| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Megumi Sumizono, Yushin Yoshizato, Takaki Imai, Akira Tani, Kazuki Nakanishi, Nao Nojima, Shogo Kakimoto, Harutoshi Sakakim. Effects of Pain Relief Through Minimal Exercise Intervention in a Rat Model of Neuropathic Pain. Cureus. vol 16. issue 6. 2024-07-24. PMID:39044893. |
in the dorsal horn of the spinal cord, iba1 and gfap were significantly decreased in the ex group than in the no-ex group at five weeks post-cci. |
2024-07-24 |
2024-07-26 |
rat |
| Noémi Bencze, Bálint Scheich, Éva Szőke, Imola Wilhelm, Sándor Körmöndi, Bálint Botz, Zsuzsanna Helye. Osteosarcoma-Induced Pain Is Mediated by Glial Cell Activation in the Spinal Dorsal Horn, but Not Capsaicin-Sensitive Nociceptive Neurons: A Complex Functional and Morphological Characterization in Mice. Cancers. vol 16. issue 10. 2024-05-25. PMID:38791867. |
microglia activation was shown by the increased ionized calcium-binding adapter molecule 1 (iba1) immunopositivity on day 14 and astrocyte activation by the enhanced glial fibrillary acidic protein (gfap)-positive cell density on day 28 in the ipsilateral spinal dorsal horn. |
2024-05-25 |
2024-05-27 |
mouse |
| Valeria Mussetto, Aurora Moen, Lidia Trofimova, Jürgen Sandkühler, Roni Hogr. Differential activation of spinal and parabrachial glial cells in a neuropathic pain model. Frontiers in cellular neuroscience. vol 17. 2023-04-21. PMID:37082205. |
using immunohistochemical staining and confocal imaging, we found that cci caused a strong increase in the expression of the astrocytic marker gfap and the microglial marker iba1 in the ipsilateral spinal dorsal horn, with peak expression observed 1 week post-injury. |
2023-04-21 |
2023-08-14 |
rat |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Dalin Wang, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834838. |
this rat in vivo study determined whether ep injury results in spinal dorsal horn sensitization (substance p, subp), microglia (iba1) and astrocytes (gfap), and evaluated their relationship with pain-related behaviors, ivd degeneration, and spinal macrophages (cd68). |
2023-02-25 |
2023-08-14 |
rat |
| Xiaona Zhao, Xinxin Li, Huiling Guo, Panmei Liu, Minyu Ma, Yanping Wan. Resolvin D1 Attenuates Mechanical Allodynia after Burn Injury: Involvement of Spinal Glia, p38 MAPK, and BDNF/TrkB signaling. Molecular pain. 2023-02-11. PMID:36765459. |
pain behavior and the expression levels of spinal dorsal horn iba-1 (microglia marker), gfap (astrocyte marker), p-p38 mitogen-activated protein kinase (mapk), brain-derived neurotrophic factor (bdnf), and tropomyosin-related kinase b (trkb) were detected by behavioral and immunocytochemical assays. |
2023-02-11 |
2023-08-14 |
rat |
| Fei Yang, Jun-Jie Jing, Si-Yin Fu, Xiu-Zhu Su, Yu-Ling Zhong, Dong-Sheng Chen, Xiao-Zhi Wu, Yi-Qing Zo. Spinal MCP-1 Contributes to Central Post-stroke Pain by Inducing Central Sensitization in Rats. Molecular neurobiology. 2023-01-05. PMID:36602702. |
immunohistochemical staining and elisa were used to assess the expression changes of c-fos, iba-1, gfap, mcp-1, and ccr2 in the dorsal horn of the lumbar spinal cord following thalamic hemorrhage, and the involvement of spinal mcp-1 in cpsp was examined by performing intrathecal anti-mcp-1 mab injection to neutralize the spinal extracellular mcp-1. |
2023-01-05 |
2023-08-14 |
rat |
| Fei Yang, Jun-Jie Jing, Si-Yin Fu, Xiu-Zhu Su, Yu-Ling Zhong, Dong-Sheng Chen, Xiao-Zhi Wu, Yi-Qing Zo. Spinal MCP-1 Contributes to Central Post-stroke Pain by Inducing Central Sensitization in Rats. Molecular neurobiology. 2023-01-05. PMID:36602702. |
accompanying cpsp, the expression of c-fos, iba-1, and gfap in the lumbar spinal dorsal horn was significantly increased up to 28 days post-intra-thalamic collagenase microinjection. |
