| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nathan D Crosby, Taylor M Gilliland, Beth A Winkelstei. Early afferent activity from the facet joint after painful trauma to its capsule potentiates neuronal excitability and glutamate signaling in the spinal cord. Pain. vol 155. issue 9. 2015-10-26. PMID:24978827. |
facet injury with saline vehicle treatment induced significant mechanical hyperalgesia (p<.027), dorsal horn neuronal hyperexcitability (p<.026), upregulation of perk1/2, pnr1, mglur5, glast, and gfap, and downregulation of glt1 (p<.032). |
2015-10-26 |
2023-08-13 |
Not clear |
| Jastrow Canlas, Phillip Holt, Alexander Carroll, Shane Rix, Paul Ryan, Lorena Davies, Dusan Matusica, Stuart M Pitson, Claire F Jessup, Ian L Gibbins, Rainer V Haberberge. Sphingosine kinase 2-deficiency mediated changes in spinal pain processing. Frontiers in molecular neuroscience. vol 8. 2015-08-18. PMID:26283908. |
similarly, sphk2(-/-) mice showed in contrast to wild-type no cpi-dependent increase in areas of the dorsal horn immunoreactive for the microglia marker iba-1 and the astrocyte marker glial fibrillary acidic protein (gfap). |
2015-08-18 |
2023-08-13 |
mouse |
| M Gao, X Yan, H-R Wen. Inhibition of glycogen synthase kinase 3β activity with lithium prevents and attenuates paclitaxel-induced neuropathic pain. Neuroscience. vol 254. 2015-02-23. PMID:24070631. |
in this study, we uncovered that increased activation of glycogen synthase kinase 3beta (gsk3β) in the spinal dorsal horn was concurrently associated with increased protein expressions of gfap, il-1β and a decreased protein expression of glial glutamate transporter 1 (glt-1), as well as the development and maintenance of taxol-induced neuropathic pain. |
2015-02-23 |
2023-08-12 |
Not clear |
| M Gao, X Yan, H-R Wen. Inhibition of glycogen synthase kinase 3β activity with lithium prevents and attenuates paclitaxel-induced neuropathic pain. Neuroscience. vol 254. 2015-02-23. PMID:24070631. |
meanwhile, protein expressions of glt-1, gfap and il-1β in the spinal dorsal horn were improved. |
2015-02-23 |
2023-08-12 |
Not clear |
| Ke-Jun Zhu, Ji-Shun Yan. Anti-allodynia effect of safranal on neuropathic pain induced by spinal nerve transection in rat. International journal of clinical and experimental medicine. vol 7. issue 12. 2015-02-09. PMID:25663997. |
meanwhile, to elucidate the mechanism, we determined the dynamic expression changes of glial activation markers (gfap and ox-42) and inflammatory cytokines (tnf-α and il-1β) in ipsilateral dorsal horn of lumbar enlargement post surgery. |
2015-02-09 |
2023-08-13 |
rat |
| Byung-Soo Ahn, Seong-Kyu Kim, Ha Neul Kim, Ji-Hye Lee, Ji-Hwan Lee, Deog Sang Hwang, Hyunsu Bae, Byung-Il Min, Sun Kwang Ki. Gyejigachulbu-Tang Relieves Oxaliplatin-Induced Neuropathic Cold and Mechanical Hypersensitivity in Rats via the Suppression of Spinal Glial Activation. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-12-16. PMID:25505922. |
immunoreactivities of glial fibrillary acidic protein (gfap, astrocyte marker) and ox-42 (microglia marker) in the spinal dorsal horn were significantly increased by an oxaliplatin injection, which were restored by gbt administration. |
2014-12-16 |
2023-08-13 |
rat |
| Vincent R R Ducourneau, Tiphaine Dolique, Sabira Hachem-Delaunay, Loïs S Miraucourt, Aurélie Amadio, Lucie Blaszczyk, Florian Jacquot, Jennifer Ly, Laurent Devoize, Stéphane H R Oliet, Radhouane Dallel, Jean-Pierre Mothet, Frédéric Nagy, Valérie S Fénelon, Daniel L Voisi. Cancer pain is not necessarily correlated with spinal overexpression of reactive glia markers. Pain. vol 155. issue 2. 2014-10-06. PMID:24120461. |
