| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lalida Rojanathammanee, Sharlene Rakoczy, John Kopchick, Holly M Brown-Bor. Effects of insulin-like growth factor 1 on glutathione S-transferases and thioredoxin in growth hormone receptor knockout mice. Age (Dordrecht, Netherlands). vol 36. issue 4. 2015-03-31. PMID:25001375. |
these mice have very low circulating igf-1 levels and high gh levels, are obese yet insulin sensitive, and live longer than their wild-type controls. |
2015-03-31 |
2023-08-13 |
mouse |
| Vinal Menon, Xu Zhi, Tanvir Hossain, Andrzej Bartke, Adam Spong, Adam Gesing, Michal M Masterna. The contribution of visceral fat to improved insulin signaling in Ames dwarf mice. Aging cell. vol 13. issue 3. 2015-03-30. PMID:24690289. |
ames dwarf (prop1(df), df/df) mice are characterized by growth hormone (gh), prolactin, and thyrotropin deficiency, remarkable extension of longevity and increased insulin sensitivity with low levels of fasting insulin and glucose. |
2015-03-30 |
2023-08-13 |
mouse |
| Stefano Zucchini, Dario Iafusco, Silvia Vannelli, Ivana Rabbone, Giuseppina Salzano, Gabriella Pozzobon, Mohamad Maghnie, Valentino Cherubini, Carla Bizzarri, Riccardo Bonfanti, Giuseppe D'Annunzio, Lorenzo Lenzi, Maria Cristina Maggio, Marco Marigliano, Andrea Scaramuzza, Stefano Tumini, Lorenzo Iughett. Combined therapy with insulin and growth hormone in 17 patients with type-1 diabetes and growth disorders. Hormone research in paediatrics. vol 82. issue 1. 2015-03-30. PMID:24925520. |
combined growth hormone (gh) and insulin therapy is rarely prescribed by pediatric endocrinologists. |
2015-03-30 |
2023-08-13 |
Not clear |
| Michael B Stout, Tamara Tchkonia, Tamar Pirtskhalava, Allyson K Palmer, Edward O List, Darlene E Berryman, Ellen R Lubbers, Carlos Escande, Adam Spong, Michal M Masternak, Ann L Oberg, Nathan K LeBrasseur, Richard A Miller, John J Kopchick, Andrzej Bartke, James L Kirklan. Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice. Aging. vol 6. issue 7. 2015-03-30. PMID:25063774. |
further studies are needed to determine if gh is directly inducing cellular senescence in wat or if gh actions on other target organs or alternative downstream alterations in insulin-like growth factor-1, insulin or glucose levels are responsible. |
2015-03-30 |
2023-08-13 |
mouse |
| Juan Salazar-Ortiz, Philippe Monget, Daniel Guillaum. The influence of nutrition on the insulin-like growth factor system and the concentrations of growth hormone, glucose, insulin, gonadotropins and progesterone in ovarian follicular fluid and plasma from adult female horses (Equus caballus). Reproductive biology and endocrinology : RB&E. vol 12. 2015-03-30. PMID:25078409. |
the objective of this experiment was to quantify igfs, igfbps, gh, glucose, insulin, gonadotropin and progesterone (p4) in blood and in preovulatory follicular fluid (ff) in relation to feeding levels in mares. |
2015-03-30 |
2023-08-13 |
Not clear |
| Jeremy R Townsend, Jay R Hoffman, Adam M Gonzalez, Adam R Jajtner, Carleigh H Boone, Edward H Robinson, Gerald T Mangine, Adam J Wells, Maren S Fragala, David H Fukuda, Jeffrey R Stou. Effects of β-Hydroxy-β-methylbutyrate Free Acid Ingestion and Resistance Exercise on the Acute Endocrine Response. International journal of endocrinology. vol 2015. 2015-03-20. PMID:25792982. |
circulating concentrations of testosterone, growth hormone (gh), insulin-like growth factor (igf-1), and insulin were assayed. |
2015-03-20 |
2023-08-13 |
Not clear |
| Jeremy R Townsend, Jay R Hoffman, Adam M Gonzalez, Adam R Jajtner, Carleigh H Boone, Edward H Robinson, Gerald T Mangine, Adam J Wells, Maren S Fragala, David H Fukuda, Jeffrey R Stou. Effects of β-Hydroxy-β-methylbutyrate Free Acid Ingestion and Resistance Exercise on the Acute Endocrine Response. International journal of endocrinology. vol 2015. 2015-03-20. PMID:25792982. |
