| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zacharias Kohl, Nada Ben Abdallah, Jonathan Vogelgsang, Lucas Tischer, Janina Deusser, Davide Amato, Scott Anderson, Christian P Müller, Olaf Riess, Eliezer Masliah, Silke Nuber, Jürgen Winkle. Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease. Neurobiology of disease. vol 85. 2016-09-21. PMID:26523794. |
the adult hippocampal dentate gyrus (dg), a unique niche of the forebrain continuously generating new neurons, may particularly present enhanced susceptibility towards accumulating alpha-synuclein levels. |
2016-09-21 |
2023-08-13 |
human |
| Zacharias Kohl, Nada Ben Abdallah, Jonathan Vogelgsang, Lucas Tischer, Janina Deusser, Davide Amato, Scott Anderson, Christian P Müller, Olaf Riess, Eliezer Masliah, Silke Nuber, Jürgen Winkle. Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease. Neurobiology of disease. vol 85. 2016-09-21. PMID:26523794. |
at the age of four months, thus prior to the occurrence of the motor phenotype, we observed a profoundly impaired dendritogenesis of neuroblasts in the hippocampal dg resulting in severely reduced survival of adult new-born neurons. |
2016-09-21 |
2023-08-13 |
human |
| Laura E Ramos-Languren, Rigoberto González-Piña, Sergio Montes, Norma Chávez-García, Alberto Ávila-Luna, Verónica Barón-Flores, Camilo Río. Sensorimotor recovery from cortical injury is accompanied by changes on norepinephrine and serotonin levels in the dentate gyrus and pons. Behavioural brain research. vol 297. 2016-09-20. PMID:26454240. |
therefore, we determined the ne and 5-ht content, in the pons and hippocampal dentate gyrus (dg) as well as motor deficit and spontaneous activity in rats after 3, 10 and 20 days cortical iron injection. |
2016-09-20 |
2023-08-13 |
rat |
| Adam K Walker, Kalyan Tripathy, Clark R Restrepo, Guanghui Ge, Yan Xu, Linda K Kwong, John Q Trojanowski, Virginia M-Y Le. An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice. Human molecular genetics. vol 24. issue 25. 2016-09-20. PMID:26476406. |
remarkably, the hippocampus showed progressive neuron loss and astrogliosis in the dentate gyrus (dg). |
2016-09-20 |
2023-08-13 |
mouse |
| Takayuki Nakajima, Ryusuke Hata, Tomohiro Kondo, Shigeo Takenak. Proteomic analysis of the hippocampus in naïve and ischemic-preconditioned rat. Journal of the neurological sciences. vol 358. issue 1-2. 2016-09-15. PMID:26342941. |
the hippocampus exhibits regional differences in vulnerability to ischemia, wherein pyramidal cells in the ca1 region are vulnerable to ischemia while pyramidal cells in the ca3 region and granule cells in the dentate gyrus (dg) region are relatively ischemia resistant. |
2016-09-15 |
2023-08-13 |
rat |
| Dong Won Kim, Jeong-Hwi Cho, Geum-Sil Cho, In Hye Kim, Joon Ha Park, Ji Hyeon Ahn, Bai Hui Chen, Bich-Na Shin, Hyun-Jin Tae, Seongkweon Hong, Jun Hwi Cho, Young-Myeong Kim, Moo-Ho Won, Jae-Chul Le. Hyperthermic preconditioning severely accelerates neuronal damage in the gerbil ischemic hippocampal dentate gyrus via decreasing SODs expressions. Journal of the neurological sciences. vol 358. issue 1-2. 2016-09-15. PMID:26365286. |
it is well known that neurons in the dentate gyrus (dg) of the hippocampus are resistant to short period of ischemia. |
2016-09-15 |
2023-08-13 |
Not clear |
| Guoxi Li, Libin Zhou, Ying Zhu, Conghui Wang, Sha Sha, Xunde Xian, Yong Ji, George Liu, Ling Che. Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARγ. Disease models & mechanisms. vol 8. issue 12. 2016-09-12. PMID:26398946. |
the present study investigated the influence of seipin deficiency on adult neurogenesis in the hippocampal dentate gyrus (dg) and the underlying mechanisms of the effects. |