however, at any time during the evolution of tumor, there was no increase in glial fibrillary acidic protein (gfap) immunoreactivity in the dorsal horn. |
2014-10-06 |
2023-08-12 |
rat |
| Vincent R R Ducourneau, Tiphaine Dolique, Sabira Hachem-Delaunay, Loïs S Miraucourt, Aurélie Amadio, Lucie Blaszczyk, Florian Jacquot, Jennifer Ly, Laurent Devoize, Stéphane H R Oliet, Radhouane Dallel, Jean-Pierre Mothet, Frédéric Nagy, Valérie S Fénelon, Daniel L Voisi. Cancer pain is not necessarily correlated with spinal overexpression of reactive glia markers. Pain. vol 155. issue 2. 2014-10-06. PMID:24120461. |
further analysis at 21days after injection of the tumor showed no increase in gfap and interleukin (il) 1β transcripts, number of superficial dorsal horn s100β protein immunoreactive astrocytes, or immunoreactivity for microglial markers (ox-42 and iba-1). |
2014-10-06 |
2023-08-12 |
rat |
| Degang Yu, Fengxiang Liu, Ming Liu, Xin Zhao, Xiaoqing Wang, Yang Li, Yuanqing Mao, Zhenan Zh. The inhibition of subchondral bone lesions significantly reversed the weight-bearing deficit and the overexpression of CGRP in DRG neurons, GFAP and Iba-1 in the spinal dorsal horn in the monosodium iodoacetate induced model of osteoarthritis pain. PloS one. vol 8. issue 10. 2014-09-04. PMID:24204985. |
the inhibition of subchondral bone lesions significantly reversed the weight-bearing deficit and the overexpression of cgrp in drg neurons, gfap and iba-1 in the spinal dorsal horn in the monosodium iodoacetate induced model of osteoarthritis pain. |
2014-09-04 |
2023-08-12 |
Not clear |
| K J Nicholson, T M Gilliland, B A Winkelstei. Upregulation of GLT-1 by treatment with ceftriaxone alleviates radicular pain by reducing spinal astrocyte activation and neuronal hyperexcitability. Journal of neuroscience research. vol 92. issue 1. 2014-07-31. PMID:24123246. |
ceftriaxone also reduced (p < 0.024) spinal gfap and glast expression, and neuronal hyperexcitability in the spinal dorsal horn, restoring the proportion of spinal neurons classified as wide dynamic range to that of normal. |
2014-07-31 |
2023-08-12 |
rat |
| Yoki Nakamura, Norimitsu Morioka, Hiromi Abe, Fang Fang Zhang, Kazue Hisaoka-Nakashima, Keyue Liu, Masahiro Nishibori, Yoshihiro Nakat. Neuropathic pain in rats with a partial sciatic nerve ligation is alleviated by intravenous injection of monoclonal antibody to high mobility group box-1. PloS one. vol 8. issue 8. 2014-06-15. PMID:23991202. |
markers of astrocyte (glial fibrillary acidic protein (gfap)), microglia (ionized calcium binding adaptor molecule 1 (iba1)) and spinal neuron (cfos) activity were greatly increased in the ipsilateral dorsal horn side compared to the sham-operated side 21 days after psnl. |
2014-06-15 |
2023-08-12 |
rat |
| Ling Dong, Jenell R Smith, Beth A Winkelstei. Ketorolac reduces spinal astrocytic activation and PAR1 expression associated with attenuation of pain after facet joint injury. Journal of neurotrauma. vol 30. issue 10. 2013-12-23. PMID:23126437. |
forepaw mechanical allodynia was measured for 7 days, and spinal cord tissue was immunolabeled for glial fibrillary acidic protein (gfap) and par1 expression in the dorsal horn on day 7. |
2013-12-23 |
2023-08-12 |
rat |
| J Morgenweck, R B Griggs, R R Donahue, J E Zadina, B K Taylo. PPARγ activation blocks development and reduces established neuropathic pain in rats. Neuropharmacology. vol 70. 2013-11-26. PMID:23415633. |
intraperitoneal pioglitazone significantly reduced the nerve injury-induced up-regulation of cd11b, gfap, and p-p38 in the dorsal horn, indicating a mechanism of action involving spinal microglia and/or astrocyte activation. |
2013-11-26 |
2023-08-12 |
rat |
