| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Angeles Luque, Sara Morcuende, Blas Torres, Luis Herrer. Kv7/M channel dysfunction produces hyperexcitability in hippocampal CA1 pyramidal cells of Fmr1 knockout mice. The Journal of physiology. 2024-07-08. PMID:38976504. |
here we show that pyramidal cells (pcs) in the dorsal ca1 region of the hippocampus elicited a larger action potential (ap) number in response to suprathreshold stimulation in juvenile fmr1 knockout (ko) than wild-type (wt) mice. |
2024-07-08 |
2024-07-12 |
mouse |
| Bohan Zhang, Jingbao Zhang, Huan Chen, Dan Qiao, Fangzhen Guo, Xiangting Hu, Chao Qin, Xiaowen Jin, Kaixi Zhang, Chang Wang, Huixian Cui, Sha L. Role of FMRP in AKT/mTOR pathway-mediated hippocampal autophagy in fragile X syndrome. Progress in neuro-psychopharmacology & biological psychiatry. vol 134. 2024-06-08. PMID:38823765. |
the mouse hippocampal neuronal cell line ht22 with knockdown of fmr1 by lentivirus showed that the protein levels of p-ulk-1 and p62 were increased, whereas lc3ii/lc3i was unchanged. |
2024-06-08 |
2024-06-11 |
mouse |
| Bohan Zhang, Jingbao Zhang, Huan Chen, Dan Qiao, Fangzhen Guo, Xiangting Hu, Chao Qin, Xiaowen Jin, Kaixi Zhang, Chang Wang, Huixian Cui, Sha L. Role of FMRP in AKT/mTOR pathway-mediated hippocampal autophagy in fragile X syndrome. Progress in neuro-psychopharmacology & biological psychiatry. vol 134. 2024-06-08. PMID:38823765. |
to explore the mechanism by which fmrp deficiency inhibits autophagy, we examined the akt/mtor signaling pathway in the hippocampus of fmr1 ko mice, found that fmrp deficiency caused overactivation of the akt/mtor pathway. |
2024-06-08 |
2024-06-11 |
mouse |
| Cui Yang, Yu-Ting Huang, Yi-Fei Yao, Jun-Yi Fu, Yue-Sheng Lon. Hippocampal proteome comparison of infant and adult Fmr1 deficiency mice reveals adult-related changes associated with postsynaptic density. Journal of proteomics. 2024-05-26. PMID:38797434. |
hippocampal proteome comparison of infant and adult fmr1 deficiency mice reveals adult-related changes associated with postsynaptic density. |
2024-05-26 |
2024-05-31 |
mouse |
| Cui Yang, Yu-Ting Huang, Yi-Fei Yao, Jun-Yi Fu, Yue-Sheng Lon. Hippocampal proteome comparison of infant and adult Fmr1 deficiency mice reveals adult-related changes associated with postsynaptic density. Journal of proteomics. 2024-05-26. PMID:38797434. |
using comparative proteomic analysis, this study identified 105 differentially expressed proteins (deps) in the hippocampus of postnatal day 7 (p7) fmr1 |
2024-05-26 |
2024-05-31 |
mouse |
| Danijela Bataveljic, Helena Pivonkova, Vidian de Concini, Betty Hébert, Pascal Ezan, Sylvain Briault, Alexis-Pierre Bemelmans, Jacques Pichon, Arnaud Menuet, Nathalie Rouac. Astroglial Kir4.1 potassium channel deficit drives neuronal hyperexcitability and behavioral defects in Fragile X syndrome mouse model. Nature communications. vol 15. issue 1. 2024-04-28. PMID:38678030. |
viral delivery of kir4.1 channels specifically to hippocampal astrocytes from fmr1 knockout mice indeed rescues normal astrocyte potassium uptake, neuronal excitability, and cognitive and social performance. |
2024-04-28 |
2024-04-30 |
mouse |
| George Ntoulas, Charalampos Brakatselos, Gerasimos Nakas, Michail-Zois Asprogerakas, Foteini Delis, Leonidas J Leontiadis, George Trompoukis, Costas Papatheodoropoulos, Dimitrios Gkikas, Dimitrios Valakos, Giannis Vatsellas, Panagiotis K Politis, Alexia Polissidis, Katerina Antonio. Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function. Translational psychiatry. vol 14. issue 1. 2024-02-20. PMID:38378836. |
