| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeannine C Foley, Sally R McIver, Philip G Haydo. Gliotransmission modulates baseline mechanical nociception. Molecular pain. vol 7. 2012-08-06. PMID:22136202. |
under baseline conditions, immunostaining in the dorsal horn of the spinal cord showed astrocyte-specific transgene expression in dnsnare mice, and no difference in expression levels of the astrocyte marker gfap and the microglia marker iba1 relative to wild-type mice. |
2012-08-06 |
2023-08-12 |
mouse |
| X Zhang, J Wang, Q Zhou, Y Xu, S Pu, J Wu, Y Xue, Y Tian, J Lu, W Jiang, D D. Brain-derived neurotrophic factor-activated astrocytes produce mechanical allodynia in neuropathic pain. Neuroscience. vol 199. 2012-04-06. PMID:22044922. |
we have found increased glial fibrillary acidic protein (gfap) expression, a hallmark of reactive gliosis, and elevated brain-derived neurotrophic factor (bdnf) expression in the dorsal horn in a rat model of allodynia induced by spinal nerve ligation (snl). |
2012-04-06 |
2023-08-12 |
rat |
| Robert R Myers, Veronica I Shubaye. The ology of neuropathy: an integrative review of the role of neuroinflammation and TNF-α axonal transport in neuropathic pain. Journal of the peripheral nervous system : JPNS. vol 16. issue 4. 2012-04-05. PMID:22176142. |
new data demonstrate that axonally transported (biotinylated) tnf-α activates and localizes with dorsal horn astrocytes within 96 h after injection into sciatic nerve, and that glial fibrillary acidic protein (gfap) activation in these glial cells is diminished in tnf receptor 1 knockout mice. |
2012-04-05 |
2023-08-12 |
mouse |
| Xuexing Zheng, Handong Ouyang, Shue Liu, Marina Mata, David J Fink, Shuanglin Ha. TNFα is involved in neuropathic pain induced by nucleoside reverse transcriptase inhibitor in rats. Brain, behavior, and immunity. vol 25. issue 8. 2012-02-01. PMID:21741472. |
we found that ddc induced overexpression of both mrna and proteins of gfap and tnfα in the spinal dorsal horn. |
2012-02-01 |
2023-08-12 |
rat |
| Xuexing Zheng, Handong Ouyang, Shue Liu, Marina Mata, David J Fink, Shuanglin Ha. TNFα is involved in neuropathic pain induced by nucleoside reverse transcriptase inhibitor in rats. Brain, behavior, and immunity. vol 25. issue 8. 2012-02-01. PMID:21741472. |
tnfα was colocalized with gfap in the spinal dorsal horn and with neun in the drg. |
2012-02-01 |
2023-08-12 |
rat |
| Ming Gu, Kan Miyoshi, Ronald Dubner, Wei Guo, Shiping Zou, Ke Ren, Koichi Noguchi, Feng We. Spinal 5-HT(3) receptor activation induces behavioral hypersensitivity via a neuronal-glial-neuronal signaling cascade. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 36. 2011-10-31. PMID:21900561. |
in addition, exogenous brain-derived neurotrophic factor-induced descending pain facilitation was accompanied by upregulation of cd11b and gfap expression in the spinal dorsal horn after microinjection in the rvm, and these events were significantly prevented by functional blockade of spinal 5-ht(3) receptors. |
2011-10-31 |
2023-08-12 |
rat |
| K Hidaka, K Ono, N Harano, T Sago, M Nunomaki, S Shiiba, O Nakanishi, H Fukushima, K Inenag. Central glial activation mediates cancer-induced pain in a rat facial cancer model. Neuroscience. vol 180. 2011-08-04. PMID:21315808. |
in immunostainings for iba1 and glial fibrillary acidic protein (gfap), although there were no morphological changes of gfap-immunopositive satellite glial cells in the trigeminal ganglion, iba1-immunopositive microglia and gfap-immunopositive astrocytes in the medullary dorsal horn showed large somata with cell proliferation. |
2011-08-04 |
2023-08-12 |
rat |
| Peter M Grace, Mark R Hutchinson, Jim Manavis, Andrew A Somogyi, Paul E Rola. A novel animal model of graded neuropathic pain: utility to investigate mechanisms of population heterogeneity. Journal of neuroscience methods. vol 193. issue 1. 2011-01-21. PMID:20817038. |
astrocyte gfap expression was positively associated with graded allodynia in the ipsilateral dorsal horn (p=0.18, r(2)>0.6) and ipsilateral dlf (p<0.05, r(2)>0.9). |
2011-01-21 |
2023-08-12 |
rat |
| H Nie, H Zhang, H R Wen. Minocycline prevents impaired glial glutamate uptake in the spinal sensory synapses of neuropathic rats. Neuroscience. vol 170. issue 3. 2011-01-11. PMID:20678556. |
the effects of minocycline treatments on the dorsal horn expression of glial gts and astrocyte marker glial fibrillary acidic protein (gfap) were analyzed by immunohistochemistry. |
2011-01-11 |
2023-08-12 |
rat |
| Sarah M Rothman, Kristen J Nicholson, Beth A Winkelstei. Time-dependent mechanics and measures of glial activation and behavioral sensitivity in a rodent model of radiculopathy. Journal of neurotrauma. vol 27. issue 5. 2010-12-14. PMID:20121422. |