the resistance exercise protocol resulted in significant elevations from pre in testosterone (p < 0.01), gh (p < 0.01), and insulin (p = 0.05) at ip, with gh (p < 0.01) and insulin (p < 0.01) remaining elevated at 30p. |
2015-03-20 |
2023-08-13 |
Not clear |
| Manuel D Gahete, José Córdoba-Chacón, Daniel D Lantvit, Rosa Ortega-Salas, Rafael Sanchez-Sanchez, Francisco Pérez-Jiménez, José López-Miranda, Steven M Swanson, Justo P Castaño, Raúl M Luque, Rhonda D Kinema. Elevated GH/IGF-I promotes mammary tumors in high-fat, but not low-fat, fed mice. Carcinogenesis. vol 35. issue 11. 2015-03-13. PMID:25085903. |
since hyperlipidemia, inflammation, insulin resistance and obesity increase breast cancer risk, elevating gh may serve to exacerbate cancer progression. |
2015-03-13 |
2023-08-13 |
mouse |
| Jose Cordoba-Chacon, Manuel D Gahete, Owen P McGuinness, Rhonda D Kinema. Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice. American journal of physiology. Endocrinology and metabolism. vol 307. issue 10. 2015-02-24. PMID:25269484. |
a reciprocal relationship between insulin sensitivity and glucose tolerance has been reported in some mouse models and humans with isolated changes in growth hormone (gh) production and signaling. |
2015-02-24 |
2023-08-13 |
mouse |
| Jose Cordoba-Chacon, Manuel D Gahete, Owen P McGuinness, Rhonda D Kinema. Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice. American journal of physiology. Endocrinology and metabolism. vol 307. issue 10. 2015-02-24. PMID:25269484. |
to determine if this could be explained in part by tissue-specific changes in insulin sensitivity, hyperinsulinemic-euglycemic clamps were performed in mice with adult-onset, isolated gh deficiency and in mice with elevated endogenous gh levels due to somatotrope-specific loss of igf-i and insulin receptors. |
2015-02-24 |
2023-08-13 |
mouse |
| Jose Cordoba-Chacon, Manuel D Gahete, Owen P McGuinness, Rhonda D Kinema. Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice. American journal of physiology. Endocrinology and metabolism. vol 307. issue 10. 2015-02-24. PMID:25269484. |
a positive relationship was also observed between gh levels and endpoints of hepatic lipid metabolism known to be regulated by insulin. |
2015-02-24 |
2023-08-13 |
mouse |
| Jose Cordoba-Chacon, Manuel D Gahete, Owen P McGuinness, Rhonda D Kinema. Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice. American journal of physiology. Endocrinology and metabolism. vol 307. issue 10. 2015-02-24. PMID:25269484. |
these results suggest hepatic insulin resistance could represent an early metabolic defect in gh deficiency. |
2015-02-24 |
2023-08-13 |
mouse |
| E M Strage, M S Lewitt, J M Hanson, U Olsson, F Norrvik, I Lilliehöök, B S Holst, T Fal. Relationship among insulin resistance, growth hormone, and insulin-like growth factor I concentrations in diestrous Swedish Elkhounds. Journal of veterinary internal medicine. vol 28. issue 2. 2015-02-19. PMID:24765678. |
progesterone stimulates local canine mammary growth hormone (gh) production, which may act systemically and contribute to insulin resistance. |
2015-02-19 |
2023-08-13 |
dog |
| E M Strage, M S Lewitt, J M Hanson, U Olsson, F Norrvik, I Lilliehöök, B S Holst, T Fal. Relationship among insulin resistance, growth hormone, and insulin-like growth factor I concentrations in diestrous Swedish Elkhounds. Journal of veterinary internal medicine. vol 28. issue 2. 2015-02-19. PMID:24765678. |