therefore, we employed a multi-level approach to study the behavioral profile and the glutamatergic and gabaergic neurotransmission status in pathophysiology-associated brain structures of fmr1 ko rats, including the recordings of evoked and spontaneous field potentials from hippocampal slices, paralleled with next-generation rna sequencing (rna-seq). |
2024-02-20 |
2024-02-23 |
mouse |
| Leonidas J Leontiadis, Panagiotis Felemegkas, George Trompoukis, Giota Tsotsokou, Athina Miliou, Evangelia Karagianni, Pavlos Rigas, Costas Papatheodoropoulo. Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat. Developmental neuroscience. 2024-02-18. PMID:38368859. |
septotemporal variation of information processing in the hippocampus of fmr1 ko rat. |
2024-02-18 |
2024-02-21 |
rat |
| Leonidas J Leontiadis, Panagiotis Felemegkas, George Trompoukis, Giota Tsotsokou, Athina Miliou, Evangelia Karagianni, Pavlos Rigas, Costas Papatheodoropoulo. Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat. Developmental neuroscience. 2024-02-18. PMID:38368859. |
method we used a fmr1 knock-out (ko) rat model of fxs and recordings of evoked field potentials from the ca1 field of transverse slices from both the dorsal and the ventral hippocampus of adult rats. |
2024-02-18 |
2024-02-21 |
rat |
| Heleen M Van't Spijker, Joel D Richte. FMRP regulation of aggrecan mRNA translation controls perineuronal net development. Journal of neurochemistry. 2024-01-15. PMID:38225196. |
examination of pnns by wfa staining at p14 and p42 in the hippocampus, somatosensory cortex, and retrosplenial cortex shows that they were reduced in these brain regions at p14 but mostly less so at p42 in fmr1 ko mice. |
2024-01-15 |
2024-01-18 |
mouse |
| Leonidas J Leontiadis, George Trompoukis, Panagiotis Felemegkas, Giota Tsotsokou, Athina Miliou, Costas Papatheodoropoulo. Increased Inhibition May Contribute to Maintaining Normal Network Function in the Ventral Hippocampus of a Fmr1-Targeted Transgenic Rat Model of Fragile X Syndrome. Brain sciences. vol 13. issue 11. 2023-11-25. PMID:38002556. |
using a fmr1 knock-out (ko) rat model of fxs, we found increased neuronal excitability in both the dorsal and ventral ko hippocampus and increased excitatory synaptic transmission in the dorsal hippocampus. |
2023-11-25 |
2023-11-28 |
rat |
| Kagistia Hana Utami, Nur Amirah Binte Muhammed Yusof, Marta Garcia-Miralles, Niels Henning Skotte, Srikanth Nama, Prabha Sampath, Sarah R Langley, Mahmoud A Poulad. Dysregulated COMT Expression in Fragile X Syndrome. Neuromolecular medicine. 2023-09-08. PMID:37684514. |
we observed a significantly reduced level of comt in in fxs human neural progenitors and neurons, as well as hippocampal neurons from fmr1 null mice. |
2023-09-08 |
2023-10-07 |
mouse |
| Caroline Zeitouny, Martin Korte, Kristin Michaelsen-Preuss. Prolonged and specific spatial training during adolescence reverses adult hippocampal network impairments in a mouse model of fragile X syndrome. Neurobiology of disease. 2023-07-29. PMID:37516137. |
a hallmark of fxs patients and the fxs mouse model (fmr1 ko) is an overabundance of immature appearing dendritic spines in the cortex and hippocampus which is associated with behavioral deficits. |
2023-07-29 |
2023-08-14 |
mouse |
| Caroline Zeitouny, Martin Korte, Kristin Michaelsen-Preuss. Prolonged and specific spatial training during adolescence reverses adult hippocampal network impairments in a mouse model of fragile X syndrome. Neurobiology of disease. 2023-07-29. PMID:37516137. |