immunohistochemistry and quantitative densitometry detected gfap and ox-42 in the dorsal horn at day 7. |
2010-12-14 |
2023-08-12 |
rat |
| R J Horvath, R P Landry, E A Romero-Sandoval, J A DeLe. Morphine tolerance attenuates the resolution of postoperative pain and enhances spinal microglial p38 and extracellular receptor kinase phosphorylation. Neuroscience. vol 169. issue 2. 2010-11-23. PMID:20493931. |
however, no changes in iba1 or gfap expression were observed in the spinal cord dorsal horn between groups. |
2010-11-23 |
2023-08-12 |
rat |
| Rachel Wodarski, Anna K Clark, John Grist, Fabien Marchand, Marzia Malcangi. Gabapentin reverses microglial activation in the spinal cord of streptozotocin-induced diabetic rats. European journal of pain (London, England). vol 13. issue 8. 2009-10-23. PMID:18977160. |
quantification of cell markers iba-1 for microglia and gfap for astrocytes revealed extensive activation of microglia in the dorsal horn of diabetic rats, whereas a reduction in the number of astrocytes could be observed. |
2009-10-23 |
2023-08-12 |
rat |
| Hayley Hernstadt, Shuxing Wang, Grewo Lim, Jianren Ma. Spinal translocator protein (TSPO) modulates pain behavior in rats with CFA-induced monoarthritis. Brain research. vol 1286. 2009-10-20. PMID:19555675. |
moreover, tspo was colocalized with iba-1, gfap and neun within the spinal cord dorsal horn. |
2009-10-20 |
2023-08-12 |
rat |
| Y S Gwak, C E Hulsebosc. Remote astrocytic and microglial activation modulates neuronal hyperexcitability and below-level neuropathic pain after spinal injury in rat. Neuroscience. vol 161. issue 3. 2009-08-24. PMID:19332108. |
in immunohistochemical studies, astrocytes and microglia in rats with spinal hemisection showed significantly increased gfap and ox-42 expression in both superficial and deep dorsal horns in the lumbar spinal dorsal horn compared to sham controls (* p<0.05) that was prevented in a dose-related manner by ppf. |
2009-08-24 |
2023-08-12 |
rat |
| Young Seob Gwak, Eric D Crown, Geda C Unabia, Claire E Hulsebosc. Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat. Pain. vol 138. issue 2. 2009-01-26. PMID:18353556. |
in addition, astrocytes and microglia showed soma hypertrophy as determined by increased soma area and increased gfap and cd11b on both sides of the lumbar dorsal horn compared to sham controls, respectively (p<0.05). |
2009-01-26 |
2023-08-12 |
rat |
| Alfonso Romero-Sandoval, Nu Chai, Nancy Nutile-McMenemy, Joyce A Dele. A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain. Brain research. vol 1219. 2008-10-08. PMID:18538310. |
following paw incision and at spinal l5 segment gfap expression was increased in laminae i-ii and iba1 in deep laminae on day 1, in the entire dorsal horn on day 4 and dissipated on day 7 after paw incision in parallel with the allodynia. |
2008-10-08 |
2023-08-12 |
rat |
| Alfonso Romero-Sandoval, Nu Chai, Nancy Nutile-McMenemy, Joyce A Dele. A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain. Brain research. vol 1219. 2008-10-08. PMID:18538310. |
conversely, gfap increased at later time points from day 4 (deep laminae) and on day 7 (entire dorsal horn). |
2008-10-08 |
2023-08-12 |
rat |
| Kristin L Schreiber, Alvin J Beitz, George L Wilco. Activation of spinal microglia in a murine model of peripheral inflammation-induced, long-lasting contralateral allodynia. Neuroscience letters. vol 440. issue 1. 2008-09-26. PMID:18541374. |
the delayed development of contralateral allodynia correlated with an increase in ox-42, but not gfap immunoreactivity in the contralateral dorsal horn. |
2008-09-26 |
2023-08-12 |
mouse |
| Dario Siniscalco, Catia Giordano, Carlo Fuccio, Livio Luongo, Franca Ferraraccio, Francesca Rossi, Vito de Novellis, Kevin A Roth, Sabatino Maion. Involvement of subtype 1 metabotropic glutamate receptors in apoptosis and caspase-7 over-expression in spinal cord of neuropathic rats. Pharmacological research. vol 57. issue 3. 2008-07-18. PMID:18325779. |
rt-pcr analysis showed increased expression of bax, apoptotic protease-activating factor-1 (apaf-1), nestin, gfap, and caspase-7 mrna in the dorsal horn spinal cord by 3 days post-cci. |
2008-07-18 |
2023-08-12 |
rat |
| Ming Qin, Jing-Jie Wang, Rong Cao, Hui Zhang, Li Duan, Bei Gao, Ying-Fei Xiong, Liang-Wei Chen, Zhi-Ren Ra. The lumbar spinal cord glial cells actively modulate subcutaneous formalin induced hyperalgesia in the rat. Neuroscience research. vol 55. issue 4. 2006-09-08. PMID:16759728. |
it was demonstrated that fos/neun immunoreactive (-ir) neurons, glial fibrillary acidic protein (gfap)-ir astrocytes and ox42-ir microglia were distributed in dorsal horn of lumbar spinal cord, predominantly in the superficial layer. |
2006-09-08 |
2023-08-12 |
rat |