic insulin resistance. PloS one. vol 8. issue 6. 2014-04-24. PMID:23840818. |
on the other hand, disabling the pten gene by transfecting the mutant pten construct c124s or sipten, disrupted the chronic gh induced insulin resistance. |
2014-04-24 |
2023-08-12 |
mouse |
| M Perotti, S Perra, A Saluzzi, G Grassi, A I Pincell. Body fat mass is a strong and negative predictor of peak stimulated growth hormone and bone mineral density in healthy adolescents during transition period. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 45. issue 10. 2014-04-02. PMID:23913118. |
however, their gh status was normal when assessed by insulin tolerance test. |
2014-04-02 |
2023-08-12 |
human |
| Helene M Markkanen, Tuula Pekkarinen, Matti J Välimäki, Henrik Alfthan, Esa Hämäläinen, Ulf-Håkan Stenma. Comparison of two growth hormone stimulation tests and their cut-off limits in healthy adults at an outpatient clinic. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 23. issue 5. 2014-03-31. PMID:23835226. |
a peak gh less than 3 μg/l to insulin tolerance test (itt) is commonly used as a threshold indicating severe adult gh deficiency (ghd). |
2014-03-31 |
2023-08-12 |
Not clear |
| Davi Vieira Teixeira da Silva, Carlos Adam Conte-Junior, Vânia Margaret Flosi Paschoalin, Thiago da Silveira Alvare. Hormonal response to L-arginine supplementation in physically active individuals. Food & nutrition research. vol 58. 2014-03-28. PMID:24678288. |
nutritional supplements based on the amino acid l-arginine have been hypothesized to improve exercise performance by increasing levels of insulin and growth hormone (gh). |
2014-03-28 |
2023-08-12 |
Not clear |
| Darlene E Berryman, Ellen R Lubbers, Vishakha Magon, Edward O List, John J Kopchic. A dwarf mouse model with decreased GH/IGF-1 activity that does not experience life-span extension: potential impact of increased adiposity, leptin, and insulin with advancing age. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 69. issue 2. 2014-03-26. PMID:23695394. |
gh receptor (ghr) null (ghr(-)(/-)) mice, which have a disruption in the ghr gene, are a well-studied example of mice that are insulin sensitive and long lived yet obese. |
2014-03-26 |
2023-08-12 |
mouse |
| K Michalakis, D G Goulis, A Vazaiou, G Mintziori, A Polymeris, A Abrahamian-Michalaki. Obesity in the ageing man. Metabolism: clinical and experimental. vol 62. issue 10. 2014-03-17. PMID:23831443. |
in addition, somatopenia (decreased gh secretion), late-onset hypogonadism (loh), changes in thyroid and adrenal function, as well as changes in appetite-related peptides (leptin, ghrelin) and, most importantly, insulin action are related to obesity, abnormal energy balance, redistribution of the adipose tissue and sarcopenia (decreased muscle mass). |
2014-03-17 |
2023-08-12 |
Not clear |
| Pinaki Dutta, Anuradha Aggarwal, Yashpal Gogate, Uma Nahar, Viral N Shah, Mandeep Singla, N Khandelwal, Anil Bhansal. Non-islet cell tumor-induced hypoglycemia: a report of five cases and brief review of the literature. Endocrinology, diabetes & metabolism case reports. vol 2013. 2014-03-11. PMID:24616774. |
low levels of insulin, c-peptide, gh, and igf1 were invariably found in all. |
2014-03-11 |
2023-08-12 |
Not clear |
| Dominic Cavlan, Shanti Vijayaraghavan, Susan Gelding, William Drak. GH replacement causing acute hyperglycaemia and ketonuria in a type 1 diabetic patient. Endocrinology, diabetes & metabolism case reports. vol 2013. 2014-03-11. PMID:24616775. |
a state of insulin resistance is common to the clinical conditions of both chronic growth hormone (gh) deficiency and gh excess (acromegaly). |
2014-03-11 |
2023-08-12 |
Not clear |
| Shingo Fujio, Hiroshi Tokimura, Hirofumi Hirano, Ryosuke Hanaya, Fumikatsu Kubo, Shunji Yunoue, Manoj Bohara, Yasuyuki Kinoshita, Atsushi Tominaga, Hiroshi Arimura, Kazunori Arit. Severe growth hormone deficiency is rare in surgically-cured acromegalics. Pituitary. vol 16. issue 3. 2014-03-03. PMID:22918542. |
we recorded the incidence of impaired gh secretory function based on the peak gh level during postoperative insulin tolerance test (itt) which lowered their nadir blood sugar to under 50 mg/dl. |
2014-03-03 |
2023-08-12 |
Not clear |