| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Ezzat, S G Ren, G D Braunstein, S Melme. Octreotide stimulates insulin-like growth factor-binding protein-1: a potential pituitary-independent mechanism for drug action. The Journal of clinical endocrinology and metabolism. vol 75. issue 6. 1993-01-15. PMID:1281485. |
in conclusion, the somatostatin analog octreotide induces igfbp-1 independently of gh and insulin. |
1993-01-15 |
2023-08-11 |
human |
| V J Coulson, J A Wass, A F Abdulla, A M Cotterill, J M Holl. Insulin-like growth factor binding proteins (IGFBPs) in acromegaly. Growth regulation. vol 1. issue 3. 1993-01-14. PMID:1726836. |
in this study, the technique of western ligand blotting followed by 2-dimensional radioactive scanning was employed to investigate the correlations between relative levels of the igfbps and the main factors implicated in their regulation: igf-i, gh and insulin, in a group of acromegalics with varying disease activity. |
1993-01-14 |
2023-08-11 |
Not clear |
| V J Coulson, J A Wass, A F Abdulla, A M Cotterill, J M Holl. Insulin-like growth factor binding proteins (IGFBPs) in acromegaly. Growth regulation. vol 1. issue 3. 1993-01-14. PMID:1726836. |
igfbp-3 levels were normal in biochemically cured acromegalics with normal gh levels, although fasting insulin levels remained higher than normal (mean 16 +/- 4 vs normal 7.4 +/- 0.4 mu/l). |
1993-01-14 |
2023-08-11 |
Not clear |
| H Hong, A C Heringto. Differentiation between the effects of IGF-1 and GH on PMSG-induced progesterone production by rat granulosa cells. Growth regulation. vol 1. issue 2. 1993-01-13. PMID:1842563. |
rat granulosa cells were cultured in different concentrations of pmsg (0-100 mu/ml) plus or minus igf-1 (4 nm) or gh (hgh, 2.5 or 10 nm) in the presence or absence of cortisol (2.4 micrograms/ml) and/or insulin (68 nm) in low (5 micrograms/ml) or high (50 micrograms/ml) concentrations of transferrin (trf). |
1993-01-13 |
2023-08-11 |
rat |
| C S Nicoll, L Liu, E Alarid, M Chiang, S M Russel. Analysis of the role of hormones and growth factors in growth control and tissue differentiation using transplanted mammalian embryos and fetal structures. Growth regulation. vol 1. issue 4. 1993-01-07. PMID:1842345. |
the direct effects of insulin, gh, igfs, basic fgf and egf on transplant growth and tissue differentiation were evaluated. |
1993-01-07 |
2023-08-11 |
human |
| C S Nicoll, L Liu, E Alarid, M Chiang, S M Russel. Analysis of the role of hormones and growth factors in growth control and tissue differentiation using transplanted mammalian embryos and fetal structures. Growth regulation. vol 1. issue 4. 1993-01-07. PMID:1842345. |
insulin directly stimulated growth of transplants in diabetic hosts but gh did not have a direct effect in hypophysectomized rats. |
1993-01-07 |
2023-08-11 |
human |
| S Bernardini, G L Spadoni, G Pòvoa, B Boscherini, K Hal. Plasma levels of insulin-like growth factor binding protein-1, and growth hormone binding protein activity from birth to the third month of life. Acta endocrinologica. vol 127. issue 4. 1992-12-29. PMID:1280390. |
serum levels of insulin-like growth factors (igf-1 and igf-2), insulin, insulin-like growth factor binding protein-1 (igfbp-1), growth hormone (gh) and growth hormone-binding protein (gh-bp) activity were assessed in a group of healthy newborns and reevaluated at one and three months of life in six of them. |
1992-12-29 |
2023-08-11 |
Not clear |
| R D Neely, D P Rooney, P M Bell, N P Bell, B Sheridan, A B Atkinson, E R Trimbl. Influence of growth hormone on glucose-glucose 6-phosphate cycle and insulin action in normal humans. The American journal of physiology. vol 263. issue 5 Pt 1. 1992-12-23. PMID:1443131. |
gh increased levels of circulating lipid intermediates despite a twofold increase in basal insulin (p < 0.005), but plasma glucose, egp, and g/g-6-p cycle activity were unchanged. |
1992-12-23 |
2023-08-11 |
human |
| R D Neely, D P Rooney, P M Bell, N P Bell, B Sheridan, A B Atkinson, E R Trimbl. Influence of growth hormone on glucose-glucose 6-phosphate cycle and insulin action in normal humans. The American journal of physiology. vol 263. issue 5 Pt 1. 1992-12-23. PMID:1443131. |
gh impaired insulin suppression of egp and lipid intermediates and impaired insulin stimulation of glucose disposal, but g/g-6-p cycle activity was unchanged. |
1992-12-23 |
2023-08-11 |
human |
| R D Neely, D P Rooney, P M Bell, N P Bell, B Sheridan, A B Atkinson, E R Trimbl. Influence of growth hormone on glucose-glucose 6-phosphate cycle and insulin action in normal humans. The American journal of physiology. vol 263. issue 5 Pt 1. 1992-12-23. PMID:1443131. |
we conclude that increased activity of the g/g-6-p cycle does not contribute to the hepatic insulin resistance induced by gh under these conditions but that changes in fatty acid metabolism may be partly responsible for the impairment in hepatic and peripheral insulin action. |
1992-12-23 |
2023-08-11 |
human |