intriguingly, only specific spatial training alleviated the cognitive symptoms and the spine phenotype shown in adult fmr1 ko mice suggesting that specific stimulation of hippocampal networks during development might be used in the future as a therapeutic strategy. |
2023-07-29 |
2023-08-14 |
mouse |
| Li Luo, Le Yang, Kun Zhang, Shi-Meng Zhou, Yan Wang, Liu-Kun Yang, Bin Feng, Shui-Bing Liu, Yu-Mei Wu, Ming-Gao Zhao, Qi Yan. Caveolin-1-Mediated Cholesterol Accumulation Contributes to Exaggerated mGluR-Dependent Long-Term Depression and Impaired Cognition in Fmr1 Knockout Mice. Molecular neurobiology. 2023-03-01. PMID:36854997. |
here, we found that only hippocampal mglur-ltd was exaggerated in adolescent fmr1 ko mice, while n-methyl-d-aspartate receptor (nmdar)-ltd was intact in mice of all ages. |
2023-03-01 |
2023-08-14 |
mouse |
| Li Luo, Le Yang, Kun Zhang, Shi-Meng Zhou, Yan Wang, Liu-Kun Yang, Bin Feng, Shui-Bing Liu, Yu-Mei Wu, Ming-Gao Zhao, Qi Yan. Caveolin-1-Mediated Cholesterol Accumulation Contributes to Exaggerated mGluR-Dependent Long-Term Depression and Impaired Cognition in Fmr1 Knockout Mice. Molecular neurobiology. 2023-03-01. PMID:36854997. |
moreover, hippocampal cav1 expression in fmr1 ko mice induced excessive endocytosis of the α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate (ampa) receptor subunit glua2. |
2023-03-01 |
2023-08-14 |
mouse |
| Jee-Yeon Hwang, Hannah R Monday, Jingqi Yan, Andrea Gompers, Adina R Buxbaum, Kirsty J Sawicka, Robert H Singer, Pablo E Castillo, R Suzanne Zuki. CPEB3-dependent increase in GluA2 subunits impairs excitatory transmission onto inhibitory interneurons in a mouse model of fragile X. Cell reports. vol 39. issue 10. 2022-06-08. PMID:35675768. |
using single-molecule mrna detection, we show that mrna encoding the ampar subunit glua2 (but not glua1) is elevated in dendrites and at transcription sites of hippocampal neurons of fmr1 ko mice, indicating elevated glua2 transcription. |
2022-06-08 |
2023-08-14 |
mouse |
| Anna Delprato, Emily Xiao, Devika Mano. Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment. Behavioral and brain functions : BBF. vol 18. issue 1. 2022-05-19. PMID:35590332. |
in this systematic review we examine the roles of the dcx, comt and fmr1 genes in the context of hippocampal neurogenesis with respect to these disorders with the aim of identifying important hubs and signaling pathways that may bridge these conditions. |
2022-05-19 |
2023-08-13 |
Not clear |
| Sahar Javadi, Yue Li, Jie Sheng, Lucy Zhao, Yao Fu, Daifeng Wang, Xinyu Zha. Sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mouse model of fragile X syndrome. BMC medicine. vol 20. issue 1. 2022-05-13. PMID:35549943. |
we have previously shown that fmr1 represses the levels and activities of ubiquitin ligase mdm2 in young adult fmr1-deficient mice, and treatment by a mdm2 inhibitor nutlin-3 rescues both hippocampal neurogenic and cognitive deficits in fmr1-deficient mice when analyzed shortly after the administration. |
2022-05-13 |
2023-08-13 |
mouse |
| Jessica L Armstrong, Clinton E Cana. Targeting 5-HT FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554052. |
for example, we show significantly decreased pnn density in hippocampal ca2 in juvenile fmr1 knockout (ko) mice, a neural system critical for social memory, compared to wild-type (wt) mice (p=0.0043, n=8 and 7, respectively). |
2022-05-13 |
2023-08-13 |
mouse |