2016-09-12 |
2023-08-13 |
mouse |
| Bing Chun Yan, Yong Hwan Jeon, Joon Ha Park, In Hye Kim, Jeong-Hwi Cho, Ji Hyeon Ahn, Bai Hui Chen, Hyun-Jin Tae, Jae-Chul Lee, Ji Yun Ahn, Dong Won Kim, Jun Hwi Cho, Moo-Ho Won, Seongkweon Hon. Increased cyclooxygenase-2 and nuclear factor-κB/p65 expression in mouse hippocampi after systemic administration of tetanus toxin. Molecular medicine reports. vol 12. issue 6. 2016-09-09. PMID:26498481. |
the present study investigated changes in inflammatory mediators in the mouse hippocampus proper (ca1‑3 regions) and dentate gyrus (dg) after tet treatment. |
2016-09-09 |
2023-08-13 |
mouse |
| Saba Shahin, Somanshu Banerjee, Surya Pal Singh, Chandra Mohini Chaturved. 2.45 GHz Microwave Radiation Impairs Learning and Spatial Memory via Oxidative/Nitrosative Stress Induced p53-Dependent/Independent Hippocampal Apoptosis: Molecular Basis and Underlying Mechanism. Toxicological sciences : an official journal of the Society of Toxicology. vol 148. issue 2. 2016-09-08. PMID:26396154. |
we have checked the alterations in hippocampal oxidative/nitrosative stress, neuronal morphology, and expression of pro-apoptotic proteins (p53 and bax), inactive executioner caspase- (pro-caspase-3), and uncleaved poly (adp-ribose) polymerase-1 in the hippocampal subfield neuronal and nonneuronal cells (dg, ca1, ca2, and ca3). |
2016-09-08 |
2023-08-13 |
mouse |
| Taito Matsuda, Kinichi Nakashim. Bidirectional communication between the innate immune and nervous systems for homeostatic neurogenesis in the adult hippocampus. Neurogenesis (Austin, Tex.). vol 2. issue 1. 2016-09-08. PMID:27604264. |
a population of proliferating neural stem/progenitor cells located in the subgranular zone of the adult hippocampal dentate gyrus (dg) gives rise to new neurons continuously throughout life, and this process is referred to as adult hippocampal neurogenesis. |
2016-09-08 |
2023-08-13 |
Not clear |
| Yezheng Tao, Li Ma, Zhaohui Liao, Qiumin Le, Jialing Yu, Xing Liu, Haohong Li, Yuejun Chen, Ping Zheng, Zhengang Yang, Lan M. Astroglial β-Arrestin1-mediated Nuclear Signaling Regulates the Expansion of Neural Precursor Cells in Adult Hippocampus. Scientific reports. vol 5. 2016-08-31. PMID:26500013. |
taken together, our data suggest that β-arr1 mediated nuclear signaling regulates the production of excretive factors derived from niche astrocytes and expansion of neural precursors in dg, thus maintaining homeostasis of adult hippocampal neurogenesis. |
2016-08-31 |
2023-08-13 |
mouse |
| Kathleen McAvoy, Craig Russo, Shannen Kim, Genelle Rankin, Amar Saha. Fluoxetine induces input-specific hippocampal dendritic spine remodeling along the septotemporal axis in adulthood and middle age. Hippocampus. vol 25. issue 11. 2016-08-29. PMID:25850664. |
our studies reveal that while chronic fluoxetine fails to augment adult hippocampal neurogenesis in middle age, the middle-aged hippocampus retains high sensitivity to changes in the dentate gyrus (dg) such as dematuration, hypoactivation, and increased glutamic acid decarboxylase 67 (gad67) expression. |
2016-08-29 |
2023-08-13 |
mouse |
| Sophie Tronel, Vanessa Charrier, Cyrille Sage, Marlene Maitre, Thierry Leste-Lasserre, Djoher N Abrou. Adult-born dentate neurons are recruited in both spatial memory encoding and retrieval. Hippocampus. vol 25. issue 11. 2016-08-29. PMID:25913775. |
adult neurogenesis occurs in the dentate gyrus (dg) of the hippocampus, which is a key structure in learning and memory. |
2016-08-29 |
2023-08-13 |
rat |
