| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sheu-Ran Choi, Alvin J Beitz, Jang-Hern Le. Inhibition of cytochrome P450c17 reduces spinal astrocyte activation in a mouse model of neuropathic pain via regulation of p38 MAPK phosphorylation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 118. 2020-02-10. PMID:31387001. |
sciatic nerve injury induced a significant increase in glial fibrillary acidic protein (gfap) expression in the superficial dorsal horn (sdh, laminae i-ii) and nucleus proprius (np, laminae iii-iv) regions of the spinal cord dorsal horn. |
2020-02-10 |
2023-08-13 |
mouse |
| Hoon-Seong Choi, Dae-Hyun Roh, Seo-Yeon Yoon, Soon-Gu Kwon, Sheu-Ran Choi, Suk-Yun Kang, Ji-Young Moon, Ho-Jae Han, Hyun-Woo Kim, Alvin J Beitz, Jang-Hern Le. The role of spinal interleukin-1β and astrocyte connexin 43 in the development of mirror-image pain in an inflammatory pain model. Experimental neurology. vol 287. issue Pt 1. 2019-11-20. PMID:27776252. |
immunohistochemistry and western blot analysis were used to determine changes in the expression of gfap and connexins (cx) in the spinal cord dorsal horn. |
2019-11-20 |
2023-08-13 |
rat |
| Hsien-Yin Liao, Ching-Liang Hsieh, Chun-Ping Huang, Yi-Wen Li. Electroacupuncture Attenuates Induction of Inflammatory Pain by Regulating Opioid and Adenosine Pathways in Mice. Scientific reports. vol 7. issue 1. 2019-07-03. PMID:29142219. |
in cfa-injected mice, a dramatic increase was observed in the expression of the following proteins in the dorsal root ganglion and spinal cord dorsal horn: the astrocytic marker gfap, s100b, rage, ppkcε, cox-2, perk, and pnfκb. |
2019-07-03 |
2023-08-13 |
mouse |
| Wenqian Yang, Qulian Guo, Zhigang Cheng, Yunjiao Wang, Nianyue Bai, Zhenghua H. [mTOR signaling pathway of spinal cord is involved in peripheral nerve injury-induced hyperalgesia in rats]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 44. issue 4. 2019-05-30. PMID:31113912. |
the lumbar spinal cords were selected and the expression of glial fibrillary acidic protein (gfap) in spinal dorsal horn were examined by immunohistochemistry in the 14th day after cci.
results: the immunohistochemistry positive particles of mtor were widely distributed in the cytoplasm of the normal spinal neurons. |
2019-05-30 |
2023-08-13 |
rat |
| Wenqian Yang, Qulian Guo, Zhigang Cheng, Yunjiao Wang, Nianyue Bai, Zhenghua H. [mTOR signaling pathway of spinal cord is involved in peripheral nerve injury-induced hyperalgesia in rats]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 44. issue 4. 2019-05-30. PMID:31113912. |
the gfap immunohistochemistry positive area and absorbance value in the dorsal horn of the lumbar spinal cord in the cci rats were decreased in the cci+early rapa group compared with the cci+early dmso group (p<0.05 or p<0.01), and which were also decreased in the cci+later rapa group compared with the cci+later dmso group (p<0.05 or p<0.01).
