| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Møller, N Pørksen, P Ovesen, K G Albert. Evidence for increased sensitivity of fuel mobilization to growth hormone during short-term fasting in humans. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 25. issue 3. 1993-05-24. PMID:8477956. |
as expected fasting induced decrements in circulating concentrations of insulin and c-peptide (p < 0.05) and increments in glucagon concentrations (p < 0.05), together with a slight increase in serum gh concentrations (p > 0.05). |
1993-05-24 |
2023-08-12 |
human |
| T J Caperna, N C Steele, C M Evock-Clover, D Brocht, J P McMurtry, R W Rosebroug. Acute effects of administration of porcine growth hormone on circulating levels of hormones and metabolites in 20-, 40-, and 60-kilogram gilts. Journal of animal science. vol 71. issue 4. 1993-05-21. PMID:8478292. |
three groups of eight gilts weighing 20, 40, or 60 kg were fitted with indwelling venous catheters to determine daily integrated circulating levels (dicl, serum concentration above baseline x time) of insulin, growth hormone (gh), glucagon, glucose, urea, and nonesterified fatty acids (nefa) in response to acute challenge with porcine pituitary gh (pgh). |
1993-05-21 |
2023-08-12 |
Not clear |
| M E Geffner, N Bersch, D W Gold. Growth hormone induces insulin resistance in Laron dwarf cells via lactogenic receptors. The Journal of clinical endocrinology and metabolism. vol 76. issue 4. 1993-05-18. PMID:8473379. |
gh (5-500 micrograms/l) caused a profound decrease in the sensitivity of normal t-lymphoblasts in response to all insulin concentrations (p < 0.0001 vs. insulin alone); pretreatment with gh and gh receptor antibody significantly improved sensitivity to all concentrations of insulin (p = ns vs. insulin alone). |
1993-05-18 |
2023-08-12 |
human |
| M E Geffner, N Bersch, D W Gold. Growth hormone induces insulin resistance in Laron dwarf cells via lactogenic receptors. The Journal of clinical endocrinology and metabolism. vol 76. issue 4. 1993-05-18. PMID:8473379. |
preincubation with gh and prl receptor antibody was associated with partial improvement in insulin sensitivity (p = 0.004 vs. insulin alone). |
1993-05-18 |
2023-08-12 |
human |
| M E Geffner, N Bersch, D W Gold. Growth hormone induces insulin resistance in Laron dwarf cells via lactogenic receptors. The Journal of clinical endocrinology and metabolism. vol 76. issue 4. 1993-05-18. PMID:8473379. |
thus, in normal t-cell lines, the major pathway of gh-induced insulin resistance appears to be directed by the gh receptor, with a smaller effect mediated through the prl receptor. |
1993-05-18 |
2023-08-12 |
human |
| M E Geffner, N Bersch, D W Gold. Growth hormone induces insulin resistance in Laron dwarf cells via lactogenic receptors. The Journal of clinical endocrinology and metabolism. vol 76. issue 4. 1993-05-18. PMID:8473379. |
while t-cell lines from laron dwarfs do not respond to gh in clonal proliferation assays, gh (50 and 100 micrograms/l) caused profound insulin resistance in these cells (p = 0.008 and p < 0.0001, respectively, vs. insulin alone). |
1993-05-18 |
2023-08-12 |
human |
| M E Geffner, N Bersch, D W Gold. Growth hormone induces insulin resistance in Laron dwarf cells via lactogenic receptors. The Journal of clinical endocrinology and metabolism. vol 76. issue 4. 1993-05-18. PMID:8473379. |
gh receptor antibody did not abrogate this effect at any insulin concentration (p = ns vs. insulin alone), but there was partial restoration of insulin sensitivity when gh and prl receptor antibody were coincubated (p = 0.0069 vs. insulin alone). |
1993-05-18 |
2023-08-12 |
human |
| M E Geffner, N Bersch, D W Gold. Growth hormone induces insulin resistance in Laron dwarf cells via lactogenic receptors. The Journal of clinical endocrinology and metabolism. vol 76. issue 4. 1993-05-18. PMID:8473379. |
the kinetics of gh-induced insulin resistance in laron t-cells were also distinct from the pattern seen in normal t-cells, and unlike in normal cells, gh had no effect on insulin-like growth factor-i-induced clonal expansion of laron t-cell lines (p = ns vs. insulin-like growth factor-i alone). |
1993-05-18 |
2023-08-12 |
human |
| N A Cole, D M Hallford, R Gallava. Influence of a glucose load in fed or unfed lambs on blood metabolites and hormone patterns. Journal of animal science. vol 71. issue 3. 1993-05-06. PMID:8096504. |
plasma or serum samples were analyzed for insulin, growth hormone (gh), somatostatin, prolactin, glucose, free fatty acids (ffa), and urea n. at the end of the period in which feed was withheld, fed lambs had greater (p < .09) serum insulin and lower plasma ffa (p < .01) and somatostatin (p < .05). |
1993-05-06 |
2023-08-12 |
Not clear |
| J G Gong, T A Bramley, R Web. The effect of recombinant bovine somatotrophin on ovarian follicular growth and development in heifers. Journal of reproduction and fertility. vol 97. issue 1. 1993-05-03. PMID:8464017. |