swedish elkhounds are predisposed to progesterone-related diabetes mellitus, and the relationship among insulin resistance, gh, and insulin-like growth factor i (igf-i) is of particular interest. |
2015-02-19 |
2023-08-13 |
dog |
| Hong-Zhu Deng, Hong Deng, Chao-Qun Cen, Kai-Yun Chen, Min-Lian D. Post-receptor crosstalk between growth hormone and insulin signal in rats born small for gestational age with catch-up growth. PloS one. vol 9. issue 6. 2015-02-07. PMID:24963636. |
this study examined the role of gh and insulin signaling crosstalk in insulin resistance of sga rats with cug. |
2015-02-07 |
2023-08-13 |
rat |
| Kevin C J Yuen, Charles T Roberts, Jan Frystyk, William D Rooney, James R Pollaro, Bethany J Klopfenstein, Jonathan Q Purnel. Short-term, low-dose GH therapy improves insulin sensitivity without modifying cortisol metabolism and ectopic fat accumulation in adults with GH deficiency. The Journal of clinical endocrinology and metabolism. vol 99. issue 10. 2015-01-22. PMID:25013996. |
short-term, low-dose gh therapy improves insulin sensitivity without modifying cortisol metabolism and ectopic fat accumulation in adults with gh deficiency. |
2015-01-22 |
2023-08-13 |
Not clear |
| Kevin C J Yuen, Charles T Roberts, Jan Frystyk, William D Rooney, James R Pollaro, Bethany J Klopfenstein, Jonathan Q Purnel. Short-term, low-dose GH therapy improves insulin sensitivity without modifying cortisol metabolism and ectopic fat accumulation in adults with GH deficiency. The Journal of clinical endocrinology and metabolism. vol 99. issue 10. 2015-01-22. PMID:25013996. |
low-dose gh (lgh) therapy has been reported to improve insulin sensitivity in gh-deficient adults; however, the mechanism is unclear. |
2015-01-22 |
2023-08-13 |
Not clear |
| Elenilde Gomes-Santos, Roberto Salvatori, Thiago O Ferrão, Carla R P Oliveira, Rachel D C A Diniz, João A M Santana, Francisco A Pereira, Rita A A Barbosa, Anita H O Souza, Enaldo V Melo, Carlos C Epitácio-Pereira, Alécia A Oliveira-Santos, Ingrid A S Oliveira, Julianne A Machado, Francisco J Santana-Júnior, José A S Barreto-Filho, Manuel H Aguiar-Oliveir. Increased visceral adiposity and cortisol to cortisone ratio in adults with congenital lifetime isolated GH deficiency. The Journal of clinical endocrinology and metabolism. vol 99. issue 9. 2015-01-12. PMID:24926956. |
adult-onset gh deficiency (ghd) increases visceral adiposity and the activity of the enzyme 11β-hydroxysteroid dehydrogenase, which converts cortisone (e) to cortisol (f), both linked to insulin resistance and increased cardiovascular risk. |
2015-01-12 |
2023-08-13 |
Not clear |
| M P Yavropoulou, K Kotsa, M Pikilidou, I Keisisoglou, J G Yovo. Effects of intracerebroventricular infusion of somatostatin-14 on peripheral glucoregulation in dogs. Journal of neuroendocrinology. vol 26. issue 1. 2015-01-10. PMID:24325321. |
serum levels of glucose, insulin and glucose-dependent insulinotrophic peptide (gip), plasma sst and serum gh levels were assayed. |
2015-01-10 |
2023-08-12 |
Not clear |
| Anna Grandone, Emanuele Miraglia del Giudice, Grazia Cirillo, Ciro Abbondanza, Michele Cioffi, Tiziana Romano, Flora Micillo, Pierluigi Marzuillo, Laura Perron. Clinical features of a new acid-labile subunit (IGFALS) heterozygous mutation: anthropometric and biochemical characterization and response to growth hormone administration. Hormone research in paediatrics. vol 81. issue 1. 2015-01-09. PMID:24356109. |
homozygous mutations in acid-labile subunit (igfals) gene result in short stature, very low circulating levels of acid-labile subunit (als), insulin growth factor 1 (igf1) and insulin growth factor binding protein 3 (igfbp3) and a poor response to growth hormone (gh). |
2015-01-09 |
2023-08-12 |
Not clear |