2023-01-05 |
2023-08-14 |
rat |
| Fei Yang, Jun-Jie Jing, Si-Yin Fu, Xiu-Zhu Su, Yu-Ling Zhong, Dong-Sheng Chen, Xiao-Zhi Wu, Yi-Qing Zo. Spinal MCP-1 Contributes to Central Post-stroke Pain by Inducing Central Sensitization in Rats. Molecular neurobiology. 2023-01-05. PMID:36602702. |
intrathecal injection of anti-mcp-1 mab was also able to reverse cpsp and reduce the expression of c-fos, iba-1, and gfap in the lumbar spinal dorsal horn. |
2023-01-05 |
2023-08-14 |
rat |
| Yaohua Chen, Yuping Li, Chunxiang Li, Dan Zhu, Oumei Cheng, Jian Cu. Dexmedetomidine alleviates pain in MPTP-treated mice by activating the AMPK/mTOR/NF-κB pathways in astrocytes. Neuroscience letters. 2022-10-25. PMID:36283628. |
immunofluorescence and western blotting were used to analyze the level of tyrosine hydroxylase (th) in the substantia nigra (sn) and the expression of c-fos, gfap, p-ampk, mtor, nf-κb, tnfα, and il-6 in the dorsal horn of the spinal cord (dhsc). |
2022-10-25 |
2023-08-14 |
mouse |
| Dan Zhu, Tingting Fan, Yaohua Chen, Xingyue Huo, Yuping Li, Danyong Liu, Yin Cai, Chi Wai Cheung, Jing Tang, Jian Cui, Zhengyuan Xi. CXCR4/CX43 Regulate Diabetic Neuropathic Pain via Intercellular Interactions between Activated Neurons and Dysfunctional Astrocytes during Late Phase of Diabetes in Rats and the Effects of Antioxidant N-Acetyl-L-Cysteine. Oxidative medicine and cellular longevity. vol 2022. 2022-07-08. PMID:35799894. |
furthermore, rats with dnp demonstrated downregulation of glial fibrillary acidic protein (gfap) as well as upregulation of c-fos in the spinal cord dorsal horn at the late phase compared to the controls, and upregulation of gfap and downregulation of c-fos were observed upon treatment with nac. |
2022-07-08 |
2023-08-14 |
human |
| Yonggang Xie, Zhen Li, Hongyu Xu, Jiahai Ma, Tao Li, Cunxian Shi, Jin Ji. Downregulation of Sp1 Inhibits the Expression of HDAC1/SOX10 to Alleviate Neuropathic Pain-like Behaviors after Spinal Nerve Ligation in Mice. ACS chemical neuroscience. 2022-04-14. PMID:35420781. |
immunofluorescence was performed to determine sp1, hdac1, and sox10 in the spinal dorsal horn neurons as well as the neuronal marker (neun), microglial marker (iba-1), and astrocyte marker (gfap). |
2022-04-14 |
2023-08-13 |
mouse |
| Zhi-Jun Weng, Shi-Xiu Hu, Fang Zhang, Zhi-Ying Zhang, Yun Zhou, Min Zhao, Yan Huang, Yu-Hu Xin, Huan-Gan Wu, Hui-Rong Li. Spinal cord astrocyte P2X7Rs mediate the inhibitory effect of electroacupuncture on visceral hypersensitivity of rat with irritable bowel syndrome. Purinergic signalling. 2022-04-07. PMID:35389158. |
p2x7 receptor antagonist a740003 can cooperate with ea to carry out analgesic effect in rats with visceral pain and downregulate the expression of nr1, nr2b, and gfap in spinal dorsal horn. |
2022-04-07 |
2023-08-13 |
rat |
| Sanjay Kumar, Manjula Vinaya. NADPH oxidase1 inhibition leads to regression of central sensitization during formalin induced acute nociception via attenuation of ERK1/2-NFκB signaling and glial activation. Neurochemistry international. vol 134. 2021-02-23. PMID:31891736. |
immunofluorescence and western blot analysis demonstrated decreased levels of nociceptive mediators like p-erk1/2, p-nfκb p65, iba1 and gfap in drg as well as in spinal cord dorsal horn; supporting anti-nociceptive potential of ml171. |
2021-02-23 |
2023-08-13 |
mouse |
| Gilson Gonçalves Dos Santos, Juan Miguel Jimenéz-Andrade, Sarah A Woller, Enriqueta Muñoz-Islas, Martha Beatriz Ramírez-Rosas, Nobuko Ohashi, Glaucilene Ferreira Catroli, Yuya Fujita, Tony L Yaksh, Maripat Cor. The neuropathic phenotype of the K/BxN transgenic mouse with spontaneous arthritis: pain, nerve sprouting and joint remodeling. Scientific reports. vol 10. issue 1. 2020-12-10. PMID:32973194. |