in a second experiment, 12 heifers were given a single injection of 10 ml saline or 320 mg bst in a sustained-release formulation to examine the temporal relationships between growth hormone (gh), insulin-like growth factor-1 (igf-1), insulin and the number of follicles. |
1993-05-03 |
2023-08-12 |
cattle |
| R Towns, J L Kostyo, D Martin, S Y Chou, M R Bennin. The stimulatory effect of insulin on diacylglycerol generation in adipocyte membranes from ob/ob mice is impaired by growth hormone. Endocrinology. vol 132. issue 4. 1993-04-30. PMID:8462467. |
physiologically, the action of insulin on carbohydrate and lipid metabolism is opposed by several hormones, including glucocorticoids, glucagon, catecholamines, and pituitary gh. |
1993-04-30 |
2023-08-12 |
mouse |
| R Towns, J L Kostyo, D Martin, S Y Chou, M R Bennin. The stimulatory effect of insulin on diacylglycerol generation in adipocyte membranes from ob/ob mice is impaired by growth hormone. Endocrinology. vol 132. issue 4. 1993-04-30. PMID:8462467. |
since the generation of diacylglycerol (dag) appears to be an early event in the insulin-signaling cascade, it was of interest to determine whether gh would interfere with this effect of insulin. |
1993-04-30 |
2023-08-12 |
mouse |
| R Towns, J L Kostyo, D Martin, S Y Chou, M R Bennin. The stimulatory effect of insulin on diacylglycerol generation in adipocyte membranes from ob/ob mice is impaired by growth hormone. Endocrinology. vol 132. issue 4. 1993-04-30. PMID:8462467. |
experiments were conducted to determine whether insulin would stimulate the generation of dag in adipocytes of the obese (ob/ob) mouse, and whether this response could be blocked by the diabetogenic gh derivative s-carboxymethylated human gh (rcm-hgh). |
1993-04-30 |
2023-08-12 |
mouse |
| C A Conover, G D Divertie, P D Le. Cortisol increases plasma insulin-like growth factor binding protein-1 in humans. Acta endocrinologica. vol 128. issue 2. 1993-04-12. PMID:7680833. |
following an overnight fast, six healthy adult volunteers received a euglycemic pancreatic clamp (somatostatin, 0.12 microgram.kg-1.min-1; gh, 3 ng.kg-1.min-1; insulin, 0.05 mu.kg-1.min-1) to block endogenous insulin secretion and to control glucose and plasma hormone concentrations at desired levels. |
1993-04-12 |
2023-08-12 |
human |
| M W Haymond, F F Horbe. The effects of human growth hormone and prednisone on whole body estimates of protein metabolism. Hormone research. vol 38 Suppl 2. 1993-04-08. PMID:1292981. |
in contrast to insulin, gh stimulates protein synthesis in skeletal muscle tissue. |
1993-04-08 |
2023-08-11 |
human |
| S Caprio, D Boulware, V Tamborlan. Growth hormone and insulin interactions. Hormone research. vol 38 Suppl 2. 1993-04-08. PMID:1292982. |
preliminary results suggest that growth hormone (gh) therapy leads to changes in glucose, amino acid and insulin responses that are qualitatively similar to those observed during puberty. |
1993-04-08 |
2023-08-11 |
Not clear |
| S Caprio, D Boulware, V Tamborlan. Growth hormone and insulin interactions. Hormone research. vol 38 Suppl 2. 1993-04-08. PMID:1292982. |
in patients with turner's syndrome, data indicate that there is an increase in the glucose-stimulated insulin response which is exaggerated by gh treatment. |
1993-04-08 |
2023-08-11 |
Not clear |
| I S Ismail, M F Scanlon, J R Peter. Cholinergic control of growth hormone (GH) responses to GH-releasing hormone in insulin dependent diabetics: evidence for attenuated hypothalamic somatostatinergic tone and decreased GH autofeedback. Clinical endocrinology. vol 38. issue 2. 1993-03-25. PMID:8094648. |
cholinergic control of growth hormone (gh) responses to gh-releasing hormone in insulin dependent diabetics: evidence for attenuated hypothalamic somatostatinergic tone and decreased gh autofeedback. |
1993-03-25 |
2023-08-12 |
Not clear |
| I S Ismail, M F Scanlon, J R Peter. Cholinergic control of growth hormone (GH) responses to GH-releasing hormone in insulin dependent diabetics: evidence for attenuated hypothalamic somatostatinergic tone and decreased GH autofeedback. Clinical endocrinology. vol 38. issue 2. 1993-03-25. PMID:8094648. |
we have investigated the effects of cholinergic modulation with pirenzepine and pyridostigmine and of gh pretreatment on the subsequent gh response to a maximal stimulatory dose of gh-releasing hormone (ghrh) in patients with insulin dependent diabetes mellitus (iddm). |
1993-03-25 |
2023-08-12 |
Not clear |
| V Coiro, R Volpi, C Marchesi, L Capretti, G Speroni, G Rossi, G Caffarri, A De Ferri, A Marcato, P Chioder. Abnormal growth hormone and cortisol, but not thyroid-stimulating hormone, responses to an intravenous glucose tolerance test in normal-weight, bulimic women. Psychoneuroendocrinology. vol 17. issue 6. 1993-03-15. PMID:1363137. |
therefore, serum gh, plasma cortisol, and plasma insulin concentrations were measured in eight women with normal weight bulimia and in eight normal women during an intravenous glucose (0.33 g/kg as an iv bolus) tolerance test (igtt). |
1993-03-15 |
2023-08-11 |
human |