| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kevin C J Yuen, Charles T Roberts, Jan Frystyk, William D Rooney, James R Pollaro, Bethany J Klopfenstein, Jonathan Q Purnel. Short-term, low-dose GH therapy improves insulin sensitivity without modifying cortisol metabolism and ectopic fat accumulation in adults with GH deficiency. The Journal of clinical endocrinology and metabolism. vol 99. issue 10. 2015-01-22. PMID:25013996. |
short-term, low-dose gh therapy improves insulin sensitivity without modifying cortisol metabolism and ectopic fat accumulation in adults with gh deficiency. |
2015-01-22 |
2023-08-13 |
Not clear |
| Kevin C J Yuen, Charles T Roberts, Jan Frystyk, William D Rooney, James R Pollaro, Bethany J Klopfenstein, Jonathan Q Purnel. Short-term, low-dose GH therapy improves insulin sensitivity without modifying cortisol metabolism and ectopic fat accumulation in adults with GH deficiency. The Journal of clinical endocrinology and metabolism. vol 99. issue 10. 2015-01-22. PMID:25013996. |
low-dose gh (lgh) therapy has been reported to improve insulin sensitivity in gh-deficient adults; however, the mechanism is unclear. |
2015-01-22 |
2023-08-13 |
Not clear |
| Elenilde Gomes-Santos, Roberto Salvatori, Thiago O Ferrão, Carla R P Oliveira, Rachel D C A Diniz, João A M Santana, Francisco A Pereira, Rita A A Barbosa, Anita H O Souza, Enaldo V Melo, Carlos C Epitácio-Pereira, Alécia A Oliveira-Santos, Ingrid A S Oliveira, Julianne A Machado, Francisco J Santana-Júnior, José A S Barreto-Filho, Manuel H Aguiar-Oliveir. Increased visceral adiposity and cortisol to cortisone ratio in adults with congenital lifetime isolated GH deficiency. The Journal of clinical endocrinology and metabolism. vol 99. issue 9. 2015-01-12. PMID:24926956. |
adult-onset gh deficiency (ghd) increases visceral adiposity and the activity of the enzyme 11β-hydroxysteroid dehydrogenase, which converts cortisone (e) to cortisol (f), both linked to insulin resistance and increased cardiovascular risk. |
2015-01-12 |
2023-08-13 |
Not clear |
| M P Yavropoulou, K Kotsa, M Pikilidou, I Keisisoglou, J G Yovo. Effects of intracerebroventricular infusion of somatostatin-14 on peripheral glucoregulation in dogs. Journal of neuroendocrinology. vol 26. issue 1. 2015-01-10. PMID:24325321. |
serum levels of glucose, insulin and glucose-dependent insulinotrophic peptide (gip), plasma sst and serum gh levels were assayed. |
2015-01-10 |
2023-08-12 |
Not clear |
| Anna Grandone, Emanuele Miraglia del Giudice, Grazia Cirillo, Ciro Abbondanza, Michele Cioffi, Tiziana Romano, Flora Micillo, Pierluigi Marzuillo, Laura Perron. Clinical features of a new acid-labile subunit (IGFALS) heterozygous mutation: anthropometric and biochemical characterization and response to growth hormone administration. Hormone research in paediatrics. vol 81. issue 1. 2015-01-09. PMID:24356109. |
homozygous mutations in acid-labile subunit (igfals) gene result in short stature, very low circulating levels of acid-labile subunit (als), insulin growth factor 1 (igf1) and insulin growth factor binding protein 3 (igfbp3) and a poor response to growth hormone (gh). |
2015-01-09 |
2023-08-12 |
Not clear |
| Yong Fan, Xin Fang, Asako Tajima, Xuehui Geng, Sarangarajan Ranganathan, Henry Dong, Massimo Trucco, Mark A Sperlin. Evolution of hepatic steatosis to fibrosis and adenoma formation in liver-specific growth hormone receptor knockout mice. Frontiers in endocrinology. vol 5. 2015-01-08. PMID:25566190. |
non-alcoholic fatty liver disease (nafld) is one of the most common forms of chronic liver diseases closely associated with obesity and insulin resistance; deficient growth hormone (gh) action in liver has been implicated as a mechanism. |
2015-01-08 |
2023-08-13 |
mouse |
| P Anil Kumar, P Swathi Chitra, Chunxia Lu, J Sobhanaditya, Ram Meno. Growth hormone (GH) differentially regulates NF-kB activity in preadipocytes and macrophages: implications for GH's role in adipose tissue homeostasis in obesity. Journal of physiology and biochemistry. vol 70. issue 2. 2015-01-02. PMID:24532264. |