| S G Ren, S Ezzat, S Melmed, G D Braunstei. Somatostatin analog induces insulin-like growth factor binding protein-1 (IGFBP-1) expression in human hepatoma cells. Endocrinology. vol 131. issue 5. 1992-12-01. PMID:1385103. |
thus, octreotide induces basal and stimulated igfbp-1 in hepatocytes independently of insulin and gh. |
1992-12-01 |
2023-08-11 |
human |
| O Söder, P Bang, A Wahab, M Parvine. Insulin-like growth factors selectively stimulate spermatogonial, but not meiotic, deoxyribonucleic acid synthesis during rat spermatogenesis. Endocrinology. vol 131. issue 5. 1992-12-01. PMID:1425434. |
the in vitro effects of insulin-like growth factor-i (igf-i), insulin-like growth factor-ii (igf-ii), truncated igf-i, insulin, and human gh (hgh) on premitotic and premeiotic dna synthesis of adult rat germ cells in vitro were investigated. |
1992-12-01 |
2023-08-11 |
human |
| J Verhaeghe, A M Suiker, W J Visser, E Van Herck, R Van Bree, R Bouillo. The effects of systemic insulin, insulin-like growth factor-I and growth hormone on bone growth and turnover in spontaneously diabetic BB rats. The Journal of endocrinology. vol 134. issue 3. 1992-11-17. PMID:1402554. |
in this study, male diabetic bb rats were infused intraperitoneally or subcutaneously for 2 weeks with hormones that are believed to stimulate skeletal growth and/or trabecular bone formation: insulin (3 or 4 u/day), human gh (hgh; 400 mu/day), recombinant human insulin-like growth factor-i (rhigf-i; 300 or 600 micrograms/day) and testosterone (80 micrograms/100 g body weight per day). |
1992-11-17 |
2023-08-11 |
human |
| G Ashcom, G Gurland, J Schwart. Growth hormone synergizes with serum growth factors in inducing c-fos transcription in 3T3-F442A cells. Endocrinology. vol 131. issue 4. 1992-11-13. PMID:1396336. |
insulin and fibroblast growth factor also synergized with gh in inducing c-fos expression. |
1992-11-13 |
2023-08-11 |
Not clear |
| C Alvarez, F Escrivá, A M Pascual-Leon. Effect of growth hormone on liver glycogen accumulation in suckling rats. Hormone research. vol 37. issue 1-2. 1992-11-06. PMID:1398475. |
seventy-two hours after the last gh administration, liver glycogen was increased without concomitant elevation of plasma insulin and corticosterone levels and in addition without sequential inactivation of glycogen synthase. |
1992-11-06 |
2023-08-11 |
rat |
| G Hildebrandt, J Zierski, G Csecsei, H W Mueller, H Strack. Results of continuous long-term intravenous application of octreotide via an implantable pump system in acromegaly resistant to operative and X-ray therapy. Acta neurochirurgica. vol 117. issue 3-4. 1992-11-04. PMID:1414517. |
the octreotide doses used permanently for a cumulative treatment period of 8.8 yr ranged between 300 and 1000 micrograms/24 h. serial evaluations of clinical findings, 24-h gh and insulin profiles, insulin growth factor-1 (igf-1), oral glucose tolerance test and pituitary function revealed sustained gh suppression, without interim escape, below 2 ng/ml in two and below 5 ng/ml in three patients, igf-1 decrease in all with normalization in two patients and no clinically relevant disturbances of carbohydrate tolerance or thyroid-stimulating hormone secretion. |
1992-11-04 |
2023-08-11 |
Not clear |
| T Momoi, C Yamanaka, M Kobayashi, T Haruta, H Sasaki, T Yorifuji, M Kaji, H Mikaw. Short stature with normal growth hormone and elevated IGF-I. European journal of pediatrics. vol 151. issue 5. 1992-10-30. PMID:1396882. |
her growth hormone (gh) sleep pattern and responses to insulin, l-dopa, arginine, propranolol-glucagon and growth hormone-releasing hormone were normal. |
1992-10-30 |
2023-08-11 |
rat |
| R M Catalioto, D Gaillard, G Ailhaud, R Négre. Terminal differentiation of mouse preadipocyte cells: the mitogenic-adipogenic role of growth hormone is mediated by the protein kinase C signalling pathway. Growth factors (Chur, Switzerland). vol 6. issue 3. 1992-10-26. PMID:1389231. |
despite the presence of insulin-like growth factor-i (igf-i) to substitute for supraphysiological concentrations of insulin and to saturate igf-i receptor, gh was still required to induce terminal differentiation of a maximal number of cells. |
1992-10-26 |
2023-08-11 |
mouse |
| b' L Altomonte, A Zoli, L Mirone, G Marchese, P Scolieri, A Barini, M Magar\\xc3\\xb. Growth hormone secretion in diffuse idiopathic skeletal hyperostosis. Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna. vol 7. issue 1. 1992-10-22. PMID:1524945.' |
serum insulin and c-peptide response to an oral glucose tolerance test (ogtt) and serum growth hormone (gh) response to an intravenous insulin tolerance test (ivitt) were investigated in six non-obese patients, with normal glucose tolerance, affected by diffuse idiopathic skeletal hyperostosis (dish). |
1992-10-22 |
2023-08-11 |
Not clear |
| b' L Altomonte, A Zoli, L Mirone, G Marchese, P Scolieri, A Barini, M Magar\\xc3\\xb. Growth hormone secretion in diffuse idiopathic skeletal hyperostosis. Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna. vol 7. issue 1. 1992-10-22. PMID:1524945.' |
basal serum insulin, c-peptide and gh values were similar in dish patients and in controls. |
1992-10-22 |
2023-08-11 |
Not clear |