conclusion: mtor signaling pathway may be involved in hyperalgesia induced by peripheral nerve injury via spinal astrocyte activation in the dorsal horn of the spinal cord. |
2019-05-30 |
2023-08-13 |
rat |
| Kelsi N Dodds, Elizabeth A H Beckett, Susan F Evans, Mark R Hutchinso. Spinal Glial Adaptations Occur in a Minimally Invasive Mouse Model of Endometriosis: Potential Implications for Lesion Etiology and Persistent Pelvic Pain. Reproductive sciences (Thousand Oaks, Calif.). vol 26. issue 3. 2019-04-17. PMID:29730970. |
spinal cords (t13-s1) from female c57bl/6 mice with endometriosis-like lesions (endo) were imaged via fluorescent immunohistochemistry for the expression of glial fibrillary acidic protein (gfap; astrocytes) and cd11b (microglia) in the dorsal horn (n = 5). |
2019-04-17 |
2023-08-13 |
mouse |
| Arden G Vanderwall, Shahani Noor, Melody S Sun, Jacob E Sanchez, Xuexian O Yang, Lauren L Jantzie, Nikolaos Mellios, Erin D Milliga. Effects of spinal non-viral interleukin-10 gene therapy formulated with d-mannose in neuropathic interleukin-10 deficient mice: Behavioral characterization, mRNA and protein analysis in pain relevant tissues. Brain, behavior, and immunity. vol 69. 2019-04-15. PMID:29113923. |
similarly, dm/pdna-il-10 treatment decreases immunoreactivity for the astrocyte activation marker gfap in lumbar spinal cord dorsal horn. |
2019-04-15 |
2023-08-13 |
mouse |
| Suzanne Doolen, Tommaso Iannitti, Renee R Donahue, Benjamin C Shaw, Carolyn M Grachen, Bradley K Taylo. Fingolimod reduces neuropathic pain behaviors in a mouse model of multiple sclerosis by a sphingosine-1 phosphate receptor 1-dependent inhibition of central sensitization in the dorsal horn. Pain. vol 159. issue 2. 2019-03-21. PMID:29140922. |
fingolimod also reduced cellular markers of central sensitization of neurons in the dorsal horn of the spinal cord: glutamate-evoked ca signaling and stimulus-evoked phospho-extracellular signal-related kinase erk (perk) expression, as well as upregulation of astrocytes (gfap) and macrophage/microglia (iba1) immunoreactivity. |
2019-03-21 |
2023-08-13 |
mouse |
| Norikazu Kiguchi, Huiping Ding, Christopher M Peters, Nancy D Kock, Shiroh Kishioka, J Mark Cline, Janice D Wagner, Mei-Chuan K. Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 1. 2018-12-11. PMID:27751964. |
by using rt-qpcr, we found that mrna expression levels of both gfap and iba1 were up-regulated in the spinal dorsal horn (sdh) of diabetic monkeys compared with non-diabetic monkeys. |
2018-12-11 |
2023-08-13 |
monkey |
| Lu Yang, Sai-Hua Wang, Yan Hu, Yan-Fang Sui, Tao Peng, Tie-Cheng Gu. Effects of Repetitive Transcranial Magnetic Stimulation on Astrocytes Proliferation and nNOS Expression in Neuropathic Pain Rats. Current medical science. vol 38. issue 3. 2018-11-02. PMID:30074216. |
double immunofluorescent labeling for glial fibrillary acidic protein (gfap) and 5-bromo-2- deoxyuridine (brdu) was employed to observe the activation and proliferation of astrocytes in the ipsilateral l4-6 spinal dorsal horn. |
2018-11-02 |
2023-08-13 |
rat |
| Lu Yang, Sai-Hua Wang, Yan Hu, Yan-Fang Sui, Tao Peng, Tie-Cheng Gu. Effects of Repetitive Transcranial Magnetic Stimulation on Astrocytes Proliferation and nNOS Expression in Neuropathic Pain Rats. Current medical science. vol 38. issue 3. 2018-11-02. PMID:30074216. |
double immunofluorescence suggested that the expression of gfap and the co-localization with brdu in astrocytes were less in the sham-operated group than those in the sham-rtms group and the 1 hz group in l4-6 spinal dorsal horn ipsilateral to the neuropathic pain. |
2018-11-02 |
2023-08-13 |
rat |
| Hsien-Yin Liao, Ching-Liang Hsieh, Chun-Ping Huang, Yi-Wen Li. Electroacupuncture Attenuates CFA-induced Inflammatory Pain by suppressing Nav1.8 through S100B, TRPV1, Opioid, and Adenosine Pathways in Mice. Scientific reports. vol 7. 2018-10-30. PMID:28211895. |
the expression of the astrocytic marker glial fibrillary acidic protein (gfap), the microglial marker iba-1, s100b, receptor for advanced glycation end-products (rage), trpv1, and other related molecules was dramatically increased in the dorsal root ganglion (drg) and spinal cord dorsal horn (scdh) of cfa-treated mice. |
2018-10-30 |
2023-08-13 |
mouse |