activation of nf-kb by gh in preadipocytes heightens inflammatory response by stimulating production of multiple cytokines including tnf-α, il-6, and mcp-1, the mediators of both local and systemic insulin resistance and chemokines that recruit macrophages. |
2015-01-02 |
2023-08-12 |
Not clear |
| P Anil Kumar, P Swathi Chitra, Chunxia Lu, J Sobhanaditya, Ram Meno. Growth hormone (GH) differentially regulates NF-kB activity in preadipocytes and macrophages: implications for GH's role in adipose tissue homeostasis in obesity. Journal of physiology and biochemistry. vol 70. issue 2. 2015-01-02. PMID:24532264. |
these findings further our understanding of the complex actions of gh on adipocytes and insulin sensitivity. |
2015-01-02 |
2023-08-12 |
Not clear |
| E Brzeziańska, D Domańska, A Jegie. Gene doping in sport - perspectives and risks. Biology of sport. vol 31. issue 4. 2014-12-01. PMID:25435666. |
in vitro studies improve the production of human recombinant proteins, such as insulin (ins), growth hormone (gh), insulin-like growth factor-1 (igf-1) and erythropoietin (epo), which could have therapeutic application. |
2014-12-01 |
2023-08-13 |
human |
| Mike Spillane, Neil Schwarz, Darryn S Willoughb. Heavy resistance training and peri-exercise ingestion of a multi-ingredient ergogenic nutritional supplement in males: effects on body composition, muscle performance and markers of muscle protein synthesis. Journal of sports science & medicine. vol 13. issue 4. 2014-12-01. PMID:25435783. |
serum insulin, igf-1, gh, and cortisol were not differentially affected (p > 0.05). |
2014-12-01 |
2023-08-13 |
Not clear |
| Mike Spillane, Neil Schwarz, Darryn S Willoughb. Heavy resistance training and peri-exercise ingestion of a multi-ingredient ergogenic nutritional supplement in males: effects on body composition, muscle performance and markers of muscle protein synthesis. Journal of sports science & medicine. vol 13. issue 4. 2014-12-01. PMID:25435783. |
key pointsin response to 42 days of heavy resistance training and either sizeon maximum performance or protein/carbohydrate/creatine supplementation, similar increases in muscle mass and strength in both groups occurred; however, the increases were not different between supplement groups.the supplementation of sizeon maximum performance had no preferential effect on augmenting serum insulin, igf-1, and gh, or in decreasing cortisol.while resistance training was effective in increasing total creatine content in skeletal muscle, myofibrillar protein, and the content of total irs-1 and akt, it was not preferentially due to sizeon maximum performance supplementation.at the daily dose of 50 g, sizeon maximum performance supplementation for 42 days combined with resistance training does not increases muscle mass and strength due to its ability to elevate serum hormones and growth factors or in its ability to augment skeletal muscle signaling pathway markers indicative of muscle protein synthesis when compared to an equivalent daily dose of protein/carbohydrate/creatine. |
2014-12-01 |
2023-08-13 |
Not clear |
| Meghan Slattery, Miriam A Bredella, Takara Stanley, Martin Torriani, Madhusmita Misr. Effects of recombinant human growth hormone (rhGH) administration on body composition and cardiovascular risk factors in obese adolescent girls. International journal of pediatric endocrinology. vol 2014. issue 1. 2014-12-01. PMID:25435886. |
the study's purpose was to use recombinant human growth hormone (rhgh) as a physiologic probe to assess the effects of reversing obesity-related gh deficiency on body composition, cardiovascular risk markers, and insulin resistance. |
2014-12-01 |
2023-08-13 |
human |
| Kosma Wolinski, Agata Czarnywojtek, Marek Ruchal. Risk of thyroid nodular disease and thyroid cancer in patients with acromegaly--meta-analysis and systematic review. PloS one. vol 9. issue 2. 2014-10-21. PMID:24551163. |