in dorsal horn, males and females show increased gfap |
2020-12-10 |
2023-08-13 |
mouse |
| Yoshiko Onodera, Megumi Kanao-Kanda, Hirotsugu Kanda, Tomoki Sasakawa, Hiroshi Iwasaki, Takayuki Kunisaw. Pregnancy suppresses neuropathic pain induced by chronic constriction injury in rats through the inhibition of TNF-α. Journal of pain research. vol 10. 2020-10-01. PMID:28331359. |
we examined the antinociceptive effect of pregnancy-induced analgesia in a neuropathic pain model and the expression of tumor necrosis factor (tnf)-α, glial fibrillary acidic protein (gfap), iba-1, and c-fos in the spinal dorsal horn just before parturition. |
2020-10-01 |
2023-08-13 |
rat |
| Hui Yang, Hui Yan, Xin Li, Jing Liu, Shousong Cao, Baisheng Huang, Dong Huang, Lixiang W. Inhibition of Connexin 43 and Phosphorylated NR2B in Spinal Astrocytes Attenuates Bone Cancer Pain in Mice. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:29867362. |
in the present study, we investigated the expressions of cx43, glial fibrillary acidic protein (gfap, a marker of astrocytes), and p-nr2b in the spinal dorsal horn (sdh) in a mouse model of bcp established by intra-femural inoculation of lewis lung carcinoma (llc) cells via intrathecal (ith) injection of the gj/hemichannel blocker carbenoxolone (carb) and the nmdar antagonist mk801, respectively. |
2020-10-01 |
2023-08-13 |
mouse |
| Constanza Stefania Meneses, Heine Yacob Müller, Daniel Eduardo Herzberg, Benjamín Uberti, Hedie Almagro Bustamante, Marianne Patricia Werne. Immunofluorescence characterization of spinal cord dorsal horn microglia and astrocytes in horses. PeerJ. vol 5. 2020-09-30. PMID:29085760. |
immunodetection of spinal cord dorsal horn astrocytes was done using a polyclonal goat antibody raised against glial fibrillary acidic protein (gfap) and a polyclonal rabbit antibody against connexin 43 (cx-43). |
2020-09-30 |
2023-08-13 |
human |
| Yu Zhong, Jialin Chen, Jing Chen, Yanhua Chen, Li Li, Yubo Xi. Crosstalk between Cdk5/p35 and ERK1/2 signalling mediates spinal astrocyte activity via the PPARγ pathway in a rat model of chronic constriction injury. Journal of neurochemistry. vol 151. issue 2. 2020-06-11. PMID:31314915. |
here, we quantified pain behaviour after cci; detected the localization of p35, cdk5, phosphorylated erk1/2 (perk1/2), phosphorylated peroxisome proliferator-activated receptor γ (ppparγ), neuronal nuclei (a neuronal marker), glial fibrillary acidic protein (gfap, an activated astrocyte marker) and ionized calcium binding adaptor molecule 1 (a microglial marker) in the dorsal horn using immunofluorescence; measured the protein levels of cdk5, p35, perk1/2, ppparγ and gfap using western blot analysis; and gauged the enzyme activity of cdk5/p35 kinase using a cdk5/p35 kinase activity assay kit. |
2020-06-11 |
2023-08-13 |
rat |
| Norimitsu Morioka, Keitaro Kodama, Mizuki Tomori, Kanade Yoshikawa, Munenori Saeki, Yoki Nakamura, Fang Fang Zhang, Kazue Hisaoka-Nakashima, Yoshihiro Nakat. Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice. Brain, behavior, and immunity. vol 78. 2020-04-13. PMID:30682503. |
intrathecal lps treatment in male mice induces hind paw mechanical hypersensitivity, and upregulation of il-1β mrna, il-6 mrna and glial fibrillary acidic protein (gfap) expression in spinal dorsal horn. |
2020-04-13 |
2023-08-13 |
mouse |
| Ke-Yu Xie, Qiang Wang, De-Jun Cao, Jia Liu, Xian-Feng Xi. Spinal astrocytic FGFR3 activation leads to mechanical hypersensitivity by increased TNF-α in spared nerve injury. International journal of clinical and experimental pathology. vol 12. issue 8. 2020-03-25. PMID:31934126. |
increased gfap expression in dorsal horn of the spinal cord indicated the participation of astrocyte in npp. |
2020-03-25 |
2023-08-13 |
Not clear |