| Giuseppe Musumeci, Paola Castrogiovanni, Sergio Castorina, Rosa Imbesi, Marta Anna Szychlinska, Soraya Scuderi, Carla Loreto, Salvatore Giunt. Changes in serotonin (5-HT) and brain-derived neurotrophic factor (BDFN) expression in frontal cortex and hippocampus of aged rat treated with high tryptophan diet. Brain research bulletin. vol 119. issue Pt A. 2016-08-29. PMID:26444078. |
interestingly, immunohistochemical analyses confirmed that high trp diet significantly elevates the number of 5-ht immunoreactive fibers in both brain areas tested and this correlated with bdnf increase in the fc and hippocampal regions ca1, ca2, ca3 and a strikingly down-regulation of neurotrophin levels in the dentate gyrus (dg) of aged rats. |
2016-08-29 |
2023-08-13 |
rat |
| Majid Motaghinejad, Manijeh Motevalian, Behnaz Shaba. Effects of chronic treatment with methylphenidate on oxidative stress and inflammation in hippocampus of adult rats. Neuroscience letters. vol 619. 2016-08-24. PMID:26687276. |
10 and 20mg/kg of mph change cell density and morphology of cells in dentate gyrus (dg) and ca1 areas of hippocampus. |
2016-08-24 |
2023-08-13 |
rat |
| Raffaella Alò, Maria Mele, Gilda Fazzari, Ennio Avolio, Marcello Canonac. Exposure to sub-chronic unpredictable stress accounts for antidepressant-like effects in hamsters treated with BDNF and CNQX. Brain research bulletin. vol 118. 2016-08-22. PMID:26409118. |
sub-chronic administration of bdnf in the hippocampal dentate gyrus (dg) of stressed hamsters was responsible for very evident (p<0.001) sucrose consumption along with notably elevated swimming bouts and reduced immobility states in the forced swim test (fst). |
2016-08-22 |
2023-08-13 |
Not clear |
| E Anne Martin, Shruti Muralidhar, Zhirong Wang, Diégo Cordero Cervantes, Raunak Basu, Matthew R Taylor, Jennifer Hunter, Tyler Cutforth, Scott A Wilke, Anirvan Ghosh, Megan E William. The intellectual disability gene Kirrel3 regulates target-specific mossy fiber synapse development in the hippocampus. eLife. vol 4. 2016-08-22. PMID:26575286. |
in this study, we demonstrate kirrel3 regulates target-specific synapse formation at hippocampal mossy fiber (mf) synapses, which connect dentate granule (dg) neurons to both ca3 and gabaergic neurons. |
2016-08-22 |
2023-08-13 |
mouse |
| M Dolores Muñoz, Mónica Antolín-Vallespín, Silvia Tapia-González, Amelia Sánchez-Capel. Smad3 deficiency inhibits dentate gyrus LTP by enhancing GABAA neurotransmission. Journal of neurochemistry. vol 137. issue 2. 2016-08-22. PMID:26826552. |
the long-term potentiation (ltp) induced in the dg by high-frequency stimulation of the medial perforant pathway is abolished in the dg of smad3-deficient mice, but not in the ca1 hippocampal region. |
2016-08-22 |
2023-08-13 |
mouse |
| M Dolores Muñoz, Mónica Antolín-Vallespín, Silvia Tapia-González, Amelia Sánchez-Capel. Smad3 deficiency inhibits dentate gyrus LTP by enhancing GABAA neurotransmission. Journal of neurochemistry. vol 137. issue 2. 2016-08-22. PMID:26826552. |
hence, smad3 signaling in the dg appears to be necessary to induce ltp by regulating gabaa neurotransmission, suggesting a central role of this intracellular signaling pathway in the hippocampal brain plasticity related to learning and memory. |
2016-08-22 |
2023-08-13 |
mouse |
| Junhong Zhao, Minghong Sui, Xiao Lü, Dongmei Jin, Zhiqiang Zhuang, Tiebin Ya. Electroacupuncture promotes neural stem cell proliferation and neurogenesis in the dentate gyrus of rats following stroke via upregulation of Notch1 expression. Molecular medicine reports. vol 12. issue 5. 2016-08-15. PMID:26328605. |
reverse transcription quantitative polymerase chain reaction (rt‑qpcr) and western blot analyses were performed to detect the expression levels of notch1 and hes1 in the dentate gyrus (dg) of the hippocampus of rats following mcao. |
2016-08-15 |
2023-08-13 |
rat |