acromegaly is a quite rare chronic disease caused by the increased secretion of growth hormone (gh) and subsequently insulin - like growth factor 1. |
2014-10-21 |
2023-08-12 |
Not clear |
| C M Reynolds, M Li, C Gray, M H Vicker. Early-life growth hormone treatment to offspring of undernourished mothers alters metabolic parameters in primary adipocytes in adulthood. Growth factors (Chur, Switzerland). vol 32. issue 1. 2014-10-10. PMID:24392751. |
overall, preweaning gh treatment alters detrimental patterns of development, which predispose un offspring to obesity and insulin resistance. |
2014-10-10 |
2023-08-12 |
rat |
| Yevgeniya Dynkevich, Kristina I Rother, Ian Whitford, Sana Qureshi, Sneha Galiveeti, Alessandra L Szulc, Ann Danoff, Tracy L Breen, Nargess Kaviani, Michael H Shanik, Derek Leroith, Riccardo Vigneri, Christian A Koch, Jesse Rot. Tumors, IGF-2, and hypoglycemia: insights from the clinic, the laboratory, and the historical archive. Endocrine reviews. vol 34. issue 6. 2014-10-01. PMID:23671155. |
typically, the elevated igf-2 levels are associated with suppressed plasma levels of insulin, igf-1, and gh. |
2014-10-01 |
2023-08-12 |
Not clear |
| Valérie Nicolas-Francès, Ségolène Arnauld, Jacques Kaminski, Emiel Ver Loren van Themaat, Marie-Claude Clémencet, Julie Chamouton, Anne Athias, Jacques Grober, Joseph Gresti, Pascal Degrace, Laurent Lagrost, Norbert Latruffe, Stéphane Mandar. Disturbances in cholesterol, bile acid and glucose metabolism in peroxisomal 3-ketoacylCoA thiolase B deficient mice fed diets containing high or low fat contents. Biochimie. vol 98. 2014-09-22. PMID:24287293. |
first, when fed a normal regulatory laboratory chow, thb(-/-) mice displayed growth retardation as well as a severe reduction in the plasma level of growth hormone (gh) and insulin growth factor-i (igf-i), suggesting alterations in the gh/igf-1 pathway. |
2014-09-22 |
2023-08-12 |
mouse |
| Thiago Silveira Alvares, Carlos Adam Conte-Junior, Joab Trajano Silva, Vânia Margaret Flosi Paschoali. L-arginine does not improve biochemical and hormonal response in trained runners after 4 weeks of supplementation. Nutrition research (New York, N.Y.). vol 34. issue 1. 2014-09-02. PMID:24418244. |
it has been hypothesized that l-arginine improves exercise performance by increasing nitric oxide synthesis and levels of insulin and growth hormone (gh). |
2014-09-02 |
2023-08-12 |
Not clear |
| Thiago Silveira Alvares, Carlos Adam Conte-Junior, Joab Trajano Silva, Vânia Margaret Flosi Paschoali. L-arginine does not improve biochemical and hormonal response in trained runners after 4 weeks of supplementation. Nutrition research (New York, N.Y.). vol 34. issue 1. 2014-09-02. PMID:24418244. |
in addition to exercise performance (total running time), plasma nitrate, nitrite, nitrate plus nitrite, cyclic guanosine monophosphate, lactate, ammonia and serum insulin, gh, insulin-like growth factor 1, and cortisol concentrations were evaluated. |
2014-09-02 |
2023-08-12 |
Not clear |
| Sang Ouk Chin, Suk Chon, You-Cheol Hwang, In-Kyung Jeong, Seungjoon Oh, Sung-Woon Ki. Change in somatostatinergic tone of acromegalic patients according to the size of growth hormone-producing pituitary tumors. Journal of Korean medical science. vol 28. issue 12. 2014-08-26. PMID:24339708. |
gh levels of 29 patients with newly diagnosed acromegaly were measured using a 75-gram oral glucose tolerance test (ogtt), an insulin tolerance test (itt), and an octreotide suppression test (ost). |
2014-08-26 |
2023-08-12 |
Not clear |
| Xunxian Li. Overstimulation can create health problems due to increases in PI3K/Akt/GSK3 insensitivity and GSK3 activity. SpringerPlus. vol 3. 2014-08-04. PMID:25089247. |
possessing little sensitive pi3k/akt for receptor activation, cells after overstimulation, although live, hardly respond to pi3k/akt activators including gh, thyroxine and insulin. |
2014-08-04 |
2023-08-13 |
Not clear |