| Benoit Michot, Ronald Deumens, Emmanuel Herman. Immunohistochemical comparison of astrocytic mGluR5 upregulation in infraorbital nerve- versus sciatic nerve-ligated rat. Neuroscience letters. vol 653. 2018-04-30. PMID:28533177. |
seven days later, mglur5 and the astrocyte marker gfap (glial fibrillary acidic protein) were overexpressed and appeared localized mainly in the superficial lamina of the trigeminal nucleus in cci-ion and the spinal cord dorsal horn in cci-sn rats. |
2018-04-30 |
2023-08-13 |
rat |
| Ruchi Yadav, Han-Rong Wen. EZH2 regulates spinal neuroinflammation in rats with neuropathic pain. Neuroscience. vol 349. 2018-01-16. PMID:28257897. |
such analgesic effects were concurrently associated with the reduced levels of ezh2, h3k27tm, iba1, gfap, tnf-α, il-1β, and mcp-1 in the spinal dorsal horn in rats with nerve injury. |
2018-01-16 |
2023-08-13 |
rat |
| Ryuji Terayama, Yuya Yamamoto, Noriko Kishimoto, Mitsuyasu Tabata, Kotaro Maruhama, Seiji Iida, Tomosada Sugimot. Differential Changes in Neuronal Excitability in the Spinal Dorsal Horn After Spinal Nerve Ligation in Rats. Neurochemical research. vol 41. issue 11. 2017-04-05. PMID:27418277. |
immunofluorescence labeling of ox-42 and gfap indicated sequential activation of microglia and astrocytes in the spinal dorsal horn. |
2017-04-05 |
2023-08-13 |
rat |
| B A Smeester, E E O'Brien, K S Michlitsch, J-H Lee, A J Beit. The relationship of bone-tumor-induced spinal cord astrocyte activation and aromatase expression to mechanical hyperalgesia and cold hypersensitivity in intact female and ovariectomized mice. Neuroscience. vol 324. 2017-01-03. PMID:26995084. |
as an extension of this work, we now report on the association of tumor-induced mechanical hyperalgesia and cold hypersensitivity to changes in spinal cord dorsal horn gfap and aromatase expression in intact (int) female mice and the effect of ovariectomy on these parameters. |
2017-01-03 |
2023-08-13 |
mouse |
| Bo Deng, Liqun Jia, Lin Pan, Aiping Song, Yuanyuan Wang, Huangying Tan, Qing Xiang, Lili Yu, Dandan K. Wen-Luo-Tong Prevents Glial Activation and Nociceptive Sensitization in a Rat Model of Oxaliplatin-Induced Neuropathic Pain. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2016-09-19. PMID:27642352. |
in the spinal dorsal horn, hypertrophy and activation of gfap-positive astrocytes were averted, and the level of gfap mrna decreased significantly. |
2016-09-19 |
2023-08-13 |
rat |
| Corinne A Lee-Kubli, Martin Ingves, Kenneth W Henry, Rani Shiao, Eileen Collyer, Mark H Tuszynski, Wendy M Campan. Analysis of the behavioral, cellular and molecular characteristics of pain in severe rodent spinal cord injury. Experimental neurology. vol 278. 2016-07-14. PMID:26808661. |
immunoblotting and immunofluorescence of c6-c8 spinal dorsal horn, reflecting sensory innervation of the forepaw, revealed: 1) expansion of cgrp immunoreactivity in lamina i/ii; 2) increased gap-43 expression; and 3) increased iba1, gfap and connexin-43 expression. |
2016-07-14 |
2023-08-13 |
human |
| Alessandro Gallo, Andrea Dimiziani, Jonathan Damblon, Benoît Michot, Anne Des Rieux, Marc De Kock, Emmanuel Hermans, Ronald Deumen. Modulation of spinal glial reactivity by intrathecal PPF is not sufficient to inhibit mechanical allodynia induced by nerve crush. Neuroscience research. vol 95. 2016-01-19. PMID:25697394. |
microglial/macrophage iba-1 and astrocytic gfap expression, increased in the dorsal horn of nerve crushed animals, was, however, effectively attenuated by propentofylline. |
2016-01-19 |
2023-08-13 |
rat |
| Jaime L Watson, Tamara J Hala, Rajarshi Putatunda, Daniel Sannie, Angelo C Lepor. Persistent at-level thermal hyperalgesia and tactile allodynia accompany chronic neuronal and astrocyte activation in superficial dorsal horn following mouse cervical contusion spinal cord injury. PloS one. vol 9. issue 9. 2015-12-21. PMID:25268642. |
following injury, an increase in the number of neurons expressing Δfosb (a marker of chronic neuronal activation), persistent astrocyte activation and proliferation (as measured by gfap and ki67 expression), and a decrease in the expression of the astrocyte glutamate transporter glt1 are observed in the ipsilateral superficial dorsal horn of cervical spinal cord. |
2015-12-21 |
2023-08-13 |
mouse |