| W Dieb, A Hafid. Astrocytes are involved in trigeminal dynamic mechanical allodynia: potential role of D-serine. Journal of dental research. vol 92. issue 9. 2013-11-05. PMID:23881719. |
two weeks after cci-ion, an important reaction of astrocytes was present in the medullary dorsal horn (mdh), as revealed by an up-regulation of glial fibrillary acidic protein (gfap) in allodynic rats. |
2013-11-05 |
2023-08-12 |
rat |
| Jing Wang, Lulu Zeng, Quanhong Zhou, Yongming Xu, Shaofeng Pu, Wei Jiang, Xin Zhang, Dongping D. L6 spinal nerve ligation produces prolonged development of mechanical allodynia and gradual increase of GFAP on ipsilateral dorsal horn. Acta neurochirurgica. vol 155. issue 5. 2013-10-29. PMID:23355062. |
l6 spinal nerve ligation produces prolonged development of mechanical allodynia and gradual increase of gfap on ipsilateral dorsal horn. |
2013-10-29 |
2023-08-12 |
rat |
| Seo-Yeon Yoon, Caleb R Robinson, Haijun Zhang, Patrick M Doughert. Spinal astrocyte gap junctions contribute to oxaliplatin-induced mechanical hypersensitivity. The journal of pain. vol 14. issue 2. 2013-07-11. PMID:23374942. |
the expression of glial fibrillary acidic protein (gfap) in spinal dorsal horn was significantly increased at day 7 but recovered at day 14 after oxaliplatin treatment, suggesting a transient activation of spinal astrocytes by chemotherapy. |
2013-07-11 |
2023-08-12 |
Not clear |
| Jianrong Guo, Donglin Jia, Baowei Jin, Feng Xu, Xiaohong Yuan, Huachun She. Effects of glial cell line-derived neurotrophic factor intrathecal injection on spinal dorsal horn glial fibrillary acidic protein expression in a rat model of neuropathic pain. The International journal of neuroscience. vol 122. issue 7. 2012-10-23. PMID:22416765. |
the present study determined gfap expression in rat spinal dorsal horn following a spinal nerve ligation (snl). |
2012-10-23 |
2023-08-12 |
rat |
| Jianrong Guo, Donglin Jia, Baowei Jin, Feng Xu, Xiaohong Yuan, Huachun She. Effects of glial cell line-derived neurotrophic factor intrathecal injection on spinal dorsal horn glial fibrillary acidic protein expression in a rat model of neuropathic pain. The International journal of neuroscience. vol 122. issue 7. 2012-10-23. PMID:22416765. |
gfap expression was significantly less in the gdnf group compared with the snl group which lasted until 14 days after surgery, suggesting that rat spinal dorsal horn gfap expression contributes to snl-induced neuropathic pain. |
2012-10-23 |
2023-08-12 |
rat |
| Jianrong Guo, Donglin Jia, Baowei Jin, Feng Xu, Xiaohong Yuan, Huachun She. Effects of glial cell line-derived neurotrophic factor intrathecal injection on spinal dorsal horn glial fibrillary acidic protein expression in a rat model of neuropathic pain. The International journal of neuroscience. vol 122. issue 7. 2012-10-23. PMID:22416765. |
the mechanisms underlying gdnf alleviation of neuropathic pain were shown to be related to the gdnf inhibition of gfap expression in the spinal dorsal horn. |
2012-10-23 |
2023-08-12 |
rat |
| Jing Wang, Bin Geng, Hai-Li Shen, Xu Xu, Hong Wang, Cui-Fang Wang, Jing-Ling Ma, Zhi-Ping Wan. Amino acid transport system A is involved in inflammatory nociception in rats. Brain research. vol 1449. 2012-08-20. PMID:22373650. |
formalin (5%, 50μl) injected subcutaneously into the unilateral hindpaw pad induced typical biphase nociceptive behaviors, including licking/biting and flinching of the injected paw and an increase of glial fibrillary acid protein (gfap, an activated astrocyte marker) expression in spinal dorsal horn, and these effects could be attenuated by intrathecal injection of the competitive inhibitor of amino acid system a transporter, methylaminoisobutyric acid (meaib, 0.1, 0.3, 0.5, and 0.7mmol), in a dose-dependent manner. |
2012-08-20 |
2023-08-12 |
rat |